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  1. Article ; Online: CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation

    Jong Hoon Won / Jacob S. Choi / Joon-Il Jun

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Intestinal stem cells contribute to homeostasis through a balance between self-renewal and differentiation. Here the authors show that CCN1 is an intestinal stem cell niche factor that activates integrin αvβ3/αvβ5 signaling to regulate proliferation and ... ...

    Abstract Intestinal stem cells contribute to homeostasis through a balance between self-renewal and differentiation. Here the authors show that CCN1 is an intestinal stem cell niche factor that activates integrin αvβ3/αvβ5 signaling to regulate proliferation and differentiation through distinct downstream pathways.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Feasibility Analysis of GPS L2C Signals for SSV Receivers on SBAS GEO Satellites

    Hak-Beom Lee / Ki-Ho Kwon / Jong-Hoon Won

    Remote Sensing, Vol 14, Iss 5329, p

    2022  Volume 5329

    Abstract: This paper analyzes the feasibility of Global Positioning System (GPS) L2C signals for use with the space service volume (SSV) receiver on satellite-based augmentation system (SBAS) geostationary orbit (GEO) satellites equipped with L1 and L5 band signal ...

    Abstract This paper analyzes the feasibility of Global Positioning System (GPS) L2C signals for use with the space service volume (SSV) receiver on satellite-based augmentation system (SBAS) geostationary orbit (GEO) satellites equipped with L1 and L5 band signal transmitters. Augmentation signals transmitted at L1 and L5 bands from SBAS GEO satellites may interfere with the same bands of SSV GPS-receiving antennas. Therefore, the use of L1 and L5 band signals for the GPS SSV receiver on SBAS GEO satellites is prohibited, and the GPS L2C signal is selected. Unlike ground systems, the various constraints of space exploration in GEO should be considered. Therefore, signal feasibility analysis is essential before considering the use of new global navigation satellite system (GNSS) signals in GEO. This paper presents satellite visibility, dilution of precision, and navigation solution error when the GPS L2C signal is used in GEO satellites through numerical simulation.
    Keywords Global Positioning System (GPS) L2C ; space service volume (SSV) ; satellite-based augmentation system (SBAS) ; geostationary orbit (GEO) ; Science ; Q
    Subject code 629
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: GNSS Signal Availability Analysis in SSV for Geostationary Satellites Utilizing multi-GNSS with First Side Lobe Signal over the Korean Region

    Gun-Hoon Ji / Ki-Ho Kwon / Jong-Hoon Won

    Remote Sensing, Vol 13, Iss 3852, p

    2021  Volume 3852

    Abstract: This paper verifies the applicability of multiple Global Navigation Satellite Systems (GNSSs) and side lobe signal utilization in Space Service Volume (SSV), especially for Geostationary Earth Orbit (GEO) missions over the Korean region. Unlike the ... ...

    Abstract This paper verifies the applicability of multiple Global Navigation Satellite Systems (GNSSs) and side lobe signal utilization in Space Service Volume (SSV), especially for Geostationary Earth Orbit (GEO) missions over the Korean region. Unlike the ground or terrestrial systems, various constraints of space exploration in SSV cause a problem when estimating position using GNSS. This is mainly due to the limit of GNSS signal availability where its dominant variables include altitude, side lobe issues, as well as longitude because of different constellations of several GNSS. The numerical simulation shows the effectiveness of additional side lobe signals from multi-GNSS. In addition, the effect of non-MEO satellites’ signals in SSV for different longitudes is presented.
    Keywords GNSS ; Space Service Volume (SSV) ; Geostationary Orbit (GEO) ; side lobe signal ; Science ; Q
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Author Correction

    Orkhon Tsogtbaatar / Jong-Hoon Won / Go-Woon Kim / Jeong-Hoon Han / Young-Kyung Bae / Kyung-Ok Cho

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    An ADAMTS Sol narae is required for cell survival in Drosophila

    2019  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: An ADAMTS Sol narae is required for cell survival in Drosophila

    Orkhon Tsogtbaatar / Jong-Hoon Won / Go-Woon Kim / Jeong-Hoon Han / Young-Kyung Bae / Kyung-Ok Cho

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Abstract Cell survival is essential for all living organisms to cope against multiple environmental insults. Intercellular signaling between dying and surviving cells plays an important role to ensure compensatory proliferation, preventing tissue loss ... ...

