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  1. Article ; Online: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19.

    Vaillancourt, Mylene / Jorth, Peter

    mBio

    2020  Volume 11, Issue 4

    Abstract: Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    MeSH term(s) Adult ; Bacteria ; Bacterial Infections ; Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Inpatients ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01806-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Variable Release of Lipoteichoic Acid From

    Algorri, Marquerita / Jorth, Peter / Wong-Beringer, Annie

    Frontiers in microbiology

    2021  Volume 11, Page(s) 609280

    Abstract: Background: Staphylococcus aureus: Methods: Seven strains of : Results: Lipoteichoic acid release varied by 4-fold amongst the clinical strains and appeared to be related to duration of bacteremia, independent of MLST type. Low LTA releasing ... ...

    Abstract Background: Staphylococcus aureus
    Methods: Seven strains of
    Results: Lipoteichoic acid release varied by 4-fold amongst the clinical strains and appeared to be related to duration of bacteremia, independent of MLST type. Low LTA releasing strains were isolated from patients who had prolonged duration of bacteremia and died. Antibiotic-mediated differences in LTA release appeared to be associated with MLST type, as ST8 strains released maximal LTA in response to tedizolid while other non-ST8 strains demonstrated high LTA release with vancomycin. Genetic variations related to the LTA biosynthesis pathway were detected in all non-ST8 strains, though ST8 strains showed no variations despite demonstrating differential LTA release.
    Conclusion: Our findings provide the basis for future studies to evaluate the relationship between LTA release-mediated host immune response and clinical outcomes as well as the potential for antibiotic modulation of LTA release as a therapeutic strategy and deserve confirmation with larger number of strains with known clinical phenotypes.
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.609280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Determining Susceptibility and Potential Mediators of Resistance for the Novel Polymyxin Derivative, SPR206, in

    Abdul-Mutakabbir, Jacinda C / Opoku, Nana Sakyi / Tan, Karen K / Jorth, Peter / Nizet, Victor / Fletcher, Hansel M / Kaye, Keith S / Rybak, Michael J

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: With the increase in carbapenem- ... ...

    Abstract With the increase in carbapenem-resistant
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13010047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Siderophores promote cooperative interspecies and intraspecies cross-protection against antibiotics in vitro.

    Galdino, Anna Clara M / Vaillancourt, Mylene / Celedonio, Diana / Huse, Kara / Doi, Yohei / Lee, Janet S / Jorth, Peter

    Nature microbiology

    2024  Volume 9, Issue 3, Page(s) 631–646

    Abstract: The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified ... ...

    Abstract The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified cefiderocol resistance mutations in Pseudomonas aeruginosa. Resistance was multifactorial in host-mimicking growth media, led to multidrug resistance and paid fitness costs in cefiderocol-free environments. However, kin selection drove some resistant populations to cross-protect susceptible individuals from killing by increasing pyoverdine secretion via a two-component sensor mutation. While pyochelin sensitized P. aeruginosa to cefiderocol killing, pyoverdine and the enterobacteria siderophore enterobactin displaced iron from cefiderocol, preventing uptake by susceptible cells. Among 113 P. aeruginosa intensive care unit clinical isolates, pyoverdine production directly correlated with cefiderocol tolerance, and high pyoverdine producing isolates cross-protected susceptible P. aeruginosa and other Gram-negative bacteria. These in vitro data show that antibiotic cross-protection can occur via degradation-independent mechanisms and siderophores can serve unexpected protective cooperative roles in polymicrobial communities.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Siderophores/metabolism ; Siderophores/pharmacology ; Cefiderocol ; Iron/metabolism ; Enterobacteriaceae/metabolism ; Pseudomonas aeruginosa/metabolism
    Chemical Substances Anti-Bacterial Agents ; Siderophores ; Cefiderocol (SZ34OMG6E8) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01601-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

    Vaillancourt, Mylene / Jorth, Peter

    mBio (Online)

    Abstract: Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #707423
    Database COVID19

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  6. Article ; Online: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

    Vaillancourt, Mylene / Jorth, Peter

    mBio

    2020  Volume 11, Issue 4

    Abstract: ABSTRACT Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent ... ...

    Abstract ABSTRACT Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    Keywords covid19
    Language English
    Publisher American Society for Microbiology
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01806-20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: In-Human Multiyear Evolution of Carbapenem-Resistant Klebsiella pneumoniae Causing Chronic Colonization and Intermittent Urinary Tract Infections: A Case Study.

    Kalu, Michelle / Tan, Karen / Algorri, Marquerita / Jorth, Peter / Wong-Beringer, Annie

    mSphere

    2022  Volume 7, Issue 3, Page(s) e0019022

    Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a frequent pathogen of the urinary tract, but how CRKP ... ...

    Abstract Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a frequent pathogen of the urinary tract, but how CRKP adapts
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenem-Resistant Enterobacteriaceae ; Carbon ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae ; Meropenem/pharmacology ; Meropenem/therapeutic use ; Phylogeny ; Urinary Tract Infections
    Chemical Substances Anti-Bacterial Agents ; Carbon (7440-44-0) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00190-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evolved bacterial siderophore-mediated antibiotic cross-protection.

    Galdino, Anna Clara M / Vaillancourt, Mylene / Celedonio, Diana / Huse, Kara / Doi, Yohei / Lee, Janet S / Jorth, Peter

    Research square

    2023  

    Abstract: Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, ... ...

    Abstract Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, including carbapenem-resistant
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2644953/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Intracellular

    Malet, Karim / Faure, Emmanuel / Adam, Damien / Donner, Jannik / Liu, Lin / Pilon, Sarah-Jeanne / Fraser, Richard / Jorth, Peter / Newman, Dianne K / Brochiero, Emmanuelle / Rousseau, Simon / Nguyen, Dao

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: Pseudomonas aeruginosa: Objectives: To detect and characterize intracellular : Methods: We sampled the lung explant tissues from CF patients undergoing lung transplantation and non-CF lung donor control. We analyzed lung tissue sections ...

    Abstract Rationale: Pseudomonas aeruginosa
    Objectives: To detect and characterize intracellular
    Methods: We sampled the lung explant tissues from CF patients undergoing lung transplantation and non-CF lung donor control. We analyzed lung tissue sections for the presence of intracellular
    Measurements and main results: P.a.
    Conclusion: This is the first study describing the presence of intracellular
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1451OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pseudomonas aeruginosa

    Vaillancourt, Mylene / Limsuwannarot, Sam P / Bresee, Catherine / Poopalarajah, Rahgavi / Jorth, Peter

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: Antibiotic- ... ...

    Abstract Antibiotic-resistant
    Language English
    Publishing date 2021-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10101164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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