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  1. Article ; Online: Combining loop and thiazide diuretics for acute heart failure across the estimated glomerular filtration rate spectrum: A post-hoc analysis of the CLOROTIC trial.

    Trullàs, Joan Carles / Morales-Rull, José Luís / Casado, Jesús / Carrera-Izquierdo, Margarita / Sánchez-Marteles, Marta / Conde-Martel, Alicia / Dávila-Ramos, Melitón Francisco / Llácer, Pau / Salamanca-Bautista, Prado / Chivite, David / Jordana-Comajuncosa, Rosa / Villalonga, Maria / Páez-Rubio, María Inmaculada / Manzano, Luís / Formiga, Francesc

    European journal of heart failure

    2023  Volume 25, Issue 10, Page(s) 1784–1793

    Abstract: Aims: In patients with acute heart failure (AHF), the addition of hydrochlorothiazide (HCTZ) to furosemide improved diuretic response in the CLOROTIC trial. This work aimed to evaluate if these effects differ across the estimated glomerular filtration ... ...

    Abstract Aims: In patients with acute heart failure (AHF), the addition of hydrochlorothiazide (HCTZ) to furosemide improved diuretic response in the CLOROTIC trial. This work aimed to evaluate if these effects differ across the estimated glomerular filtration rate (eGFR) spectrum.
    Methods and results: This post-hoc analysis of the CLOROTIC trial analysed 230 patients with AHF and explored the influence of eGFR on primary and secondary endpoints. The median eGFR was 43 ml/min/1.73 m
    Conclusion: The addition of eGFR-adjusted doses of oral HCTZ to loop diuretics in patients with AHF improved diuretic response across the eGFR spectrum.
    Clinical trial registration: ClinicalTrials.gov: NCT01647932; EudraCT number: 2013-001852-36.
    MeSH term(s) Humans ; Diuretics/therapeutic use ; Furosemide/therapeutic use ; Glomerular Filtration Rate ; Heart Failure ; Hydrochlorothiazide/therapeutic use ; Sodium Chloride Symporter Inhibitors/therapeutic use
    Chemical Substances Diuretics ; Furosemide (7LXU5N7ZO5) ; Hydrochlorothiazide (0J48LPH2TH) ; Sodium Chloride Symporter Inhibitors
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Heart Failure with Recovered Ejection Fraction in a Cohort of Elderly Patients with Chronic Heart Failure.

    Trullàs, Joan Carles / Manzano, Luís / Formiga, Francesc / Aramburu-Bodas, Oscar / Quesada-Simón, María Angustias / Arias-Jiménez, José Luís / García-Escrivá, David / Romero-Requena, Jorge Manuel / Jordana-Comajuncosa, Rosa / Montero-Pérez-Barquero, Manuel

    Cardiology

    2016  Volume 135, Issue 3, Page(s) 196–201

    Abstract: Objective: The aim of this study was to determine whether patients with heart failure (HF) who recover left ventricular ejection fraction (LVEF), termed here as 'Rec-HF', have a distinct clinical profile and prognosis compared with patients with HF and ... ...

    Abstract Objective: The aim of this study was to determine whether patients with heart failure (HF) who recover left ventricular ejection fraction (LVEF), termed here as 'Rec-HF', have a distinct clinical profile and prognosis compared with patients with HF and reduced LVEF (HF-REF) or HF and preserved LVEF (HF-PEF).
    Methods: We evaluated and classified patients from the Spanish Heart Failure Registry into three categories based on enrollment/follow-up echocardiograms: HF-PEF (LVEF ≥50%), HF-REF (LVEF persistently <50%) and Rec-HF (LVEF on enrollment <50% but normalized during follow-up).
    Results: A total of 1,202 patients were included, 1,094 with HF-PEF, 81 with HF-REF and 27 with Rec-HF. The three groups included patients of advanced age (mean age 75 years) with comorbidities. Rec-HF patients were younger, with a better functional status, lower prevalence of diabetes mellitus, dementia and cerebrovascular disease, and higher prevalence of COPD. The etiology of HF was more frequently ischemic and alcoholic and less frequently hypertensive. After a median follow-up of 367 days, the unadjusted hazard ratios for death in the Rec-HF versus HF-PEF and HF-REF groups were 0.11 (95% CI 0.02-080; p = 0.029) and 0.31 (95% CI 0.04-2.5; p = 0.274). Results were statistically nonsignificant in multivariate-adjusted models.
    Conclusion: Rec-HF is also present in elderly patients with HF but it is necessary to further investigate the natural history and optimal pharmacologic management of this 'new HF syndrome'.
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000447287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Etiología y tratamiento de la anemia en la insuficiencia cardíaca. Estudio GESAIC.

    Grau Amorós, Jorge / Formiga, Francesc / Jordana Comajuncosa, Rosa / Urrutia, Agustín / Arias Jiménez, José L / Salvador Mínguez, Juan P

    Medicina clinica

    2009  Volume 132, Issue 12, Page(s) 447–453

    Abstract: Background and objective: Studies about anemia in heart failure (HF) tend to link the anemia to a cardio-renal dysfunction, and its syndromic value is seldom evaluated. Our objective was to assess the etiology and clinical management of anemia in HF ... ...

