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  1. Article ; Online: Cancer- and infection-induced T cell exhaustion are distinct.

    Buck, Jessica / Joshi, Nikhil S

    Nature immunology

    2023  Volume 24, Issue 10, Page(s) 1604–1605

    MeSH term(s) Humans ; T-Cell Exhaustion ; CD8-Positive T-Lymphocytes ; Infections ; Neoplasms
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01624-9
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  2. Article ; Online: Editorial: Perspectives on the landscape of immunology from Nikhil Joshi.

    Joshi, Nikhil S / Delgoffe, Greg M

    Immunology

    2022  Volume 165, Issue 4, Page(s) 369–370

    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Editorial
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13467
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  3. Article ; Online: T follicular helper cells in cancer, tertiary lymphoid structures, and beyond.

    Cui, Can / Craft, Joseph / Joshi, Nikhil S

    Seminars in immunology

    2023  Volume 69, Page(s) 101797

    Abstract: With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has ... ...

    Abstract With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cells and B cells in cancer, highlighting the important role of their crosstalk and interactions with other immune cell components in the tumor microenvironment. These interactions also occur in tumor-associated tertiary lymphoid structures (TLS), which resemble secondary lymphoid organs (SLOs) with orchestrated vascular, chemokine, and cellular infrastructures that support the developmental pathways of functional immune cells. In this review, we discuss recent breakthroughs on TFH biology and T cell-B cell interactions in tumor immunology, and their potential as novel therapeutic targets to advance cancer treatment.
    MeSH term(s) Humans ; Tertiary Lymphoid Structures ; T Follicular Helper Cells/metabolism ; T Follicular Helper Cells/pathology ; Neoplasms ; B-Lymphocytes ; CD8-Positive T-Lymphocytes ; Tumor Microenvironment
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101797
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  4. Article: Novel Mouse Models for Cancer Immunology.

    Connolly, Kelli A / Fitzgerald, Brittany / Damo, Martina / Joshi, Nikhil S

    Annual review of cancer biology

    2022  Volume 6, Issue 1, Page(s) 269–291

    Abstract: Mouse models for the study of cancer immunology provide excellent systems in which to test biological mechanisms of the immune response against cancer. Historically, these models have been designed to have different strengths based on the current major ... ...

    Abstract Mouse models for the study of cancer immunology provide excellent systems in which to test biological mechanisms of the immune response against cancer. Historically, these models have been designed to have different strengths based on the current major research questions at the time. As such, many mouse models of immunology used today were not originally developed to study questions currently plaguing the relatively new field of cancer immunology, but instead have been adapted for such purposes. In this review, we discuss various mouse model of cancer immunology in a historical context as a means to provide a fuller perspective of each model's strengths. From this outlook, we discuss the current state of the art and strategies for tackling future modeling challenges.
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2472-3428
    ISSN 2472-3428
    DOI 10.1146/annurev-cancerbio-070620-105523
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  5. Article ; Online: T

    Damo, Martina / Joshi, Nikhil S

    Nature immunology

    2019  Volume 20, Issue 6, Page(s) 674–675

    MeSH term(s) Adaptation, Physiological ; CD8-Positive T-Lymphocytes ; Humans ; Interleukin-10 ; Neoplasms ; T-Lymphocytes, Regulatory
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2019-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-019-0389-y
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  6. Article ; Online: Lineage Specifiers in Lung Cancer Are Ahead of Their TIME.

    Connolly, Kelli A / Fitzgerald, Brittany / Joshi, Nikhil S

    Immunity

    2018  Volume 49, Issue 4, Page(s) 587–589

    Abstract: The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of cancer remain poorly understood. In this issue of Immunity, Mollaoglu et al. (2018) reveal a mechanistic link between the function of lineage specifiers SOX2 ... ...

    Abstract The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of cancer remain poorly understood. In this issue of Immunity, Mollaoglu et al. (2018) reveal a mechanistic link between the function of lineage specifiers SOX2 and NKX2-1 and the presence of neutrophils in the tumor-immune microenvironment of lung cancer.
    MeSH term(s) Cell Differentiation ; Humans ; Lung Neoplasms ; SOXB1 Transcription Factors ; Tumor Microenvironment
    Chemical Substances SOX2 protein, human ; SOXB1 Transcription Factors
    Language English
    Publishing date 2018-10-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2018.10.004
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  7. Article ; Online: Intestinal tuft cell immune privilege enables norovirus persistence.

