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  1. Article: Dual Role of

    Jelača, Sanja / Jovanovic, Ivan / Bovan, Dijana / Jovanovic, Marina Z / Jurisevic, Milena M / Dunđerović, Duško / Dajic-Stevanovic, Zora / Arsenijevic, Nebojsa / Mijatović, Sanja / Maksimović-Ivanić, Danijela

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Ethnomedicinal records have long mentioned the historical usage ... ...

    Abstract Ethnomedicinal records have long mentioned the historical usage of
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metformin promotes antitumor activity of NK cells via overexpression of miRNA-150 and miRNA-155.

    Petrovic, Andjela R / Jovanovic, Ivan P / Jurisevic, Milena M / Jovanovic, Marina Z / Jovanovic, Marina M / Pavlovic, Sladjana P / Arsenijevic, Nebojsa N / Supic, Gordana M / Vojvodic, Danilo V / Jovanovic, Milan M / Gajovic, Nevena M

    American journal of translational research

    2023  Volume 15, Issue 4, Page(s) 2727–2737

    Abstract: Objectives: Metformin, an oral anti-diabetic drug, is known to possess a powerful antitumor effect by modulating the tumor-immune interaction. The precise influence of metformin on natural killer (NK) cells, a crucial innate immunity player, is not ... ...

    Abstract Objectives: Metformin, an oral anti-diabetic drug, is known to possess a powerful antitumor effect by modulating the tumor-immune interaction. The precise influence of metformin on natural killer (NK) cells, a crucial innate immunity player, is not completely understood. In our study, analyses of the effect of metformin on the NK cell functional phenotype were performed, and the potential mechanisms underlying it were investigated.
    Methods: BALB/C wild type mice were treated with metformin, and the functional phenotype of splenocytes and potential underlying mechanisms were investigated.
    Results: Metformin significantly boosts NK cell cytotoxicity and the percentage of NKp46
    Conclusions: These findings suggest that metformin can directly potentiate NK cell activation and cytotoxicity. This research may contribute to dissecting key mechanisms of metformin exerting antitumor activity to advance the use of metformin as an antitumor agent.
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dual blockage of PD-L/PD-1 and IL33/ST2 axes slows tumor growth and improves antitumor immunity by boosting NK cells

    Jovanovic, Marina Z. / Geller, David A. / Gajovic, Nevena M. / Jurisevic, Milena M. / Arsenijevic, Nebojsa N. / Jovanovic, Milan M. / Supic, Gordana M. / Vojvodic, Danilo V. / Jovanovic, Ivan P.

    Elsevier Inc. Life sciences. 2022 Jan. 15, v. 289

    2022  

    Abstract: Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.4T1 breast cancer and CT26 colon cancer were inducted in BALB/C wild type (WT) ... ...

    Abstract Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.4T1 breast cancer and CT26 colon cancer were inducted in BALB/C wild type (WT) and BALB/C ST2 knockout mice, after which mice underwent anti PD-1 and anti IL-33 treatment.Co-blockage of IL33/ST2 and PD-L/PD-1 delayed tumor appearance and slowed tumor growth. Enhanced NK cell cytotoxicity against 4T1 tumor cells in ST2 knockout anti-PD-1 treated mice was associated with overexpression of miRNA-150 and miRNA-155, upregulation of NFκB and STAT3, increased expression of activation markers and decreased expression of immunosuppressive markers in splenic and primary tumor derived NK cells. NK cells from ST2 knockout anti-PD-1 treated mice tend to proliferate more and are less prone to apoptosis. Accumulation of immunosuppressive myeloid derived suppressor cells and regulatory T cells was significantly impaired in spleen and primary tumor of ST2 knockout anti-PD-1 treated mice.Co-blockage of IL3/ST2 and PD-L/PD-1 axes impedes tumor progression more efficiently than single blockage of either axes, thus offering potential new approach to immunotherapy of tumors.
    Keywords apoptosis ; breast neoplasms ; colorectal neoplasms ; cytotoxicity ; immunosuppression ; immunotherapy ; neoplasm progression ; spleen
    Language English
    Dates of publication 2022-0115
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2021.120214
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 73/732: Show issues

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  4. Article ; Online: Dual blockage of PD-L/PD-1 and IL33/ST2 axes slows tumor growth and improves antitumor immunity by boosting NK cells.

    Jovanovic, Marina Z / Geller, David A / Gajovic, Nevena M / Jurisevic, Milena M / Arsenijevic, Nebojsa N / Jovanovic, Milan M / Supic, Gordana M / Vojvodic, Danilo V / Jovanovic, Ivan P

    Life sciences

    2021  Volume 289, Page(s) 120214

    Abstract: Aims: Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.: Main methods: 4T1 breast cancer and CT26 colon cancer were inducted ... ...

    Abstract Aims: Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.
    Main methods: 4T1 breast cancer and CT26 colon cancer were inducted in BALB/C wild type (WT) and BALB/C ST2 knockout mice, after which mice underwent anti PD-1 and anti IL-33 treatment.
    Key findings: Co-blockage of IL33/ST2 and PD-L/PD-1 delayed tumor appearance and slowed tumor growth. Enhanced NK cell cytotoxicity against 4T1 tumor cells in ST2 knockout anti-PD-1 treated mice was associated with overexpression of miRNA-150 and miRNA-155, upregulation of NFκB and STAT3, increased expression of activation markers and decreased expression of immunosuppressive markers in splenic and primary tumor derived NK cells. NK cells from ST2 knockout anti-PD-1 treated mice tend to proliferate more and are less prone to apoptosis. Accumulation of immunosuppressive myeloid derived suppressor cells and regulatory T cells was significantly impaired in spleen and primary tumor of ST2 knockout anti-PD-1 treated mice.
    Significance: Co-blockage of IL3/ST2 and PD-L/PD-1 axes impedes tumor progression more efficiently than single blockage of either axes, thus offering potential new approach to immunotherapy of tumors.
    MeSH term(s) Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Colonic Neoplasms/immunology ; Immunity, Cellular ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/immunology ; Interleukin-33/genetics ; Interleukin-33/immunology ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology
    Chemical Substances B7-H1 Antigen ; Cd274 protein, mouse ; Il1rl1 protein, mouse ; Il33 protein, mouse ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2021.120214
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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