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  1. Article: Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era.

    Wang, Shuaiqi / Ju, Dianwen / Zeng, Xian

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate ... ...

    Abstract The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate relationship between the gut microbiota and pharmaceuticals, uncovering profound implications for drug metabolism, efficacy, and safety. This review depicted the landscape of molecular mechanisms and clinical implications of dynamic human gut Microbiota-Drug Interactions (MDI), with an emphasis on the impact of MDI on drug responses and individual variations. This review also discussed the therapeutic potential of modulating the gut microbiota or harnessing its metabolic capabilities to optimize clinical treatments and advance personalized medicine, as well as the challenges and future directions in this emerging field.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Community series in combinational immunotherapy of cancer: novel targets, mechanisms, and strategies, volume II.

    Xu, Caili / Ju, Dianwen / Zhang, Xuyao

    Frontiers in immunology

    2023  Volume 14, Page(s) 1256691

    MeSH term(s) Humans ; Anti-Bacterial Agents ; Penicillins ; Anti-Infective Agents ; Pulmonary Surfactants ; Neoplasms/therapy
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; Anti-Infective Agents ; Pulmonary Surfactants
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1256691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: Combinational immunotherapy of cancer: novel targets, mechanisms, and strategies.

    Nan, Yanyang / Ju, Dianwen / Zhang, Xuyao

    Frontiers in immunology

    2023  Volume 14, Page(s) 1250975

    MeSH term(s) Humans ; Anti-Bacterial Agents ; Penicillins ; Anti-Infective Agents ; Pulmonary Surfactants ; Neoplasms/therapy
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; Anti-Infective Agents ; Pulmonary Surfactants
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1250975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy.

    Xu, Caili / Ju, Dianwen / Zhang, Xuyao

    Frontiers in immunology

    2022  Volume 13, Page(s) 923598

    Abstract: As nano-sized materials prepared by isolating, disrupting and extruding cell membranes, cellular vesicles are emerging as a novel vehicle for immunotherapeutic drugs to activate antitumor immunity. Cell membrane-derived vesicles inherit the surface ... ...

    Abstract As nano-sized materials prepared by isolating, disrupting and extruding cell membranes, cellular vesicles are emerging as a novel vehicle for immunotherapeutic drugs to activate antitumor immunity. Cell membrane-derived vesicles inherit the surface characteristics and functional properties of parental cells, thus having superior biocompatibility, low immunogenicity and long circulation. Moreover, the potent antitumor effect of cellular vesicles can be achieved through surface modification, genetic engineering, hybridization, drug encapsulation, and exogenous stimulation. The capacity of cellular vesicles to combine drugs of different compositions and functions in physical space provides a promising vehicle for combinational immunotherapy of cancer. In this review, the latest advances in cellular vesicles as vehicles for combinational cancer immunotherapy are systematically summarized with focuses on manufacturing processes, cell sources, therapeutic strategies and applications, providing an insight into the potential and existing challenges of using cellular vesicles for cancer immunotherapy.
    MeSH term(s) Cell Membrane ; Drug Delivery Systems ; Humans ; Immunity, Cellular ; Immunotherapy ; Neoplasms/therapy
    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.923598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chimeric antigen receptor T-cell therapy: challenges and opportunities in lung cancer.

    Xu, Caili / Ju, Dianwen / Zhang, Xuyao

    Antibody therapeutics

    2022  Volume 5, Issue 1, Page(s) 73–83

    Abstract: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the paradigm in hematological malignancies treatment, driving an ever-expanding number of basic research and clinical trials of genetically engineering T cells to treat solid tumors. CAR T- ...

    Abstract Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the paradigm in hematological malignancies treatment, driving an ever-expanding number of basic research and clinical trials of genetically engineering T cells to treat solid tumors. CAR T-cell therapies based on the antibodies targeting Mesothelin, CEA, EGFR, EGFR, MUC1, DLL3, and emerging novel targets provide promising efficacy for lung cancer patients. However, clinical application of CAR T-cell therapy against lung cancer remains limited on account of physical and immune barriers, antigen escape and heterogeneity, on-target off-tumor toxicity, and many other reasons. Understanding the evolution of CAR structure and the generalizable requirements for manufacturing CAR T cells as well as the interplay between lung tumor immunology and CAR T cells will improve clinical translation of this therapeutic modality in lung cancer. In this review, we systematically summarize the latest advances in CAR T-cell therapy in lung cancer, focusing on the CAR structure, target antigens, challenges, and corresponding new strategies.
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2516-4236
    ISSN (online) 2516-4236
    DOI 10.1093/abt/tbac006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of interleukin-22 in lung health and its therapeutic potential for COVID-19.

