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  1. Article ; Online: Cutaneous ulcers in association with sprue‐like enteropathy secondary to Losartan

    Francis Essien / Juakiem Wassem / Joshua Tate / Jared Roberts

    Clinical Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract Losartan is an angiotensin II receptor blocker (ARB) which may cause severe sprue‐like enteropathy (SLE) with skin manifestation. Clinicians should be informed of this side effect and its reversibility after cessation of the drug. ...

    Abstract Abstract Losartan is an angiotensin II receptor blocker (ARB) which may cause severe sprue‐like enteropathy (SLE) with skin manifestation. Clinicians should be informed of this side effect and its reversibility after cessation of the drug.
    Keywords angiotensin II receptor blocker ; chronic diarrhea ; Losartan ; sprue‐like enteropathy ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Peribiliary cysts masquerading as choledocholithiasis.

    Narayan, Raja R / Juakiem, Wassem Y / Poultsides, George A / El-Dika, Samer

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 8, Issue 9, Page(s) 351–353

    Abstract: Video 1The major papilla was cannulated with a sphincterotome over a straight wire. The polypoid saccular structures were identified by cholangioscopy. ...

    Abstract Video 1The major papilla was cannulated with a sphincterotome over a straight wire. The polypoid saccular structures were identified by cholangioscopy.
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2023.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Partial Gastric Resection for Symptomatic Anemia following Diagnosis of Merkel Cell Carcinoma (MCC) of the Skin with Gastric Metastasis.

    Eagle, Zachary / Essien, Francis / Shahin, George / Jones, Amia / McKee, John / Elkins, Camille / Juakiem, Wassem

    Clinical medicine insights. Case reports

    2022  Volume 15, Page(s) 11795476221112382

    Abstract: Merkel Cell Carcinoma (MCC) is a rare dermatologic malignancy with significant morbidity and mortality associated with metastatic disease. In this case, we discuss and extremely rare presentation of MCC with metastasis to the stomach in a patient that ... ...

    Abstract Merkel Cell Carcinoma (MCC) is a rare dermatologic malignancy with significant morbidity and mortality associated with metastatic disease. In this case, we discuss and extremely rare presentation of MCC with metastasis to the stomach in a patient that presented with profound anemia. Unfortunately, mortality following diagnosis of MCC with gastric metastasis approaches 67% at 4 months based on available published reports. Due to its rarity and high rate of mortality, there is a lack of available research and literature to help guide treatment of this rare presentation of MCC. This case report presents a positive outcome associated with a partial gastrectomy for the treatment of symptomatic MCC with gastric metastasis and continued survival with persistently stable hemoglobin at 12 months.
    Key clinical message: Anemia may be a significant cause of the morbidity and mortality associated with MCC with gastric metastasis. Our case demonstrates a positive outcome associated with partial gastric resection and presents a possible treatment option for this rare disease process.
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2580498-4
    ISSN 1179-5476
    ISSN 1179-5476
    DOI 10.1177/11795476221112382
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  4. Article ; Online: Analysis of reported adverse events related to single-use duodenoscopes and duodenoscopes with detachable endcaps.

    Ofosu, Andrew / Ramai, Daryl / Mozell, Daniel / Facciorusso, Antonio / Juakiem, Wassem / Adler, Douglas G / Barakat, Monique T

    Gastrointestinal endoscopy

    2022  Volume 96, Issue 1, Page(s) 67–72

    Abstract: Background and aims: Single-use duodenoscopes and duodenoscopes with detachable/disposable caps emerged in the market to mitigate the risk of ERCP-related infections. We aimed to investigate adverse events associated with these devices occurring after U. ...

    Abstract Background and aims: Single-use duodenoscopes and duodenoscopes with detachable/disposable caps emerged in the market to mitigate the risk of ERCP-related infections. We aimed to investigate adverse events associated with these devices occurring after U.S. Food and Drug Administration (FDA) approval.
    Methods: We analyzed postmarketing surveillance data from the FDA Manufacturer and User Facility Device Experience (MAUDE) database from July 2018 to June 2021.
    Results: One hundred eighty-five reports comprising 201 device issues and 118 patient adverse events were identified from July 2018 through June 2021. Most device issues related to the single-use duodenoscope were due to optical problems (7 reports). Other reported device issues included difficulty in advancing the duodenoscope (2 reports), fluid leak (2 reports), and use-of-device problems (2 reports). Among the duodenoscopes with detachable/disposable caps, most device issues were related to bacterial contamination (53 reports), followed by issues with device use (31 reports), detachment/separation of the device (25 reports), and crack/dent in device material (16 reports). Overall, the most frequently reported patient adverse events were tissue injury (63 reports), perforation (8 reports), and bleeding (7 reports). Ninety reports of microbial contamination of duodenoscopes with detachable/disposable caps were identified, of which Pseudomonas aeruginosa was most common.
    Conclusions: Findings from the MAUDE database highlight patient and device adverse events that endoscopists should be aware of in using single-use duodenoscopes and duodenoscopes with detachable/disposable caps. Whereas these devices mitigate the risk of transmitting infection, they are associated with additional device-associated adverse events.
    MeSH term(s) Databases, Factual ; Duodenoscopes/adverse effects ; Duodenoscopes/microbiology ; Equipment Failure ; Humans ; United States/epidemiology ; United States Food and Drug Administration
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.02.013
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  5. Article ; Online: Safety, Efficacy and Clinical Utility of the 5.1mm EndoRotor Powered Debridement Catheter for Treatment of Walled-Off Pancreatic Necrosis.

