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  1. Article ; Online: Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.

    Jorgensen, Ashton N / Rashdan, Nabil A / Rao, K N Shashanka / Delgadillo, Luisa F / Kolluru, Gopi K / Krzywanski, David M / Pattillo, Christopher B / Kevil, Christopher G / Nam, Hyung W

    Redox biology

    2024  Volume 70, Page(s) 103085

    Abstract: Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular ... ...

    Abstract Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular Ca
    MeSH term(s) Animals ; Humans ; Mice ; Endothelial Cells/metabolism ; Hydrogen Peroxide/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Diseases/metabolism ; Neurogranin/metabolism ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Neurogranin (132654-77-4) ; Nitric Oxide (31C4KY9ESH) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurogranin regulates calcium-dependent cardiac hypertrophy.

    Jorgensen, Ashton N / Abdullah, Chowdhury S / Bhuiyan, Md Shenuarin / Watt, Megan / Dominic, Paari / Kolluru, Gopi K / Kevil, Christopher G / Nam, Hyung W

    Experimental and molecular pathology

    2022  Volume 127, Page(s) 104815

    Abstract: Intracellular ... ...

    Abstract Intracellular Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calmodulin/metabolism ; Cardiomegaly/metabolism ; Fibrosis ; Mice ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Neurogranin/genetics ; Neurogranin/metabolism
    Chemical Substances Calmodulin ; Neurogranin (132654-77-4) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2022.104815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Multiple factors are involved in regulation of extracellular membrane vesicle biogenesis in Streptococcus mutans.

    Wen, Zezhang T / Jorgensen, Ashton N / Huang, Xiaochang / Ellepola, Kassapa / Chapman, Lynne / Wu, Hui / Jeannine Brady, L

    Molecular oral microbiology

    2020  Volume 36, Issue 1, Page(s) 12–24

    Abstract: Streptococcus mutans, a major etiological agent of human dental caries, produces membrane vesicles (MVs) that contain protein and extracellular DNA. In this study, functional genomics, along with in vitro biofilm models, was used to identify factors that ...

    Abstract Streptococcus mutans, a major etiological agent of human dental caries, produces membrane vesicles (MVs) that contain protein and extracellular DNA. In this study, functional genomics, along with in vitro biofilm models, was used to identify factors that regulate MV biogenesis. Our results showed that when added to growth medium, MVs significantly enhanced biofilm formation by S. mutans, especially during growth in sucrose. This effect occurred in the presence and absence of added human saliva. Functional genomics revealed several genes, including sfp, which have a major effect on S. mutans MVs. In Bacillus sp. sfp encodes a 4'-phosphopantetheinyl transferase that contributes to surfactin biosynthesis and impacts vesiculogenesis. In S. mutans, sfp resides within the TnSmu2 Genomic Island that supports pigment production associated with oxidative stress tolerance. Compared to the UA159 parent, the Δsfp mutant, TW406, demonstrated a 1.74-fold (p < .05) higher MV yield as measured by BCA protein assay. This mutant also displayed increased susceptibility to low pH and oxidative stressors, as demonstrated by acid killing and hydrogen peroxide challenge assays. Deficiency of bacA, a putative surfactin synthetase homolog within TnSmu2, and especially dac and pdeA that encode a di-adenylyl cyclase and a phosphodiesterase, respectively, also significantly increased MV yield (p < .05). However, elimination of bacA2, a bacitracin synthetase homolog, resulted in a >1.5-fold (p < .05) reduction of MV yield. These results demonstrate that S. mutans MV properties are regulated by genes within and outside of the TnSmu2 island, and that as a major particulate component of the biofilm matrix, MVs significantly influence biofilm formation.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Culture Media ; Dental Caries ; Gene Expression Regulation, Bacterial ; Humans ; Streptococcus mutans/genetics ; Streptococcus mutans/metabolism
    Chemical Substances Bacterial Proteins ; Culture Media
    Language English
    Publishing date 2020-12-03
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2537726-7
    ISSN 2041-1014 ; 2041-1006
    ISSN (online) 2041-1014
    ISSN 2041-1006
    DOI 10.1111/omi.12318
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Deficiency of MecA in

    De, Arpan / Jorgensen, Ashton N / Beatty, Wandy L / Lemos, Jose / Wen, Zezhang T

    Frontiers in microbiology

    2018  Volume 9, Page(s) 2130

    Abstract: MecA is an adaptor protein that guides the ClpC/P-mediated proteolysis. ... ...

    Abstract MecA is an adaptor protein that guides the ClpC/P-mediated proteolysis. A
    Language English
    Publishing date 2018-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.02130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens.

    Nam, Hyung W / Grant, Caleb A / Jorgensen, Ashton N / Holtz-Heppelmann, Carrie J / Trutschl, Marjan / Cvek, Urska

    Proteomics

    2019  Volume 20, Issue 1, Page(s) e1900266

    Abstract: Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N-methyl-d-aspartate receptor (NMDAR) ...

    Abstract Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N-methyl-d-aspartate receptor (NMDAR) hypo-function by regulating the intracellular calcium-calmodulin (Ca
    MeSH term(s) Animals ; Central Nervous System Depressants/administration & dosage ; Central Nervous System Depressants/pharmacokinetics ; Central Nervous System Depressants/pharmacology ; Chromatography, Liquid/methods ; Ethanol/administration & dosage ; Ethanol/pharmacokinetics ; Ethanol/pharmacology ; Genotype ; Glutamic Acid/metabolism ; Male ; Mice, Knockout ; Microdialysis/methods ; Neurogranin/genetics ; Neurogranin/metabolism ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Proteome/metabolism ; Proteomics/methods ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Tandem Mass Spectrometry/methods ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Central Nervous System Depressants ; Proteome ; Neurogranin (132654-77-4) ; Ethanol (3K9958V90M) ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2019-12-23
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201900266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 1868: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Neurogranin regulates eNOS function and endothelial activation.

    Cheriyan, Vino T / Alfaidi, Mabruka / Jorgensen, Ashton N / Alam, Md Ashiqul / Abdullah, Chowdhury S / Kolluru, Gopi K / Bhuiyan, Md Shenuarin / Kevil, Christopher G / Orr, A Wayne / Nam, Hyung W

    Redox biology

    2020  Volume 34, Page(s) 101487

    Abstract: Endothelial nitric oxide (NO) is a critical mediator of vascular function and vascular remodeling. NO is produced by endothelial nitric oxide synthase (eNOS), which is activated by calcium ( ... ...

    Abstract Endothelial nitric oxide (NO) is a critical mediator of vascular function and vascular remodeling. NO is produced by endothelial nitric oxide synthase (eNOS), which is activated by calcium (Ca
    MeSH term(s) Animals ; Cells, Cultured ; Endothelial Cells/metabolism ; Mice ; Neurogranin ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Phosphorylation
    Chemical Substances Neurogranin (132654-77-4) ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, mouse (EC 1.14.13.39)
    Language English
    Publishing date 2020-03-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2020.101487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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