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  1. Article ; Online: Antiphospholipid Antibody Syndrome Unmasked: A Rare Cause of Recurrent Early Coronary Stent Thrombosis.

    Bukhari, Syed / Ghoweba, Mohamed / Joseph, Douglas

    The American journal of medicine

    2023  Volume 137, Issue 2, Page(s) e19–e21

    MeSH term(s) Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antibodies, Antiphospholipid ; Thrombophlebitis ; Stents/adverse effects ; Coronary Thrombosis/diagnostic imaging ; Coronary Thrombosis/etiology
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Handbook of human genetic linkage

    Terwilliger, Joseph Douglas / Ott, Jurg

    (A Johns Hopkins paperback : Genetics)

    1994  

    Author's details Joseph Douglas Terwilliger and Jurg Ott
    Series title A Johns Hopkins paperback : Genetics
    Keywords Linkage (Genetics) ; Humangenetik ; Verwandtschaft ; Datenanalyse ; Molekulargenetik
    Subject Statistische Auswertung ; Datenauswertung ; Statistische Datenanalyse ; Data analysis ; Data-analysis ; Medizinische Genetik ; Anthropogenetik ; Mensch ; Medizin ; Molekulare Genetik ; Biochemische Genetik ; Verwandter ; Verwandte
    Language English
    Size X, 307 S. : graph. Darst.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006632077
    ISBN 0-8018-4803-2 ; 978-0-8018-4803-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1995 A 2550 order for loan Magazin

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  3. Article ; Online: TP53 in Acute Myeloid Leukemia

    Binsah George / Hagop Kantarjian / Natalia Baran / Joseph Douglas Krocker / Adan Rios

    International Journal of Molecular Sciences, Vol 22, Iss 10782, p

    Molecular Aspects and Patterns of Mutation

    2021  Volume 10782

    Abstract: Mutation of the tumor suppressor gene, TP53 , is associated with abysmal survival outcomes in acute myeloid leukemia (AML). Although it is the most commonly mutated gene in cancer, its occurrence is observed in only 5–10% of de novo AML, and in 30% of ... ...

    Abstract Mutation of the tumor suppressor gene, TP53 , is associated with abysmal survival outcomes in acute myeloid leukemia (AML). Although it is the most commonly mutated gene in cancer, its occurrence is observed in only 5–10% of de novo AML, and in 30% of therapy related AML (t-AML). TP53 mutation serves as a prognostic marker of poor response to standard-of-care chemotherapy, particularly in t-AML and AML with complex cytogenetics. In light of a poor response to traditional chemotherapy and only a modest improvement in outcome with hypomethylation-based interventions, allogenic stem cell transplant is routinely recommended in these cases, albeit with a response that is often short lived. Despite being frequently mutated across the cancer spectrum, progress and enthusiasm for the development of p53 targeted therapeutic interventions is lacking and to date there is no approved drug that mitigates the effects of TP53 mutation. There is a mounting body of evidence indicating that p53 mutants differ in functionality and form from typical AML cases and subsequently display inconsistent responses to therapy at the cellular level. Understanding this pathobiological activity is imperative to the development of effective therapeutic strategies. This review aims to provide a comprehensive understanding of the effects of TP53 on the hematopoietic system, to describe its varying degree of functionality in tumor suppression, and to illustrate the need for the adoption of personalized therapeutic strategies to target distinct classes of the p53 mutation in AML management.
    Keywords TP53 mutations ; acute myeloid leukemia ; clonal hematopoiesis ; variable allele frequency ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample.

    Khalid, Muhammad Umar / Prasada, Sameer / Jennings, Courtney / Bartholomew, John R / McCarthy, Meghann / Hornacek, Deborah A / Joseph, Douglas / Chen, Wei / Schwarz, Graham / Bhandari, Rohan / Elbadawi, Ayman / Cameron, Scott J

    Vascular medicine (London, England)

    2024  Volume 29, Issue 1, Page(s) 42–47

    Abstract: Background: Patients with lymphedema and lipedema share physical exam findings that may lead to misdiagnosis. Poor mobility is common in patients with obesity and patients with lymphedema and lipedema. This may constitute a risk factor for venous ... ...

