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  1. AU="Jorge Pereira, B"
  2. AU=Kamps Frederik S.
  3. AU="Sowińska-Baranowska, Anna"
  4. AU="Štefek, Milan"
  5. AU="El Khatib, Mohammad"
  6. AU="Puccioni, Caterina"
  7. AU="Kostopoulos, Ioannis"
  8. AU=Kumar Adarsh
  9. AU="Millar, Amanda"
  10. AU="da Cruz Perez, Danyel Elias"
  11. AU="Henry des Tureaux, Thierry"
  12. AU="Mária Bucová"
  13. AU="Darling, Corbin"
  14. AU="Rosenthal, Philip"
  15. AU="Farley, John M B"
  16. AU="Longo, Lauren O"
  17. AU="Ogawa, Kumiko"
  18. AU="Min Gyu Lee"

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  1. Artikel: Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?

    Leonel Almeida, Pedro / Jorge Pereira, Bruno

    Prostate cancer

    2018  Band 2018, Seite(n) 2654572

    Abstract: Background: Advances in technological, laboratorial, and imaging studies and new treatments available in the last decades significantly improved prostate cancer survival rates. However, this did not occur in metastatic prostate cancer (mPCa) at ... ...

    Abstract Background: Advances in technological, laboratorial, and imaging studies and new treatments available in the last decades significantly improved prostate cancer survival rates. However, this did not occur in metastatic prostate cancer (mPCa) at diagnosis which, in young and fit patients, will become invariably resistant to the established treatments. Progression will lead to an impairment in patients' quality of life and disease-related death.
    Methods: The authors intend to perform a literature review of the advantages of primary treatment of mPCa. Articles were retrieved and filtered for relevance from PubMed, SciELO, and ScienceDirect until March 2017.
    Results: Primary treatment is currently indicated only in cases of nonmetastatic PCa. Nonetheless, there might be some benefits in doing local treatment in mPCa in order to control local disease, prevent new metastasis, and improve the efficacy of chemotherapy and hormonotherapy with similar complications rate when compared to locally confined cancer. Independent factors that have a negative influence are age above 70 years, cT4 stage or high-grade disease, PSA ≥ 20 ng/ml, and pelvic lymphadenopathies. The presence of 3 or more of these factors conditions CSS and OS is the same between patients who performed local treatment and those who did not. Metastasis degree and location number can also influence outcome. Meanwhile, patients with visceral metastases have worse results.
    Conclusions: There is growing evidence supporting local treatment in cases of metastatic prostate cancer at diagnosis in the context of a multimodal approach. However, it should be kept in mind that most of the existing studies are retrospective and it would be important to make consistent prospective studies with well-defined patient selection criteria in order to sustain the existing data and understand the main indications to select patients and perform primary treatment in mPCa.
    Sprache Englisch
    Erscheinungsdatum 2018-03-19
    Erscheinungsland Egypt
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2627965-4
    ISSN 2090-312X ; 2090-3111
    ISSN (online) 2090-312X
    ISSN 2090-3111
    DOI 10.1155/2018/2654572
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  2. Artikel ; Online: [Titelangabe fehlt]

    Palmas, Artur / Jorge Pereira, Bruno / Graça, Bruno / Eufrásio, Pedro / Silva, Alberto / Santos, Sérgio / Cardoso, Pepe / Tomada, Nuno / Vendeira, Pedro

    Revista internacional de andrologia

    2022  Band 20, Heft 4, Seite(n) 237–239

    Abstract: Patients with genital HPV lesion, as well as partners, usually present higher psychological stress, than the actual medical consequences of the lesion. Follow-up of these patients should be based on education and counseling. HPV molecular tests are not ... ...

    Titelübersetzung Consensos em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Seguimento.
    Abstract Patients with genital HPV lesion, as well as partners, usually present higher psychological stress, than the actual medical consequences of the lesion. Follow-up of these patients should be based on education and counseling. HPV molecular tests are not recommended as a follow-up test, or for screening partners. Development and implementation of protocols, by the centers or units, that follow these patients, are recommended.
    Mesh-Begriff(e) Andrology ; Condylomata Acuminata/diagnosis ; Condylomata Acuminata/pathology ; Consensus ; Follow-Up Studies ; Humans ; Male ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/prevention & control ; Portugal ; Reproduction
    Sprache Spanisch
    Erscheinungsdatum 2022-08-12
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 1698-0409
    ISSN (online) 1698-0409
    DOI 10.1016/j.androl.2021.02.006
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  3. Artikel ; Online: Complications of transrectal prostate biopsy in our context. International multicenter study of 3350 patients.

