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Article ; Online: Independence and Sex Differences in Physical Activity and Sedentary Behavior Trends from Middle Adolescence to Emerging Adulthood

Yan Luo / Juan Zhong

International Journal of Environmental Research and Public Health, Vol 19, Iss 2647, p

A Latent Class Growth Curve Analysis

2022 Volume 2647

Abstract: The purpose of this study was to examine the relationship and sex differences in the growth patterns of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) from middle adolescence (around age 15) to emerging adulthood (18–29 years ... ...

Abstract	The purpose of this study was to examine the relationship and sex differences in the growth patterns of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) from middle adolescence (around age 15) to emerging adulthood (18–29 years old). We used the secondary data from the National Longitudinal Study of Adolescent Health’s (Add Health) publicly accessible database. MVPA and SB were assessed four times (1995, 1996, 2000–2001, and 2008–2009) for a total of 681 individuals from middle adolescence to emerging adulthood. Latent class growth modeling was utilized to identify heterogeneous growth patterns in MVPA and SB. Chi-square tests were used to assess group dependence and sex differences in MVPA and SB growth patterns. Seven quadratic growth patterns for MVPA and two linear growth patterns for SB were found. Both MVPA and SB growth patterns exhibited slow or rapid rate of change at different periods of adolescence and emerging adulthood. MVPA growth patterns included: decline (slow)-and-rise (rapid), rise-and-decline (both rapid), decline-and-rise (both rapid), consistently low, consistently high, decline (rapid)-and-decline (slow), and decline (rapid)-and-rise (slow). SB growth patterns included: consistently low (slow decline) and consistently high (rapid decline). While women were more likely to be involved in consistently low group for MVPA and consistently low (slow decline) group for SB, men were more likely to be involved in rise-and-decline (both rapid) group, consistently high group, and decline (rapid)-and-rise (slow) group for MVPA and consistently high (rapid decline) group for SB. SB growth patterns were independent of MVPA growth patterns. SB should not be assumed to decrease as a result of MVPA intervention. Treatment of MVPA should prioritize adolescence over emerging adulthood, with an emphasis on preventing men’s MVPA levels from decreasing in emerging adulthood and increasing women’s overall MVPA levels.
Keywords	adolescent ; emerging adult ; health behavior ; Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of social hotspots on case-based teaching method during the teaching of endocrinology

FANG Hong-juan, ZHONG Li-yong

Jichu yixue yu linchuang, Vol 41, Iss 10, Pp 1542-

2021 Volume 1545

Abstract: In order to improve the quality of clinical endocrinology courses, social hotspots penetrated into professional instructions of endocrinology and well tailored with curriculum knowledge. Social hotspots merged into the case-based teaching can enrich ... ...

Abstract	In order to improve the quality of clinical endocrinology courses, social hotspots penetrated into professional instructions of endocrinology and well tailored with curriculum knowledge. Social hotspots merged into the case-based teaching can enrich teaching materials and broaden students' scope of knowledge; enliven classroom dynamics and make teaching more efficient. In addition, precise selection of hotspots can make the learning more interesting. This paper introduced the application cases of hotspots in endocrinology teaching, analyzed the advantages of such a method as compared to conventional methods. In addition, the paper made practical suggestions for maximizing the learning outcomes to support the education of talent medical students.
Keywords	social hotspots\|case-based teaching method\|clinical endocrinology teaching\|discussion-based teaching ; Medicine ; R
Language	Chinese
Publishing date	2021-10-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Artificial Intelligence Algorithm-Based MRI in Evaluating the Treatment Effect of Acute Cerebral Infarction

Xiaojie He / Guangxiang Liu / Chunying Zou / Rongrui Li / Juan Zhong / Hong Li

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Abstract: The study is aimed at exploring the application of artificial intelligence algorithm-based magnetic resonance imaging (MRI) in the diagnosis of acute cerebral infarction, expected to provide a reference for diagnosis and effect evaluation of acute ... ...