    Abstract Abstract Cell survival is essential for all living organisms to cope against multiple environmental insults. Intercellular signaling between dying and surviving cells plays an important role to ensure compensatory proliferation, preventing tissue loss after environmental stresses. Here, we show that Sol narae (Sona), a Disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in Drosophila is required for cell survival. sona exhibited a positive genetic interaction with Death-associated inhibitor of apoptosis 1 (Diap1), and a negative genetic interaction with reaper (rpr). Transcription patterns of sona, Diap1, and rpr genes in the pouch region of wing discs were coordinately changed after irradiation. Interestingly, there was a negative correlation in the expression levels of Sona and DIAP1, and both cell types, one with high Sona level and the other with high Diap1 level, were resistant to irradiation-induced cell death. The sona-expressing cells rarely entered into cell cycle themselves but promoted the nearby cells to proliferate in irradiation conditions. We found that these sona-expressing cells are able to upregulate Cyclin D (Cyc D) and increase tissue size. Furthermore, transient Sona overexpression increased survival rate and promoted development of flies in irradiation conditions. We propose that the two types of radiation-resistant cells, one with high Sona level and the other with high Diap1 level, communicate with dying cells and between each other for cell survival and proliferation in response to irradiation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation

    Sang-Soo Lee / Jong-Hoon Won / Gippeum J. Lim / Jeongran Han / Ji Youn Lee / Kyung-Ok Cho / Young-Kyung Bae

    Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Abstract Background Extracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from diverse cell types are ... ...

    Abstract Abstract Background Extracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from diverse cell types are essential for understanding their signaling properties. Methods In this study, EVs from the culture media were isolated by ultracentrifugation and analyzed by electron microscopy (EM) and nanoparticle tracking analyses. Conditioned media (CM) from HEK293 cells culture grown either in serum-free (SF) or 10% fetal bovine serum (FBS) containing media were centrifuged at 100,000×g to separate the SNΔ supernatant and the P100 pellet in which exosomes are enriched. Then, the SNΔ fraction was centrifuged at 200,000×g to yield the P200 pellet fraction containing novel EVs smaller than exosomes. The exosomal markers in the EV subgroups were examined by western blotting and immune-EM, and the functional analyses of EVs were conducted on HEK293 and THP-1 cell culture. Results We identified a new group of EVs in the P200 fraction that was smaller than exosomes in size. Typical exosome markers such as Hsp70, TSG101, and CD63 were found in both P100 exosomes and the P200 vesicles, but CD81 was highly enriched in exosomes but not in the P200 vesicles. Furthermore, chemicals that inhibit the major exosome production pathway did not decrease the level of P200 vesicles. Therefore, these small EVs indeed belong to a distinguished group of EVs. Exosomes and the P200 vesicles were found in CM of human cell lines as well as FBS. Addition of the exosomes and the P200 vesicles to human cell cultures enhanced exosome production and cell proliferation, respectively. Conclusions Our study identifies a novel population of EVs present in the P200 fraction. This EV population is distinguished from exosomes in size, protein contents, and biogenesis pathway. Furthermore, exosomes promote their own production whereas the P200 vesicles support cell proliferation. In sum, we report a new group of EVs ...
    Keywords Extracellular vesicles ; Exosomes ; Cell proliferation ; P200 fraction ; CD81 ; Medicine ; R ; Cytology ; QH573-671
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Cell type-specific responses to wingless, hedgehog and decapentaplegic are essential for patterning early eye-antenna disc in Drosophila.

    Jong-Hoon Won / Orkhon Tsogtbaatar / Wonseok Son / Amit Singh / Kwang-Wook Choi / Kyung-Ok Cho

    PLoS ONE, Vol 10, Iss 4, p e

    2015  Volume 0121999

    Abstract: The Drosophila eye-antenna imaginal disc (ead) is a flattened sac of two-layered epithelia, from which most head structures are derived. Secreted morphogens like Wingless (Wg), Hedgehog (Hh), and Decapentaplegic (Dpp) are important for early patterning ... ...

    Abstract The Drosophila eye-antenna imaginal disc (ead) is a flattened sac of two-layered epithelia, from which most head structures are derived. Secreted morphogens like Wingless (Wg), Hedgehog (Hh), and Decapentaplegic (Dpp) are important for early patterning of ead, but the underlying mechanisms are still largely unknown. To understand how these morphogens function in the ead of early larval stages, we used wg-LacZ and dpp-Gal4 markers for the examination of wild-type and mutant eads. We found that the ead immediately after hatching was crescent-shaped with the Bolwig's nerve at the ventral edge, suggesting that it consists of dorsal domain. In a subsequent step, transcriptional induction of dpp in the cells along the Bolwig's nerve was followed by rapid growth of the ventral domain. Both Wg and Hh were required for the formation of the ventral domain. Wg was crucial for the growth of the entire ead, but Hh was essential for cell division only in the dorsal domain. In the ventral domain, Hh regulated dpp transcription. Based on these data, we propose that signaling among distinct groups of cells expressing Wg, Dpp, or Hh in the ead of the first-instar larvae are critical for coordinated growth and patterning of ead.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Correction

    Jong-Hoon Won / Orkhon Tsogtbaatar / Wonseok Son / Amit Singh / Kwang-Wook Choi / Kyung-Ok Cho

    PLoS ONE, Vol 10, Iss 5, p e

    Cell type-specific responses to wingless, hedgehog and decapentaplegic are essential for patterning early eye-antenna disc in Drosophila.

