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  1. AU="Jović, Ines"
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  1. Article ; Online: The Influence of

    Šmit, Iva / Potočnjak, Dalibor / Matijatko, Vesna / Torti, Marin / Jović, Ines / Grden, Darko / Crnogaj, Martina / Beck, Relja

    Veterinary sciences

    2023  Volume 10, Issue 12

    Abstract: ... Giardia ... ...

    Abstract Giardia duodenalis
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10120694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabolome Profiling in the Plasma of Dogs with Idiopathic Dilated Cardiomyopathy: A Multiplatform Mass-Spectrometry-Based Approach.

    Rubić, Ivana / Weidt, Stefan / Burchmore, Richard / Kovačević, Alan / Kuleš, Josipa / Eckersall, Peter David / Torti, Marin / Jović, Ines / Kovačić, Mislav / Gotić, Jelena / Barić Rafaj, Renata / Novak, Predrag / Samardžija, Marko / Mrljak, Vladimir

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Dilated cardiomyopathy is one of the important diseases in dogs and humans. The second most common cause of heart failure in dogs is idiopathic dilated cardiomyopathy (iDCM), which results in heart failure or sudden cardiac death due to arrhythmia. This ... ...

    Abstract Dilated cardiomyopathy is one of the important diseases in dogs and humans. The second most common cause of heart failure in dogs is idiopathic dilated cardiomyopathy (iDCM), which results in heart failure or sudden cardiac death due to arrhythmia. This study aimed to determine changes in the plasma metabolome of dogs with iDCM compared to healthy dogs. For that purpose, a multiplatform mass-spectrometry-based approach was used. In this study, we included two groups of dogs: 12 dogs with iDCM and 8 healthy dogs. A total of 272 metabolites were detected in the plasma samples of dogs by combining three approaches but four MS-based platforms (GC-MS, LC-MS (untargeted), LC-MS (targeted), and FIA-MS (targeted) methods). Our findings demonstrated changes in the canine plasma metabolome involved in the development of iDCM, including the different concentrations of amino acids, biogenic amines, acylcarnitines, triglycerides and diglycerides, sphingomyelins, and organic acids. The results of this study will enable the detection and monitoring of pathophysiological mechanisms involved in the development of iDCM in the future.
    MeSH term(s) Humans ; Dogs ; Animals ; Cardiomyopathy, Dilated/metabolism ; Heart Failure ; Metabolome ; Amino Acids/metabolism ; Gas Chromatography-Mass Spectrometry
    Chemical Substances Amino Acids
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015182
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  3. Article ; Online: Systemic lupus erythematosus - diagnostic and treatment challenges

    Brkljačić Mirna / Kajin Filip / Torti Marin / Jović Ines / Kiš Ivana / Šmit Iva / Crnogaj Martina / Matijatko Vesna

    Veterinarski Glasnik, Vol 71, Iss 2, Pp 134-

    2017  Volume 140

    Abstract: ... ...

    Abstract nema
    Keywords nema ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Faculty of Veterinary Medicine, Belgrade
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Serum proteome profiling in canine idiopathic dilated cardiomyopathy using TMT-based quantitative proteomics approach.

    Bilić, Petra / Guillemin, Nicolas / Kovačević, Alan / Beer Ljubić, Blanka / Jović, Ines / Galan, Asier / Eckersall, Peter David / Burchmore, Richard / Mrljak, Vladimir

    Journal of proteomics

    2018  Volume 179, Page(s) 110–121

    Abstract: Idiopathic dilated cardiomyopathy (iDCM) is a primary myocardial disorder with an unknown aetiology, characterized by reduced contractility and ventricular dilation of the left or both ventricles. Naturally occurring canine iDCM was used herein to ... ...

