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Article: Impact of Intensive Care Unit Critical Care Management on Patients Diagnosed with Acute Respiratory Distress Syndrome.

Ju, Dan / Ji, Xiaodong / Zhou, Yanran

Alternative therapies in health and medicine

2024

Abstract: Objective: To investigate the impact of critical care management on patients diagnosed with acute respiratory distress syndrome (ARDS) during their stay in intensive care units (ICU).: Methods: A total of 62 ARDS patients admitted to the ICU of our ... ...

Abstract	Objective: To investigate the impact of critical care management on patients diagnosed with acute respiratory distress syndrome (ARDS) during their stay in intensive care units (ICU). Methods: A total of 62 ARDS patients admitted to the ICU of our hospital between March 2020 and March 2023 were enrolled as research participants. The patients were randomly assigned to either the research group (n=31) receiving critical care management or the control group (n=31) receiving routine care. Key parameters, including the duration of ICU stay, mean hospital length of stay (HLOS), duration of mechanical ventilation, and the incidence of ventilator-associated pneumonia (VAP), were recorded. Additionally, changes in the Self-rating Anxiety/Depression Scale (SAS/SDS), Pittsburgh Sleep Quality Index (PSQI), Acute Physiology and Chronic Health Evaluation II (APACHE), and Clinical Pulmonary Infection Score (CPIS) were assessed before and after the intervention. A self-designed questionnaire was employed to evaluate nursing quality and patient satisfaction. Results: In comparison to the control group, the research group exhibited significantly shorter durations of ICU stay, mean HLOS, and mechanical ventilation, along with a reduced incidence of VAP (P < .05). Moreover, the SAS, SDS, PSQI, APACHE II, and CPIS scores in the research group were lower than those in the control group, while the quality of care and satisfaction scores were notably higher (P < .05). Conclusions: ICU critical care management demonstrates the potential to enhance the rehabilitation of ARDS patients and decrease the incidence of VAP, suggesting its clinical applicability.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Hunter-gatherer admixture facilitated natural selection in Neolithic European farmers.

Davy, Tom / Ju, Dan / Mathieson, Iain / Skoglund, Pontus

Current biology : CB

2023 Volume 33, Issue 7, Page(s) 1365–1371.e3

Abstract: Ancient DNA has revealed multiple episodes of admixture in human prehistory during geographic expansions associated with cultural innovations. One important example is the expansion of Neolithic agricultural groups out of the Near East into Europe and ... ...

Abstract	Ancient DNA has revealed multiple episodes of admixture in human prehistory during geographic expansions associated with cultural innovations. One important example is the expansion of Neolithic agricultural groups out of the Near East into Europe and their consequent admixture with Mesolithic hunter-gatherers.
MeSH term(s)	Humans ; Farmers ; Europe ; DNA ; Alleles ; Selection, Genetic
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.02.049
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Article ; Online: The evolution of skin pigmentation-associated variation in West Eurasia.

Ju, Dan / Mathieson, Iain

Proceedings of the National Academy of Sciences of the United States of America

2020 Volume 118, Issue 1

Abstract: Skin pigmentation is a classic example of a polygenic trait that has experienced directional selection in humans. Genome-wide association studies have identified well over a hundred pigmentation-associated loci, and genomic scans in present-day and ... ...

