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Article ; Online: COVID-19 convalescent plasma transfusion

Dante Mário Langhi, Junior / Gil Cunha De Santis / José Orlando Bordin

Hematology, Transfusion and Cell Therapy, Vol 42, Iss 2, Pp 113-

2020 Volume 115

Keywords	Diseases of the blood and blood-forming organs ; RC633-647.5 ; covid19
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aloimunização após transfusão de concentrado de hemácias em pacientes atendidos em um serviço de emergência Post-transfusion red cell alloimmunisation in patients with acute disorders and medical emergencies

José Orlando Bordin

Revista Brasileira de Hematologia e Hemoterapia, Vol 29, Iss 4, Pp 339-

2007 Volume 340

Keywords	Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-12-01T00:00:00Z
Publisher	Sociedade Brasileira de Hematologia e Hemoterapia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple myeloma with cells typically seen in storage diseases

Edmir Boturão Neto / Mihoko Yamamoto / Yara Menezes / José Orlando Bordin

Revista Brasileira de Hematologia e Hemoterapia, Vol 33, Iss 1, Pp 82-

2011 Volume 82

Abstract: We report on a rare case of multiple myeloma with atypically large cells containing a great amount of azurophilic inclusions usually seen in storage diseases. ...

Abstract	We report on a rare case of multiple myeloma with atypically large cells containing a great amount of azurophilic inclusions usually seen in storage diseases.
Keywords	Multiple myeloma ; Plasma cells ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-02-01T00:00:00Z
Publisher	Associação Brasileira de Hematologia e Hemoterapia e da
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Avaliação da hemorragia feto-materna em puérperas com indicação para ministração de imunoglobulina anti-D Evaluation of fetomaternal hemorrhage in postpartum patients with indication for administration of anti-D immunoglobulin

Eduardo Baiochi / Luiz Camano / José Orlando Bordin

Cadernos de Saúde Pública, Vol 21, Iss 5, Pp 1357-

2005 Volume 1365

Abstract: Avaliamos a ocorrência da hemorragia feto-materna entre 343 puérperas que receberiam profilaxia da aloimunização Rh com emprego de imunoglobulina anti-D. Realizamos o teste de roseta para triagem dos casos que necessitariam determinação quantitativa do ... ...

Abstract	Avaliamos a ocorrência da hemorragia feto-materna entre 343 puérperas que receberiam profilaxia da aloimunização Rh com emprego de imunoglobulina anti-D. Realizamos o teste de roseta para triagem dos casos que necessitariam determinação quantitativa do volume de sangue fetal transferido para circulação materna, que foi então apurado pelo teste de Kleihauer-Betke (K-B). O teste de roseta apresentou resultado positivo em 22 casos (6,4%). Em cinco dessas amostras o teste de K-B não apontou hemorragia feto-materna (falso positivo do teste de roseta de 1,45%) e noutra a leitura do teste não foi conclusiva. Tivemos oito casos com volume apurado de hemorragia feto-materna < 10ml (2,3%), seis com hemorragia feto-materna entre 10 e 30ml (1,7%) e duas puérperas apresentaram transferência sangüínea feto-materna maior que 30ml (0,58%), necessitando suplementação além da dose padrão de anti-D. O teste de roseta dispensou 93,6% das pacientes da avaliação adicional da hemorragia feto-materna por método quantitativo. This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measured by the Kleihauer-Betke test (K-B). The rosette test was positive in 22 cases (6.4%). In five of these cases, K-B did not show fetomaternal hemorrhage (a 1.45% false-positive rate for the rosette test), and in one case the test was inconclusive. There were 8 cases with FMH < 10ml (2.3%), 6 cases with FMH from 10 to 30ml (1.7%), and two cases with FMH > 30ml (0.58%), requiring a supplementary dose of anti-D. The study concludes that following the rosette test, additional evaluation of FMH using a quantitative test was unnecessary in 93.6% of the cases.
Keywords	Eritroblastose Fetal ; Transfusão Feto-materna ; Imunoglobina Rho(D) ; Fetal Erythroblastosis ; Fetomaternal Transfusion ; Rho(D) Immune Globulin ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2005-10-01T00:00:00Z
Publisher	Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lesão pulmonar aguda associada à transfusão Transfusion-related acute lung injury

Antonio Fabron Junior / Larissa Barbosa Lopes / José Orlando Bordin

Jornal Brasileiro de Pneumologia, Vol 33, Iss 2, Pp 206-

2007 Volume 212

Abstract: Lesão pulmonar aguda associada à transfusão (transfusion-related acute lung injury, TRALI) é uma complicação clínica grave relacionada à transfusão de hemocomponentes que contêm plasma. Recentemente, TRALI foi considerada a principal causa de morte ... ...