    Fang, Si / Ju, Dianwen / Lin, Yong / Chen, Wei

    Frontiers in immunology

    2022  Volume 13, Page(s) 951107

    Abstract: Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best- ... ...

    Abstract Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.
    MeSH term(s) COVID-19/immunology ; Cytokines/immunology ; Cytokines/therapeutic use ; Humans ; Interleukins/immunology ; Interleukins/therapeutic use ; Lung/immunology ; COVID-19 Drug Treatment ; Interleukin-22
    Chemical Substances Cytokines ; Interleukins
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.951107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Research progress of interleukin-15 in cancer immunotherapy.

    Cai, Menghan / Huang, Xuan / Huang, Xiting / Ju, Dianwen / Zhu, Yi Zhun / Ye, Li

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1184703

    Abstract: Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have ... ...

    Abstract Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells. Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are undergoing clinical trials. In this review, we will summarize the recent progress in interleukin-15 research over the past 5 years, highlighting its potential applications in cancer immunotherapy and the progress of interleukin-15 agonist development.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1184703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications.

    Zai, Wenjing / Chen, Wei / Liu, Hongrui / Ju, Dianwen

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders and can progress into a series of liver diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even liver cancer. Interleukin-22 (IL-22), ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders and can progress into a series of liver diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even liver cancer. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is predominantly produced by lymphocytes but acts exclusively on epithelial cells. IL-22 was proven to favor tissue protection and regeneration in multiple diseases. Emerging evidence suggests that IL-22 plays important protective functions against NAFLD by improving insulin sensitivity, modulating lipid metabolism, relieving oxidative and endoplasmic reticulum (ER) stress, and inhibiting apoptosis. By directly interacting with the heterodimeric IL-10R2 and IL-22R1 receptor complex on hepatocytes, IL-22 activates the Janus kinase 1 (JAK1)/ signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase (JNK) and extracellular-signal regulated kinase (ERK) pathways to regulate the subsequent expression of genes involved in inflammation, metabolism, tissue repair, and regeneration, thus alleviating hepatitis and steatosis. However, due to the wide biodistribution of the IL-22 receptor and its proinflammatory effects, modifications such as targeted delivery of IL-22 expression and recombinant IL-22 fusion proteins to improve its efficacy while reducing systemic side effects should be taken for further clinical application. In this review, we summarized recent progress in understanding the physiological and pathological importance of the IL-22-IL-22R axis in NAFLD and the mechanisms of IL-22 in the protection of NAFLD and discussed the potential strategies to maneuver this specific cytokine for therapeutic applications for NAFLD.
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates.

    Zhang, Jinhua / Dong, Yuanzhen / Ju, Dianwen / Feng, Jun

    Bioorganic & medicinal chemistry

    2021  Volume 44, Page(s) 116291

    Abstract: Twelve double fatty chains and ... ...

    Abstract Twelve double fatty chains and Aib
    MeSH term(s) Amino Acids/chemistry ; Drug Design ; Esters/chemical synthesis ; Esters/chemistry ; Glucagon-Like Peptide 1/chemical synthesis ; Glucagon-Like Peptide 1/chemistry ; Molecular Structure ; Solid-Phase Synthesis Techniques ; Succinimides/chemical synthesis ; Succinimides/chemistry
    Chemical Substances Amino Acids ; Esters ; Succinimides ; succinimide (10X90O3503) ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2021.116291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Inflammasome: A Double-Edged Sword in Liver Diseases.

    Luan, Jingyun / Ju, Dianwen

    Frontiers in immunology

    2018  Volume 9, Page(s) 2201

    Abstract: Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the ... ...

    Abstract Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.
    MeSH term(s) Caspase 1/immunology ; Caspase 1/metabolism ; Fas Ligand Protein/immunology ; Fas Ligand Protein/metabolism ; Humans ; Immunity, Innate ; Immunotherapy/methods ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inflammasomes/therapeutic use ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interleukin-18/immunology ; Interleukin-18/metabolism ; Interleukin-1beta/immunology ; Interleukin-1beta/metabolism ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Liver/cytology ; Liver/immunology ; Liver/pathology ; Liver Diseases/immunology ; Liver Diseases/pathology ; Liver Diseases/therapy ; Pyroptosis/immunology
    Chemical Substances FASLG protein, human ; Fas Ligand Protein ; IFNG protein, human ; IL18 protein, human ; IL1B protein, human ; Inflammasomes ; Interleukin-18 ; Interleukin-1beta ; Interferon-gamma (82115-62-6) ; Caspase 1 (EC 3.4.22.36)
    Keywords covid19
    Language English
    Publishing date 2018-09-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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