Abstract	Skin pigmentation is a classic example of a polygenic trait that has experienced directional selection in humans. Genome-wide association studies have identified well over a hundred pigmentation-associated loci, and genomic scans in present-day and ancient populations have identified selective sweeps for a small number of light pigmentation-associated alleles in Europeans. It is unclear whether selection has operated on all of the genetic variation associated with skin pigmentation as opposed to just a small number of large-effect variants. Here, we address this question using ancient DNA from 1,158 individuals from West Eurasia covering a period of 40,000 y combined with genome-wide association summary statistics from the UK Biobank. We find a robust signal of directional selection in ancient West Eurasians on 170 skin pigmentation-associated variants ascertained in the UK Biobank. However, we also show that this signal is driven by a limited number of large-effect variants. Consistent with this observation, we find that a polygenic selection test in present-day populations fails to detect selection with the full set of variants. Our data allow us to disentangle the effects of admixture and selection. Most notably, a large-effect variant at
MeSH term(s)	Alleles ; Asia ; Asian Continental Ancestry Group/genetics ; Biological Evolution ; DNA, Ancient/analysis ; Databases, Genetic ; Europe ; European Continental Ancestry Group/genetics ; Gene Frequency/genetics ; Genome-Wide Association Study/methods ; Genotype ; Haplotypes/genetics ; Humans ; Multifactorial Inheritance/genetics ; Polymorphism, Single Nucleotide/genetics ; Selection, Genetic/genetics ; Skin Pigmentation/genetics ; Skin Pigmentation/physiology
Chemical Substances	DNA, Ancient
Language	English
Publishing date	2020-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2009227118
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Zs.A 1148: Show issues

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Article ; Online: Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine.

Ju, Dan / Hui, Daniel / Hammond, Dorothy A / Wonkam, Ambroise / Tishkoff, Sarah A

Annual review of biomedical data science

2022 Volume 5, Page(s) 321–339

Abstract: One goal of genomic medicine is to uncover an individual's genetic risk for disease, which generally requires data connecting genotype to phenotype, as done in genome-wide association studies (GWAS). While there may be clinical promise to employing ... ...

Abstract	One goal of genomic medicine is to uncover an individual's genetic risk for disease, which generally requires data connecting genotype to phenotype, as done in genome-wide association studies (GWAS). While there may be clinical promise to employing prediction tools such as polygenic risk scores (PRS), it currently stands that individuals of non-European ancestry may not reap the benefits of genomic medicine because of underrepresentation in large-scale genetics studies. Here, we discuss why this inequity poses a problem for genomic medicine and the reasons for the low transferability of PRS across populations. We also survey the ancestry representation of published GWAS and investigate how estimates of ancestry diversity in GWASparticipants might be biased. We highlight the importance of expanding genetic research in Africa, one of the most underrepresented regions in human genomics research, and discuss issues of ethics, resources, and technology for equitable advancement of genomic medicine.
MeSH term(s)	Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Genotype ; Human Genetics ; Humans ; Precision Medicine
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2574-3414
ISSN (online)	2574-3414
DOI	10.1146/annurev-biodatasci-122220-112550
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Article ; Online: Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.

Maskarinec, Gertraud / Ju, Dan / Shvetsov, Yurii B / Horio, David / Chan, Owen / Loo, Lenora W M / Hernandez, Brenda Y

Cancer epidemiology

2020 Volume 65, Page(s) 101685

Abstract: Background: This study investigated the association of breast lobular involution status and three inflammatory markers as predictors of survival among breast cancer patients in the Multiethnic Cohort.: Methods: Lobular involution was evaluated in ... ...

Abstract	Background: This study investigated the association of breast lobular involution status and three inflammatory markers as predictors of survival among breast cancer patients in the Multiethnic Cohort. Methods: Lobular involution was evaluated in tissue sections of normal breast tissue and COX-2, TNF-α, and TGF-β proteins were assessed by immunohistochemistry in tumor microarrays. A summary score added the expression levels of the three markers. Cox regression was applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CI) with age as the time metric and adjustment for factors known to affect mortality. Results: Among 254 women (mean age = 61.7 ± 8.7 years) with pathologic blocks and follow-up information, 54 all-cause and 10 breast cancer-specific deaths were identified after a mean follow-up time of 16.0 ± 3.1 years. For 214 participants, an inflammatory score was available and 157 women had information on lobular involution. Lobular involution was not significantly associated with survival. Expression of both COX-2 and TNF-α were significant predictors of lower survival (p = 0.02 and 0.04), while the association for TGF-β was weaker (p = 0.09). When combined into one overall inflammation score, both intermediate (HR = 2.72; 95 % CI 0.90-8.28) and high (HR = 4.21; 95 % CI 1.51-11.8) scores were associated with higher mortality but only the latter was statistically significant. No significant association with breast cancer-specific mortality was detected. Conclusions: These results suggest that strong expression of inflammatory markers in breast tissue predicts a poorer prognosis possibly due to a system-wide state of chronic inflammation.
MeSH term(s)	Breast Neoplasms/ethnology ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cohort Studies ; Ethnic Groups/statistics & numerical data ; Female ; Hawaii/epidemiology ; Humans ; Inflammation/pathology ; Inflammatory Breast Neoplasms/ethnology ; Inflammatory Breast Neoplasms/mortality ; Inflammatory Breast Neoplasms/pathology ; Middle Aged ; Survival Analysis
Language	English
Publishing date	2020-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2020.101685
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Zs.A 1427: Show issues

