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Book ; Thesis: Identifikation und Quantifizierung von Metaboliten und makromolekularen Substanzen im Gehirn mit Methoden der Magnetresonanz

Jost, Gregor

2005

Author's details	vorgelegt von Gregor Jost
Language	German
Size	142 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2005
HBZ-ID	HT014497190
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: New Contrast Media for K-Edge Imaging With Photon-Counting Detector CT.

Jost, Gregor / McDermott, Michael / Gutjahr, Ralf / Nowak, Tristan / Schmidt, Bernhard / Pietsch, Hubertus

Investigative radiology

2023 Volume 58, Issue 7, Page(s) 515–522

Abstract: Abstract: The recent technological developments in photon-counting detector computed tomography (PCD-CT) and the introduction of the first commercially available clinical PCD-CT unit open up new exciting opportunities for contrast media research. With ... ...

Abstract	Abstract: The recent technological developments in photon-counting detector computed tomography (PCD-CT) and the introduction of the first commercially available clinical PCD-CT unit open up new exciting opportunities for contrast media research. With PCD-CT, the efficacy of available iodine-based contrast media improves, allowing for a reduction of iodine dosage or, on the other hand, an improvement of image quality in low contrast indications. Virtual monoenergetic image reconstructions are routinely available and enable the virtual monoenergetic image energy to be adapted to the diagnostic task.A key property of PCD-CT is the ability of spectral separation in combination with improved material decomposition. Thus, the discrimination of contrast media from intrinsic or pathological tissues and the discrimination of 2 or more contrasting elements that characterize different tissues are attractive fields for contrast media research. For these approaches, K-edge imaging in combination with high atomic number elements such as the lanthanides, tungsten, tantalum, or bismuth plays a central role.The purpose of this article is to present an overview of innovative contrast media concepts that use high atomic number elements. The emphasis is on improving contrast enhancement for cardiovascular plaque imaging, stent visualization, and exploring new approaches using 2 contrasting elements. Along with the published research, new experimental findings with a contrast medium that incorporates tungsten are included.Both the literature review and the new experimental data demonstrate the great potential and feasibility for new contrast media to significantly increase diagnostic performance and to enable new clinical fields and indications in combination with PCD-CT.
MeSH term(s)	Contrast Media ; Iodine ; Phantoms, Imaging ; Photons ; Tomography, X-Ray Computed/methods ; Tungsten
Chemical Substances	Contrast Media ; Iodine (9679TC07X4) ; Tungsten (V9306CXO6G)
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000000978
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Article ; Online: AI as a New Frontier in Contrast Media Research: Bridging the Gap Between Contrast Media Reduction, the Contrast-Free Question and New Application Discoveries.

Haubold, Johannes / Hosch, René / Jost, Gregor / Kreis, Felix / Forsting, Michael / Pietsch, Hubertus / Nensa, Felix

Investigative radiology

2023 Volume 59, Issue 2, Page(s) 206–213

Abstract: Abstract: Artificial intelligence (AI) techniques are currently harnessed to revolutionize the domain of medical imaging. This review investigates 3 major AI-driven approaches for contrast agent management: new frontiers in contrast agent dose reduction, ...

Abstract	Abstract: Artificial intelligence (AI) techniques are currently harnessed to revolutionize the domain of medical imaging. This review investigates 3 major AI-driven approaches for contrast agent management: new frontiers in contrast agent dose reduction, the contrast-free question, and new applications. By examining recent studies that use AI as a new frontier in contrast media research, we synthesize the current state of the field and provide a comprehensive understanding of the potential and limitations of AI in this context. In doing so, we show the dose limits of reducing the amount of contrast agents and demonstrate why it might not be possible to completely eliminate contrast agents in the future. In addition, we highlight potential new applications to further increase the radiologist's sensitivity at normal doses. At the same time, this review shows which network architectures provide promising approaches and reveals possible artifacts of a paired image-to-image conversion. Furthermore, current US Food and Drug Administration regulatory guidelines regarding AI/machine learning-enabled medical devices are highlighted.
MeSH term(s)	United States ; Artificial Intelligence ; Contrast Media ; Machine Learning ; Artifacts ; United States Food and Drug Administration
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000001028
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Article ; Online: Signal Enhancement and Enhancement Kinetics of Gadobutrol, Gadoteridol, and Gadoterate Meglumine in Various Body Regions: A Comparative Animal Study.

