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  1. Article ; Online: Letter: is the AHHS score really useful in clinically severe alcoholic hepatitis?

    Buchard, Benjamin / Sévigné, Luc / Darcha, Claude / Muti, Leon / Joubert, Juliette / Abergel, Armand

    Alimentary pharmacology & therapeutics

    2021  Volume 53, Issue 10, Page(s) 1160–1161

    MeSH term(s) Hepatitis, Alcoholic/diagnosis ; Histological Techniques ; Humans ; Liver Cirrhosis ; Prognosis
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16307
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    Zs.A 2206: Show issues Location:
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  2. Article ; Online: Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohn's disease.

    Decousus, Stéphanie / Boucher, Anne-Laure / Joubert, Juliette / Pereira, Bruno / Dubois, Anne / Goutorbe, Felix / Déchelotte, Pierre J / Bommelaer, Gilles / Buisson, Anthony

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2016  Volume 48, Issue 7, Page(s) 753–758

    Abstract: Background: As surgical resection is not curative in Crohn's disease, postoperative recurrence remains a crucial issue. The selection of patients, according to available risk factors, remains disappointing in clinical practice highlighting the need for ... ...

    Abstract Background: As surgical resection is not curative in Crohn's disease, postoperative recurrence remains a crucial issue. The selection of patients, according to available risk factors, remains disappointing in clinical practice highlighting the need for better criteria, such as histologic features.
    Aims: To investigate whether submucosal and myenteric plexitis increase the risk of endoscopic, clinical and surgical postoperative recurrence in Crohn's disease.
    Methods: From the pathology department database, we retrospectively retrieved the data of all the patients who have undergone ileocolonic resection for Crohn's disease. Two pathologists, blinded from clinical data, reviewed all specimens to evaluate the presence of plexitis at the proximal resection margin.
    Results: Of the 75 included CD patients, 19 (25.3%) had histological involvement of resection margin. Inflammatory cells count for myenteric and submucosal plexus were performed in 56 patients. In multivariate analysis, the myenteric plexitis was a risk factor for endoscopic postoperative recurrence (HR 8.83 CI95% [1.6-48.6], p=0.012), and the presence of at least one myenteric lymphocyte (HR 4.02 CI95% [1.4-11.2], p=0.008) was predictive of clinical postoperative recurrence. We observed no histologic predictor for surgical postoperative recurrence.
    Conclusion: Myenteric plexitis in proximal margins of ileocolonic resection specimens is independently associated with endoscopic and clinical postoperative recurrence in Crohn's disease.
    MeSH term(s) Adult ; Anastomosis, Surgical ; Colectomy/adverse effects ; Colectomy/methods ; Colon/pathology ; Colon/surgery ; Crohn Disease/surgery ; Databases, Factual ; Endoscopy ; Female ; Follow-Up Studies ; France ; Humans ; Ileum/pathology ; Ileum/surgery ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Myenteric Plexus/pathology ; Neuritis/diagnosis ; Postoperative Period ; Prognosis ; Recurrence ; Retrospective Studies ; Risk Factors ; Young Adult
    Language English
    Publishing date 2016-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2016.02.023
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    Zs.A 1134: Show issues Location:
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  3. Article ; Online: Pancreatic intubation facilitated by methylene blue injection decreases the risk for postpapillectomy acute pancreatitis.

    Poincloux, Laurent / Scanzi, Julien / Goutte, Marion / Pereira, Bruno / Devaud, Hervé / Joubert, Juliette / Dapoigny, Michel / Bommelaer, Gilles / Abergel, Armand

    European journal of gastroenterology & hepatology

    2014  Volume 26, Issue 9, Page(s) 990–995

    Abstract: Objectives: Endoscopic snare papillectomy (ESP) is a viable alternative to surgical treatment of ampullary adenomas and T1N0 stage ampullary carcinomas. The main drawback of this technique is the high risk of acute pancreatitis post procedure.The aim of ...

