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  1. Article: Ultra Long Stent in an Aberrant Right Coronary Artery.

    Vinayakumar, Desabandhu / Jose, Jomy Vadasseril

    Journal of the Saudi Heart Association

    2020  Volume 32, Issue 3, Page(s) 396–398

    Abstract: The prevalence of anomalous origin of right coronary artery from the left sinus is about 0.92%. A percutaneous coronary intervention (PCI) in such a vessel is challenging especially when maneuvering long stents. We report a case of 75-year old female ... ...

    Abstract The prevalence of anomalous origin of right coronary artery from the left sinus is about 0.92%. A percutaneous coronary intervention (PCI) in such a vessel is challenging especially when maneuvering long stents. We report a case of 75-year old female patient with recent acute coronary syndrome. The angiogram showed significant lesions in the left anterior descending coronary artery and the left circumflex coronary artery with an aberrant RCA originating from the left sinus close to the origin of LMCA with multiple tight lesions. The aberrant RCA was stented with a 50 mm long stent. To the best of our knowledge, the placement of such a long stent in an aberrant coronary artery has hitherto never been reported in the literature.
    Language English
    Publishing date 2020-09-01
    Publishing country Saudi Arabia
    Document type Case Reports
    ZDB-ID 2515647-0
    ISSN 1016-7315
    ISSN 1016-7315
    DOI 10.37616/2212-5043.1161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metastatic bronchogenic carcinoma with myocardial and endocardial secondaries.

    Jose, Jomy Vadasseril / Rajesh, Gopalan Nair

    Journal of echocardiography

    2020  Volume 20, Issue 1, Page(s) 64–66

    MeSH term(s) Carcinoma, Bronchogenic/pathology ; Carcinoma, Bronchogenic/secondary ; Humans ; Lung Neoplasms
    Language English
    Publishing date 2020-11-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-020-00499-1
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  3. Article ; Online: Clinical profile and one-year outcomes of patients with mural infective endocarditis: - A tertiary care centre study based on data from a seven-year registry.

    Rajesh, Gopalan Nair / Vellani, Haridasan / Vadasseril Jose, Jomy / Mohanan, Sandeep / Sajeev, C G

    Indian heart journal

    2022  Volume 74, Issue 3, Page(s) 163–169

    Abstract: Background: Infective endocarditis patients present very rarely with vegetations on the mural endocardium. Only very few studies are available comparing Mural infective endocarditis with commoner valvular or device related infective endocarditis.: Aim! ...

    Abstract Background: Infective endocarditis patients present very rarely with vegetations on the mural endocardium. Only very few studies are available comparing Mural infective endocarditis with commoner valvular or device related infective endocarditis.
    Aim: To analyse the clinical features, microbiological profile and clinical course of mural endocarditis in comparison to valvular endocarditis.
    Methods: This was a retrospective analysis of data from a registry of infective endocarditis. Patients enrolled between April 2012 and April 2019 were included. Patients who were reported to have vegetations on the mural endocardial surface were taken as a group and compared with rest of the patients. Clinical profile, laboratory parameters including culture and outcomes were compared between the two groups.
    Results: Out of 278 patients in the study, 15 (5.38%) had vegetations on the mural endocardium. Of them, only 4 patients had structural heart diseases. All the patients with mural endocarditis were NYHA class II or below at presentation. Ventricles were the commonest sites of vegetations. Inflammatory markers like ESR and CRP were low in mural endocarditis compared to rest. Culture positivity was high in mural endocarditis and Staphylococcus Aureus was the commonest organism. Mural endocarditis patients had similar in hospital mortality to rest of the patients. Cardiac complications were not reported in mural endocarditis, but they had similar incidence of embolic complications including neurological events.
    Conclusion: Mural endocarditis is a rare clinical entity with similar morbidity and mortality to that of endocarditis with valvular vegetation.
    MeSH term(s) Endocarditis/complications ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/epidemiology ; Humans ; Registries ; Retrospective Studies ; Tertiary Care Centers
    Language English
    Publishing date 2022-05-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Primary Antiphospholipid Antibody Syndrome Presenting as Acute Myocardial Infarction.