    Title translation Etiology and clinical management of anemia in heart failure. GESAIC Study.
    Abstract Background and objective: Studies about anemia in heart failure (HF) tend to link the anemia to a cardio-renal dysfunction, and its syndromic value is seldom evaluated. Our objective was to assess the etiology and clinical management of anemia in HF patients in a hospital setting.
    Patients and method: Initial cross-sectional analysis of a multi-center and prospective cohort of patients with HF and anemia. Anemia was defined according to the WHO criteria; the Modification of Diet in Renal Disease equation was used to assess glomerular filtration and the etiology of anemia was defined according to common criteria.
    Results: We evaluated 228 patients, with a median age of 79.1 years and 59.65% women. Iron deficiency anemia was present in 36,8% of patients and anemia of chronic disease in 30.3%. Of note, 12.7% cases did not meet any etiological criteria. The main factor associated with iron deficiency was anti-platelet therapy (OR=1.99; 95% CI, 1.16-1.68) and the main factors associated with anemia of chronic disease were the use of angiotensin converting enzyme inhibitors (ACEI) or angiotensin II receptor antagonists (ARA-II) (OR=3.29; 95% CI, 1.36-7.94). The main factor associated with undefined anemia was initial heart failure (OR=5.41; 95% CI, 1.65-17.65). On the other hand, 8.1% of patients required transfusion, 6% were treated with erythropoietin and 25.3% were treated with iron. Both age (OR=1.04; 95% CI, 1-1.08) and hemoglobin level at admission (OR=1.81; 95% CI, 1.46-2.25) were associated with active treatment for anemia.
    Conclusions: A clinical study of anemia in patients with HF can establish an etiological diagnosis in 70% of cases, resulting in a more effective treatment.
    MeSH term(s) Aged ; Anemia/etiology ; Anemia/therapy ; Cross-Sectional Studies ; Female ; Heart Failure/complications ; Humans ; Male ; Prospective Studies
    Language Spanish
    Publishing date 2009-04-04
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Multicenter Study
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2008.10.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Heart Failure with Recovered Ejection Fraction in a Cohort of Elderly Patients with Chronic Heart Failure

    Trullàs, Joan Carles / Manzano, Luís / Formiga, Francesc / Aramburu-Bodas, Oscar / Quesada-Simón, María Angustias / Arias-Jiménez, José Luís / García-Escrivá, David / Romero-Requena, Jorge Manuel / Jordana-Comajuncosa, Rosa / Montero-Pérez-Barquero, Manuel

    Cardiology

    2016  Volume 135, Issue 3, Page(s) 196–201

    Abstract: Objective: The aim of this study was to determine whether patients with heart failure (HF) who recover left ventricular ejection fraction (LVEF), termed here as ‘Rec-HF', have a distinct clinical profile and prognosis compared with patients with HF and ... ...

    Institution Internal Medicine Service, Hospital d'Olot i Comarcal de la Garrotxa, Olot Medical Science Department, University of Girona, Girona Heart Failure and Vascular Risk Unit, Internal Medicine Department, Hospital Universitario Ramón y Cajal, University of Alcalá, and Internal Medicine Department, Hospital Universitario La Paz, Madrid Internal Medicine Department, IDIBELL, Hospital Universitario de Bellvitge, L'Hospitalet del Llobregat, and Internal Medicine Department, Corporació Sanitaria Parc Taulí, Sabadell, Barcelona Internal Medicine Department, Hospital Universitario Virgen Macarena, Sevilla Internal Medicine Department, Hospital General Universitario de Valencia, Valencia Internal Medicine Department, Hospital Perpetuo Socorro, Badajoz, and Internal Medicine Department, IMBIC/Hospital Reina Sofía, University of Córdoba, Córdoba, Spain
    Abstract Objective: The aim of this study was to determine whether patients with heart failure (HF) who recover left ventricular ejection fraction (LVEF), termed here as ‘Rec-HF', have a distinct clinical profile and prognosis compared with patients with HF and reduced LVEF (HF-REF) or HF and preserved LVEF (HF-PEF). Methods: We evaluated and classified patients from the Spanish Heart Failure Registry into three categories based on enrollment/follow-up echocardiograms: HF-PEF (LVEF ≥50%), HF-REF (LVEF persistently <50%) and Rec-HF (LVEF on enrollment <50% but normalized during follow-up). Results: A total of 1,202 patients were included, 1,094 with HF-PEF, 81 with HF-REF and 27 with Rec-HF. The three groups included patients of advanced age (mean age 75 years) with comorbidities. Rec-HF patients were younger, with a better functional status, lower prevalence of diabetes mellitus, dementia and cerebrovascular disease, and higher prevalence of COPD. The etiology of HF was more frequently ischemic and alcoholic and less frequently hypertensive. After a median follow-up of 367 days, the unadjusted hazard ratios for death in the Rec-HF versus HF-PEF and HF-REF groups were 0.11 (95% CI 0.02-080; p = 0.029) and 0.31 (95% CI 0.04-2.5; p = 0.274). Results were statistically nonsignificant in multivariate-adjusted models. Conclusion: Rec-HF is also present in elderly patients with HF but it is necessary to further investigate the natural history and optimal pharmacologic management of this ‘new HF syndrome'.
    Keywords Systolic heart failure ; Diastolic heart failure ; Left ventricular dysfunction ; Heart failure
    Language English
    Publishing date 2016-07-19
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Short Communication
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000447287
    Database Karger publisher's database

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