    Perán Teruel, M / Lorenzo-Gómez, M F / Veiga Canuto, N / Padilla-Fernández, B Y / Valverde-Martínez, L S / Migliorini, F / Jorge Pereira, B / Pires Coelho, H M / Osca García, J M

    Actas urologicas espanolas

    2020  Band 44, Heft 3, Seite(n) 196–204

    Abstract: Introduction: Prostate cancer is the most common visceral neoplasm in men and the second one in the United States with the highest mortality behind lung cancer and ahead of colorectal cancer. While prostate cancer mortality rates have been reduced in ... ...

    Titelübersetzung Complicaciones de la biopsia transrectal de próstata en nuestro medio. Estudio multicéntrico internacional de 3.350 pacientes.
    Abstract Introduction: Prostate cancer is the most common visceral neoplasm in men and the second one in the United States with the highest mortality behind lung cancer and ahead of colorectal cancer. While prostate cancer mortality rates have been reduced in the United States, Austria, United Kingdom and France, 5-year survival rates have been incremented in Sweden, probably due to a higher diagnostic activity and non-lethal tumor detection. TRPB usually has low rates of serious complications, with a not negligible number of minor complications. Mortality directly associated with this procedure is low and usually related to septic shock. The main complications derived from prostate biopsy can be infectious (mild or severe) and non-infectious (hematuria consistent with hemorrhage, urethral bleeding, rectal bleeding or hemospermia, acute urinary retention, pain or vasovagal reactions).
    Material and method: The objective of the study is to compare three usual TRPB protocols and their relationship with the incidence of complications. Retrospective multicenter observational study conducted in three countries (Spain, Italy and Portugal). We have reviewed the medical records of 3350 men who underwent TRPB to evaluate the existence of prostate cancer, with a minimum evolutionary control of 6months.
    Results: The mean age was 65,50years, median 66, range 43-79. The subgroup analysis showed that younger patients had higher rates of acute urine retention (AUR) (P=.0000001). Likewise, our results revealed that younger patients presented more procedural pain (P=.0000001) than older patients. Regarding PSA, the mean value was 10.44, SD 7.73, median 8.15, range 0.98-68.09. A higher body mass index (BMI) was not associated with further infection (P=.000004). When performing the multivariate analysis, it was found that the significant variables in the general group were: age (P=.0013), PSA (P=.0402), local infiltration anesthesia (P=.0001) and prophylaxis with metronidazole +tobramycin +amoxicillin/clavulanic acid +gentamicin (P=.0001), presenting a normal distribution with high confidence interval (95%) and significant correlation. Prophylaxis is the most significant variable for no complications and pain (P=.0001), age (P=.0013) and prophylaxis (P=.0001) are for bleeding, age (P=.0013), prophylaxis and PSA (P=.0001) are for infection, and finally, age (P=.0013), anesthesia with local infiltration and prophylaxis (P=.0001) and PSA (P=.0402) are for AUR.
    Conclusions: Sedation has fewer side effects and complications related to the transrectal prostate biopsy procedure with respect to transrectal local anesthesia. The choice of the antibiotic prophylaxis scheme is decisive in the onset of complications arising from the performance of a transrectal prostate biopsy.
    Mesh-Begriff(e) Adult ; Aged ; Biopsy/adverse effects ; Biopsy/methods ; Clinical Protocols ; Humans ; Italy ; Male ; Middle Aged ; Portugal ; Postoperative Complications/etiology ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Rectum ; Retrospective Studies ; Spain
    Sprache Spanisch
    Erscheinungsdatum 2020-02-29
    Erscheinungsland Spain
    Dokumenttyp Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuro.2019.11.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: New Therapeutic Perspectives in Premature Ejaculation.

    Simões Paço, Joana / Jorge Pereira, Bruno

    Urology

    2016  Band 88, Seite(n) 87–92

    Abstract: Objective: To review potential therapeutic targets and future therapeutic molecules in premature ejaculation (PE). PE is the most prevalent sexual dysfunction and affects about 23% of the male population. It is a universal disorder: it is independent of ...

    Abstract Objective: To review potential therapeutic targets and future therapeutic molecules in premature ejaculation (PE). PE is the most prevalent sexual dysfunction and affects about 23% of the male population. It is a universal disorder: it is independent of age and social or marital status. Men with PE typically refer associated comorbidities and report a significant impact not only on their quality of life but also on the satisfaction of the partner. Although common and treatable in most cases, the drugs currently available may affect sexual spontaneity and the cost can prove to be a hindrance.
    Materials and methods: A comprehensive literature revision was performed using PubMed and Scopus to identify relevant articles published in the fields of PE and its treatment until May 2015.
    Results: The main central targets identified include serotonergic, dopaminergic, and oxytocinergic neurotransmitters, opioid receptors, and mechanisms involved in the control of the spinal ejaculatory generator, located at the T12-L1-2 spinal cord level. On the other hand, peripheral interventions at semen's transport may also delay ejaculation by decreasing sequential contractions of the epididymis, vas deferens, seminal vesicles, prostate, and bladder neck.
    Conclusion: There is a wide range of future options with regard to the treatment of PE. Molecules like DA-8031, Promescent, silodosin, Botulinum toxin-A, and resiniferatoxin may be near future treatments for this disorder.
    Mesh-Begriff(e) Humans ; Male ; Penis/drug effects ; Penis/innervation ; Premature Ejaculation/drug therapy
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2015.11.003
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1142: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Artikel ; Online: Consensos em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Tratamento.