    Faizal, Ali / Yoonus, Sajid / Nair, Shreetal Rajan / Kayakkal, Shajudeen / Jose, Jomy Vadasseril

    The Journal of invasive cardiology

    2021  Volume 33, Issue 11, Page(s) E918

    Abstract: A 46-year-old woman with no significant past history presented to the emergency department with history of sudden-onset central chest discomfort and diaphoresis. With a preliminary diagnosis of acute myocardial infarction, she was subjected to coronary ... ...

    Abstract A 46-year-old woman with no significant past history presented to the emergency department with history of sudden-onset central chest discomfort and diaphoresis. With a preliminary diagnosis of acute myocardial infarction, she was subjected to coronary angiography, which showed occlusion of the distal left anterior descending artery with otherwise normal epicardial coronary arteries. Aspiration was performed in the vessel and yielded pinkish friable tissue. The histopathological examination revealed fibrin-rich thrombus. The patient was treated with enoxaparin and switched to oral anticoagulation with warfarin. On follow-up, the nodular mass on the mitral valve reduced considerably in size and she was advised that life-long anticoagulation was necessary.
    MeSH term(s) Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Coronary Angiography ; Female ; Humans ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Thromboembolism ; Warfarin
    Chemical Substances Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3701: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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  5. Article: Spontaneous chondrosarcoma in Wistar rat: a case report.

    Balani, Seema / Mulla, Mohmad Sadik / Subramanian, Vijayakumar / Jose, Jomy / Bhatnagar, Upendra

    Journal of toxicologic pathology

    2021  Volume 34, Issue 1, Page(s) 119–122

    Abstract: In rats, chondrosarcomas have been reported to occur both spontaneously and secondary to chemical induction. In a rare case, a spontaneous chondrosarcoma was identified in the deformed femur of a young male Wistar rat. After gross examination of the ... ...

    Abstract In rats, chondrosarcomas have been reported to occur both spontaneously and secondary to chemical induction. In a rare case, a spontaneous chondrosarcoma was identified in the deformed femur of a young male Wistar rat. After gross examination of the femur and knee joint, tissue was collected and preserved. The formalin-fixed tissue was decalcified, embedded in paraffin, sectioned, and stained with hematoxylin and eosin. Microscopic examinations revealed a large, highly proliferative, noncapsulated growth of chondrocytic or chondroblastic origin in the femoral bone, with proliferating chondrocytes invading the bone and surrounding tissues in an infiltrative growth pattern. Based on its histomorphological features, the lesion was diagnosed as a malignant cartilaginous neoplasm of spontaneous origin.
    Language English
    Publishing date 2021-01-05
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2128461-1
    ISSN 1881-915X ; 0914-9198
    ISSN (online) 1881-915X
    ISSN 0914-9198
    DOI 10.1293/tox.2020-0031
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  6. Article ; Online: Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation.

    Ganneru, Brunda / Jogdand, Harsh / Daram, Vijaya Kumar / Das, Dipankar / Molugu, Narasimha Reddy / Prasad, Sai D / Kannappa, Srinivas V / Ella, Krishna M / Ravikrishnan, Rajaram / Awasthi, Amit / Jose, Jomy / Rao, Panduranga / Kumar, Deepak / Ella, Raches / Abraham, Priya / Yadav, Pragya D / Sapkal, Gajanan N / Shete-Aich, Anita / Desphande, Gururaj /
    Mohandas, Sreelekshmy / Basu, Atanu / Gupta, Nivedita / Vadrevu, Krishna Mohan

    iScience

    2021  Volume 24, Issue 4, Page(s) 102298

    Abstract: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. We used a well-characterized SARS- ... ...

