Article ; Online: Ambulatory microdose induction of buprenorphine-naloxone in two adolescent patients with sickle cell disease.
2020 Volume 68, Issue 1, Page(s) e28766
Abstract: Sickle cell disease (SCD) is a hematologic disorder defined by presence of sickle-shaped red blood cells that can occlude blood vessels and cause tissue ischemia and pain. Treating SCD pain adequately and safely is difficult given today's opioid climate. ...
Abstract | Sickle cell disease (SCD) is a hematologic disorder defined by presence of sickle-shaped red blood cells that can occlude blood vessels and cause tissue ischemia and pain. Treating SCD pain adequately and safely is difficult given today's opioid climate. Buprenorphine-naloxone has been described as an alternative option to treat chronic pain in the adult literature; however, it historically required discontinuation of full-agonist opioids before initiation, resulting in opioid withdrawal. Herein we present two adolescents with SCD who successfully weaned off large doses of full-agonist opioids by using microdose induction of buprenorphine-naloxone in clinic, without experiencing significant opioid withdrawal. Ambulatory microdose induction may remove hurdles that otherwise would discourage patients from trying this regimen while still controlling pain safely. |
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MeSH term(s) | Adolescent ; Adult ; Analgesics, Opioid/therapeutic use ; Anemia, Sickle Cell/complications ; Buprenorphine, Naloxone Drug Combination/therapeutic use ; Dose-Response Relationship, Drug ; Humans ; Male ; Pain/drug therapy ; Pain/etiology ; Pain/pathology ; Prognosis ; Young Adult |
Chemical Substances | Analgesics, Opioid ; Buprenorphine, Naloxone Drug Combination |
Language | English |
Publishing date | 2020-10-27 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 2131448-2 |
ISSN | 1545-5017 ; 1545-5009 |
ISSN (online) | 1545-5017 |
ISSN | 1545-5009 |
DOI | 10.1002/pbc.28766 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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