Knobloch, Gesine / Frenzel, Thomas / Pietsch, Hubertus / Jost, Gregor

Investigative radiology

2020 Volume 55, Issue 6, Page(s) 367–373

Abstract: Objectives: The signal enhancement (SE) and enhancement kinetics of gadolinium-based contrast agents (GBCAs) in T1-weighted magnetic resonance (MR) images depend on the relaxivity of the GBCA and its pharmacokinetic profile. This in vivo study ... ...

Abstract	Objectives: The signal enhancement (SE) and enhancement kinetics of gadolinium-based contrast agents (GBCAs) in T1-weighted magnetic resonance (MR) images depend on the relaxivity of the GBCA and its pharmacokinetic profile. This in vivo study systematically compared the SE (technical efficacy) and the enhancement kinetics of the 3 macrocyclic GBCAs gadobutrol, gadoteridol, and gadoterate meglumine in various body regions. Materials and methods: A total of 15 healthy male white New Zealand rabbits were randomly divided into 3 groups (n = 5/group). The GBCAs were injected intravenously (0.1 mmol/kg body weight) and signal intensities from multiphase T1-weighted MR images (1.5 T; volumetric interpolated breath-hold examination (VIBE); repetition time/echo time/α: 4.74 milliseconds/2.38 milliseconds/10°) before and up to approximately 23 minutes after contrast injection were determined in the brain, tongue, submandibular gland, liver, spleen, prostate, muscle, and blood/aorta). Thirty minutes after injection, the animals were sacrificed and Gadolinium (Gd) concentrations were determined in the above-mentioned tissue samples by inductively coupled plasma optical emission spectrometry. Gadolinium tissue concentrations were correlated with the respective SE measurements in each tissue. Results: The time course of SE, representing the pharmacokinetic profile of the GBCA, was similar for all 3 agents in all tissues. The magnitude of SE was, however, tissue dependent and consistently higher for gadobutrol (P < 0.05 in all tissues but brain). No significant difference in the magnitude of SE was found between gadoteridol and gadoterate meglumine. The inductively coupled plasma optical emission spectrometry analysis revealed no differences in Gd-tissue concentrations between the GBCAs. A linear correlation was observed between SE and the respective Gd concentrations for all 3 GBCAs. A significantly higher enhancement efficacy, that is, SE per Gd concentration, was observed for gadobutrol. Conclusions: Gadobutrol-enhanced MR imaging showed greater SE compared with gadoteridol and gadoterate meglumine, whereas the SE kinetics were similar among the 3 GBCAs. For all 3 GBCAs, the SE was independent of the body region.
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Contrast Media/pharmacokinetics ; Gadolinium/pharmacokinetics ; Heterocyclic Compounds/pharmacokinetics ; Humans ; Injections, Intravenous ; Liver/diagnostic imaging ; Liver/metabolism ; Magnetic Resonance Imaging/methods ; Male ; Meglumine/pharmacokinetics ; Models, Animal ; Organometallic Compounds/pharmacokinetics ; Prostate/diagnostic imaging ; Rabbits
Chemical Substances	Contrast Media ; Heterocyclic Compounds ; Organometallic Compounds ; gadoteridol (0199MV609F) ; Meglumine (6HG8UB2MUY) ; Gadolinium (AU0V1LM3JT) ; gadoterate meglumine (L0ND3981AG)
Language	English
Publishing date	2020-01-26
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000000645
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Article ; Online: The Effect of Gadolinium-Based Contrast Agents on Longitudinal Changes of Magnetic Resonance Imaging Signal Intensities and Relaxation Times in the Aging Rat Brain.