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Article ; Online: Solution processed membrane-based wearable ZnO/graphene Schottky UV photodetectors with imaging application.

Ju, Dan / Liu, Xuhai / Zhu, Zhengfeng / Wang, Shalong / Liu, Shuting / Gu, Yu / Chang, Jianhua / Liu, Qingquan / Zou, Yousheng

Nanotechnology

2019 Volume 30, Issue 37, Page(s) 375701

Abstract: Flexible and wearable electrical devices have attracted extensive research attention in recent years. In the device fabrication process, the low-cost and compatibility with industrialized mass production are of great importance. Herein, membrane-based ... ...

Abstract	Flexible and wearable electrical devices have attracted extensive research attention in recent years. In the device fabrication process, the low-cost and compatibility with industrialized mass production are of great importance. Herein, membrane-based flexible photodetectors (PDs) based on Polyvinylidene Fluoride filter membrane with the structure of Ag nanowires (NWs)/ZnO NWs/graphene were fabricated by a full-solution method. The built-in electric field due to the ZnO/graphene Schottky junction is in favor of the separation and transport of photo-generated carriers, leading to enhanced device performance. The I
Language	English
Publishing date	2019-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ab26ed
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Article ; Online: Assembling tungsten oxide hydrate nanocrystal colloids formed by laser ablation in liquid into fast-response electrochromic films.

Wang, Shalong / Dou, Kang / Zou, Yousheng / Dong, Yuhang / Li, Jubin / Ju, Dan / Zeng, Haibo

Journal of colloid and interface science

2017 Volume 489, Page(s) 85–91

Abstract: High-performance electrochromic films based on tungsten oxide hydrate ([ ... ...

Abstract	High-performance electrochromic films based on tungsten oxide hydrate ([WO
Language	English
Publishing date	2017-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2016.08.072
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Article ; Online: Soy Food Intake and Biomarkers of Breast Cancer Risk: Possible Difference in Asian Women?

Maskarinec, Gertraud / Ju, Dan / Morimoto, Yukiko / Franke, Adrian A / Stanczyk, Frank Z

Nutrition and cancer

2017 Volume 69, Issue 1, Page(s) 146–153

Abstract: Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between ... ...

Abstract	Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between Asian and non-Asian premenopausal women in two soy intervention trials. One study randomized 220 women to a 2-yr intervention and the other one randomized 96 women in a crossover design to examine the effects of consumption of 2 daily soy servings on nipple aspirate fluid (NAF) volume; estrogens in serum, NAF, and urine; insulin-like growth factor-1 (IGF-1), IGF-binding protein 3, and inflammatory markers in serum; and mammographic densities. Mixed linear models were applied to assess ethnic differences in biomarkers and response to the soy diet. Serum C-reactive protein, serum leptin, NAF volume, and NAF estrone sulfate were lower, while urinary isoflavones were higher in Asian than in non-Asian women. A significant interaction (p
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2017.1250924
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Zs.A 1496: Show issues

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Article: Boosting Fiber-Shaped Photodetectors via âSoftâ Interfaces

Zhu, Zhengfeng / Dong Yuhui / Ju Dan / Luo Linbao / Shan Dan / Zeng Haibo / Zhang Tengfei / Zou Yousheng

ACS Applied Materials & Interfaces. 2017 Apr. 05, v. 9, no. 13

2017

Abstract: Lightweight, flexible fiber-shaped devices that can be woven into wearable electronic products have received great attention in recent years. However, the bending and poor interfaces of fiber-shaped devices typically lead to ineluctable performance ... ...