    Abstract Objectives: Endoscopic snare papillectomy (ESP) is a viable alternative to surgical treatment of ampullary adenomas and T1N0 stage ampullary carcinomas. The main drawback of this technique is the high risk of acute pancreatitis post procedure.The aim of this study was to assess the efficacy, safety, and long-term results of this procedure, and to determine whether routine pancreatic intubation facilitated by intraductal methylene blue (MB) injection reduces the risk for pancreatitis.
    Patients and methods: Between 2004 and 2011, 56 consecutive patients underwent ESP. Before resection, the pancreatic duct was cannulated, and MB was injected intraductally to facilitate stent placement after ampullectomy.
    Results: ESP was performed en bloc in 45 patients with histological findings of low-grade dysplasia (39%), high-grade dysplasia (25%), carcinoma (32.5%), and others (3.5%). The morbidity rate was 19.5%: acute pancreatitis (n=6), bleeding (n=4), perforation (n=1), and sepsis (n=1). Pancreatic intubation was performed in 89% of the patients. Postprocedure pancreatitis occurred significantly less in the patients with a pancreatic stent than in those without: 3/49 versus 3/6, P=0.013. ESP was considered as curative in 39 patients (75%). Of the 12 recurrences (25%), 10 were managed endoscopically, but with higher morbidity (acute pancreatitis=40%).
    Conclusion: Endoscopic papillectomy is safe and effective in the hands of experts. Pancreatic-duct stent placement in fewer cannulation attempts could be facilitated by injection of MB before papillectomy, and this decreases the risk for postprocedure pancreatitis. Recurrences can be managed endoscopically, but with a higher risk for pancreatitis.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Ampulla of Vater ; Coloring Agents ; Common Bile Duct Neoplasms/surgery ; Duodenoscopy/adverse effects ; Duodenoscopy/methods ; Female ; Humans ; Intubation/methods ; Male ; Methylene Blue ; Middle Aged ; Pancreatic Ducts ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Risk Reduction Behavior ; Stents ; Young Adult
    Chemical Substances Coloring Agents ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000000146
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    Zs.A 2932: Show issues Location:
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  4. Article ; Online: Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease.

    Boucher, Anne-Laure / Pereira, Bruno / Decousus, Stéphanie / Goutte, Marion / Goutorbe, Felix / Dubois, Anne / Gagniere, Johan / Borderon, Corinne / Joubert, Juliette / Pezet, Denis / Dapoigny, Michel / Déchelotte, Pierre J / Bommelaer, Gilles / Buisson, Anthony

    World journal of gastroenterology

    2016  Volume 22, Issue 21, Page(s) 5068–5078

    Abstract: Aim: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.: Methods: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn' ... ...

    Abstract Aim: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.
    Methods: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease (CD) in our center (1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy (median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy.
    Results: From 205 patients who underwent surgery, 161 patients (follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype (B3) were postoperative risk factors. Previous perianal abscess/fistula (other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management (n = 49/161) prevented clinical (HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence (HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).
    Conclusion: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation.
    MeSH term(s) Adult ; Chi-Square Distribution ; Colectomy/adverse effects ; Colonoscopy ; Crohn Disease/pathology ; Crohn Disease/surgery ; Disease-Free Survival ; Female ; France ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Proportional Hazards Models ; Recurrence ; Reoperation ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v22.i21.5068
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    Zs.A 6039: Show issues Location:
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  5. Article ; Online: microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data.