    Abstract Background: Patients with lymphedema and lipedema share physical exam findings that may lead to misdiagnosis. Poor mobility is common in patients with obesity and patients with lymphedema and lipedema. This may constitute a risk factor for venous thromboembolism (VTE). Our objective was to evaluate the association of VTE in obese patients with lymphedema and lipedema.
    Methods: The National Inpatient Sample (NIS) was searched from 2016 to 2020 to identify hospital admissions of obese female patients with lymphedema and lipedema. Patients were analyzed in the context of presence or absence of VTE while adjusting for complex cluster sampling techniques. Predictors of VTE were accessed by multivariable regression.
    Results: Lymphedema was identified in 189,985 patients and lipedema in 50,645 patients. VTE was observed in 3.12% (
    Conclusions: In this hypothesis-generating study, lymphedema and lipedema show a positive association with VTE after adjusting for baseline patient characteristics such as obesity, which is a known independent risk factor for VTE. Mechanisms whereby lymphedema and lipedema are associated with VTE should be investigated.
    MeSH term(s) Humans ; Female ; Lipedema/diagnosis ; Lipedema/epidemiology ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Inpatients ; Lymphedema/diagnosis ; Lymphedema/epidemiology ; Risk Factors ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X231219006
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  5. Article ; Online: TP53

    George, Binsah / Kantarjian, Hagop / Baran, Natalia / Krocker, Joseph Douglas / Rios, Adan

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Mutation of the tumor suppressor gene, ...

    Abstract Mutation of the tumor suppressor gene,
    MeSH term(s) Antineoplastic Agents/pharmacology ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Molecular Targeted Therapy ; Mutation ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Antineoplastic Agents ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910782
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  6. Article ; Online: Update to coagulopathy in COVID-19: Manifestations and management.

    Mucha, Simon R / Dugar, Siddharth / McCrae, Keith / Joseph, Douglas / Bartholomew, John / Sacha, Gretchen L / Militello, Michael

    Cleveland Clinic journal of medicine

    2021  

    Abstract: Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory ... ...

    Abstract Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19-associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients with COVID-19, with more aggressive prophylaxis and screening recommended for critically ill patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus.
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc024-up
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Reply: COVID-19 coagulopathy.

    Mucha, Simon R / Dugar, Siddharth / McCrae, Keith / Joseph, Douglas / Bartholomew, John / Sacha, Gretchen L / Militello, Michael

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 12, Page(s) 712

    MeSH term(s) Betacoronavirus ; Blood Coagulation Disorders ; COVID-19 ; Humans ; Pandemics
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/cjm.87c.12002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Coagulopathy in COVID-19: Manifestations and management.

    Mucha, Simon R / Dugar, Siddharth / McCrae, Keith / Joseph, Douglas / Bartholomew, John / Sacha, Gretchen L / Militello, Michael

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 8, Page(s) 461–468

    Abstract: Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory ... ...

    Abstract Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19- associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients, with more aggressive prophylaxis and screening recommended for patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus.
    MeSH term(s) Anticoagulants/pharmacology ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/therapy ; Blood Coagulation Tests/methods ; COVID-19 ; Chemoprevention/methods ; Coronavirus Infections/blood ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Monitoring, Physiologic/methods ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Coagulopathy in COVID-19: Manifestations and management

    Mucha, Simon R / Dugar, Siddharth / McCrae, Keith / Joseph, Douglas / Bartholomew, John / Sacha, Gretchen L / Militello, Michael

    Cleve Clin J Med

    Abstract: Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory ... ...

    Abstract Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19- associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients, with more aggressive prophylaxis and screening recommended for patients with D-dimer levels above 3.0 µg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #266450
    Database COVID19

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  10. Article: Coagulopathy in COVID-19

    Mucha, Simon R / Dugar, Siddharth / McCrae, Keith / Joseph, Douglas E / Bartholomew, John / Sacha, Gretchen / Militello, Michael

    Clevel. clin. j. med

    Abstract: COVID-19-associated coagulopathy is common in patients with COVID-19, causing high rates of thrombotic complications that increase the morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory ... ...

    Abstract COVID-19-associated coagulopathy is common in patients with COVID-19, causing high rates of thrombotic complications that increase the morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings and correlate with severity of illness and risk of thrombosis. Aggressive VTE prophylaxis is paramount for all patients with COVID-19. Patients with very high D-dimer levels (6 times the upper limit of normal, greater than 3,000 ng/mL) have the greatest risk of thrombosis and may benefit from active screening and more intensive VTE prophylaxis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32409435
    Database COVID19

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