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  1. Article: Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathology.

    Figdore, Daniel J / Wiste, Heather J / Bornhorst, Joshua A / Bateman, Randall J / Li, Yan / Graff-Radford, Jonathan / Knopman, David S / Vemuri, Prashanthi / Lowe, Val J / Jr, Clifford R Jack / Petersen, Ronald C / Algeciras-Schimnich, Alicia

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2024  Volume 16, Issue 1, Page(s) e12545

    Abstract: Introduction: This study evaluated the performance of the Lumipulse plasma beta-amyloid (Aβ) 42/40 and pTau181 compared to other assays to detect an abnormal amyloid-positron emission tomography (PET).: Methods: Plasma samples from cognitively ... ...

    Abstract Introduction: This study evaluated the performance of the Lumipulse plasma beta-amyloid (Aβ) 42/40 and pTau181 compared to other assays to detect an abnormal amyloid-positron emission tomography (PET).
    Methods: Plasma samples from cognitively unimpaired (
    Results: Lumipulse and IP-MS Aβ42/40 exhibited the highest diagnostic accuracy for detecting an abnormal amyloid-PET (areas under the curve [AUCs] of 0.81 and 0.84, respectively). The Lumipulse and Simoa pTau181 assays exhibited lower performance (AUCs of 0.74 and 0.72, respectively). The Simoa Aβ42/40 assay demonstrated the lowest diagnostic accuracy (AUC 0.57). Combining Aβ42/40 and pTau181 did not significantly improve performance over Aβ42/40 alone for Lumipulse (AUC 0.83) or over pTau181 alone for Simoa (AUC 0.71).
    Discussion: The Lumipulse Aβ42/40 assay showed similar performance to the IP-MS Aβ42/40 assay for detection of an abnormal amyloid-PET; and both assays performed better than the two p-tau181 immunoassays. The Simoa Aβ42/Aβ40 assay was the least accurate at predicting an abnormal amyloid-PET status.
    Highlights: Lumipulse plasma Aβ42/Aβ40 AUC for abnormal amyloid-PET detection was 0.81.This performance was comparable to previously reported IP-MS and higher than Simoa.Performance of Alzheimer's disease blood biomarkers varies between assays.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Longitudinal rates of atrophy and tau accumulation differ between the visual and language variants of atypical Alzheimer's disease.

    Sintini, Irene / Graff-Radford, Jonathan / Schwarz, Christopher G / Machulda, Mary M / Singh, Neha Atulkumar / Carlos, Arenn F / Senjem, Matthew L / Jr, Clifford R Jack / Lowe, Val J / Josephs, Keith A / Whitwell, Jennifer L

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 10, Page(s) 4396–4406

    Abstract: Introduction: Atypical variants of Alzheimer's disease (AD) include the visual variant, known as posterior cortical atrophy (PCA), and the language variant, known as logopenic progressive aphasia (LPA). Clinically, rates of disease progression differ ... ...

    Abstract Introduction: Atypical variants of Alzheimer's disease (AD) include the visual variant, known as posterior cortical atrophy (PCA), and the language variant, known as logopenic progressive aphasia (LPA). Clinically, rates of disease progression differ between them.
    Methods: We evaluated 34 PCA and 29 LPA participants. Structural magnetic resonance imaging and
    Results: PCA had faster rates of occipital atrophy. LPA had faster rates of left temporal atrophy and faster rates of tau accumulation in the parietal, right temporal, and occipital lobes. Age was negatively associated with rates of atrophy and tau accumulation.
    Discussion: Longitudinal patterns of neuroimaging abnormalities differed between PCA and LPA, although with divergent results for tau accumulation and atrophy.
    Highlights: The language variant of Alzheimer's disease accumulates tau faster than the visual variant. Each variant shows faster rates of atrophy than the other in its signature regions. Age negatively influences rates of atrophy and tau accumulation in both variants.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; tau Proteins/metabolism ; Brain/pathology ; Neuroimaging ; Positron-Emission Tomography ; Magnetic Resonance Imaging ; Atrophy/pathology
    Chemical Substances tau Proteins
    Language English
    Publishing date 2023-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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