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Article ; Online: Platelet-rich fibrin

Pavlovic Voja / Ciric Milan / Jovanovic Vladimir / Trandafilovic Milena / Stojanovic Predrag

Open Medicine, Vol 16, Iss 1, Pp 446-

Basics of biological actions and protocol modifications

2021 Volume 454

Abstract: Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, ... ...

Abstract	Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components and to provide insight into the new developmental approach. Also, this review summarizes the evolution of platelet concentrates and biologic properties of different modifications of PRF procedure.
Keywords	platelet-rich fibrin ; platelets ; growth factors ; wound healing ; Medicine ; R
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tunnel junction sensing of TATP explosive at the single-molecule level.

Tomović, Aleksandar Ž / Miljkovic, Helena / Dražić, Miloš S / Jovanović, Vladimir P / Zikic, Radomir

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 39, Page(s) 26648–26658

Abstract: Triacetone triperoxide (TATP) is a highly potent homemade explosive commonly used in terrorist attacks. Its detection poses a significant challenge due to its volatility, and the lack of portability of current sensing techniques. To address this issue, ... ...

Abstract	Triacetone triperoxide (TATP) is a highly potent homemade explosive commonly used in terrorist attacks. Its detection poses a significant challenge due to its volatility, and the lack of portability of current sensing techniques. To address this issue, we propose a novel approach based on single-molecule TATP detection in the air using a device where tunneling current in N-terminated carbon-nanotubes nanogaps is measured. By employing the density functional theory combined with the non-equilibrium Green's function method, we show that current of tens of nanoamperes passes through TATP trapped in the nanogap, with a discrimination ratio of several orders of magnitude even against prevalent indoor volatile organic compounds (VOCs). This high tunneling current through TATP's highest occupied molecular orbital (HOMO) is facilitated by the strong electric field generated by N-C polar bonds at the electrode ends and by the hybridization between TATP and the electrodes, driven by oxygen atoms within the probed molecule. The application of the same principle is discussed for graphene nanogaps and break-junctions.
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp02767h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Platelet-rich fibrin: Basics of biological actions and protocol modifications.

Pavlovic, Voja / Ciric, Milan / Jovanovic, Vladimir / Trandafilovic, Milena / Stojanovic, Predrag

Open medicine (Warsaw, Poland)

2021 Volume 16, Issue 1, Page(s) 446–454

Abstract	Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components and to provide insight into the new developmental approach. Also, this review summarizes the evolution of platelet concentrates and biologic properties of different modifications of PRF procedure.
Language	English
Publishing date	2021-03-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2021-0259
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Article ; Online: Behavioral context affects social signal representations within single primate prefrontal cortex neurons.

Jovanovic, Vladimir / Fishbein, Adam Ryan / de la Mothe, Lisa / Lee, Kuo-Fen / Miller, Cory Thomas

Neuron

2022 Volume 110, Issue 8, Page(s) 1318–1326.e4

Abstract: We tested whether social signal processing in more traditional, head-restrained contexts is representative of the putative natural analog-social communication-by comparing responses to vocalizations within individual neurons in marmoset prefrontal cortex ...

Abstract	We tested whether social signal processing in more traditional, head-restrained contexts is representative of the putative natural analog-social communication-by comparing responses to vocalizations within individual neurons in marmoset prefrontal cortex (PFC) across a series of behavioral contexts ranging from traditional to naturalistic. Although vocalization-responsive neurons were evident in all contexts, cross-context consistency was notably limited. A response to these social signals when subjects were head-restrained was not predictive of a comparable neural response to the identical vocalizations during natural communication. This pattern was evident both within individual neurons and at a population level, as PFC activity could be reliably decoded for the behavioral context in which vocalizations were heard. These results suggest that neural representations of social signals in primate PFC are not static but highly flexible and likely reflect how nuances of the dynamic behavioral contexts affect the perception of these signals and what they communicate.
MeSH term(s)	Animals ; Callithrix ; Humans ; Neurons/physiology ; Prefrontal Cortex/physiology ; Vocalization, Animal/physiology
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2022.01.020
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Interdimensional radial discrete diffraction in Mathieu photonic lattices.

Vasiljević, Jadranka M / Jovanović, Vladimir P / Tomović, Aleksandar Ž / Timotijević, Dejan V / Žikic, Radomir / Belić, Milivoj R / Jović Savić, Dragana M

Optics express

2023 Volume 31, Issue 18, Page(s) 28946–28953

Abstract: We demonstrate transitional dimensionality of discrete diffraction in radial-elliptical photonic lattices. Varying the order, characteristic structure size, and ellipticity of the Mathieu beams used for the photonic lattices generation, we control the ... ...

Abstract	We demonstrate transitional dimensionality of discrete diffraction in radial-elliptical photonic lattices. Varying the order, characteristic structure size, and ellipticity of the Mathieu beams used for the photonic lattices generation, we control the shape of discrete diffraction distribution over the combination of the radial direction with the circular, elliptic, or hyperbolic. We also investigate the transition from one-dimensional to two-dimensional discrete diffraction by varying the input probe beam position. The most pronounced discrete diffraction is observed along the crystal anisotropy direction.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.497795
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Article ; Online: More than just an intermediate: hydrogen sulfide signalling in plants.

