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  1. Article: Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment

    Joseph, Jan Felix / Parr, Maria Kristina

    Bioengineering, 6(3):62

    2019  

    Abstract: Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation. To complement classical CQA, bevacizumab and infliximab were subjected to oxidative stress by H2O2 ... ...

    Abstract Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation. To complement classical CQA, bevacizumab and infliximab were subjected to oxidative stress by H2O2 for 24, 48, or 72 h to probe their oxidation susceptibility. For investigation, a middle-up approach was used utilizing liquid chromatography hyphenated with mass spectrometry (LC-QTOF-MS). In both mAbs, the Fc/2 subunit was completely oxidized. Additional oxidations were found in the light chain (LC) and in the Fd’ subunit of infliximab, but not in bevacizumab. By direct comparison of methionine positions, the oxidized residues in infliximab were assigned to M55 in LC and M18 in Fd’. The forced oxidation approach was further exploited for comparison of respective biosimilar products. Both for bevacizumab and infliximab, comparison of posttranslational modification profiles demonstrated high similarity of the unstressed reference product (RP) and the biosimilar (BS). However, for bevacizumab, comparison after forced oxidation revealed a higher susceptibility of the BS compared to the RP. It may thus be considered a useful tool for biopharmaceutical engineering, biosimilarity assessment, as well as for quality control of protein drugs.
    Keywords middle-up approach ; QTOF-MS ; bevacizumab ; biosimilar ; biopharmaceuticals ; forced stability testing ; infliximab ; liquid chromatography-mass spectrometry (LC-MS) ; structure reactivity relationship
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Book: Drowning

    Bierens, Joost J. L. M.

    prevention, rescue, treatment

    2014  

    Author's details Joost J.L.M. Bierens ed
    Language English
    Size XXXVIII, 1269 S. : Ill., graph. Darst., 25 cm
    Edition 2. ed.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018706952
    ISBN 978-3-642-04252-2 ; 9783642042539 ; 3-642-04252-X ; 3642042538
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 2553 available for loan (reading room) Lesesaal EG

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  3. Book: Esophageal adenocarcinoma

    Lanschot, Joseph Jan-Baptist van

    (Best practice & research : Clinical gastroenterology ; 20,5)

    2006  

    Author's details J. J. B. van Lanschot ..., guest ed
    Series title Best practice & research : Clinical gastroenterology ; 20,5
    Best practice & research
    Best practice & research ; Clinical gastroenterology
    Collection Best practice & research
    Best practice & research ; Clinical gastroenterology
    Language English
    Size S. 801 - 978 : Ill.
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014873457
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1098 -20,5- verfügbar in Königswinter Königswinter

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  4. Book: Gastrointestinal surgical research in the Netherlands

    Lanschot, Joseph Jan-Baptist van

    8 tables

    (Digestive surgery ; 22,4)

    2005  

    Author's details guest eds.:J. J. B. van Lanschot
    Series title Digestive surgery ; 22,4
    Collection
    Language English
    Size S. 221 - 293 : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015029088
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2004 -22- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: ASO Author Reflections: Opting for a Cost-Effective Treatment Allocation in Patients with Esophageal Cancer.

    Gao, Xing / van Lanschot, Joseph Jan-Baptist / Chao, Yin-Kai

    Annals of surgical oncology

    2022  Volume 29, Issue 6, Page(s) 3654–3655

    MeSH term(s) Cost-Benefit Analysis ; Esophageal Neoplasms/surgery ; Esophagectomy ; Humans ; Rare Diseases ; Treatment Outcome
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11230-4
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  6. Book ; Online: CLSA-CIM

    Pelke, Rebecca / Cubero-Cascante, Jose / Bosbach, Nils / Staudigl, Felix / Leupers, Rainer / Joseph, Jan Moritz

    A Cross-Layer Scheduling Approach for Computing-in-Memory Architectures

    2024  

    Abstract: The demand for efficient machine learning (ML) accelerators is growing rapidly, driving the development of novel computing concepts such as resistive random access memory (RRAM)-based tiled computing-in-memory (CIM) architectures. CIM allows to compute ... ...