Abstract	Lesão pulmonar aguda associada à transfusão (transfusion-related acute lung injury, TRALI) é uma complicação clínica grave relacionada à transfusão de hemocomponentes que contêm plasma. Recentemente, TRALI foi considerada a principal causa de morte associada à transfusão nos Estados Unidos e Reino Unido. É manifestada tipicamente por dispnéia, hipoxemia, hipotensão, febre e edema pulmonar não cardiogênico, que ocorre durante ou dentro de 6 h, após completada a transfusão. Embora o exato mecanismo não tenha sido totalmente elucidado, postula-se que TRALI esteja associada à infusão de anticorpos contra antígenos leucocitários (classes I ou II ou aloantígenos específicos de neutrófilos) e a mediadores biologicamente ativos presentes em componentes celulares estocados. A maioria dos doadores implicados em casos da TRALI são mulheres multíparas. TRALI, além de ser pouco diagnosticada, pode ainda ser confundida com outras situações de insuficiência respiratória aguda. Um melhor conhecimento sobre TRALI pode ser crucial na prevenção e tratamento desta severa complicação transfusional. Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related death in the United States and United Kingdom. This complication typically presents as shortness of breath, hypoxemia, hypotension, fever and noncardiogeneic pulmonary edema, all occurring during or within 6 h after transfusion. Although the mechanism of TRALI has not been fully elucidated, it has been associated with human leukocyte antigen antibodies (class I, class II or neutrophil alloantigens) and with biologically active mediators in stored cellular blood components. Most of the donors implicated in cases of TRALI are multiparous women. Rarely diagnosed, TRALI can be confused with other causes of acute respiratory failure. Greater knowledge regarding TRALI on the part of clinicians could be crucial in preventing and treating this severe complication of blood transfusion.
Keywords	Transfusão de sangue ; Insuficiência respiratória ; Antígenos HLA ; Blood transfusion ; Respiratory insufficiency ; HLA antigens ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2007-04-01T00:00:00Z
Publisher	Sociedade Brasileira de Pneumologia e Tisiologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and epidemiological profile of female blood donors with positive serology for viral hepatitis B

Janaína Luz Narciso-Schiavon / Leonardo de Lucca Schiavon / Roberto José de Carvalho-Filho / Christine Takemi Emori / Fernando Akio Maryia / José Orlando Bordin / Antonio Eduardo Benedito Silva / Maria Lucia Gomes Ferraz

Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 5, Pp 524-

2015 Volume 531

Abstract: ABSTRACTINTRODUCTION:Since women are frequently the minority among blood donors worldwide, studies evaluating this population usually reflect male features. We assessed the features of female blood donors with positive serology for HBV and compared them ... ...

Abstract	ABSTRACTINTRODUCTION:Since women are frequently the minority among blood donors worldwide, studies evaluating this population usually reflect male features. We assessed the features of female blood donors with positive serology for HBV and compared them with those of men.METHODS The study comprised consecutive blood donors referred to a specialized liver disease center to be evaluated due to HBsAg- and/or anti-HBc-positive tests.RESULTS: The study encompassed 1,273 individuals, 219 (17.2%) of whom were referred due to positive HBsAg test and 1,054 (82.8%) due to reactive anti-HBc test. Subjects' mean age was 36.8±10.9 years, and 28.7% were women. Female blood donors referred for positive HBsAg screening tests demonstrated higher prevalence of healthcare workers (9.3% vs 2.5%) and lower prevalence of sexual risk behaviors (15.1% vs 41.1%) and alcohol abuse (1.9% vs 19.8%) compared to men. Women had lower ALT (0.6 vs 0.8×ULN), AST (0.6 vs 0.8×ULN), direct bilirubin (0.2 vs 0.3mg/dL), and alkaline phosphatase (0.5 vs 0.6×ULN) levels and higher platelet count (223,380±50,293 vs 195,020±53,060/mm3). Women also had a higher prevalence of false-positive results (29.6% vs 17.0%). No differences were observed with respect to liver biopsies. Female blood donors referenced for reactive anti-HBc screening tests presented similar clinical, epidemiological, and biochemical characteristics to those reported for positive HBsAg screening tests and similarly had a higher prevalence of false-reactive results.CONCLUSIONS: Compared to men, female blood donors with positive HBsAg and/or anti-HBc screening tests demonstrated higher prevalence of professional risk and false-positive results and reduced alteration of liver chemistry.
Keywords	Blood donos ; HBsAg ; Anti-HBc ; Women ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	610
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is there justification for universal leukoreduction?

Alfredo Mendrone Jr. / Antonio Fabron Jr. / Dante Langhi Jr. / Dimas Tadeu Covas / Carla Luana Dinardo / Eugênia Amorim Ubiali / José Francisco Comenalli Marques Jr. / José Orlando Bordin / Marilia Rugani

Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 4, Pp 237-

2014 Volume 237

Keywords	Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Hematologia e Hemoterapia
Document type	Article ; Online
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Article ; Online: Reduction of exposure to blood donors in preterm infants submitted to red blood cell transfusions using pediatric satellite packs

Cristina Lika Uezima / Ariane Moreira Barreto / Ruth Guinsburg / Akemi Kuroda Chiba / José Orlando Bordin / Melca Maria O. Barros / Amélia Miyashiro N. dos Santos

Revista Paulista de Pediatria, Vol 31, Iss 3, Pp 285-

2013 Volume 292

Abstract: OBJECTIVE: In preterm newborn infants transfused with erythrocytes stored up to 28 days, to compare the reduction of blood donor exposure in two groups of infants classified according to birth weight. METHODS: A prospective study was conducted with ... ...

