LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Extending the toxic stress model into adolescence: Profiles of cortisol reactivity.

    Joos, Celina M / McDonald, Ashley / Wadsworth, Martha E

    Psychoneuroendocrinology

    2019  Volume 107, Page(s) 46–58

    Abstract: The toxic stress model posits that extended activation of stress response systems in the absence of a supportive relationship with an adult may over time lead to physiological alterations to these same systems, and ultimately to poorer physical and ... ...

    Abstract The toxic stress model posits that extended activation of stress response systems in the absence of a supportive relationship with an adult may over time lead to physiological alterations to these same systems, and ultimately to poorer physical and mental health outcomes. However, empirical tests of model hypotheses in adolescence, a critical period of development, are lacking. This study expands the toxic stress model to include more developmentally-appropriate risk and protective factors for adolescents experiencing overwhelming and uncontrollable stressors. Data were collected for a study of early adolescents from urban low-income households (N = 101; 10-12 years old; 59% female). Participants and a caregiver completed questionnaires; youths completed the modified Trier Social Stress Task alone and provided six saliva samples. Using latent profile analysis, three profiles of cortisol reactivity were identified in early adolescents exposed to chronic environmental stress: Elevated and Reactive (11%), Moderate and Non-Reactive (26%), and Blunted and Non-Reactive (63%). In accordance with the toxic stress model, exposure to more community violence and less family support were associated with blunted cortisol reactivity, and Reactive profile membership was associated with fewer trauma symptoms. Overall, the findings provide empirical support for the extension of the toxic stress model in early adolescence through the application of developmentally-sensitive measures and provide implications for future interventions.
    MeSH term(s) Adult ; Adverse Childhood Experiences ; Child ; Child Abuse/psychology ; Female ; Humans ; Hydrocortisone/analysis ; Hypothalamo-Hypophyseal System/metabolism ; Male ; Middle Aged ; Parents ; Pituitary-Adrenal System/metabolism ; Protective Factors ; Risk Factors ; Saliva/chemistry ; Stress, Psychological/physiopathology ; Surveys and Questionnaires
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2019-05-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2019.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Tobacco withdrawal-induced changes in sensorimotor filtering as a predictor of smoking lapse in trauma-exposed individuals.

    Pineles, Suzanne L / Ni, Pengsheng / Pandey, Shivani / Japuntich, Sandra J / Cesare, Nina / Shor, Rachel / Carpenter, Joseph K / Gregor, Kristin / Joos, Celina M / Blumenthal, Terry D / Rasmusson, Ann M

    Addictive behaviors

    2023  Volume 148, Page(s) 107868

    Abstract: Prepulse inhibition (PPI) is a measure of sensorimotor filtering thought to shield the processing of initial weaker auditory stimuli from interruption by a later startle response. Previous studies have shown smoking withdrawal to have a negative impact ... ...

    Abstract Prepulse inhibition (PPI) is a measure of sensorimotor filtering thought to shield the processing of initial weaker auditory stimuli from interruption by a later startle response. Previous studies have shown smoking withdrawal to have a negative impact on sensorimotor filtering, particularly in individuals with psychopathology. Because tobacco use may alleviate sensory and sensorimotor filtering deficits, we examined whether smoking withdrawal-induced changes in PPI were associated with maintenance of smoking abstinence in trauma-exposed individuals with and without PTSD who were attempting to quit smoking. Thirty-eight individuals (n = 24 with current or past PTSD; 14 trauma-exposed healthy controls) made an acute biochemically-verified smoking cessation attempt supported by 8 days of contingency management (CM) and cognitive behavioral therapy (CBT) for smoking. Participants completed a PPI task at the pre-quit baseline, 2 days post-quit, and 5 days post-quit. Post-quit changes in PPI were compared between those who remained abstinent for the first 8-days of the quit attempt and those who lapsed back to smoking. PPI changes induced by biochemically-verified smoking abstinence were associated with maintenance of abstinence across the 8-day CM/CBT-supported quit attempt. As compared to those who maintained tobacco abstinence, participants who lapsed to smoking had significantly lower PPI at 2 and 5 days post-quit relative to baseline. Thus, among trauma-exposed individuals, decreases in PPI during acute smoking cessation supported by CM/CBT are associated with lapse back to smoking. Interventions that improve PPI during early smoking abstinence may facilitate smoking cessation among such individuals who are at high risk for chronic, refractory tobacco use.
    MeSH term(s) Humans ; Smoking/therapy ; Smoking/psychology ; Tobacco Smoking ; Smoking Cessation/psychology ; Tobacco Use Disorder/psychology ; Tobacco Products
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2023.107868
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Methods to reduce false reporting of substance abstinence in clinical research.