    Abstract We report the development and evaluation of safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established Vero cell platform to produce large-scale GMP-grade highly purified inactivated antigen. Product development and manufacturing process were carried out in a BSL-3 facility. Immunogenicity and safety were determined at two antigen concentrations (3μg and 6μg), with two different adjuvants, in mice, rats, and rabbits. Our results show that BBV152 vaccine formulations generated significantly high antigen-binding and neutralizing antibody titers (NAb), at both concentrations, in all three species with excellent safety profiles. The inactivated vaccine formulation contains TLR7/8 agonist adjuvant-induced Th1-biased antibody responses with elevated IgG2a/IgG1 ratio and increased levels of SARS-CoV-2-specific IFN-γ
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.102298
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  7. Article ; Online: Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

    Ganneru, Brunda / Jogdand, Harsh / Dharam, Vijaya Kumar / Reddy, Narasimha / Prasad, Sai D / Vellimudu, Srinivas / Ella, Krishna M / Ravikrishnan, Rajaram / Awasthi, Amit / Jose, Jomy / Rao, Panduranga / Kumar, Deepak / Ella, Raches / Abraham, Priya / Yadav, Pragya / Sapkal, Gajanan N / Shete, Anita / Desphande, Gururaj Rao / Mohandas, Sreelekshmy /
    Basu, Ananth / Gupta, Nievedita / Bhargava, Balram / Mohan, Krishna Vadrevu

    bioRxiv

    Abstract: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or a novel TLR7/8 agonist adsorbed Algel. We used a well-characterized SARS- ... ...

    Abstract We report the development and evaluation of safety and immunogenicity of a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or a novel TLR7/8 agonist adsorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established vero cell platform to produce large-scale GMP grade highly purified inactivated antigen, BBV152. Product development and manufacturing were carried out in a BSL-3 facility. Immunogenicity was determined at two antigen concentrations (3μg and 6μg), with two different adjuvants, in mice, rats, and rabbits. Our results show that BBV152 vaccine formulations generated significantly high antigen-binding and neutralizing antibody titers, at both concentrations, in all three species with excellent safety profiles. The inactivated vaccine formulation containing TLR7/8 agonist adjuvant-induced Th1 biased antibody responses with elevated IgG2a/IgG1 ratio and increased levels of SARS-CoV-2 specific IFN-γ+ CD4 T lymphocyte response. Our results support further development for Phase I/II clinical trials in humans.
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.09.09.285445
    Database COVID19

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  8. Article ; Online: Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

    Ganneru, Brunda / Jogdand, Harsh / Dharam, Vijaya Kumar / Reddy, Narasimha / Prasad, Sai D / Vellimudu, Srinivas / Ella, Krishna M / Ravikrishnan, Rajaram / Awasthi, Amit / Jose, Jomy / Rao, Panduranga / Kumar, Deepak / Ella, Raches / Abraham, Priya / Yadav, Pragya / Sapkal, Gajanan N / Shete, Anita / Desphande, Gururaj Rao / Mohandas, Sreelekshmy /
    Basu, Atanu / Gupta, Nievedita / Mohan, Krishna Vadrevu

    bioRxiv

    Abstract: We report the development and evaluation of safety and immunogenicity of a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or a novel TLR7/8 agonist adsorbed Algel. We used a well-characterized SARS- ... ...

    Abstract We report the development and evaluation of safety and immunogenicity of a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or a novel TLR7/8 agonist adsorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established vero cell platform to produce large-scale GMP grade highly purified inactivated antigen, BBV152. Product development and manufacturing were carried out in a BSL-3 facility. Immunogenicity was determined at two antigen concentrations (3g and 6g), with two different adjuvants, in mice, rats, and rabbits. Our results show that BBV152 vaccine formulations generated significantly high antigen-binding and neutralizing antibody titers, at both concentrations, in all three species with excellent safety profiles. The inactivated vaccine formulation containing TLR7/8 agonist adjuvant-induced Th1 biased antibody responses with elevated IgG2a/IgG1 ratio and increased levels of SARS-CoV-2 specific IFN-{gamma}+ CD4 T lymphocyte response. Our results support further development for Phase I/II clinical trials in humans.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #285445
    DOI 10.1101/2020.09.09.285445
    Database COVID19

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