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Article ; Online: Factors Affecting Depression in Middle-Aged and Elderly Men Living Alone

Hye-Seung Choi / Jong-Eun Lee

American Journal of Men's Health, Vol

A Cross-Sectional Path Analysis Model

2022 Volume 16

Abstract: The main objectives of this cross-sectional study were to determine the relationship between socioeconomic status (SES) and depression and to estimate the mediating effects of social network satisfaction, self-esteem, and perceived health status among ... ...

Abstract	The main objectives of this cross-sectional study were to determine the relationship between socioeconomic status (SES) and depression and to estimate the mediating effects of social network satisfaction, self-esteem, and perceived health status among middle-aged and elderly men living alone, based on the reserve capacity model. Secondary data from a sample of 394 middle-aged and elderly men aged 45 years or older from the 15th Korea Welfare Panel Study (KOWEPS) were analyzed. A path analysis model was constructed to evaluate the relationship among SES, social network satisfaction, self-esteem, perceived health status, and depression. The path analysis exhibited significant direct effects of social network satisfaction, self-esteem, and perceived health status on depression and significant indirect effects of SES on depression. There was no direct effect of SES on depression. Social network satisfaction and self-esteem had significant mediating effects of SES on depression. Among middle-aged and elderly men, intrapersonal reserves, which are psychosocial factors including social network satisfaction, self-esteem, and perceived health status, showed more association with depression than tangible reserves such as SES. This suggests that interventions promoting self-esteem and perceived health status could prevent depression.
Keywords	Medicine ; R
Subject code	300
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors Affecting COVID-19 Preventive Behaviors of Young Adults based on eHealth Literacy and the Health Belief Model

Hye Seung Choi PhD, RN / Jong-Eun Lee PhD, RN

Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol

A Cross-Sectional Study

2023 Volume 60

Abstract: Following the COVID-19 pandemic, disease prevention and preventive behaviors have become crucial for public health. In young adults, the internet is a popular source of health information. However, research that explores the factors associated with ... ...

Abstract	Following the COVID-19 pandemic, disease prevention and preventive behaviors have become crucial for public health. In young adults, the internet is a popular source of health information. However, research that explores the factors associated with disease preventive behaviors based on the eHealth literacy (eHL) and the Health Belief Model (HBM) in young adults is lacking. A cross-sectional study design was used. Snowball sampling was used to recruit the participants through social network services. Proportionate stratified sampling was applied according to age, sex, and education level to mitigate sampling bias. The URL link for the online survey was provided via their mobile phones. A total of 324 participants, aged 20 to 39, completed the structured questionnaires (response rate = 98.2%). Frequency and descriptive statistical analyses, independent t -tests, one-way analyses of variance, Pearson’s correlation coefficients, and multiple linear regression analyses were performed. Factors associated with COVID-19 preventive behaviors were COVID-19-related eHL (β = .376, P < .001) and self-efficacy (β = .221, P < .001), which were positively associated with COVID-19 preventive behaviors. Boosting self-efficacy and the ability to find, evaluate, and apply health information with sufficient evidence from the Internet can improve COVID-19 preventive behaviors. The government and healthcare personnel should consider psychological factors such as self-efficacy when developing COVID-19 disease prevention behavioral guidelines for the Internet.
Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disrupted stepwise functional brain organization in overweight individuals

Hyebin Lee / Junmo Kwon / Jong-eun Lee / Bo-yong Park / Hyunjin Park

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 9

Abstract: Hyebin Lee et al. use a stepwise functional connectivity technique to study differences in functional connectivity between overweight and healthy weight individuals. They find disrupted functional network organization along the hierarchical axis of the ... ...

Abstract	Hyebin Lee et al. use a stepwise functional connectivity technique to study differences in functional connectivity between overweight and healthy weight individuals. They find disrupted functional network organization along the hierarchical axis of the brain in overweight individuals that relates to behavioral traits
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pathophysiology and Role of Coronary CT Angiography in Stable Angina

Jong Eun Lee / Hye Mi Park / Yongwhan Lim / Won GI Jeong / Yun-Hyeon Kim

대한영상의학회지, Vol 83, Iss 1, Pp 42-

2022 Volume 53

Abstract: The clinical concept of coronary artery disease (CAD) has seen a paradigm shift over the last decade. CAD is mostly a progressive disease, and patients with CAD can develop acute coronary syndromes at any point in disease progression. In this clinical ... ...

