Article ; Online: Impact of surgery on immunologic function: comparison between minimally invasive techniques and conventional laparotomy for surgical resection of colorectal tumors.
2009 Volume 197, Issue 2, Page(s) 238–245
Abstract: Background: Surgical trauma suppresses host immune function, potentially creating an environment vulnerable to tumor cell growth. This study compared immune function after laparoscopy, minilaparotomy, and conventional colorectal tumor resections.: ... ...
| Abstract | Background: Surgical trauma suppresses host immune function, potentially creating an environment vulnerable to tumor cell growth. This study compared immune function after laparoscopy, minilaparotomy, and conventional colorectal tumor resections. Methods: Seventy-one patients underwent surgery (20 laparoscopy, 21 minilaparotomy, and 30 conventional). Blood samples were taken before surgery and at 3 hours, 24 hours, and 5 days after surgery. White blood cell constitution was determined using monoclonal antibodies. Levels of TH1 cytokines interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL)-2 and TH2 cytokines IL-10, -4, and -6 were measured in plasma and from supernatants of activated peripheral blood mononuclear cells. Results: At 5 days after surgery, lymphocyte counts remained low in the conventional and minilaparotomy groups (P = .001 and P = .008) but had resolved in laparoscopic patients. Three-hour postoperative serum IL-6 concentrations were lower in laparoscopic than in conventional patients (P = .028). Production of TH1 cytokines 3 hours after surgery were significantly increased in laparoscopic patients (interferon-gamma P = .018, tumor necrosis factor-alpha P = .011, and IL-2 P = .037). Conclusions: TH1 lymphocyte function is improved transiently and immune homeostasis restored earlier in patients undergoing laparoscopic colorectal cancer resection, which may influence disease recurrence. |
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| MeSH term(s) | Aged ; Colorectal Neoplasms/surgery ; Female ; Humans ; Immune System Diseases/etiology ; Immune System Diseases/immunology ; Laparotomy/adverse effects ; Male ; Minimally Invasive Surgical Procedures/adverse effects ; Th1 Cells/immunology | |||||
| Language | English | |||||
| Publishing date | 2009-02 | |||||
| Publishing country | United States | |||||
| Document type | Comparative Study ; Journal Article | |||||
| ZDB-ID | 2953-1 | |||||
| ISSN | 1879-1883 ; 0002-9610 | |||||
| ISSN (online) | 1879-1883 | |||||
| ISSN | 0002-9610 | |||||
| DOI | 10.1016/j.amjsurg.2008.01.021 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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