Abstract	Lightweight, flexible fiber-shaped devices that can be woven into wearable electronic products have received great attention in recent years. However, the bending and poor interfaces of fiber-shaped devices typically lead to ineluctable performance degradation, which is still a great challenge yet to be dealt with. Here, taking a fiber-shaped photodetector as an example, we proposed an effective strategy, constructing inorganicâorganicâgraphene hybrid interfaces on a single fiber, to greatly improve the performances of fiber-shaped device. In the proposed structure, the ZnO nanorod array is grown vertically on the surface of a Zn wire (center core) and then wrapped by PVK and graphene (outmost layer) as the two outer layers. These âsoftâ interfaces successfully built compact contacts between various functional layers even on curved interfaces, which markedly reduced the contact resistance. Meanwhile, the whole structure also exhibited excellent durability toward the bending operations. Evidently, the Iâáµ¢gââ/Idâáµ£â ratio and photoresponsivity under bias of 0.5 V are as high as 7.2 and 0.9 A/W. In particular, the photoresponse speed has been greatly improved with the rise time of 280 ms, which was 1 order of magnitude faster than that of other fiber-shaped photodetectors without the above âsoftâ interfaces.
Keywords	durability ; graphene ; nanorods ; zinc ; zinc oxide
Language	English
Dates of publication	2017-0405
Size	p. 12092-12099.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021%2Facsami.7b00811
Database	NAL-Catalogue (AGRICOLA)

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Article: Narrowing Resection of Parametrial Tissues Is Feasible in Low-Risk Cases of Stage IA2-IB1 Cervical Cancer.

Li, Xue-Lian / Liu, Xiao-Xia / Cao, Guan-Shu / Ju, Dan-Dan / Jiang, Hua

Journal of Cancer

2016 Volume 7, Issue 11, Page(s) 1481–1486

Abstract: Background: Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for patients with stage IA2-IB1 cervical cancer, but the wide excision increases the complications.: Objective: To analyze the feasibility of narrowing ... ...

Abstract	Background: Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for patients with stage IA2-IB1 cervical cancer, but the wide excision increases the complications. Objective: To analyze the feasibility of narrowing resection of parametrial tissues in stage IA2-IB1 cervical cancer. Study design: Retrospectively analyzed the pathological and clinical data of patients with stage IA2-IB1 cervical cancer who received radical hysterectomy with pelvic lymphadenectomy in OB/GYN Hospital, Fudan University, China from Jan 2008 to Dec 2011. The affected factors of parametrial metastases and outcomes were discussed. The single factor analysis was made with χ2 test, and the relationship of the resection width of parametrial tissues and the patients' outcomes was analyzed with χ2 test and log-rank. P-values <0.05 were considered statistically significant. Results: There were 31 cases recurred, 26 cases died of cervical cancer in 513 patients during the follow-up period (from 2 months to 66 months, averaged 39 months). The low-risk factors included diameter of tumor ≤2cm, depth of cervical myometrial invasion<1/2 and without lymph vascular involvement. There were no parametrial metastases in cases with all three low-risk factors. Whether the resection width of parametrial tissues ≥3cm or not had no statistically significant effect on progression free survival (PFS) or overall survival (OS) of low-risk patients. D2-40 and CD31 were related with parametrial metastases, but not with recurrence or outcomes. Conclusions: The resection width of parametrial tissues has no effect on PFS and OS of low-risk patients, and narrowing resection of parametrial tissues (<3cm) is feasible.
Language	English
Publishing date	2016-07-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.15466
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