LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Therapeutic Targeting of the Tumor Microenvironment.

    Bejarano, Leire / Jordāo, Marta J C / Joyce, Johanna A

    Cancer discovery

    2021  Volume 11, Issue 4, Page(s) 933–959

    Abstract: Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of- ... ...

    Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of-care therapies. Here, we summarize the current knowledge regarding the most advanced TME-directed therapies, which have either been clinically approved or are currently being evaluated in trials, including immunotherapies, antiangiogenic drugs, and treatments directed against cancer-associated fibroblasts and the extracellular matrix. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Cancer-Associated Fibroblasts ; Extracellular Matrix ; Humans ; Immunotherapy/trends ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-1808
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Microglia contribute to the glia limitans around arteries, capillaries and veins under physiological conditions, in a model of neuroinflammation and in human brain tissue.

    Joost, Emely / Jordão, Marta J C / Mages, Bianca / Prinz, Marco / Bechmann, Ingo / Krueger, Martin

    Brain structure & function

    2019  Volume 224, Issue 3, Page(s) 1301–1314

    Abstract: Microglia represent resident immune cells of the central nervous system (CNS), which have been shown to be involved in the pathophysiology of practically every neuropathology. As microglia were described to participate in the formation of the astroglial ... ...

    Abstract Microglia represent resident immune cells of the central nervous system (CNS), which have been shown to be involved in the pathophysiology of practically every neuropathology. As microglia were described to participate in the formation of the astroglial glia limitans around CNS vessels, they are part of the neurovascular unit (NVU). Since the NVU is a highly specialized structure, being functionally and morphologically adapted to differing demands in the arterial, capillary, and venous segments, the present study was aimed to systematically investigate the microglial contribution to the glia limitans along the vascular tree. Thereby, the microglial participation in the glia limitans was demonstrated for arteries, capillaries, and veins by immunoelectron microscopy in wild-type mice. Furthermore, analysis by confocal laser scanning microscopy revealed the highest density of microglial endfeet contacting the glial basement membrane around capillaries, with significantly lower densities around arteries and veins. Importantly, this pattern appeared to be unaltered in the setting of experimental autoimmune encephalomyelitis (EAE) in CX3CR1
    MeSH term(s) Actins/metabolism ; Animals ; Arteries/metabolism ; Arteries/pathology ; Arteries/physiology ; Arteries/ultrastructure ; Brain ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Calcium-Binding Proteins/metabolism ; Calcium-Binding Proteins/ultrastructure ; Capillaries/metabolism ; Capillaries/pathology ; Capillaries/ultrastructure ; Collagen Type IV/metabolism ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Laminin/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microfilament Proteins/metabolism ; Microfilament Proteins/ultrastructure ; Microscopy, Electron ; Microscopy, Fluorescence ; Neuroglia/metabolism ; Neuroglia/pathology ; Neuroglia/ultrastructure ; Veins/metabolism ; Veins/pathology ; Veins/physiology ; Veins/ultrastructure
    Chemical Substances Actins ; Aif1 protein, mouse ; CX3C Chemokine Receptor 1 ; Calcium-Binding Proteins ; Collagen Type IV ; Cx3cr1 protein, mouse ; Laminin ; Microfilament Proteins ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2019-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-019-01834-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top