Filipovic, Milos R / Jovanovic, Vladimir M

Journal of experimental botany

2017 Volume 68, Issue 17, Page(s) 4733–4736

MeSH term(s)	Arabidopsis Proteins/metabolism ; Cysteine/metabolism ; Hydrogen Sulfide/metabolism ; Plant Proteins/metabolism ; Plants/metabolism ; Signal Transduction
Chemical Substances	Arabidopsis Proteins ; Plant Proteins ; Cysteine (K848JZ4886) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2017-10-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erx352
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Article ; Online: Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies

Kleo, Karsten / Jovanovic, Vladimir M. / Arndold, Alexander / Lehmann, Annika / Lammert, Hedwig / Berg, Erika / Harloff, Hannah / Treese, Christoph / Hummel, Michael / Daum, S.

J Cancer Res Clin Oncol. 2023 Mar., v. 149, no. 3, p. 1049-1061

2023 , Page(s) 1049–1061

Abstract: OBJECTIVES: Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85% of patients do not respond to this treatment. The aim ...

Abstract	OBJECTIVES: Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85% of patients do not respond to this treatment. The aim of our study was the identification of predictive biomarkers in pre-therapeutic endoscopic tumor biopsies from patients with histopathologic response (Becker-1) versus non-response (Becker-2/3) to preoperative chemotherapy. METHODS: Formalin-fixed paraffin-embedded biopsies from 36 Caucasian patients (Becker-1 n = 11, Becker-2 n = 7, Becker-3 n = 18) with AEG/AS, taken prior to neoadjuvant chemotherapy were selected. For RNA expression analysis, we employed the NanoString nCounter System. To identify genomic alterations like single nucleotide variants (SNV), copy number variation (CNV) and fusion events, we used Illumina TST170 gene panel. For HER2 and FGFR2 protein expression, immunostaining was performed. Furthermore, we analyzed the microsatellite instability (MSI) and Epstein–Barr virus (EBV) infection status by EBER in situ hybridization. RESULTS: Heat map and principal component analyses showed no clustering by means of gene expression according to regression grade. Concerning two recently proposed predictive markers, our data showed equal distribution for MSI (Becker-1: 2; Becker-2: 1; Becker-3: 3; out of 29 tested) and EBV infection was rare (1/32). We could not reveal discriminating target genes concerning SNV, but found a higher mutational burden in non-responders versus responders and fusion (in 6/14) and CNV events (in 5/14) exclusively in Becker-3. CONCLUSIONS: Although we could not identify discriminating target genes, our data suggest that molecular alterations are in general more prevalent in patients with AEG/AS belonging to the non-responding Becker group 3.
Keywords	Human gammaherpesvirus 4 ; RNA ; adenocarcinoma ; biomarkers ; copy number variation ; drug therapy ; esophageal sphincter ; fibroblast growth factor receptor 2 ; gene expression ; genes ; genomics ; heat ; histopathology ; hybridization ; microsatellite repeats ; prediction ; protein synthesis ; stomach
Language	English
Dates of publication	2023-03
Size	p. 1049-1061
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-03944-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Improved TGA-MS measurements for evolved gas analysis (EGA) during pyrolysis process of various biomass feedstocks. Syngas energy balance determination

Radojević, Miloš / Janković, Bojan / Stojiljković, Dragoslava / Jovanović, Vladimir / Čeković, Ivana / Manić, Nebojša

Thermochimica acta. 2021 May, v. 699

2021

Abstract: This paper provides in-depth knowledge about the evolved gas analysis interpretation via newly proposed semi-quantitative approach, arising from thermogravimetric analysis (TGA) – mass spectrometry (MS) coupled measurements, for studying pyrolysis ... ...

Abstract	This paper provides in-depth knowledge about the evolved gas analysis interpretation via newly proposed semi-quantitative approach, arising from thermogravimetric analysis (TGA) – mass spectrometry (MS) coupled measurements, for studying pyrolysis behavior of three kinds of biomass waste materials (spent coffee grounds, beech sawdust and wheat straw). TGA – MS coupling allows accurate correlation between molecular ion peak and fragment peaks to the corresponding mass loss rates from derivative thermogravimetry curves. Within proposed semi-quantitative analysis, MS spectra were interpreted through the comparative analysis of compounds fragments and of the compound itself, where the single atomic mass unit was identified by multiple compounds exhibition. It was shown that by this procedure which involves overlapping multiple curves supervising, the identification of gases in volatiles complex scheme becomes more simplified. By setting up semi-quantitative formulas, easy and reliable calculations of gaseous products yield and syngas energy capacities are possible to achieve. The H₂/CO ratio derived from the proposed method for wood waste product (sawdust) is in an excellent agreement with H₂/CO ratio for sawdust syngas production, in fuel reactor for biomass gasiﬁcation and H₂ production.
Keywords	Fagus ; biomass ; energy balance ; feedstocks ; mass spectrometry ; pyrolysis ; sawdust ; synthesis gas ; thermogravimetry ; waste wood ; wheat straw
Language	English
Dates of publication	2021-05
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500974-9
ISSN	0040-6031
ISSN	0040-6031
DOI	10.1016/j.tca.2021.178912
Database	NAL-Catalogue (AGRICOLA)

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Article: Predicting Finite-Bias Tunneling Current Properties from Zero-Bias Features: The Frontier Orbital Bias Dependence at an Exemplar Case of DNA Nucleotides in a Nanogap.