    Zuffa, Simone / Schmid, Robin / Bauermeister, Anelize / P Gomes, Paulo Wender / Caraballo-Rodriguez, Andres M / El Abiead, Yasin / Aron, Allegra T / Gentry, Emily C / Zemlin, Jasmine / Meehan, Michael J / Avalon, Nicole E / Cichewicz, Robert H / Buzun, Ekaterina / Terrazas, Marvic Carrillo / Hsu, Chia-Yun / Oles, Renee / Ayala, Adriana Vasquez / Zhao, Jiaqi / Chu, Hiutung /
    Kuijpers, Mirte C M / Jackrel, Sara L / Tugizimana, Fidele / Nephali, Lerato Pertunia / Dubery, Ian A / Madala, Ntakadzeni Edwin / Moreira, Eduarda Antunes / Costa-Lotufo, Leticia Veras / Lopes, Norberto Peporine / Rezende-Teixeira, Paula / Jimenez, Paula C / Rimal, Bipin / Patterson, Andrew D / Traxler, Matthew F / Pessotti, Rita de Cassia / Alvarado-Villalobos, Daniel / Tamayo-Castillo, Giselle / Chaverri, Priscila / Escudero-Leyva, Efrain / Quiros-Guerrero, Luis-Manuel / Bory, Alexandre Jean / Joubert, Juliette / Rutz, Adriano / Wolfender, Jean-Luc / Allard, Pierre-Marie / Sichert, Andreas / Pontrelli, Sammy / Pullman, Benjamin S / Bandeira, Nuno / Gerwick, William H / Gindro, Katia / Massana-Codina, Josep / Wagner, Berenike C / Forchhammer, Karl / Petras, Daniel / Aiosa, Nicole / Garg, Neha / Liebeke, Manuel / Bourceau, Patric / Kang, Kyo Bin / Gadhavi, Henna / de Carvalho, Luiz Pedro Sorio / Silva Dos Santos, Mariana / Pérez-Lorente, Alicia Isabel / Molina-Santiago, Carlos / Romero, Diego / Franke, Raimo / Brönstrup, Mark / Vera Ponce de León, Arturo / Pope, Phillip Byron / La Rosa, Sabina Leanti / La Barbera, Giorgia / Roager, Henrik M / Laursen, Martin Frederik / Hammerle, Fabian / Siewert, Bianka / Peintner, Ursula / Licona-Cassani, Cuauhtemoc / Rodriguez-Orduña, Lorena / Rampler, Evelyn / Hildebrand, Felina / Koellensperger, Gunda / Schoeny, Harald / Hohenwallner, Katharina / Panzenboeck, Lisa / Gregor, Rachel / O'Neill, Ellis Charles / Roxborough, Eve Tallulah / Odoi, Jane / Bale, Nicole J / Ding, Su / Sinninghe Damsté, Jaap S / Guan, Xue Li / Cui, Jerry J / Ju, Kou-San / Silva, Denise Brentan / Silva, Fernanda Motta Ribeiro / da Silva, Gilvan Ferreira / Koolen, Hector H F / Grundmann, Carlismari / Clement, Jason A / Mohimani, Hosein / Broders, Kirk / McPhail, Kerry L / Ober-Singleton, Sidnee E / Rath, Christopher M / McDonald, Daniel / Knight, Rob / Wang, Mingxun / Dorrestein, Pieter C

    Nature microbiology

    2024  Volume 9, Issue 2, Page(s) 336–345

    Abstract: microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and ...

    Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health.
    MeSH term(s) Humans ; Tandem Mass Spectrometry ; Metabolomics/methods ; Databases, Factual
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01575-9
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  6. Article ; Online: Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants.

    Vallin, Mélanie / Sturm, Nathalie / Lamblin, Géraldine / Guillaud, Olivier / Hilleret, Marie-Noëlle / Hervieu, Valérie / Joubert, Juliette / Abergel, Armand / Leroy, Vincent / Boillot, Olivier / Dumortier, Jérôme / Scoazec, Jean-Yves

    Clinical transplantation

    2013  Volume 27, Issue 3, Page(s) 403–409

    Abstract: Liver cirrhosis is a recognized risk factor for intrahepatic cholangiocarcinoma (I-CCa). Small I-CCa nodules might be undiagnosed or misdiagnosed as hepatocellular carcinoma (HCC) in the context of liver cirrhosis. The aim of this study was to determine ... ...

    Abstract Liver cirrhosis is a recognized risk factor for intrahepatic cholangiocarcinoma (I-CCa). Small I-CCa nodules might be undiagnosed or misdiagnosed as hepatocellular carcinoma (HCC) in the context of liver cirrhosis. The aim of this study was to determine the prevalence and clinical impact of undetected I-CCa in liver explants of adult cirrhotic patients undergoing liver transplantation (LT). From December 1985 to November 2008, a first LT was performed in 993 adult cirrhotic patients in three French academic Hospitals. All liver explants were analyzed for the presence of nodules. The diagnosis of HCC was made in 331 cases (33.3% of the patients). Similarly, an I-CCa was identified in 10 (1%) patients, with a mean size of 31 ± 17 mm. The mean age at transplantation was 58.8 yr (range 45 - 66), and all the patients were men. The mean follow-up after LT was 33 months (range 4-52). Post-transplant tumor recurrence was observed in five patients (50%), after a mean delay of 10 months. All five patients died. Malignant recurrence was associated with the presence of venous emboli on liver explants. Our results suggest that unrecognized I-CCa complicating liver cirrhosis is a rare entity, associated with high risk of recurrence and poor prognosis.
    MeSH term(s) Adult ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/mortality ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/mortality ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/mortality ; Liver Cirrhosis/surgery ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/mortality ; Liver Transplantation/adverse effects ; Liver Transplantation/mortality ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/mortality ; Prognosis ; Risk Factors ; Survival Rate
    Language English
    Publishing date 2013-05
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.12108
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    Zs.A 2204: Show issues Location:
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  7. Article ; Online: Non-occlusive colonic ischemia induced by verapamil ER overdose.