Green, Claudia / Jost, Gregor / Frenzel, Thomas / Boyken, Janina / Schwenke, Carsten / Pietsch, Hubertus

Investigative radiology

2022 Volume 57, Issue 7, Page(s) 453–462

Abstract: Objectives: The aim of the study was to investigate the possible influence of changes in the brain caused by age on relaxometric and relaxation time-weighted magnetic resonance imaging (MRI) parameters in the deep cerebellar nuclei (DCN) and the globus ... ...

Abstract	Objectives: The aim of the study was to investigate the possible influence of changes in the brain caused by age on relaxometric and relaxation time-weighted magnetic resonance imaging (MRI) parameters in the deep cerebellar nuclei (DCN) and the globus pallidus (GP) of Gd-exposed and control rats over the course of 1 year. Materials and methods: Twenty-five Wistar-Han rats were equally subdivided into 5 groups and initially received 8 injections on 4 consecutive days per week of either 3.6 mL/kg body weight saline (group I-III) or 1.8 mmol Gd/kg body weight gadobutrol (group IV) or gadodiamide (group V). T1- and T2-weighted scans, as well as relaxation maps, were acquired at 1 week (all groups); 5, 12, 20, and 26 weeks (saline II, gadobutrol, gadodiamide); and at 35, 44, and 52 weeks (saline III, gadobutrol, gadodiamide) after the last administration. Saline I was euthanized after 1 week, saline II after 26 weeks, and the remaining groups after 52 weeks. Signal intensities (SIs) were evaluated for the DCN/pons (P) and the GP/piriform cortex (PC) ratios, and relaxation times for the DCN and the GP. Brain tissue was extracted, and the gadolinium, iron, and manganese contents were quantified with inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation-ICP-MS imaging. Results: T1-weighted SI ratios did not show any significant trend with age in any region. The between-group analysis at 52 weeks resulted in a significant difference for the DCN/P and GP/PC region ratio between gadodiamide and its comparators. T1 relaxation times dropped with increasing age in the GP with a 10% to 20% difference between first and last measurement for all groups, and in the DCN <10% with a significant decrease for the gadodiamide group only (DCN: P = 0.0158). Group-related differences were observed at the last measurement time point for T1 values between gadodiamide and saline III in the DCN (P = 0.0153) and gadodiamide and gadobutrol in the GP (P = 0.0287). Analysis of the SI ratios of the T2-weighted images revealed a significant increase for the DCN/P and a decrease for the GP/PC with increasing age for all groups and no differences at 52 weeks after the last injection between groups. T2 values of the GP showed a significant linear decrease over time for all groups (saline I-III: P = 0.0101; gadobutrol: P = 0.0001; gadodiamide: P = 0.0142) in the aging rat brain. Quantitative imaging of manganese and iron by laser ablation-ICP-MS showed a linear increase for the saline groups in the GP for both metals (Fe: P < 0.0001; Mn: P = 0.0306) and in the DCN for manganese only (P = 0.0187), but no differences between groups at 52 weeks. Conclusions: Extensive MRI evaluation did not reveal an indication of SI or relaxation time changes associated with multiple exposure to the macrocyclic-chelated GBCA gadobutrol in the DCN and the GP. With increasing age, a T1 and T2 shortening in the GP and an increase in T2-weighted SI ratio in the DCN/P, as well as a decrease in the GP/PC, were observed for all groups. Such age-related changes can potentially bias MRI results as an indicator for gadolinium presence in the brain.
MeSH term(s)	Aging ; Animals ; Body Weight ; Brain/diagnostic imaging ; Cerebellar Nuclei/diagnostic imaging ; Contrast Media ; Gadolinium ; Gadolinium DTPA ; Iron ; Magnetic Resonance Imaging/methods ; Manganese ; Organometallic Compounds ; Rats ; Rats, Wistar ; Retrospective Studies
Chemical Substances	Contrast Media ; Organometallic Compounds ; Manganese (42Z2K6ZL8P) ; Gadolinium (AU0V1LM3JT) ; Iron (E1UOL152H7) ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000000857
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Article ; Online: Photon-counting detector coronary CT angiography: impact of virtual monoenergetic imaging and iterative reconstruction on image quality.