    2015  Volume 0128169

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: 3, 5, 3′-Triiodothyroacetic acid (TRIAC) is an anti-inflammatory drug that targets toll-like receptor 2

    Ha, Hae Chan / Ji Min Jang / Dan Zhou / Han Gyeol Kim / Moon Jung Back / In Chul Shin / So Yoon Yun / Yongwei Piao / Jong Min Choi / Jong Hoon Won / Dae Kyong Kim

    Archives of pharmacal research. 2018 Oct., v. 41, no. 10

    2018  

    Abstract: Drug repositioning is a strategy that explores new pharmaceutical applications of previously launched or failed drugs, and is advantageous since it saves capital and time. In this study, we examined the inhibition of TLR2 signaling by drug candidates. ... ...

    Abstract Drug repositioning is a strategy that explores new pharmaceutical applications of previously launched or failed drugs, and is advantageous since it saves capital and time. In this study, we examined the inhibition of TLR2 signaling by drug candidates. HEK-Blue™-hTLR2 cells were pretreated with drugs and stimulated using the TLR2 ligand, Pam3CSK4. Among the drugs that inhibited TLR2 signaling, we selected TRIAC, which is yet to be patented. Pretreatment with TRIAC decreased the TLR2 level and the phosphorylation of Akt and MAPKs in HEK-Blue™-hTLR2 cells. Since TLR2 is overexpressed in patients with acute hepatitis, we confirmed that TRIAC alleviates necrosis in a mouse model of Con A-induced acute hepatitis. The serum AST and ALT levels are indicators of liver damage, and are increased in Con A-induced hepatitis. Additionally, TLR2 and inflammatory cytokine levels are increased following administration of Con A and lead to liver damage. TRIAC decreased the serum levels of AST and ALT, and reduced liver tissue necrosis in mice with Con A-induced acute fulminant liver damage, by reducing the levels of inflammatory cytokines. In conclusion, TRIAC alleviates inflammation in mouse models of Con A-induced hepatitis by inhibiting the phosphorylation of Akt and MAPKs, the sub-mechanisms underlying TLR2 signaling.
    Keywords Toll-like receptor 2 ; alanine transaminase ; animal models ; anti-inflammatory agents ; aspartate transaminase ; blood serum ; capital ; concanavalin A ; cytokines ; hepatitis ; inflammation ; ligands ; liver ; mice ; mitogen-activated protein kinase ; necrosis ; patients ; phosphorylation
    Language English
    Dates of publication 2018-10
    Size p. 995-1008.
    Publishing place Pharmaceutical Society of Korea
    Document type Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-018-1057-8
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury

    Jang, You Jin / Moon Jung Back / Zhicheng Fu / Joo Hyun Lee / Jong Hoon Won / Hae Chan Ha / Hae Kyung Lee / Ji Min Jang / Jong Min Choi / Dae Kyong Kim

    Archives of pharmacal research. 2016 Dec., v. 39, no. 12

    2016  

    Abstract: Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro- ... ...

    Abstract Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not been developed. The objective of this study was to investigate protective effects of parthenolide, a sesquiterpene lactone produced in feverfew, on LPS-induced lung injury. In the present study, parthenolide treatment reduced infiltration of inflammatory cells, airway permeability and production of pro-inflammatory cytokines in LPS-induced ALI mouse model. Further, LPS-stimulated phosphorylation of NF-κB, the key regulatory transcription factor in ALI, was inhibited by parthenolide treatment in lung epithelial BEAS-2B cells and alveolar macrophage MH-S cells. These results suggest that parthenolide may provide a beneficial therapeutic strategy for ALI.
    Keywords Tanacetum parthenium ; animal models ; cytokines ; epithelium ; macrophages ; mortality ; neutrophils ; patients ; permeability ; phosphorylation ; protective effect ; sesquiterpenoids ; therapeutics ; transcription factor NF-kappa B
    Language English
    Dates of publication 2016-12
    Size p. 1716-1725.
    Publishing place Pharmaceutical Society of Korea
    Document type Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-016-0716-x
    Database NAL-Catalogue (AGRICOLA)

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