    Perbet, Sébastien / Constantin, Jean-Michel / Guérin, Renaud / Faure, Mickael / Brugère, Charlotte / Da Inès, David / Joubert, Juliette / Bazin, Jean-Etienne

    Intensive care medicine

    2008  Volume 35, Issue 5, Page(s) 956–957

    MeSH term(s) Colon/blood supply ; Colon/surgery ; Drug Overdose ; Humans ; Ischemia/chemically induced ; Male ; Middle Aged ; Suicide, Attempted/psychology ; Vasodilator Agents/poisoning ; Verapamil/poisoning
    Chemical Substances Vasodilator Agents ; Verapamil (CJ0O37KU29)
    Language English
    Publishing date 2008-12-20
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-008-1375-2
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    Zs.A 1089: Show issues Location:
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  8. Article: A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data.

    Zuffa, Simone / Schmid, Robin / Bauermeister, Anelize / Gomes, Paulo Wender P / Caraballo-Rodriguez, Andres M / Abiead, Yasin El / Aron, Allegra T / Gentry, Emily C / Zemlin, Jasmine / Meehan, Michael J / Avalon, Nicole E / Cichewicz, Robert H / Buzun, Ekaterina / Terrazas, Marvic Carrillo / Hsu, Chia-Yun / Oles, Renee / Ayala, Adriana Vasquez / Zhao, Jiaqi / Chu, Hiutung /
    Kuijpers, Mirte C M / Jackrel, Sara L / Tugizimana, Fidele / Nephali, Lerato Pertunia / Dubery, Ian A / Madala, Ntakadzeni Edwin / Moreira, Eduarda Antunes / Costa-Lotufo, Leticia Veras / Lopes, Norberto Peporine / Rezende-Teixeira, Paula / Jimenez, Paula C / Rimal, Bipin / Patterson, Andrew D / Traxler, Matthew F / de Cassia Pessotti, Rita / Alvarado-Villalobos, Daniel / Tamayo-Castillo, Giselle / Chaverri, Priscila / Escudero-Leyva, Efrain / Quiros-Guerrero, Luis-Manuel / Bory, Alexandre Jean / Joubert, Juliette / Rutz, Adriano / Wolfender, Jean-Luc / Allard, Pierre-Marie / Sichert, Andreas / Pontrelli, Sammy / Pullman, Benjamin S / Bandeira, Nuno / Gerwick, William H / Gindro, Katia / Massana-Codina, Josep / Wagner, Berenike C / Forchhammer, Karl / Petras, Daniel / Aiosa, Nicole / Garg, Neha / Liebeke, Manuel / Bourceau, Patric / Kang, Kyo Bin / Gadhavi, Henna / de Carvalho, Luiz Pedro Sorio / Dos Santos, Mariana Silva / Pérez-Lorente, Alicia Isabel / Molina-Santiago, Carlos / Romero, Diego / Franke, Raimo / Brönstrup, Mark / de León, Arturo Vera Ponce / Pope, Phillip Byron / Rosa, Sabina Leanti La / Barbera, Giorgia La / Roager, Henrik M / Laursen, Martin Frederik / Hammerle, Fabian / Siewert, Bianka / Peintner, Ursula / Licona-Cassani, Cuauhtemoc / Rodriguez-Orduña, Lorena / Rampler, Evelyn / Hildebrand, Felina / Koellensperger, Gunda / Schoeny, Harald / Hohenwallner, Katharina / Panzenboeck, Lisa / Gregor, Rachel / O'Neill, Ellis Charles / Roxborough, Eve Tallulah / Odoi, Jane / Bale, Nicole J / Ding, Su / Sinninghe Damsté, Jaap S / Guan, Xueli Li / Cui, Jerry J / Ju, Kou-San / Silva, Denise Brentan / Silva, Fernanda Motta Ribeiro / da Silva, Gilvan Ferreira / Koolen, Hector H F / Grundmann, Carlismari / Clement, Jason A / Mohimani, Hosein / Broders, Kirk / McPhail, Kerry L / Ober-Singleton, Sidnee E / Rath, Christopher M / McDonald, Daniel / Knight, Rob / Wang, Mingxun / Dorrestein, Pieter C

    Research square

    2023  

    Abstract: MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and ...

    Abstract MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3189768/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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