LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Lack of Excess Cardiovascular Risks among First Degree Relatives of Persons with Diabetes Mellitus

    Taiwo H Raimi / Bolade Folasade Dele-Ojo / Samuel A Dada / Joseph O Fadare

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 2, Pp OC33-OC

    Is Lifestyle the Cause?

    2021  Volume 37

    Abstract: Introduction: The prevalence of Diabetes Mellitus (DM) is rising worldwide with a projected increase of more than 50% in next three decades. Family History of Diabetes (FHD) is a recognised risk factor for DM, but development of DM in relatives of people ...

    Abstract Introduction: The prevalence of Diabetes Mellitus (DM) is rising worldwide with a projected increase of more than 50% in next three decades. Family History of Diabetes (FHD) is a recognised risk factor for DM, but development of DM in relatives of people with the disease, who carry susceptible genes, is dependent on interaction with other factors such as nutrition, physical activity and environment. Aim: To determine the prevalence of metabolic syndrome and impact of lifestyle on the CVD risk factors among adult Nigerian with FHD. Materials and Methods: This was a cross-sectional study among staff and students of Ekiti State University and Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Eightysix participants with FHD were age and sex-matched with 86 participants who had no FHD. Relevant demographic and lifestyle information were obtained, and clinical measurements of Body Mass Index (BMI), waist and hip circumferences and blood pressures were obtained by standard protocols. Fasting plasma glucose and lipid panel were determined. Metabolic syndrome was defined according to the International Diabetes Federation criteria (IDF). The clinical, laboratory and other variables of the people with FHD and those without FHD were compared with Pearson’s Chi-Square and Student’s t-test. Results: The age, clinical, anthropometric and laboratory parameters were similar between the two groups. Participants with FHD consume more poultry (17.6% vs 3.5%) and less red meat (27.1% vs 37.2%) than those without FHD (p=0.036), but the level of physical activity and consumption of fruits/ vegetables, and smoking did not differ between the two groups. Metabolic syndrome was equally prevalent between the people with or without FHD (p=0.846). There was no significant difference (p>0.05), in the prevalence of CVD risk factors, such as hypertension, hyperglycaemia, dyslipidaemia, and obesity between the two groups. Conclusion: The prevalence of metabolic syndrome was similar among people with or without FHD. Healthy ...
    Keywords genetics ; metabolic syndrome ; type 2 diabetes ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: COVID-19 vaccine uptake and associated factors among adolescents and youths

    Steward Mudenda / Johanna C. Meyer / Joseph O. Fadare / Olayinka O. Ogunleye / Zikria Saleem / Scott K. Matafwali / Victor Daka / Billy Chabalenge / Jacob Chama / Moses Mukosha / Phumzile Skosana / Bwalya A. Witika / Aubrey C. Kalungia / Audrey Hamachila / Webrod Mufwambi / Brian Godman

    PLOS Global Public Health, Vol 3, Iss

    Findings and implications for future vaccination programmes

    2023  Volume 9

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Knowledge of medical ethics among Nigerian medical doctors

    Joseph O Fadare / Olufemi O Desalu / Abiodun C Jemilohun / Oluwole A Babatunde

    Nigerian Medical Journal, Vol 53, Iss 4, Pp 226-

    2012  Volume 230

    Abstract: Background: The knowledge of medical ethics is essential for health care practitioners worldwide. The main objective of this study was to evaluate the knowledge of medical doctors in a tertiary care hospital in Nigeria in the area of medical ethics. ... ...