Djurišić, Ivana / Jovanović, Vladimir P / Dražić, Miloš S / Tomović, Aleksandar Ž / Zikic, Radomir

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 11

Abstract: The electrical current properties of single-molecule sensing devices based on electronic (tunneling) transport strongly depend on molecule frontier orbital energy, spatial distribution, and position with respect to the electrodes. Here, we present an ... ...

Abstract	The electrical current properties of single-molecule sensing devices based on electronic (tunneling) transport strongly depend on molecule frontier orbital energy, spatial distribution, and position with respect to the electrodes. Here, we present an analysis of the bias dependence of molecule frontier orbital properties at an exemplar case of DNA nucleotides in the gap between H-terminated (3, 3) carbon nanotube (CNT) electrodes and its relation to transversal current rectification. The electronic transport properties of this simple single-molecule device, whose characteristic is the absence of covalent bonding between electrodes and a molecule between them, were obtained using density functional theory and non-equilibrium Green's functions. As in our previous studies, we could observe two distinct bias dependences of frontier orbital energies: the so-called strong and the weak pinning regimes. We established a procedure, from zero-bias and empty-gap characteristics, to estimate finite-bias electronic tunneling transport properties, i.e., whether the molecular junction would operate in the weak or strong pinning regime. We also discuss the use of the zero-bias approximation to calculate electric current properties at finite bias. The results from this work could have an impact on the design of new single-molecule applications that use tunneling current or rectification applicable in high-sensitivity sensors, protein, or DNA sequencing.
Language	English
Publishing date	2021-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11113021
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Article: Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism

Jojić, Vida / Čabrilo, Borislav / Bjelić-Čabrilo, Olivera / Jovanović, Vladimir M. / Budinski, Ivana / Vujošević, Mladen / Blagojević, Jelena

Frontiers in zoology. 2021 Dec., v. 18, no. 1

2021

Abstract: BACKGROUND: Mammalian mandible and cranium are well-established model systems for studying canalization and developmental stability (DS) as two elements of developmental homeostasis. Nematode infections are usually acquired in early life and increase in ... ...

Abstract	BACKGROUND: Mammalian mandible and cranium are well-established model systems for studying canalization and developmental stability (DS) as two elements of developmental homeostasis. Nematode infections are usually acquired in early life and increase in intensity with age, while canalization and DS of rodent skulls could vary through late postnatal ontogeny. We aimed to estimate magnitudes and describe patterns of mandibular and cranial canalization and DS related to age and parasite intensity (diversity) in adult yellow-necked mice (Apodemus flavicollis). RESULTS: We found the absence of age-related changes in the levels of canalization for mandibular and cranial size and DS for mandibular size. However, individual measures of mandibular and cranial shape variance increased, while individual measures of mandibular shape fluctuating asymmetry (FA) decreased with age. We detected mandibular and cranial shape changes during postnatal ontogeny, but revealed no age-related dynamics of their covariance structure among and within individuals. Categories regarding parasitism differed in the level of canalization for cranial size and the level of DS for cranial shape. We observed differences in age-related dynamics of the level of canalization between non-parasitized and parasitized animals, as well as between yellow-necked mice parasitized by different number of nematode species. Likewise, individual measures of mandibular and cranial shape FA decreased with age for the mandible in the less parasitized category and increased for the cranium in the most parasitized category. CONCLUSIONS: Our age-related results partly agree with previous findings. However, no rodent study so far has explored age-related changes in the magnitude of FA for mandibular size or mandibular and cranial FA covariance structure. This is the first study dealing with the nematode parasitism-related canalization and DS in rodents. We showed that nematode parasitism does not affect mandibular and cranial shape variation and covariance structure among and within individuals. However, parasite intensity (diversity) is related to ontogenetic dynamics of the levels of canalization and DS. Overall, additional studies on animals from natural populations are required before drawing some general conclusions.
Keywords	Apodemus flavicollis ; Nematoda ; adults ; asymmetry ; covariance ; homeostasis ; mice ; ontogeny ; parasites ; parasitism ; skull ; variance
Language	English
Dates of publication	2021-12
Size	p. 55.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2164409-3
ISSN	1742-9994
ISSN	1742-9994
DOI	10.1186/s12983-021-00439-4
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