Sartoretti, Thomas / McDermott, Michael / Mergen, Victor / Euler, André / Schmidt, Bernhard / Jost, Gregor / Wildberger, Joachim E / Alkadhi, Hatem

The British journal of radiology

2023 Volume 96, Issue 1143, Page(s) 20220466

Abstract: Objectives: To assess the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on image quality of clinical photon-counting detector coronary CT angiography (CCTA).: Methods: CCTA with PCD-CT ( ... ...

Abstract	Objectives: To assess the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on image quality of clinical photon-counting detector coronary CT angiography (CCTA). Methods: CCTA with PCD-CT (prospective ECG-triggering, 120 kVp, automatic tube current modulation) was performed in a high-end cardiovascular phantom with dynamic flow, pulsatile heart motion, and including different calcified plaques with various stenosis grades and in 10 consecutive patients. VMI at 40,50,60 and 70 keV were reconstructed without (QIR-off) and with all quantum iterative reconstruction (QIR) levels (QIR-1 to 4). In the phantom, noise power spectrum, vessel attenuation, contrast-to-noise-ratio (CNR), and vessel sharpness were measured. Two readers graded stenoses in the phantom and graded overall image quality, subjective noise, vessel sharpness, vascular contrast, and coronary artery plaque delineation on 5-point Likert scales in patients. Results: In the phantom, noise texture was only slightly affected by keV and QIR while noise increased by 69% from 70 keV QIR-4 to 40 keV QIR-off. Reconstructions at 40 keV QIR-4 exhibited the highest CNR (46.1 ± 1.8), vessel sharpness (425 ± 42 ∆HU/mm), and vessel attenuation (1098 ± 14 HU). Stenosis measurements were not affected by keV or QIR level ( Conclusion: Forty keV VMI with QIR-4 significantly improved image quality of CCTA with PCD-CT. Advances in knowledge: PCD-CT at 40 keV and QIR-4 improves image quality of CCTA.
MeSH term(s)	Humans ; Computed Tomography Angiography ; Constriction, Pathologic ; Prospective Studies ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed/methods ; Plaque, Atherosclerotic ; Radiographic Image Interpretation, Computer-Assisted/methods ; Retrospective Studies
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20220466
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Article ; Online: Impact of brain tumors and radiotherapy on the presence of gadolinium in the brain after repeated administration of gadolinium-based contrast agents: an experimental study in rats.

Jost, Gregor / Frenzel, Thomas / Boyken, Janina / Pietsch, Hubertus

Neuroradiology

2019 Volume 61, Issue 11, Page(s) 1273–1280

Abstract: Purpose: To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a ... ...

Abstract	Purpose: To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a linear gadolinium-based contrast agent in rats. Methods: Eighteen Fischer rats were divided into a tumor (gliosarcoma, GS9L model), a radiotherapy, and a control group. All animals received 5 daily injections (1.8 mmol/kg) of gadopentetate dimeglumine. For tumor-bearing animals, the BBB disruption was confirmed by contrast-enhanced MRI. Animals from the tumor and radiation group underwent radiotherapy in 6 fractions of 5 Gray. The SI ratio between DCN and brain stem was evaluated on T1-weigthed MRI at baseline and 1 week after the last administration. Subsequently, the brain was dissected for gadolinium quantification by inductively coupled plasma-mass spectrometry. Statistical analysis was done with the Kruskal-Wallis test. Results: An increased but similar DCN/brain stem SI ratio was found for all three groups (p = 0.14). The gadolinium tissue concentrations (median, nmol/g) were 6.7 (tumor), 6.3 (radiotherapy), and 6.8 (control) in the cerebellum (p = 0.64) and 17.8/14.6 (tumor), 20.0/18.9 (radiotherapy), and 17.8/15.9 (control) for the primary tumor (p = 0.98) and the contralateral hemisphere (p = 0.41) of the cerebrum, respectively. Conclusion: An experimental brain tumor treated by radiotherapy or radiotherapy alone did not alter DCN signal hyperintensity and gadolinium concentration in the rat brain 1 week after repeated administration of gadopentetate. This suggests that a local BBB disruption does not affect the amount of retained gadolinium in the brain.
MeSH term(s)	Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/radiation effects ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/radiotherapy ; Contrast Media/pharmacokinetics ; Gadolinium DTPA/pharmacokinetics ; Magnetic Resonance Imaging/methods ; Neoplasms, Experimental/diagnostic imaging ; Neoplasms, Experimental/radiotherapy ; Rats ; Rats, Inbred F344
Chemical Substances	Contrast Media ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2019-07-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-019-02256-3
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Article ; Online: Gadolinium Presence in Rat Skin: Assessment of Histopathologic Changes Associated with Small Fiber Neuropathy.