    Jorge Pereira, Bruno / Graça, Bruno / Palmas, Artur / Eufrásio, Pedro / Lebre, Ana / Andrade, Pedro / Louro, Nuno / Azinhais, Paulo / Cardoso, Pepe / Tomada, Nuno / Vendeira, Pedro

    Revista internacional de andrologia

    2020  Band 19, Heft 3, Seite(n) 150–159

    Abstract: The treatment of condyloma is generally a challenge in clinical practice. Although the spontaneous resolution rate is high, a significant proportion of patients seek treatment, not because of symptomatology, but mainly for aesthetic issues and concerns ... ...

    Titelübersetzung Consensus on HPV of the Portuguese Society of Andrology, Sexual Medicine and Reproduction: Treatment.
    Abstract The treatment of condyloma is generally a challenge in clinical practice. Although the spontaneous resolution rate is high, a significant proportion of patients seek treatment, not because of symptomatology, but mainly for aesthetic issues and concerns related to the transmission or worsening of existing lesions. The available treatments should be applied only for clinically evident macroscopic lesions. Ideally, available therapies should have rapid action onset and clearance, resolve symptoms, reduce recurrence rate and viral load, be effective in treating small lesions, and be well tolerated. However, none of the currently available treatments is clearly more effective than the others and there is no ideal treatment for all patients or for all condyloma. Therefore, the therapeutic decision should be based on the clinician's experience, available resources, lesion morphology, size, number and location, primary or recurrent lesions, disease severity, patient preference and expectations, patient's immune competence, convenience, tolerance, cost of treatment and results of previous therapies. The available treatments are divided into three groups: applied by the patient himself (imiquimod 3.75 or 5%, podophyllotoxin .5%, synecatekines 10% or 15%), applied by the health care provider (bi- and tricloacetic acids 80%-90%, intralesional interferon alpha, cryotherapy, surgical removal, electrofulguration, laser ablation) and experimental or alternative therapies (topical cidofovir, intralesional bleomycin, photodynamic therapy). Treatment methodologies can be further divided into their action - ablative or destructive treatment (cryotherapy, electrofulguration, laser ablation, surgical excision), cytotoxic or proapoptotic treatments (podophyllotoxin .5%, 5-fluoruracil, bleomycin) and immunomodulatory treatments (imiquimod 3.75% or 5%, synecatekines 10% or 15%, intralesional interferon alpha). The overall success rate of the various treatments available ranges from 23% to 94%. Only treatments that include cryotherapy or surgical excision are suitable in condyloma with any anatomical location and that have the highest success rate in monotherapy. Recurrences are common regardless of the treatment received. In contrast, immunomodulatory therapies despite having lower initial clearance rates appear to have higher probabilities of cure in the medium term, with low recurrence rates. Some treatments may be combined with each other and the effectiveness of combined therapies appears to be superior to monotherapy (proactive sequential treatment). The consensuses for the treatment of HPV also consider special situations: immunocompromised patients, meatus and intraurethral lesions and treatment of the partner.
    Mesh-Begriff(e) Adjuvants, Immunologic/therapeutic use ; Aminoquinolines/therapeutic use ; Andrology/standards ; Antimetabolites/therapeutic use ; Antiviral Agents/therapeutic use ; Condylomata Acuminata/therapy ; Condylomata Acuminata/virology ; Consensus ; Cryotherapy ; Decision Making ; Humans ; Immunologic Factors/therapeutic use ; Interferons/therapeutic use ; Keratolytic Agents/therapeutic use ; Papillomavirus Infections/therapy ; Papillomavirus Infections/virology ; Podophyllin/therapeutic use ; Podophyllotoxin/therapeutic use ; Portugal ; Practice Guidelines as Topic ; Warts/drug therapy
    Chemische Substanzen Adjuvants, Immunologic ; Aminoquinolines ; Antimetabolites ; Antiviral Agents ; Immunologic Factors ; Keratolytic Agents ; Podophyllin (9000-55-9) ; Interferons (9008-11-1) ; Podophyllotoxin (L36H50F353)
    Sprache Portugiesisch
    Erscheinungsdatum 2020-07-16
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 1698-0409
    ISSN (online) 1698-0409
    DOI 10.1016/j.androl.2020.01.007
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  6. Artikel ; Online: Recomendações em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Prevenção.

