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  1. AU="Josiah, S M"
  2. AU="Yanjun Guo"
  3. AU="Klapp, Sabine H L"
  4. AU="Cipolat, Lauriane"
  5. AU="Rhee, Hwanseok"
  6. AU="El-Khatabi, K"
  7. AU="Lee, Seung Hee"
  8. AU=Torres Antoni
  9. AU="Baldacini, Mathieu"
  10. AU="Stahl, Alexander"
  11. AU="Karimbumkara, Seena Narayanan"
  12. AU="Welz Mirosław"
  13. AU="Jintao Ding"
  14. AU="Mei-Fang Chen"

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  1. Artikel ; Online: Genomic and phenotypic characterization of finger millet indicates a complex diversification history

    Bančič, J / Odeny, D A / Ojulong, H F / Josiah, S M / Buntjer, J / Gaynor, R C / Hoad, S P / Gorjanc, G

    2023  

    Abstract: Advances in sequencing technologies mean that insights into crop diversification can now be explored in crops beyond major staples. We use a genome assembly of finger millet, an allotetraploid orphan crop, to analyze DArTseq single nucleotide ... ...

    Abstract Advances in sequencing technologies mean that insights into crop diversification can now be explored in crops beyond major staples. We use a genome assembly of finger millet, an allotetraploid orphan crop, to analyze DArTseq single nucleotide polymorphisms (SNPs) at the whole and sub-genome level. A set of 8778 SNPs and 13 agronomic traits was used to characterize a diverse panel of 423 landraces from Africa and Asia. Through principal component analysis (PCA) and discriminant analysis of principal components, four distinct groups of accessions were identified that coincided with the primary geographic regions of finger millet cultivation. Notably, East Africa, presumed to be the crop's origin, exhibited the lowest genetic diversity. The PCA of phenotypic data also revealed geographic differentiation, albeit with differing relationships among geographic areas than indicated with genomic data. Further exploration of the sub-genomes A and B using neighbor-joining trees revealed distinct features that provide supporting evidence for the complex evolutionary history of finger millet. Although genome-wide association study found only a limited number of significant marker-trait associations, a clustering approach based on the distribution of marker effects obtained from a ridge regression genomic model was employed to investigate trait complexity. This analysis uncovered two distinct clusters. Overall, the findings suggest that finger millet has undergone complex and context-specific diversification, indicative of a lengthy domestication history. These analyses provide insights for the future development of finger millet.
    Schlagwörter Finger Millet ; Genetics and Genomics
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Verlag Crop Science Society of America
    Erscheinungsland in
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Regions of the human neurokinin A receptor involved in the generation of second messengers and in receptor desensitization.

    Josiah, S M / Cyr, C R / Chu, V / Grumet, M / Gardner, J P / Kris, R M

    Biochemical and biophysical research communications

    1994  Band 199, Heft 2, Seite(n) 626–632

    Abstract: Deletion analysis was used to study sites of human Neurokinin A receptor (HNKAR) necessary for signal transduction in CHO cells. Deletion of 62 and 81 amino acids from the c-terminus of HNKAR forms mutant receptors HNKAR delta 62 and HNKAR delta 81, ... ...

    Abstract Deletion analysis was used to study sites of human Neurokinin A receptor (HNKAR) necessary for signal transduction in CHO cells. Deletion of 62 and 81 amino acids from the c-terminus of HNKAR forms mutant receptors HNKAR delta 62 and HNKAR delta 81, which bind neurokinin A with high affinity but are functionally different. Wild type HNKAR and HNKAR delta 62 are functionally active whereas HNKAR delta 81 is functionally inactive. In addition, HNKAR and HNKAR delta 62 were both desensitized to the neurokinin A signal within 5 minutes. The data indicates: 1) an intact cytoplasmic tail of the HNKAR is not critical for signal transduction, but the n-terminal amino acids of the cytoplasmic tail are necessary for signaling and 2) the c-terminal 62 amino acids are not necessary for desensitization.
    Mesh-Begriff(e) Amino Acid Sequence ; Animals ; CHO Cells ; Calcium/metabolism ; Codon/genetics ; Cricetinae ; DNA Primers ; Humans ; Kinetics ; Molecular Sequence Data ; Mutagenesis ; Neurokinin A/pharmacology ; Polymerase Chain Reaction ; Protein Conformation ; Receptors, Neurokinin-2/biosynthesis ; Receptors, Neurokinin-2/chemistry ; Receptors, Neurokinin-2/physiology ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Second Messenger Systems/physiology ; Sequence Deletion ; Signal Transduction/physiology ; Transfection
    Chemische Substanzen Codon ; DNA Primers ; Receptors, Neurokinin-2 ; Recombinant Proteins ; Neurokinin A (86933-74-6) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 1994-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1006/bbrc.1994.1274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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