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  2. AU="Chen, Liang-Min"

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  1. Article: National Patterns in Utilization of Knee and Hip Arthroscopy: An Analysis of Racial, Ethnic, and Geographic Disparities in the United States.

    Amen, Troy B / Chatterjee, Abhinaba / Rudisill, Samuel S / Joseph, Gabriel P / Nwachukwu, Benedict U / Ode, Gabriella E / Williams, Riley J

    Orthopaedic journal of sports medicine

    2023  Volume 11, Issue 8, Page(s) 23259671231187447

    Abstract: Background: Racial and ethnic disparities in the field of orthopaedic surgery have been reported extensively across many subspecialties. However, these data remain relatively sparse in orthopaedic sports medicine, especially with respect to commonly ... ...

    Abstract Background: Racial and ethnic disparities in the field of orthopaedic surgery have been reported extensively across many subspecialties. However, these data remain relatively sparse in orthopaedic sports medicine, especially with respect to commonly performed procedures including knee and hip arthroscopy.
    Purpose: To assess (1) differences in utilization of knee and hip arthroscopy between White, Black, Hispanic, and Asian or Pacific Islander patients in the United States (US) and (2) how these differences vary by geographical region.
    Study design: Descriptive epidemiology study.
    Methods: The study sample was acquired from the 2019 National Ambulatory Surgery Sample database. Racial and ethnic differences in age-standardized utilization rates of hip and knee arthroscopy were calculated using survey weights and population estimates from US census data. Poisson regression was used to model age-standardized utilization rates for hip and knee arthroscopy while controlling for several demographic and clinical variables.
    Results: During the study period, rates of knee arthroscopy utilization among White patients were significantly higher than those of Black, Hispanic, and Asian or Pacific Islander patients (ie, per 100,000, White: 180.5, Black: 113.2, Hispanic: 122.2, and Asian: 58.6). Disparities were even more pronounced among patients undergoing hip arthroscopy, with White patients receiving the procedure at almost 4 to 5 times higher rates (ie, per 100,000, White: 12.6, Black: 3.2, Hispanic: 2.3, Asian or Pacific Islander: 1.8). Disparities in knee and hip arthroscopy utilization between White and non-White patients varied significantly by region, with gaps in knee arthroscopy being most pronounced in the Midwest (adjusted rate ratio, 2.0 [95% CI, 1.9-2.1]) and those in hip arthroscopy being greatest in the West (adjusted rate ratio, 5.3 [95% CI, 4.9-5.6]).
    Conclusion: Racial and ethnic disparities in the use of knee and hip arthroscopy were found across the US, with decreased rates among Black, Hispanic, and Asian or Pacific Islander patients compared with White patients. Disparities were most pronounced in the Midwest and South and greater for hip than knee arthroscopy, possibly demonstrating emerging inequality in a rapidly growing and evolving procedure across the country.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671231187447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mindset correlates with health-related quality of life assessment in patients with adolescent idiopathic scoliosis.

    Joseph, Gabriel P / Segovia, Nicole A / Wright, Robert C / Mueller, Claudia / Tileston, Kali R

    Spine deformity

    2020  Volume 9, Issue 2, Page(s) 349–354

    Abstract: Purpose: Mindset theory describes two different belief systems regarding ability: "fixed", in which a particular personal characteristic is seen as unchangeable, and "growth", in which the characteristic is viewed as malleable and subject to improvement. ...

    Abstract Purpose: Mindset theory describes two different belief systems regarding ability: "fixed", in which a particular personal characteristic is seen as unchangeable, and "growth", in which the characteristic is viewed as malleable and subject to improvement. The purpose of this study is to evaluate how that mindset toward one's health correlates with health-related quality of life assessments (HRQoL) in patients with adolescent idiopathic scoliosis (AIS).
    Methods: Patients undergoing brace treatment for AIS were prospectively recruited for this study and completed both an SRS-30 and Health Mindset Scale questionnaire. Inclusion criteria for patients are based on Scoliosis Research Society standardized criteria for bracing studies: diagnosis of AIS, a prescribed TLSO brace for full-time wear, skeletal immaturity at brace initiation (Risser 0-2), Cobb angles 25-50 degrees, no prior treatment, and, if female, no more than 1 year post-menarchal at the time of brace initiation. Statistical analysis was performed utilizing Mann-Whitney U tests for skewed data and two-sample t tests for normally distributed data. Multivariable models were also used to evaluate the relationships of SRS-30 subscores with health mindset, adjusting for age, gender, and pre-treatment curve magnitudes.
    Results: Among the 110 enrolled patients, a stronger growth mindset was associated with significantly higher SRS-30 scores overall (p = 0.001), as well as in the appearance (p = 0.003), and mental (p = 0.001) subscores.
    Conclusion: We demonstrate that health mindset affects an AIS patients' HRQoL. Prior studies have demonstrated that mindset is malleable and can be altered. Further studies are required to determine whether changing health mindset from a fixed to a growth mindset can also improve HRQoL in patients with scoliosis.
    MeSH term(s) Adolescent ; Braces ; Female ; Humans ; Kyphosis ; Quality of Life ; Retrospective Studies ; Scoliosis/therapy
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-020-00243-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytomegalovirus as an oncomodulatory agent in the progression of glioma.

    Joseph, Gabriel P / McDermott, Ryan / Baryshnikova, Maria A / Cobbs, Charles S / Ulasov, Ilya V

    Cancer letters

    2017  Volume 384, Page(s) 79–85

    Abstract: Glioblastoma multiforme (GBM) is the most aggressive neoplastic brain tumor in humans with a median survival of less than 2 years. It is therefore critical to understand the mechanism of glioma progression and to identify future targets for intervention. ...

    Abstract Glioblastoma multiforme (GBM) is the most aggressive neoplastic brain tumor in humans with a median survival of less than 2 years. It is therefore critical to understand the mechanism of glioma progression and to identify future targets for intervention. We investigate the mechanisms of cytomegalovirus as an oncomodulatory agent implicated in glioma progression, as well as immunosuppression. This review provides a comprehensive evaluation of recent investigative developments concerning the role of CMV in cellular processes during glioma growth. The manners in which CMV and its viral products interact with regulatory cellular signaling pathways in the host are of primary interest. Here, we examine some of the most significant oncomodulatory effects that CMV can confer in brain tumors, including the inhibition of apoptosis and promoting the growth of glioma stem cells, which are tightly linked to tumor survival and recurrence.
    MeSH term(s) Animals ; Apoptosis ; Brain Neoplasms/epidemiology ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Brain Neoplasms/virology ; Cell Cycle ; Cell Proliferation ; Cell Transformation, Viral ; Cytomegalovirus/immunology ; Cytomegalovirus/metabolism ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Disease Progression ; Glioma/epidemiology ; Glioma/immunology ; Glioma/pathology ; Glioma/virology ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Tumor Escape ; Tumor Virus Infections/epidemiology ; Tumor Virus Infections/immunology ; Tumor Virus Infections/metabolism ; Tumor Virus Infections/virology
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2017--01
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2016.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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