    Japuntich, Sandra J / Arditte Hall, Kimberly A / Joos, Celina M / Rasmusson, Ann M / Pineles, Suzanne L

    International journal of methods in psychiatric research

    2018  Volume 27, Issue 3, Page(s) e1603

    Abstract: Objectives: Substance use may influence study results in human subjects research. This study aims to report the concordance between self-report and biochemical assessments of substance use and test the effect of methods to reduce false reports of ... ...

    Abstract Objectives: Substance use may influence study results in human subjects research. This study aims to report the concordance between self-report and biochemical assessments of substance use and test the effect of methods to reduce false reports of abstinence in trauma-exposed women participating in a research study.
    Methods: In this pilot study, substance use was assessed during telephone prescreening and via self-report and biochemical verification (i.e., urine toxicology and alcohol breathalyzer tests) at an in-person evaluation. Due to the high number of participants who tested positive for substances despite self-reporting abstinence during prescreening, study procedures were modified to disincentivize false self-reports of substance use two thirds of the way through recruitment. New potential participants were explicitly informed during prescreening and informed consent that a positive drug or alcohol test during screening would result in exclusion from the study and withholding of payment.
    Results: Prior to modifying study methods, 20% of participants who had reported abstinence during the telephone prescreen had a positive substance use test at the in-person visit. Modifying study procedures resulted in an 81% decrease in positive substance use assessments.
    Conclusions: Adoption of this methodology may decrease inadvertent confounding of clinical research outcomes by undetected and/or misreported substance use.
    MeSH term(s) Adolescent ; Adult ; Alcohol Abstinence ; Biomedical Research/standards ; Breath Tests ; Female ; Humans ; Middle Aged ; Pilot Projects ; Self Report/standards ; Substance Abuse Detection/standards ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/metabolism ; Telephone ; Urinalysis ; Young Adult
    Language English
    Publishing date 2018-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1078002-6
    ISSN 1557-0657 ; 1049-8931
    ISSN (online) 1557-0657
    ISSN 1049-8931
    DOI 10.1002/mpr.1603
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3262: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Contingency management and cognitive behavioral therapy for trauma-exposed smokers with and without posttraumatic stress disorder.

    Japuntich, Sandra J / Lee, Lewina O / Pineles, Suzanne L / Gregor, Kristin / Joos, Celina M / Patton, Samantha C / Krishnan-Sarin, Suchitra / Rasmusson, Ann M

    Addictive behaviors

    2018  Volume 90, Page(s) 136–142

    Abstract: Introduction: Trauma-exposed individuals with and without posttraumatic stress disorder (PTSD) are more likely to smoke and less successful in quit attempts than individuals without psychopathology. Contingency management (CM) techniques (i.e., ... ...

    Abstract Introduction: Trauma-exposed individuals with and without posttraumatic stress disorder (PTSD) are more likely to smoke and less successful in quit attempts than individuals without psychopathology. Contingency management (CM) techniques (i.e., incentives for abstinence) have demonstrable efficacy for smoking cessation in some populations with psychopathology, but have not been well tested in PTSD. This pilot study examined the feasibility of CM plus brief cognitive behavioral therapy (CBT) in promoting smoking cessation among trauma-exposed individuals with and without PTSD.
    Methods: Fifty trauma-exposed smokers (18 with PTSD) were asked to abstain from tobacco and nicotine replacement therapy for one month. During week one of cessation, CBT was provided daily and increasing CM stipends were paid for each continuous day of biochemically-verified abstinence; CM stipends were withheld in response to smoking lapses and reset to the initial payment level upon abstinence resumption. CBT and fixed payments for study visits were provided during the subsequent three weeks.
    Results: Of the 50 eligible participants who attended at least one pre-quit visit (49% female, 35% current PTSD), 43 (86%) attended the first post-quit study visit, 32 (64%) completed the first week of CM/CBT treatment, and 26 (52%) completed the study. Post-quit seven-day point prevalence abstinence rates for participants with and without PTSD, respectively, were similar: 39% vs. 38% (1 week), 33% vs. 28% (2 weeks), 22% vs. 19% (3 weeks), and 22% vs. 13% (4 weeks).
    Conclusions: Use of CM + CBT to support tobacco abstinence is a promising intervention for trauma-exposed smokers with and without PTSD.
    MeSH term(s) Adolescent ; Adult ; Cognitive Behavioral Therapy/methods ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Smokers/psychology ; Smokers/statistics & numerical data ; Smoking Cessation/methods ; Smoking Cessation/psychology ; Smoking Cessation/statistics & numerical data ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/psychology ; Stress Disorders, Post-Traumatic/therapy ; Tobacco Use Disorder/complications ; Tobacco Use Disorder/psychology ; Tobacco Use Disorder/therapy ; Young Adult
    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2018.10.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Co-activation of SAM and HPA responses to acute stress: A review of the literature and test of differential associations with preadolescents' internalizing and externalizing.