    Strine, Madison S / Fagerberg, Eric / Darcy, Patrick W / Barrón, Gabriel M / Filler, Renata B / Alfajaro, Mia Madel / D'Angelo-Gavrish, Nicole / Wang, Fang / Graziano, Vincent R / Menasché, Bridget L / Damo, Martina / Wang, Ya-Ting / Howitt, Michael R / Lee, Sanghyun / Joshi, Nikhil S / Mucida, Daniel / Wilen, Craig B

    Science immunology

    2024  Volume 9, Issue 93, Page(s) eadi7038

    Abstract: The persistent murine norovirus strain ... ...

    Abstract The persistent murine norovirus strain MNV
    MeSH term(s) Mice ; Humans ; Animals ; CD8-Positive T-Lymphocytes ; Tuft Cells ; Norovirus/physiology ; Immune Privilege ; Intestines
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adi7038
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  8. Article ; Online: ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.

    Mann, Jacqueline E / Lucca, Liliana / Austin, Matthew R / Merkin, Ross D / Robert, Marie E / Al Bawardy, Badr / Raddassi, Khadir / Aizenbud, Lilach / Joshi, Nikhil S / Hafler, David A / Abraham, Clara / Herold, Kevan C / Kluger, Harriet M

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 8

    Abstract: Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types. Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative ... ...

    Abstract Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types. Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative cancer therapies may be available. Checkpoint inhibitor induced colitis (ICI-colitis) is a common toxicity for which the underlying mechanisms are poorly defined. To better understand the changing colon-specific and peripheral immune environments over the course of progression and treatment of colitis, we collected blood and colon tissue from a patient with Merkel cell carcinoma who developed colitis on treatment with pembrolizumab. We performed single-cell RNA sequencing and T-cell receptor sequencing on samples collected before, during and after pembrolizumab and after various interventions to mitigate toxicity. We report T-cells populations defined by cytotoxicity, memory, and proliferation markers at various stages of colitis. We show preferential depletion of CD8+ T cells with biologic therapy and nominate both circulating and colon-resident T-cell subsets as potential drivers of inflammation and response to immune suppression. Our findings highlight the need for further exploration of the colon immune environment and rationalize future studies evaluating biologics for ICI-colitis, including in the context of ICI re-challenge.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Single-Cell Gene Expression Analysis ; Colitis/chemically induced ; T-Lymphocyte Subsets ; Skin Neoplasms
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-007358
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  9. Article ; Online: Immunology. Guilty by association.

    Joshi, Nikhil S / Jacks, Tyler

    Science (New York, N.Y.)

    2013  Volume 339, Issue 6124, Page(s) 1160–1161

    MeSH term(s) Animals ; Female ; Immune Tolerance ; Male ; Prostate/immunology ; Prostatic Neoplasms/immunology ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland/growth & development ; Thymus Gland/immunology ; Transcription Factors/immunology ; AIRE Protein
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2013-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1235528
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  10. Article: Guilty by Association

    Joshi, Nikhil S / Tyler Jacks

    Science. 2013 Mar. 8, v. 339, no. 6124

    2013  

    Abstract: Developing tumors face a multifaceted immune response that can ultimately "edit" the tumor by eliminating cells that cannot evade antitumor responses. Consequentially, tumors employ many mechanisms to evade immune responses, including expression of ... ...

    Abstract Developing tumors face a multifaceted immune response that can ultimately "edit" the tumor by eliminating cells that cannot evade antitumor responses. Consequentially, tumors employ many mechanisms to evade immune responses, including expression of inhibitory chemokines or cytokines and recruitment of immunosuppressive cells such as regulatory T cells (T ᵣₑgₛ) (1 , 2). T ᵣₑgₛ are known for suppressing immune responses and maintaining immune homeostasis, but are also often found in the tumor microenvironment where their presence correlates with poorer patient outcomes. Moreover, acute T ᵣₑg depletion in transplant models of cancer results in more potent antitumor immune responses. Thus, T ᵣₑgₛ are considered important players in tumor development. However, relatively little is known about why T ᵣₑgₛ infiltrate tumors or how they are formed. On page 1219 of this issue, Malchow et al. (3) address these questions and discover that developing tumors do not elicit novel T ᵣₑg responses, but rather they recruit and/or expand T ᵣₑg populations naturally found within the tissue from which the tumor arises.
    Keywords chemokines ; homeostasis ; immune response ; immunosuppression ; models ; neoplasms ; patients ; T-lymphocytes
    Language English
    Dates of publication 2013-0308
    Size p. 1160-1161.
    Publishing place American Association for the Advancement of Science
    Document type Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1235528
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