Abstract	OBJECTIVE: In preterm newborn infants transfused with erythrocytes stored up to 28 days, to compare the reduction of blood donor exposure in two groups of infants classified according to birth weight. METHODS: A prospective study was conducted with preterm infants with birth weight <1000g (Group 1) and 1000-1499g (Group 2), born between April, 2008 and December, 2009. Neonates submitted to exchange transfusions, emergency erythrocyte transfusion, or those who died in the first 24 hours of life were excluded. Transfusions were indicated according to the local guideline using pediatric transfusion satellite bags. Demographic and clinical data, besides number of transfusions and donors were assessed. . Logistic regression analysis was performed to determine factors associated with multiple transfusions. RESULTS: 30 and 48 neonates were included in Groups 1 and 2, respectively. The percentage of newborns with more than one erythrocyte transfusion (90 versus 11%), the median number of transfusions (3 versus 1) and the median of blood donors (2 versus 1) were higher in Group 1 (p<0.001), compared to Group 2. Among those with multiple transfusions, 14 (82%) and one (50%) presented 50% reduction in the number of blood donors, respectively in Groups 1 and 2. Factors associated with multiple transfusions were: birth weight <1000g (OR 11.91; 95%CI 2.14-66.27) and presence of arterial umbilical catheter (OR 8.59; 95%CI 1.94-38.13), adjusted for confounders. CONCLUSIONS: The efficacy of pediatrics satellites bags on blood donor reduction was higher in preterm infants with birth weight <1000g.
Keywords	Prematuro ; anemia ; transfusión de eritrocitos ; donantes de sangre ; Pediatrics ; RJ1-570 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2013-09-01T00:00:00Z
Publisher	Sociedade de Pediatria de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Delayed hemolytic transfusion reaction presenting as a painful crisis in a patient with sickle cell anemia

Antonio Fabron Junior / Gilberto Moreira Junior / José Orlando Bordin

São Paulo Medical Journal, Vol 117, Iss 1, Pp 38-

1999 Volume 39

Abstract: CONTEXT: Patients with sickle cell anemia (SCA) are frequently transfused with red blood cells (RBC). Recently, we reported that the calculated risk of RBC alloimmunization per transfused unit in Brazilian patients with SCA is 1.15%. We describe a ... ...

Abstract	CONTEXT: Patients with sickle cell anemia (SCA) are frequently transfused with red blood cells (RBC). Recently, we reported that the calculated risk of RBC alloimmunization per transfused unit in Brazilian patients with SCA is 1.15%. We describe a delayed hemolytic transfusion reaction (DHTR) presenting as a painful crisis in a patient with SCA. CASE REPORT: A 35-year-old Brazilian female with homozygous SCA was admitted for a program of partial exchange transfusion prior to cholecystectomy. Her blood group was O RhD positive and no atypical RBC alloantibody was detected using the indirect antiglobulin technique. Pre-transfusional hemoglobin (Hb) was 8.7 g/dL and isovolumic partial exchange transfusion was performed using 4 units of ABO compatible packed RBC. Five days after the last transfusion she developed generalized joint pain and fever of 39°C. Her Hb level dropped from 12.0 g/dL to 9.3 g/dL and the unconjugated bilirrubin level rose to 27 mmol/L. She was jaundiced and had hemoglobinuria. Hemoglobin electrophoresis showed 48.7% HbS, 46.6% HbA1, 2.7% HbA2, and 2.0% HbF. The patient’s extended RBC phenotype was CDe, K-k+, Kp(a-b+), Fy(a-b-), M+N+s+, Le(a+b-), Di(a-). An RBC alloantibody with specificity to the Rh system (anti-c, titer 1:16.384) was identified by the indirect antiglobulin test. The Rh phenotype of the RBC used in the last packed RBC transfusion was CcDEe. The patient was discharged, asymptomatic, 7 days after admission.
Keywords	Sickle cell anemia ; Transfusion reaction ; Painful crisis ; Medicine ; R
Subject code	616
Language	English
Publishing date	1999-01-01T00:00:00Z
Publisher	Associação Paulista de Medicina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon

Aparecida Maria Fontes / Simone Kashima / Ricardo Bonfim-Silva / Rochele Azevedo / Kuruvilla Joseph Abraham / Sérgio Roberto Lopes Albuquerque / José Orlando Bordin / Dante Mário Langhi Júnior / Dimas Tadeu Covas

Genetics and Molecular Biology, Vol 34, Iss 4, Pp 539-

2011 Volume 545

Abstract: Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the ... ...

Abstract	Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Keywords	Brazilian Amazon population ; CR1 haplotypes ; Knops blood group polymorphism ; malaria ; Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Genetics ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	616
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Genética
Document type	Article ; Online
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