    Shinn, Brianna / Burdick, James / Berk, Kevin / Hwang, Joo Ha / El-Dika, Samer / Juakiem, Wassem / Han, Samuel / Krishna, Somashekar / Khashab, Mouen A / Mony, Shruti / Kadkhodayan, Kambiz / Khara, Harshit S / Ahmed, Ali M / Boortalary, Tina / Agnohortri, Abhishek / Kumar, Anand / Chiang, Austin / Kamal, Faisal / Schlachterman, Alexander /
    Loren, David / Kowalski, Thomas

    Gastrointestinal endoscopy

    2024  

    Abstract: Background and aims: Direct endoscopic necrosectomy (DEN) is a recommended strategy for treatment of walled-off-necrosis (WON). DEN uses a variety of devices including the EndoRotor (Interscope, Inc.) debridement catheter. Recently, a 5.1 mm EndoRotor ... ...

    Abstract Background and aims: Direct endoscopic necrosectomy (DEN) is a recommended strategy for treatment of walled-off-necrosis (WON). DEN uses a variety of devices including the EndoRotor (Interscope, Inc.) debridement catheter. Recently, a 5.1 mm EndoRotor with increased chamber size and rate of tissue removal was introduced. The aim of this study was to assess the efficacy and safety of this device.
    Methods: A multi-center cohort study was conducted at eight institutions including patients who underwent DEN with the 5.1 mm EndoRotor. The primary outcome was the number of DEN sessions needed for WON resolution. Secondary outcomes included the average percent reduction in solid WON debris and decrease in WON area per session, total time spent performing EndoRotor therapy for WON resolution, and adverse events.
    Results: 64 procedures in 41 patients were included. For patients in which the 5.1 mm EndoRotor catheter was the sole therapeutic modality, an average of 1.6 DEN sessions resulted in WON resolution with an average cumulative time of 85.5 minutes. Of the 21 procedures with data regarding percent of solid debris, the average reduction was 85% +/- 23% per session. Of the 19 procedures with data regarding WON area, the mean area significantly decreased from 97.6 +/- 72.0 cm
    Conclusions: This is the first multi-center retrospective study to investigate the efficacy and safety of the 5.1 mm EndoRotor catheter for WON. Results from this study showed an average of 1.6 DEN sessions were needed to achieve WON resolution with an 85% single session reduction in solid debris and a 70% single session decrease in WON area with minimal adverse events.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2024.02.016
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  6. Article ; Online: A review of the rationale for the testing of the calcineurin inhibitor tacrolimus for post-ERCP pancreatitis prevention.

    Barakat, Monique T / Khalid, Asna / Yu, Mang / Ding, Ying / Murayi, Judy-April / Jayaraman, Thottala / Poropatich, Ronald / Akshintala, Venkat / Juakiem, Wassem / Wen, Li / Papachristou, Georgios I / Husain, Sohail Z

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2022  Volume 22, Issue 6, Page(s) 678–682

    Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients ... ...

    Abstract Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients undergoing ERCP. A substantial body of preclinical data support a mechanistic rationale for calcineurin inhibitors in preventing PEP. The findings are coupled with recent clinical data suggesting lower rates of PEP in patients who concurrently use the calcineurin inhibitor tacrolimus (e.g., solid organ transplant recipients). In this review, we will firstly summarize data in support of testing the use of tacrolimus for PEP prophylaxis, either in combination with rectal indomethacin or by itself. Secondly, we propose that administering tacrolimus through the rectal route could be favorable for PEP prophylaxis over other routes of administration.
    MeSH term(s) Administration, Rectal ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Calcineurin Inhibitors/therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Humans ; Pancreatitis/drug therapy ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Risk Factors ; Tacrolimus/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Calcineurin Inhibitors ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2022.07.003
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  7. Article ; Online: Nutrition in cirrhosis and chronic liver disease.

    Juakiem, Wassem / Torres, Dawn M / Harrison, Stephen A

    Clinics in liver disease

    2014  Volume 18, Issue 1, Page(s) 179–190

    Abstract: Nutrition has not been a primary focus of many medical conditions despite its importance in the development and the severity of these diseases. This is certainly the case with nutrition and end-stage liver disease despite the well-established association ...

    Abstract Nutrition has not been a primary focus of many medical conditions despite its importance in the development and the severity of these diseases. This is certainly the case with nutrition and end-stage liver disease despite the well-established association of nutritional deficiencies and increased rates of complications and mortality in cirrhosis. This review provides an overview of nutrition in chronic liver disease with an emphasis on its pathogenesis as well as ways to assess nutritional status and intervene in an effort to improve nutrition.
    MeSH term(s) Amino Acids, Branched-Chain/therapeutic use ; Chronic Disease ; Digestion ; Humans ; Intestinal Absorption ; Liver Cirrhosis/complications ; Liver Cirrhosis/diet therapy ; Liver Cirrhosis/physiopathology ; Liver Diseases/complications ; Liver Diseases/diet therapy ; Liver Diseases/physiopathology ; Malnutrition/complications ; Malnutrition/etiology ; Malnutrition/physiopathology ; Nutrition Assessment ; Nutritional Status ; Probiotics/therapeutic use
    Chemical Substances Amino Acids, Branched-Chain
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2013.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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