    Abstract Idiopathic dilated cardiomyopathy (iDCM) is a primary myocardial disorder with an unknown aetiology, characterized by reduced contractility and ventricular dilation of the left or both ventricles. Naturally occurring canine iDCM was used herein to identify serum proteomic signature of the disease compared to the healthy state, providing an insight into underlying mechanisms and revealing proteins with biomarker potential. To achieve this, we used high-throughput label-based quantitative LC-MS/MS proteomics approach and bioinformatics analysis of the in silico inferred interactome protein network created from the initial list of differential proteins. To complement the proteomic analysis, serum biochemical parameters and levels of know biomarkers of cardiac function were measured. Several proteins with biomarker potential were identified, such as inter-alpha-trypsin inhibitor heavy chain H4, microfibril-associated glycoprotein 4 and apolipoprotein A-IV, which were validated using an independent method (Western blotting) and showed high specificity and sensitivity according to the receiver operating characteristic curve analysis. Bioinformatics analysis revealed involvement of different pathways in iDCM, such as complement cascade activation, lipoprotein particles dynamics, elastic fibre formation, GPCR signalling and respiratory electron transport chain.
    Significance: Idiopathic dilated cardiomyopathy is a severe primary myocardial disease of unknown cause, affecting both humans and dogs. This study is a contribution to the canine heart disease research by means of proteomic and bioinformatic state of the art analyses, following similar approach in human iDCM research. Importantly, we used serum as non-invasive and easily accessible biological source of information and contributed to the scarce data on biofluid proteome research on this topic. Bioinformatics analysis revealed biological pathways modulated in canine iDCM with potential of further targeted research. Also, several proteins with biomarker potential have been identified and successfully validated.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Chromatography, Liquid ; Dog Diseases/metabolism ; Dog Diseases/pathology ; Dogs ; Female ; Male ; Muscle Proteins/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; Proteome/metabolism ; Proteomics ; Tandem Mass Spectrometry
    Chemical Substances Biomarkers ; Muscle Proteins ; Proteome
    Language English
    Publishing date 2018-03-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2018.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Serum proteome profiling in canine chronic valve disease using a TMT-based quantitative proteomics approach.

    Kuleš, Josipa / Bilić, Petra / Horvatić, Anita / Kovačević, Alan / Guillemin, Nicolas / Ljubić, Blanka Beer / Galan, Asier / Jović, Ines / Torti, Marin / Rubić, Ivana / Eckersall, Peter David / Mrljak, Vladimir

    Journal of proteomics

    2020  Volume 223, Page(s) 103825

    Abstract: Chronic valve disease (CVD) is the most common clinically significant heart disease of dogs, affecting 20 to 40% of dogs. The aim of this study was to evaluate the serum protein profile of healthy and CVD affected dogs, by means of an isobaric tandem ... ...

    Abstract Chronic valve disease (CVD) is the most common clinically significant heart disease of dogs, affecting 20 to 40% of dogs. The aim of this study was to evaluate the serum protein profile of healthy and CVD affected dogs, by means of an isobaric tandem mass tag (TMT) label-based high-resolution quantitative proteomic approach. Additionally, conventional cardiac biomarkers were measured in the serum, functional bioinformatics analysis was employed for elucidating molecular mechanisms and pathways associated with CVD, and validation of proteomic results was performed by immunoassays and Western blotting. Of 290 identified and quantified proteins, 15 proteins showed significantly different abundances (p < .05), including antithrombin-III, alpha-2-antiplasmin, tetranectin, apolipoprotein M, adiponectin, inter-alpha-trypsin inhibitor heavy chain H1, gelsolin and apolipoprotein B-100. The identified proteins with differently abundances are involved in a number of pathways, such as complement and coagulation cascades, haemostasis, regulation of actin cytoskeleton, lipid metabolism and transport. We found comparative similarities with human disease in terms of identified proteins and GO pathways, which confirmed similar pathophysiology of this disease, but also differences, mainly in lipid metabolism. SIGNIFICANCE: There have been few investigations of canine serum proteome despite the potential for biomarker discovery and comparative disease analysis. Establishing serum proteomic signatures in healthy dogs and dogs with CVD will benefit for understanding the aetiology of disease in dogs, identify putative biomarkers and provide models of comparative human disease. Circulating biomarkers are important for understanding of the mechanisms of cardiovascular disease and high incidence of CVD in dogs prioritizes the search for novel biomarkers.
    MeSH term(s) Animals ; Biomarkers ; Computational Biology ; Dog Diseases ; Dogs ; Proteome ; Proteomics
    Chemical Substances Biomarkers ; Proteome
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2020.103825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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