    Eufrásio, Pedro / Jorge Pereira, Bruno / Graça, Bruno / Palmas, Artur / Santiago, Felicidade / Borges, Ricardo / Bollini, Sílvio / Rebelo, Teresa / Cardoso, Pepe / Tomada, Nuno / Vendeira, Pedro

    Revista internacional de andrologia

    2020  Band 19, Heft 3, Seite(n) 187–194

    Abstract: The prevention of HPV-related diseases is an important healthcare issue due to its increasing incidence. Primary prevention is most important in males as it avoids initial infection and includes the use of condom, circumcision and vaccination. Primary ... ...

    Titelübersetzung Recommendations in Male HPV from the Portuguese Society of Andrology, Sexual Medicine and Reproduction: Prevention.
    Abstract The prevention of HPV-related diseases is an important healthcare issue due to its increasing incidence. Primary prevention is most important in males as it avoids initial infection and includes the use of condom, circumcision and vaccination. Primary prevention with vaccination is effective in decreasing HPV-related lesions in women up to 45 years old and the existing data for men comes from the experience from vaccinating women. Although it is the only vaccine that prevents cancer, the worldwide rates of vaccination in males is very low due to lack of information related to efficacy and side effects, lack of recommendation from the treating doctor, price and concern about encouragement of sexual promiscuity.
    Mesh-Begriff(e) Andrology ; Condylomata Acuminata ; Humans ; Male ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines/administration & dosage ; Portugal ; Primary Prevention ; Societies, Medical ; Warts
    Chemische Substanzen Papillomavirus Vaccines
    Sprache Spanisch
    Erscheinungsdatum 2020-07-16
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 1698-0409
    ISSN (online) 1698-0409
    DOI 10.1016/j.androl.2020.01.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Consensos em HPV masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: diagnóstico.

    Graça, Bruno / Jorge Pereira, Bruno / Palmas, Artur / Eufrásio, Pedro / Serrão, Vasco / Lourenço Reis, José / Pinheiro Lopes, Sofia / Ilgenfritz, Raquel / Cardoso, Pepe / Tomada, Nuno / Vendeira, Pedro

    Revista internacional de andrologia

    2020  Band 19, Heft 2, Seite(n) 102–106

    Abstract: HPV infection affects about 50% of sexually active individuals at least once in a lifetime. Diagnosis is made on careful inspection of the genital area and can be divided into benign lesions (genital warts or condyloma acuminatum) and pre-malignant ... ...

    Titelübersetzung The consensus of the Portuguese Society of Andrology, Sexual Medicine and Reproduction on Male HPV: diagnosis.
    Abstract HPV infection affects about 50% of sexually active individuals at least once in a lifetime. Diagnosis is made on careful inspection of the genital area and can be divided into benign lesions (genital warts or condyloma acuminatum) and pre-malignant lesions (intraepithelial neoplasia) that can lead to cancer (invasive neoplasia). Diagnostic recommendations are reviewed in Male, Female, Couple and in the immunocompromised host. Recent histological concepts are also discussed.
    Mesh-Begriff(e) Andrology/standards ; Condylomata Acuminata/diagnosis ; Consensus ; Female ; Humans ; Male ; Papillomaviridae ; Papillomavirus Infections/diagnosis ; Portugal ; Reproduction ; Societies, Medical
    Sprache Portugiesisch
    Erscheinungsdatum 2020-06-18
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 1698-0409
    ISSN (online) 1698-0409
    DOI 10.1016/j.androl.2019.11.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Sexual dysfunction in uraemic patients undergoing haemodialysis: predisposing and related conditions.

    Leão, R / Sousa, L / Azinhais, P / Conceição, P / Jorge Pereira, B / Borges, R / Grenha, V / Retroz, E / Temido, P / Cristo, L / Sobral, F

    Andrologia

    2010  Band 42, Heft 3, Seite(n) 166–175

    Abstract: Chronic kidney disease and sexual dysfunction are common entities in clinical practice in haemodialysis (HD) units. This article is a review of some articles that focus on sexual dysfunction in patients undergoing HD and its possible relationship in ... ...

    Abstract Chronic kidney disease and sexual dysfunction are common entities in clinical practice in haemodialysis (HD) units. This article is a review of some articles that focus on sexual dysfunction in patients undergoing HD and its possible relationship in multiple ways.
    Mesh-Begriff(e) Endocrine System/physiopathology ; Humans ; Quality of Life ; Renal Dialysis ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/psychology ; Sexual Dysfunction, Physiological/therapy ; Uremia/complications ; Uremia/physiopathology ; Uremia/psychology ; Uremia/therapy
    Sprache Englisch
    Erscheinungsdatum 2010-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/j.1439-0272.2009.00974.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 665: Hefte anzeigen Standort:
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