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  1. Article ; Online: Unwinding the Long Road that leads to Understanding Autoimmunity

    Florencia Rosetti / José C. Crispín

    Revista de Investigación Clínica, Vol 73, Iss

    2021  Volume 5

    Abstract: Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current ... ...

    Abstract Systemic autoimmune diseases are complex clinical conditions that arise in genetically predisposed individuals as a result of the interplay between their immune system and their environment. In this perspective, we briefly discuss our current understanding of the pathogenesis of autoimmunity and indicate four research avenues whose exploration will bring us closer to resolving fundamental questions that remain unanswered in this enigmatic field.
    Keywords Autoimmunity. Autoimmune diseases. Immune system ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Cancer immunosurveillance by CD8 T cells [version 1; peer review

    José C Crispin / George C Tsokos

    F1000Research, Vol

    3 approved]

    2020  Volume 9

    Abstract: Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the ... ...

    Abstract Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function. In particular, we review recent literature that has reported on the phenotype and transcriptome of tumor-infiltrating CD8 T cells and deciphered the mechanisms associated with failed tumor rejection.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: IL-17 in Systemic Lupus Erythematosus

    José C. Crispín / George C. Tsokos

    Journal of Biomedicine and Biotechnology, Vol

    2010  Volume 2010

    Abstract: IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4−CD8− (double negative) T ... ...

    Abstract IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.
    Keywords Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: IL-17 in Systemic Lupus Erythematosus

    José C. Crispín / George C. Tsokos

    Journal of Biomedicine and Biotechnology, Vol

    2010  Volume 2010

    Keywords Biotechnology ; TP248.13-248.65 ; Medicine ; R
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection

    Sergio Fragoso-Saavedra / David A. Iruegas-Nunez / Alejandro Quintero-Villegas / H. Benjamín García-González / Isaac Nuñez / Sergio L. Carbajal-Morelos / Belem M. Audelo-Cruz / Sarahi Arias-Martínez / Yanink Caro-Vega / Juan José Calva / Verónica Luqueño-Martínez / Alejandra González-Duarte / Brenda Crabtree-Ramírez / José C. Crispín / Juan Sierra-Madero / Pablo F. Belaunzarán-Zamudio / Sergio I. Valdés-Ferrer

    BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-

    the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

    2020  Volume 7

    Abstract: Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of coronavirus disease 2019 (COVID-19), may lead to severe systemic inflammatory response, pulmonary damage, and even acute respiratory ... ...

    Abstract Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of coronavirus disease 2019 (COVID-19), may lead to severe systemic inflammatory response, pulmonary damage, and even acute respiratory distress syndrome (ARDS). This in turn may result in respiratory failure and in death. Experimentally, acetylcholine (ACh) modulates the acute inflammatory response, a neuro-immune mechanism known as the inflammatory reflex. Recent clinical evidence suggest that electrical and chemical stimulation of the inflammatory reflex may reduce the burden of inflammation in chronic inflammatory diseases. Pyridostigmine (PDG), an ACh-esterase inhibitor (i-ACh-e), increases the half-life of endogenous ACh, therefore mimicking the inflammatory reflex. This clinical trial is aimed at evaluating if add-on of PDG leads to a decrease of invasive mechanical ventilation and death among patients with severe COVID-19. Methods A parallel-group, multicenter, randomized, double-blinded, placebo-controlled, phase 2/3 clinical trial to test the efficacy of pyridostigmine bromide 60 mg/day P.O. to reduce the need for invasive mechanical ventilation and mortality in hospitalized patients with severe COVID-19. Discussion This study will provide preliminary evidence of whether or not -by decreasing systemic inflammation- add-on PDG can improve clinical outcomes in patients with severe COVID-19. Trial registration ClinicalTrials.gov NCT04343963 (registered on April 14, 2020).
    Keywords COVID-19 ; SARS-Cov-2 ; Mortality ; Invasive mechanical ventilation ; Immunomodulation ; Pyridostigmine ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: ICER is requisite for Th17 differentiation

    Nobuya Yoshida / Denis Comte / Masayuki Mizui / Kotaro Otomo / Florencia Rosetti / Tanya N. Mayadas / José C. Crispín / Sean J. Bradley / Tomohiro Koga / Michihito Kono / Maria P. Karampetsou / Vasileios C. Kyttaris / Klaus Tenbrock / George C. Tsokos

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 13

    Abstract: ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity. ...

    Abstract ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.
    Keywords Science ; Q
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients

    Josefina Alberu / Maria Inés Vargas-Rojas / Luis E. Morales-Buenrostro / Jose C. Crispin / Roxana Rodríguez-Romo / Norma O. Uribe-Uribe / Gabriel Carrasco / Diana Gómez-Martín / Jorge Alcocer-Varela

    Journal of Transplantation, Vol

    A Place for Interaction?

    2012  Volume 2012

    Keywords Surgery ; RD1-811 ; Medicine ; R
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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