Abstract	The clinical concept of coronary artery disease (CAD) has seen a paradigm shift over the last decade. CAD is mostly a progressive disease, and patients with CAD can develop acute coronary syndromes at any point in disease progression. In this clinical context, a new term, “chronic coronary syndrome,” was published in the 2019 European Society of Cardiology guidelines, reflecting the importance of early diagnosis and active management. Recent advances have been made in the evaluation of CAD using coronary CT angiography (CCTA). The clinical usefulness of CCTA in patients with stable angina or chronic coronary syndrome begins with the detection of early asymptomatic CAD. The characterization of atherosclerotic plaque and its role in determining treatment strategies for CAD have been demonstrated for all stages of the disease. This review describes the pathophysiology of stable angina to aid in the understanding of the clinical applications of CCTA.
Keywords	angina ; stable ; plaque ; atherosclerotic ; coronary angiography ; computed tomography angiography ; coronary artery disease ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	The Korean Society of Radiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinicoradiological Features of Pulmonary Cryptococcosis in Immunocompetent Patients

Hong Seok Choi / Yun-Hyeon Kim / Won Gi Jeong / Jong Eun Lee / Hye Mi Park

Journal of the Korean Society of Radiology, Vol 84, Iss 1, Pp 253-

2023 Volume 262

Abstract: Purpose To assess the clinicoradiological features of pulmonary cryptococcosis in immunocompetent patients. Materials and Methods This retrospective study included immunocompetent patients who had been diagnosed with pulmonary cryptococcosis on the ... ...

Abstract	Purpose To assess the clinicoradiological features of pulmonary cryptococcosis in immunocompetent patients. Materials and Methods This retrospective study included immunocompetent patients who had been diagnosed with pulmonary cryptococcosis on the histopathologic exam and underwent chest CT between January 2008 and November 2019. Imaging features were divided into major imaging patterns, distributions, and ancillary imaging findings. Univariable analysis was performed to evaluate clinicoradiological features according to the presence of serum cryptococcal antigen. Results Thirty-one patients were evaluated (mean age: 60 years, range: 19–78 years). A single nodular lesion confined to a single lobe was the most common imaging pattern (14/31, 45.2%). Serum cryptococcal antigen tests were performed in 19 patients (19/31, 61.3%). The presence of serum cryptococcal antigen was observed in six patients (6/19, 31.6%), all of whom showed a consolidation-dominant pattern. The presence of serum cryptococcal antigen was significantly associated with the consolidationdominant pattern compared to those associated with a nodule-dominant pattern (p = 0.011). Conclusion A combination of CT findings of consolidation and a positive serum cryptococcal antigen test may be helpful for diagnosing pulmonary cryptococcosis in immunocompetent patients.
Keywords	immunocompetence ; cryptococcosis ; lung ; multidetector computed tomography ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610 ; 616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	The Korean Society of Radiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mediastinal Teratoma

Sang Gyun Kim / Won Gi Jeong / Sang Yun Song / Taebum Lee / Jong Eun Lee / Hye Mi Park / Yun-Hyeon Kim

대한영상의학회지, Vol 83, Iss 3, Pp 597-

A Pictorial Essay

2022 Volume 607

Abstract: The mediastinum is the most prevalent site of extragonadal teratomas. Patients with mediastinal mature teratomas are usually young adults, and the condition does not show significant sexual differences. Mediastinal teratomas are mostly located in the ... ...