Boyken, Janina / Lohrke, Jessica / Treu, Axel / Neddens, Joerg / Jost, Gregor / Ulbrich, Hannes-Friedrich / Balzer, Thomas / Frenzel, Thomas / Prokesch, Manuela / Thuss, Uwe / Pietsch, Hubertus

Radiology

2024 Volume 310, Issue 1, Page(s) e231984

Abstract: Background The presence of gadolinium traces in the skin after administration of gadolinium-based contrast agents (GBCAs) raised safety concerns regarding a potential association with small fiber neuropathy (SFN). Purpose To investigate signs of SFN in ... ...

Abstract	Background The presence of gadolinium traces in the skin after administration of gadolinium-based contrast agents (GBCAs) raised safety concerns regarding a potential association with small fiber neuropathy (SFN). Purpose To investigate signs of SFN in rat foot pads by quantification of the intraepidermal nerve fiber density (IENFD) after multiple GBCA administrations and to evaluate gadolinium concentration, chemical species, and clearance. Materials and Methods Fifty rats received eight intravenous injections of either gadodiamide, gadobutrol, gadoterate, gadoteridol (8 × 0.6 mmol per kilogram of body weight), or saline (1.2 mL per kilogram of body weight), within 2 weeks and were sacrificed 5 days or 5 weeks after the last injection. IENFD was determined with protein gene product (PGP) 9.5 immunofluorescent staining and blinded and automated image analysis. The gadolinium and GBCA concentrations were measured with inductively coupled plasma mass spectrometry (ICP-MS), laser ablation ICP-MS, and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI).
MeSH term(s)	Animals ; Rats ; Gadolinium ; Small Fiber Neuropathy ; Contrast Media ; Body Weight ; Heterocyclic Compounds ; Organometallic Compounds ; Gadolinium DTPA
Chemical Substances	gadoteridol (0199MV609F) ; gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate (99J2XUF1JT) ; gadodiamide (84F6U3J2R6) ; gadobutrol (1BJ477IO2L) ; Gadolinium (AU0V1LM3JT) ; Contrast Media ; Heterocyclic Compounds ; Organometallic Compounds ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.231984
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Article ; Online: Piston-Based vs Peristaltic Pump-Based CT Injector Systems.

Chaya, Amy / Jost, Gregor / Endrikat, Jan

Radiologic technology

2019 Volume 90, Issue 4, Page(s) 344–352

Abstract: Purpose: To compare the fluid delivery performance of 2 different technologies for administration of iodinated contrast media in computed tomography (CT).: Methods: The maximum achievable flow rate and the steady-state flow rate variance of a piston- ... ...