    Abstract The demand for efficient machine learning (ML) accelerators is growing rapidly, driving the development of novel computing concepts such as resistive random access memory (RRAM)-based tiled computing-in-memory (CIM) architectures. CIM allows to compute within the memory unit, resulting in faster data processing and reduced power consumption. Efficient compiler algorithms are essential to exploit the potential of tiled CIM architectures. While conventional ML compilers focus on code generation for CPUs, GPUs, and other von Neumann architectures, adaptations are needed to cover CIM architectures. Cross-layer scheduling is a promising approach, as it enhances the utilization of CIM cores, thereby accelerating computations. Although similar concepts are implicitly used in previous work, there is a lack of clear and quantifiable algorithmic definitions for cross-layer scheduling for tiled CIM architectures. To close this gap, we present CLSA-CIM, a cross-layer scheduling algorithm for tiled CIM architectures. We integrate CLSA-CIM with existing weight-mapping strategies and compare performance against state-of-the-art (SOTA) scheduling algorithms. CLSA-CIM improves the utilization by up to 17.9 x , resulting in an overall speedup increase of up to 29.2 x compared to SOTA.
    Keywords Computer Science - Hardware Architecture ; Computer Science - Emerging Technologies ; Computer Science - Machine Learning
    Subject code 004
    Publishing date 2024-01-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines.

    Parr, Maria Kristina / Joseph, Jan F

    Journal of pharmaceutical and biomedical analysis

    2018  Volume 164, Page(s) 536–549

    Abstract: Batch recalls for valsartan containing pharmaceutical products in July 2018 initiated a discussion on possible contaminations with N-nitrosodimethylamine (NDMA). It appeared that NDMA was generated during synthesis of the active pharmaceutical ingredient ...

    Abstract Batch recalls for valsartan containing pharmaceutical products in July 2018 initiated a discussion on possible contaminations with N-nitrosodimethylamine (NDMA). It appeared that NDMA was generated during synthesis of the active pharmaceutical ingredient (API) from the solvent dimethylformamide (DMF) and the reagent nitrite. Discussion on NDMA as API impurity is extended to other drugs since then. Already several years before scientific literature reported NDMA as impurity of several other drugs, thus underlining the apparent risk. At present none of the pharmacopoeias tests for NDMA and only very limited publications of methods for its determination in pharmaceuticals are published so far. This review summarizes aspects for the analyses of nitrosamines (NAs) with special focus on NDMA and discusses their potential applicability for drug analyses. The majority of recent publications utilize GC-MS or GC-MS/MS due to its high selectivity and low detection levels. GC-TEA also provides high selectivity for nitrosamines. However, current availability of this combination is very limited. Alternatively, LC-MS/MS is also performed in NA analysis. An integration of a general test in future pharmacopoeias is suggested due to the toxicological relevance and broader spectrum of possible APIs that may be affected.
    MeSH term(s) Analytic Sample Preparation Methods/methods ; Chemical Fractionation/methods ; Chemistry, Pharmaceutical/methods ; Chromatography, Liquid/methods ; Dimethylnitrosamine/analysis ; Drug Contamination/prevention & control ; Gas Chromatography-Mass Spectrometry/methods ; Tandem Mass Spectrometry/methods ; Valsartan/analysis
    Chemical Substances Valsartan (80M03YXJ7I) ; Dimethylnitrosamine (M43H21IO8R)
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2018.11.010
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    Zs.A 1850: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Cascades of energy and electron transfer in a panchromatic absorber.

    Joseph, Jan / Bauroth, Stefan / Charisiadis, Asterios / Charalambidis, Georgios / Coutsolelos, Athanassios G / Guldi, Dirk M

    Nanoscale

    2022  Volume 14, Issue 26, Page(s) 9304–9312

    Abstract: The investigation of molecular model systems is fundamental towards a deeper understanding of key photochemical steps in natural photosynthesis. Herein, we report an entirely non-covalent triad consisting of boron dipyrromethene (BDP), porphyrin (ZnP), ... ...