Abstract	The mediastinum is the most prevalent site of extragonadal teratomas. Patients with mediastinal mature teratomas are usually young adults, and the condition does not show significant sexual differences. Mediastinal teratomas are mostly located in the anterior mediastinum. Patients are usually asymptomatic, although they can have several complications when the teratomas become large or rupture. Most mediastinal teratomas can be diagnosed using CT. Diagnosing ruptured or malignant teratomas is challenging because of their atypical clinical and radiological presentations. In this article, we describe various manifestations of mediastinal teratomas, with an emphasis on radiologic features.
Keywords	mediastinum ; teratoma ; malignant teratoma ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	The Korean Society of Radiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Radiomics Approach on Chest CT Distinguishes Primary Lung Cancer from Solitary Lung Metastasis in Colorectal Cancer Patients

Jong Eun Lee / Luu Ngoc Do / Won Gi Jeong / Hyo Jae Lee / Kum Ju Chae / Yun Hyeon Kim / Ilwoo Park

Journal of Personalized Medicine, Vol 12, Iss 1859, p

2022 Volume 1859

Abstract: Purpose: This study utilized a radiomics approach combined with a machine learning algorithm to distinguish primary lung cancer (LC) from solitary lung metastasis (LM) in colorectal cancer (CRC) patients with a solitary pulmonary nodule (SPN). Materials ... ...

Abstract	Purpose: This study utilized a radiomics approach combined with a machine learning algorithm to distinguish primary lung cancer (LC) from solitary lung metastasis (LM) in colorectal cancer (CRC) patients with a solitary pulmonary nodule (SPN). Materials and Methods: In a retrospective study, 239 patients who underwent chest computerized tomography (CT) at three different institutions between 2011 and 2019 and were diagnosed as primary LC or solitary LM were included. The data from the first institution were divided into training and internal testing datasets. The data from the second and third institutions were used as an external testing dataset. Radiomic features were extracted from the intra and perinodular regions of interest (ROI). After a feature selection process, Support vector machine (SVM) was used to train models for classifying between LC and LM. The performances of the SVM classifiers were evaluated with both the internal and external testing datasets. The performances of the model were compared to those of two radiologists who reviewed the CT images of the testing datasets for the binary prediction of LC versus LM. Results: The SVM classifier trained with the radiomic features from the intranodular ROI and achieved the sensitivity/specificity of 0.545/0.828 in the internal test dataset, and 0.833/0.964 in the external test dataset, respectively. The SVM classifier trained with the combined radiomic features from the intra- and perinodular ROIs achieved the sensitivity/specificity of 0.545/0.966 in the internal test dataset, and 0.833/1.000 in the external test data set, respectively. Two radiologists demonstrated the sensitivity/specificity of 0.545/0.966 and 0.636/0.828 in the internal test dataset, and 0.917/0.929 and 0.833/0.929 in the external test dataset, which were comparable to the performance of the model trained with the combined radiomics features. Conclusion: Our results suggested that the machine learning classifiers trained using radiomics features of SPN in CRC patients can be used ...
Keywords	solitary pulmonary nodule ; colorectal neoplasms ; lung neoplasms ; machine learning ; computed tomography ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lipid Emulsion Improves Functional Recovery in an Animal Model of Stroke

Motomasa Tanioka / Wyun Kon Park / Joohyun Park / Jong Eun Lee / Bae Hwan Lee

International Journal of Molecular Sciences, Vol 21, Iss 7373, p

2020 Volume 7373

Abstract: Stroke is a life-threatening condition that leads to the death of many people around the world. Reperfusion injury after ischemic stroke is a recurrent problem associated with various surgical procedures that involve the removal of blockages in the brain ...