Abstract	The study is aimed at exploring the application of artificial intelligence algorithm-based magnetic resonance imaging (MRI) in the diagnosis of acute cerebral infarction, expected to provide a reference for diagnosis and effect evaluation of acute cerebral infarction. In this study, 80 patients diagnosed with suspected acute cerebral infarction per Diagnostic Criteria for Cerebral Infarction were selected as the research subjects. MRI images were reconstructed by deep dictionary learning to improve their recognition ability. At the same time, the same diagnostic operation was performed by Computed Tomography (CT) images to compare with MRI. The results of the interalgorithm comparison showed the image reconstruction effect of the deep dictionary learning model is significantly better than SAE reconstruction, single-layer dictionary reconstruction model, and KAVD reconstruction. After comparison, the results of MRI based on artificial intelligence algorithm and CT evaluation were statistically significant (P<0.05). In the lesion image, the diameter of MRI lesions (3.81±0.77 cm) based on artificial intelligence algorithm and the diameter of lesions in CT (3.66±1.65 cm) also had significant statistical significance (P<0.05). The results showed that MRI based on deep learning was more sensitive than CT imaging for diagnosis and evaluation of patients with acute cerebral infarction, with only 1 case misdiagnosed. The rate of disease detection and lesion image quality had a higher improvement. The results can provide effective support for the clinical application of MRI based on artificial intelligence algorithm in the diagnosis of acute cerebral infarction.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ma-Huang-Fu-Zi-Xi-Xin Decoction for Allergic Rhinitis

Juan Zhong / Dan Lai / Yun Zheng / Gang Li

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review

2018 Volume 2018

Abstract: Background. The treatment effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction for patients with allergic rhinitis have yet to be clarified. Objectives. The aim of this study is to evaluate the effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction in ... ...

Abstract	Background. The treatment effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction for patients with allergic rhinitis have yet to be clarified. Objectives. The aim of this study is to evaluate the effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction in patients with allergic rhinitis. Methods. We searched PubMed, EMBASE (Excerpta Medical Database), Cochrane Library, Chinese Cochrane Centre’s Controlled Trials Register Platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure (CNKI) Database, and VIP Chinese Science and Technique Journals Database to collect randomized controlled trials of Ma-Huang-Fu-Zi-Xi-Xin decoction (MHFZXXD) for allergic rhinitis (AR) prior to May 8, 2017. RevMan 5.3 software was used to conduct a meta-analysis. GRADE methodology was applied to evaluate the evidence quality for each outcome. Results. Six randomized controlled trials (RCTs) involving 576 participants (10–78 years old) were included. A meta-analysis revealed that the overall effect of MHFZXXD for AR was not better than western medical treatment (RR: 0.41; 95% CI: 0.26–0.65; P=0.0001) for all included studies. However, the evidence quality of these western medical intervention studies was low or very low due to a high risk of bias, small sample sizes, and poor-quality design.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm

Zhenguo Wang / Xiangjie Zhao / Guizhen Zhao / Yanhong Guo / Haocheng Lu / Wenjuan Mu / Juan Zhong / Minerva Garcia-Barrio / Jifeng Zhang / Y. Eugene Chen / Lin Chang

JCI Insight, Vol 8, Iss

2023 Volume 11

Abstract: Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis. The ...

Abstract	Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis. The transcriptional regulator PR domain–containing protein 16 (PRDM16) is highly expressed in the aorta, but its functions in the aorta are largely unknown. By RNA-seq analysis, we found that vascular smooth muscle cell–specific (VSMC-specific) Prdm16-knockout (Prdm16SMKO) mice already showed extensive changes in the expression of genes associated with extracellular matrix (ECM) remodeling and inflammation in the abdominal aorta under normal housing conditions without any pathological stimuli. Human AAA lesions displayed lower PRDM16 expression. Periadventitial elastase application to the suprarenal region of the abdominal aorta aggravated AAA formation in Prdm16SMKO mice. During AAA development, VSMCs undergo apoptosis because of both intrinsic and environmental changes, including inflammation and ECM remodeling. Prdm16 deficiency promoted inflammation and apoptosis in VSMCs. A disintegrin and metalloproteinase 12 (ADAM12) is a gelatinase that can degrade various ECMs. We found that ADAM12 is a target of transcriptional repression by PRDM16. Adam12 knockdown reversed VSMC apoptosis induced by Prdm16 deficiency. Our study demonstrated that PRDM16 deficiency in VSMCs promoted ADAM12 expression and aggravates AAA formation, which may provide potential targets for AAA treatment.
Keywords	Autoimmunity ; Vascular biology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

Yunhang Wang / Hong Su / Juan Zhong / Zuxiong Zhan / Qin Zhao / Yuan Liu / Sen Li / Haiyan Wang / Ce Yang / Lehua Yu / Botao Tan / Ying Yin

Molecular Biomedicine, Vol 4, Iss 1, Pp 1-

2023 Volume 18

Abstract: Abstract In this study, we examined the combined impact of osteopontin (OPN) and treadmill training on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP into the sensorimotor cortex, followed by a left incomplete C5 ... ...