    Abstract Background: The knowledge of medical ethics is essential for health care practitioners worldwide. The main objective of this study was to evaluate the knowledge of medical doctors in a tertiary care hospital in Nigeria in the area of medical ethics. Materials and Methods: A cross-sectional questionnaire-based study involving 250 medical doctors of different levels was carried out. The questionnaire, apart from the bio-data, also sought information on undergraduate and postgraduate training in medical ethics, knowledge about the principles of biomedical ethics and the ethical dilemmas encountered in daily medical practice. Results: One hundred and ninety (190) respondents returned the filled questionnaire representing a response rate of 76%. One hundred and fifty-two respondents (80%) have had some sort of medical ethics education during their undergraduate level in the medical education. The median duration of formal training or exposure to medical ethics education was 3.00 hours (range: 0-15). One hundred and twenty-nine respondents have read at least once the code of medical ethics of the Medical and Dental Council of Nigeria while 127 (66.8%) have some general knowledge of the principles of biomedical ethics. The breakdown of the identified ethical dilemmas shows that discharge against medical advice was the most identified by the respondents (69.3%) followed by religious/cultural issues (56.6%) while confidentiality was recognized by 53.4%. Conclusion: The knowledge of medical ethics by Nigerian medical doctors is grossly inadequate. There is an urgent need for enhancement of the teaching of the discipline at both undergraduate and postgraduate levels in Nigeria.
    Keywords Biomedical ethics ; developing countries ; ethical dilemma ; medical education ; physicians ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 170
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Healthcare workers knowledge and attitude toward palliative care in an emerging tertiary centre in South-West Nigeria

    Joseph O Fadare / Abimbola M Obimakinde / Jide M Afolayan / Sunday O Popoola / Tolulope Aduloju / Patrick T Adegun

    Indian Journal of Palliative Care, Vol 20, Iss 1, Pp 1-

    2014  Volume 5

    Abstract: Background: Palliative care is an emerging area of medicine with potential to affect positively many chronically ill patients. This study investigated the knowledge and attitude of healthcare workers in a tertiary level hospital in Nigeria where a ... ...

    Abstract Background: Palliative care is an emerging area of medicine with potential to affect positively many chronically ill patients. This study investigated the knowledge and attitude of healthcare workers in a tertiary level hospital in Nigeria where a palliative care unit is being established. Material and Methods: The study was a cross-sectional questionnaire-based study carried out among healthcare workers in Ekiti State University Teaching Hospital, Ado-Ekiti, south-west Nigeria. The questionnaire had sections about definition of palliative care, its philosophy, communication issues, medications, and contexts about its practice. The information obtained from the questionnaire was coded, entered, and analyzed using IBM SPSS version 19. Results: A total of 170 questionnaires were returned within the stipulated time frame with response rate of 66.7%. Majority, (135, 86%) respondents felt palliative care was about the active management of the dying while 70.5% of respondents equated palliative care to pain management. Regarding the philosophy of palliative care, 70 (57.9%) thought that it affirms life while 116 (78.4%) felt palliative care recognizes dying as a normal process. One hundred and twenty-two (78.7%) respondents were of the opinion that all dying patients would require palliative care. The patient should be told about the prognosis according to 122 (83%) respondents and not doing so could lead to lack of trust (85%). Regarding the area of opioid use in palliative care, 76% of respondents agreed that morphine improves the quality of life of patients. Conclusion: There are plausible gaps in the knowledge of the healthcare workers in the area of palliative care. Interventions are needed to improve their capacity.
    Keywords Healthcare workers ; Knowledge ; Palliative care ; Perception ; Oncology ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: CORRELATION OF THE SERUM LEVEL OF CARBAMAZEPINE WITH SEIZURE CONTROL AND ADVERSE DRUG REACTIONS AMONG EPILEPTICS IN IBADAN, NIGERIA

    Joseph O. Fadare / Catherine O. Falade / Oluseye O. Bolaji / Adesola Ogunniyi

    International Journal of Drug Development & Research, Vol 2, Iss 4, Pp 690-

    2010  Volume 697

    Abstract: Background: Epilepsy is a chronic neurological disorder requiring long-term treatment. Seizure control requires adequate blood levels of anti-seizure drugs. Carbarmazepine is one of the most prescribed antiepileptic drugs in Nigeria. This study was ... ...