    Abstract The investigation of molecular model systems is fundamental towards a deeper understanding of key photochemical steps in natural photosynthesis. Herein, we report an entirely non-covalent triad consisting of boron dipyrromethene (BDP), porphyrin (ZnP), and fullerene (C60). Non-covalent binding motifs such as an amidinium-carboxylate salt bridge as well as axial pyridyl-metal coordination offer substantial electronic coupling and establish efficient pathways for photoactivated energy and electron transfer processes along a well-tuned gradient. Experimental findings from steady-state and time-resolved spectroscopic assays, as well as (spectro-)electrochemical measurements corroborate the formation of BDP|ZnP|C60 in solution, on one hand, and significant communication in the excited states, on the other hand. BDP acts as an energy harvesting antenna towards ZnP, which eventually undergoes charge separation with C60 by electron transfer from ZnP to C60. Notably, full spectral deconvolution of the transient species was achieved, supporting the successful self-assembly as well as giving a clear view onto the occurring photophysical processes and their spectral footprints upon photoexcitation.
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr02404g
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  9. Article ; Online: Unique multiphthalocyanine coordination systems: vibrationally hot excited states and charge transfer states that power high energy triplet charge separated states.

    Joseph, Jan / Lourenço, Leandro M O / Tomé, João P C / Torres, Tomás / Guldi, Dirk M

    Nanoscale

    2022  Volume 14, Issue 36, Page(s) 13155–13165

    Abstract: Controlling the molecular architecture of well-organized organic building blocks and linking their functionalities with the impact of solar-light converting systems constitutes a grand challenge in materials science. Strong absorption cross-sections ... ...

    Abstract Controlling the molecular architecture of well-organized organic building blocks and linking their functionalities with the impact of solar-light converting systems constitutes a grand challenge in materials science. Strong absorption cross-sections across the visible range of the solar spectrum as well as a finely balanced energy- and redox-gradient are all important features that pave the way for either funneling excited state energy or transducing charges. In light of this, we used thiopyridyl-phthalocyanines (PcSPy) and ruthenium (
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr03721a
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  10. Article ; Online: Neoadjuvant Therapy Versus Upfront Surgery for Patients With Clinical Stage 2 or 3 Esophageal Squamous Cell Carcinoma: A Cost-Effectiveness Analysis.

    Gao, Xing / Wen, Yu-Wen / van Lanschot, Joseph Jan Baptist / Chao, Yin-Kai

    Annals of surgical oncology

    2022  Volume 29, Issue 6, Page(s) 3644–3653

    Abstract: Background: Although neoadjuvant therapy followed by surgery (NT) is the standard of care for esophageal cancer in Western countries, upfront surgery (US) followed by adjuvant therapy (when indicated) still is commonly used in Asia to minimize ... ...

    Abstract Background: Although neoadjuvant therapy followed by surgery (NT) is the standard of care for esophageal cancer in Western countries, upfront surgery (US) followed by adjuvant therapy (when indicated) still is commonly used in Asia to minimize overtreatment. This study investigated the cost-effectiveness of NT versus US for patients with esophageal squamous cell carcinoma (ESCC).
    Methods: Patients with a diagnosis of ESCC between 2010 and 2015 were divided into NT or US according to the intention to treat. Two propensity score-matched groups of patients with clinical stage 2 (135 pairs) or stage 3 (194 pairs) disease were identified and compared in terms of overall survival (OS) and direct costs incurred within 3 years after diagnosis.
    Results: The esophagectomy rates after NT were 82% for stage 2 and 88% for stage 3 disease. Compared with US, surgery after NT was associated with higher R0 resection rates, a lower number of dissected lymph nodes, and similar postoperative mortality. On an intention-to-treat analysis, stage 3 patients who received NT had a significantly better 3-year OS rate (45%) than those treated with US (37%) (p = 0.029) without significant cost increases (p = 0.89). However, NT for clinical stage 2 disease neither increased costs nor improved 3-year OS rates (47% vs 47%; p = 0.88). At a willingness-to-pay level of US$50,000 per life-year, the probability of NT being cost-effective was 92% for stage 3 versus 59% for stage 2 ESCC.
    Conclusion: Because of its higher cost-effectiveness, NT is preferable to US for patients with clinical stage 3 ESCC, but US remains a viable option for stage 2 disease.
    MeSH term(s) Cost-Benefit Analysis ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/surgery ; Esophagectomy ; Humans ; Neoadjuvant Therapy ; Neoplasm Staging ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11207-3
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