Abstract	Stroke is a life-threatening condition that leads to the death of many people around the world. Reperfusion injury after ischemic stroke is a recurrent problem associated with various surgical procedures that involve the removal of blockages in the brain arteries. Lipid emulsion was recently shown to attenuate ischemic reperfusion injury in the heart and to protect the brain from excitotoxicity. However, investigations on the protective mechanisms of lipid emulsion against ischemia in the brain are still lacking. This study aimed to determine the neuroprotective effects of lipid emulsion in an in vivo rat model of ischemic reperfusion injury through middle cerebral artery occlusion (MCAO). Under sodium pentobarbital anesthesia, rats were subjected to MCAO surgery and were administered with lipid emulsion through intra-arterial injection during reperfusion. The experimental animals were assessed for neurological deficit wherein the brains were extracted at 24 h after reperfusion for triphenyltetrazolium chloride staining, immunoblotting and qPCR. Neuroprotection was found to be dosage-dependent and the rats treated with 20% lipid emulsion had significantly decreased infarction volumes and lower Bederson scores. Phosphorylation of Akt and glycogen synthase kinase 3-β (GSK3-β) were increased in the 20% lipid-emulsion treated group. The Wnt-associated signals showed a marked increase with a concomitant decrease in signals of inflammatory markers in the group treated with 20% lipid emulsion. The protective effects of lipid emulsion and survival-related expression of genes such as Akt, GSK-3β, Wnt1 and β-catenin were reversed by the intra-peritoneal administration of XAV939 through the inhibition of the Wnt/β-catenin signaling pathway. These results suggest that lipid emulsion has neuroprotective effects against ischemic reperfusion injury in the brain through the modulation of the Wnt signaling pathway and may provide potential insights for the development of therapeutic targets.
Keywords	neuroprotection ; stroke ; ischemia ; middle cerebral artery occlusion ; reperfusion injury ; lipid emulsion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adiponectin

Jong Youl Kim / Sumit Barua / Ye Jun Jeong / Jong Eun Lee

International Journal of Molecular Sciences, Vol 21, Iss 6419, p

The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease

2020 Volume 6419

Abstract: Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer’s disease (AD). AD, a degenerative brain disease, is the most common cause of dementia and is characterized by the presence of extracellular amyloid ...

Abstract	Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer’s disease (AD). AD, a degenerative brain disease, is the most common cause of dementia and is characterized by the presence of extracellular amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles disposition. Some studies have recently demonstrated that Aβ and tau cannot fully explain the pathophysiological development of AD and that metabolic disease factors, such as insulin, adiponectin, and antioxidants, are important for the sporadic onset of nongenetic AD. Obesity prevention and treatment can be an efficacious and safe approach to AD prevention. Adiponectin is a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation. It has been shown to be inversely correlated with adipose tissue dysfunction and may enhance the risk of AD because a range of neuroprotection adiponectin mechanisms is related to AD pathology alleviation. In this study, we summarize the recent progress that addresses the beneficial effects and potential mechanisms of adiponectin in AD. Furthermore, we review recent studies on the diverse medications of adiponectin that could possibly be related to AD treatment, with a focus on their association with adiponectin. A better understanding of the neuroprotection roles of adiponectin will help clarify the precise underlying mechanism of AD development and progression.
Keywords	Alzheimer’s disease ; metabolic disease ; adiponectin ; insulin ; antioxidants ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening

Eun Sol Lim / Sung Mo Kim / Sang Soo Shin / Suk Hee Heo / Jong Eun Lee / Yong Yeon Jeong

대한영상의학회지, Vol 82, Iss 5, Pp 1218-

A Comparison to Conventional Dynamic Contrast-Enhanced MRI

2021 Volume 1230

Abstract: Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high- ... ...

Abstract	Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total of 201 consecutive patients at high-risk for HCC, who underwent 3T liver MRI, were included in this retrospective study. The AMRI protocol comprised T2-weighted imaging, hepatobiliary phase imaging after GA injection, and diffusion-weighted imaging. For each patient, two AMRI and CMRI image sets were independently reviewed by two radiologists. Inter-reader agreement was assessed using Cohen’s kappa value. A composite reference standard was used to determine the diagnostic performance of each image set for each reader. Results A total of 93 HCCs were detected in 79 patients. The inter-reader agreement was almost perfect for both image sets (κ = 0.839, 0.948). In AMRI, the per-patient sensitivity and negative predictive values (NPV) were 94.9% and 96.4%, respectively. In CMRI, the per-patient sensitivity and NPV were 96.2% and 97.5%, respectively. Conclusion AMRI, using only three sequences, had a comparable diagnostic performance to CMRI in screening early-stage HCC. AMRI could be an alternative HCC screening tool for highrisk HCC patients.
Keywords	hepatocellular carcinoma ; liver ; magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	The Korean Society of Radiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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