    Abstract Background: Epilepsy is a chronic neurological disorder requiring long-term treatment. Seizure control requires adequate blood levels of anti-seizure drugs. Carbarmazepine is one of the most prescribed antiepileptic drugs in Nigeria. This study was carried out to investigate the correlation between serum levels of carbamazepine and seizure control and adverse drug reactions among epileptics in Ibadan, Nigeria. Methods: In a cross-sectional study, sixty-nine patients with confirmed diagnosis of epilepsy who had been on treatment with carbamazepine alone or in combination with phenytoin for at least one month were enrolled into the study and divided into two groups based on seizure control. Drug level in pre-dose (steady state) venous blood was analyzed using high performance liquid chromatography. Result: The mean serum concentration of carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) was 13.5±9.3ìg/mL and 6.34±12.61ìg/mL respectively. Patients with good seizure control had mean serum CBZ concentration of 12.7 ± 9.2ìg/mL versus 15.02 ± 9.7ìg/mL among patients with poor seizure control (P=0.33). The serum concentration of CBZ-EP in patients with good seizure control was 8.05 ± 15.2ìg/mL while it was 3.11 ± 3.5ìg/mL in the second group (P=0.122). Drowsiness was the commonest adverse drug reaction (26.1%) and it did not necessitate withdrawal of the drug. Conclusion The study showed that serum level of carbamazepine does not correlate with seizure control and adverse drug reactions.
    Keywords epilepsy ; carbamazepine ; serum level ; seizure control ; Nigeria ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2010-12-01T00:00:00Z
    Publisher Chauhan Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Barriers for Access to New Medicines

    Brian Godman / Anna Bucsics / Patricia Vella Bonanno / Wija Oortwijn / Celia C. Rothe / Alessandra Ferrario / Simone Bosselli / Andrew Hill / Antony P. Martin / Steven Simoens / Amanj Kurdi / Mohamed Gad / Jolanta Gulbinovič / Angela Timoney / Tomasz Bochenek / Ahmed Salem / Iris Hoxha / Robert Sauermann / Amos Massele /
    Augusto Alfonso Guerra / Guenka Petrova / Zornitsa Mitkova / Gnosia Achniotou / Ott Laius / Catherine Sermet / Gisbert Selke / Vasileios Kourafalos / John Yfantopoulos / Einar Magnusson / Roberta Joppi / Margaret Oluka / Hye-Young Kwon / Arianit Jakupi / Francis Kalemeera / Joseph O. Fadare / Oyvind Melien / Maciej Pomorski / Magdalene Wladysiuk / Vanda Marković-Peković / Ileana Mardare / Dmitry Meshkov

    Frontiers in Public Health, Vol

    Searching for the Balance Between Rising Costs and Limited Budgets

    2018  Volume 6

    Abstract: Introduction: There is continued unmet medical need for new medicines across countries especially for cancer, immunological diseases, and orphan diseases. However, there are growing challenges with funding new medicines at ever increasing prices along ... ...

    Abstract Introduction: There is continued unmet medical need for new medicines across countries especially for cancer, immunological diseases, and orphan diseases. However, there are growing challenges with funding new medicines at ever increasing prices along with funding increased medicine volumes with the growth in both infectious diseases and non-communicable diseases across countries. This has resulted in the development of new models to better manage the entry of new medicines, new financial models being postulated to finance new medicines as well as strategies to improve prescribing efficiency. However, more needs to be done. Consequently, the primary aim of this paper is to consider potential ways to optimize the use of new medicines balancing rising costs with increasing budgetary pressures to stimulate debate especially from a payer perspective.Methods: A narrative review of pharmaceutical policies and implications, as well as possible developments, based on key publications and initiatives known to the co-authors principally from a health authority perspective.Results: A number of initiatives and approaches have been identified including new models to better manage the entry of new medicines based on three pillars (pre-, peri-, and post-launch activities). Within this, we see the growing role of horizon scanning activities starting up to 36 months before launch, managed entry agreements and post launch follow-up. It is also likely there will be greater scrutiny over the effectiveness and value of new cancer medicines given ever increasing prices. This could include establishing minimum effectiveness targets for premium pricing along with re-evaluating prices as more medicines for cancer lose their patent. There will also be a greater involvement of patients especially with orphan diseases. New initiatives could include a greater role of multicriteria decision analysis, as well as looking at the potential for de-linking research and development from commercial activities to enhance affordability.Conclusion: ...
    Keywords managed entry ; health policy ; pharmaceuticals ; financing ; cancer ; orphan diseases ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top