Abstract	Purpose: To compare the fluid delivery performance of 2 different technologies for administration of iodinated contrast media in computed tomography (CT). Methods: The maximum achievable flow rate and the steady-state flow rate variance of a piston-based contrast media injector system (Stellant MP, MEDRAD) was compared with peristaltic pump-based injector systems (CT motion, Ulrich Medical; CT Exprès, Bracco). The contrast media iopromide (Ultravist) and iopamidol (Isovue) were used at 2 concentrations each (300 and 370 mg I/mL) and 3 catheter sizes (18, 20, and 22 G) to test the injector performance. Results: Average maximum achievable flow rates for room temperature iopromide (370 mg I/mL) using a 20 G catheter were 7.6, 7.1, and 4.8 mL per second for the Stellant MP injector, CT motion injector, and CT Exprès injector, respectively. The Stellant MP injector achieved significantly higher flow rates compared to the CT Exprès injector for all catheter sizes tested ( Discussion: To the authors' knowledge, this is the first reported laboratory study providing preliminary evidence of differences between the fluid delivery performance of CT injection systems. Additional investigations using a dedicated flow phantom simulating human physiological flow parameters should be conducted, and depending on the results, a clinical study could assess the effect on image quality. Conclusion: The piston-based injector demonstrated higher maximum achievable flow rates and more consistent steady-state flow when compared to peristaltic pump-based injectors.
MeSH term(s)	Catheterization/instrumentation ; Contrast Media/administration & dosage ; Equipment Design ; Humans ; Injections, Intravenous/instrumentation ; Iohexol/administration & dosage ; Iohexol/analogs & derivatives ; Iopamidol/administration & dosage ; Tomography, X-Ray Computed
Chemical Substances	Contrast Media ; Iohexol (4419T9MX03) ; iopromide (712BAC33MZ) ; Iopamidol (JR13W81H44)
Language	English
Publishing date	2019-04-25
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	414079-5
ISSN	1943-5657 ; 0033-8397
ISSN (online)	1943-5657
ISSN	0033-8397
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Article ; Online: Effect of Gadoxetic Acid Injection Duration on Tumor Enhancement in Arterial Phase Liver MRI.

Tsuboyama, Takahiro / Jost, Gregor / Pietsch, Hubertus / Tomiyama, Noriyuki

Academic radiology

2019 Volume 27, Issue 8, Page(s) e216–e223

Abstract: Rationale and objectives: Rapid injection of gadoxetic acid has been shown not to increase tumor enhancement in arterial phase liver MRI for unknown reasons. This study aimed to investigate the effect of injection durations on peak contrast ... ...

Abstract	Rationale and objectives: Rapid injection of gadoxetic acid has been shown not to increase tumor enhancement in arterial phase liver MRI for unknown reasons. This study aimed to investigate the effect of injection durations on peak contrast concentration in tumors and to correlate it with signal enhancement in gadoxetic acid-enhanced arterial phase MRI. Materials and methods: Gadoxetic acid-enhanced arterial phase MRI was obtained using a bolus-tracking technique with injection durations of 1, 3, and 6s in six rabbits with VX2 liver tumors. The peak concentration of gadoxetic acid in the aorta and tumor was estimated by iopromide-enhanced time-resolved CT using the same injection volume and durations with those for MRI. Signal enhancement on MRI and peak enhancement on CT were compared and correlated. Results: There was no significant difference in MR signal enhancement of tumors among the 3 injection durations (p = 0.87). In CT, shorter injection durations significantly increased peak contrast concentration in the aorta (p < 0.01) but produced equivalent peak contrast concentration in tumors (p = 0.24). The longer injections resulted in the stronger correlation between peak contrast concentration in CT and MR signal enhancement in tumors (r = 0.31, 0.43, and 0.86 with 1s-, 3s-, and 6s-injection, respectively) with a statistical significance only found with 6s-injection (p = 0.03). Conclusion: Estimation of contrast concentration by CT demonstrated that shorter injections did not increase peak contrast concentration in tumors despite increased peak concentration in the aorta. Furthermore, tumor signal enhancement in gadoxetic acid-enhanced arterial phase MRI was less correlated with the peak contrast concentration with shorter injections.
MeSH term(s)	Animals ; Contrast Media ; Gadolinium DTPA ; Image Enhancement ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Magnetic Resonance Imaging ; Rabbits
Chemical Substances	Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2019-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2019.10.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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