    Wadsworth, Martha E / Broderick, Amanda V / Loughlin-Presnal, John E / Bendezu, Jason J / Joos, Celina M / Ahlkvist, Jarl A / Perzow, Sarah E D / McDonald, Ashley

    Developmental psychobiology

    2019  Volume 61, Issue 7, Page(s) 1079–1093

    Abstract: Understanding co-activation patterns of the hypothalamic-pituitary-adrenal axis (HPA) and sympathetic adrenal medullary (SAM) during early adolescence may illuminate risk for development of internalizing and externalizing problems. The present study ... ...

    Abstract Understanding co-activation patterns of the hypothalamic-pituitary-adrenal axis (HPA) and sympathetic adrenal medullary (SAM) during early adolescence may illuminate risk for development of internalizing and externalizing problems. The present study advances empirical work on the topic by examining SAM-HPA co-activation during both the reactivity and recovery phases of the stress response following acute stress exposure. Fourth and fifth grade boys and girls (N = 149) provided cortisol and alpha-amylase via saliva at seven times throughout a 95-min assessment in which they were administered the modified Trier Social Stress Test. Parents reported on adolescents' life stress, pubertal development, medication use, and externalizing problems. Adolescents reported their own internalizing symptoms. Multiple linear regressions tested both direct and interactive effects of SAM and HPA reactivity and recovery on internalizing and externalizing problems. Results from these analyses showed that whereas SAM and HPA reactivity interacted to predict internalizing symptoms, it was their interaction during the recovery phase that predicted externalizing. Concurrent high SAM and HPA reactivity scores predicted high levels of internalizing and concurrently low SAM and HPA recovery scores predicted high levels of externalizing. Implications of the findings for further study and clinical application are discussed.
    MeSH term(s) Behavioral Symptoms/physiopathology ; Child ; Child Behavior/physiology ; Female ; Humans ; Hydrocortisone/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Male ; Salivary alpha-Amylases/metabolism ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology
    Chemical Substances Salivary alpha-Amylases (EC 3.2.1.1) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2019-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 4107-5
    ISSN 1098-2302 ; 0012-1630
    ISSN (online) 1098-2302
    ISSN 0012-1630
    DOI 10.1002/dev.21866
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1102: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Reducing the Biological and Psychological Toxicity of Poverty-related Stress: Initial Efficacy of the BaSICS Intervention for Early Adolescents.

    Wadsworth, Martha E / McDonald, Ashley / Joos, Celina M / Ahlkvist, Jarl A / Perzow, Sarah E D / Tilghman-Osborne, Emile M / Creavey, Kristine / Brelsford, Gina M

    American journal of community psychology

    2019  Volume 65, Issue 3-4, Page(s) 305–319

    Abstract: This proof-of-concept study tests the initial efficacy of the Building a Strong Identity and Coping Skills (BaSICS) intervention, a selective prevention of internalizing problems program for early adolescents exposed to high levels of poverty-related ... ...

    Abstract This proof-of-concept study tests the initial efficacy of the Building a Strong Identity and Coping Skills (BaSICS) intervention, a selective prevention of internalizing problems program for early adolescents exposed to high levels of poverty-related stress. Eighty-four early adolescents (M
    MeSH term(s) Adaptation, Psychological ; Adolescent ; Child ; Cognition ; Depression/psychology ; Female ; Humans ; Hydrocortisone/analysis ; Knowledge ; Male ; Parents ; Pennsylvania ; Poverty/psychology ; Stress, Physiological ; Stress, Psychological/psychology ; Stress, Psychological/therapy
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2019-10-11
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 222658-3
    ISSN 1573-2770 ; 0091-0562
    ISSN (online) 1573-2770
    ISSN 0091-0562
    DOI 10.1002/ajcp.12400
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1176: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top