Abstract	Abstract In this study, we examined the combined impact of osteopontin (OPN) and treadmill training on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP into the sensorimotor cortex, followed by a left incomplete C5 crush injury two weeks later. Mice (Ex or Ex + OPN group) were trained at 50% maximum running speed for 8 weeks. To analyze the effects, we used biotinylated dextran amine (BDA) for tracing the corticospinal tract (CST) and performed Western blotting and immunohistochemical methods to assess the activation of the mammalian target of rapamycin (mTOR). We also examined axonal regeneration and conducted behavioral tests to measure functional recovery. The results demonstrated that treadmill training promoted the expression of neurotrophic factors such as brain-derived neurotrophic factor (BNDF) and insulin-like growth factor I (IGF-1) and activated mTOR signaling. OPN amplified the effect of treadmill training on activating mTOR signaling indicated by upregulated phosphorylation of ribosomal protein S6 kinase (S6). The combination of OPN and exercise further promoted functional recovery and facilitated limited CST axonal regeneration which did not occur with treadmill training and OPN treatment alone. These findings indicate that OPN enhances the effects of treadmill training in the treatment of SCI and offer new therapeutic insights for spinal cord injury.
Keywords	Osteopontin ; Treadmill training ; Functional recovery ; Spinal cord injury ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Low methane emission in rice cultivars with high radial oxygen loss

Zheng, Huabin / Juan Zhong / Wenfei Long / Zhiqiang Fu

Plant and soil. 2018 Oct., v. 431, no. 1-2

2018

Abstract: BACKGROUND AND AIMS: Studies have found significant differences in methane (CH4) emissions among rice cultivars; however, it is unclear whether this difference is related to radial oxygen loss (ROL) from the roots. METHODS: Based on a 2-year in situ ... ...

Abstract	BACKGROUND AND AIMS: Studies have found significant differences in methane (CH4) emissions among rice cultivars; however, it is unclear whether this difference is related to radial oxygen loss (ROL) from the roots. METHODS: Based on a 2-year in situ field study and solution culture experiments on 16 rice cultivars, we investigated CH4 emission levels and their dependence on ROL. RESULTS: We detected significant differences in CH4 emission and ROL among rice cultivars. The lowest and highest CH4 emission levels were 4.10 and 7.35 g m−2 for early rice, and 14.36 and 23.33 g m−2 for late rice, respectively. The maximum and minimum ROL values were 3.77 and 1.73 mmol plant−1 h−1 for early rice, and 4.18 and 2.08 mmol plant−1 h−1 for late rice, respectively. Seasonal total CH4 emission was negatively correlated with ROL in the early rice season (p < 0.01), and (p < 0.01) in the late rice season. ROL was positively correlated with the number of roots per plant (RN), root tips per plant (RT), and root volume per plant (RV). CONCLUSIONS: We suggest that ROL can be used as a predictive index for CH4 emissions. RN, RT, and RV were the most important factors influencing ROL in rice cultivars.
Keywords	cultivars ; greenhouse gas emissions ; methane ; oxygen ; rice ; root tips
Language	English
Dates of publication	2018-10
Size	p. 119-128.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	208908-7
ISSN	1573-5036 ; 0032-079X
ISSN (online)	1573-5036
ISSN	0032-079X
DOI	10.1007/s11104-018-3747-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ear Acupressure for Allergic Rhinitis

Juan Zhong / Shuqin Liu / Dan Lai / Tao Lu / Yifeng Shen / Qisheng Gong / Peijia Li / Qinxiu Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 Volume 2021

Abstract: Background. The treatment effects and safety of ear acupressure (EAP) for patients with allergic rhinitis (AR) have yet to be clarified. Objective. To evaluate the effects and safety of EAP in AR patients. Design. Systematic review of published studies. ... ...

Abstract	Background. The treatment effects and safety of ear acupressure (EAP) for patients with allergic rhinitis (AR) have yet to be clarified. Objective. To evaluate the effects and safety of EAP in AR patients. Design. Systematic review of published studies. Methods. A total of 24 English and Chinese databases (PubMed, EMBASE (Excerpta Medical Database), Cochrane Central Register of Controlled Trials, CINAHL, Informit, ScienceDirect, LILACS (Latin American and Caribbean Health Sciences), ProQuest, AMED, Blackwell Synergy, PsycINFO, Panteleimon, AcuBriefs, KoreaMed, IndMed, Ingenta, mRCT, ISI Web of Knowledge, ERIC, VIP Information (http://www.cqvip.com), China National Knowledge Infrastructure (http://www.cnki.net), Cochrane Library, Chinese Cochrane Centre Controlled Trials Register Platform, and Wanfang Chinese Digital Periodical and Conference Database) were searched from their respective inceptions to August 2020 to collect randomized controlled trials of ear acupressure for allergic rhinitis. We performed literature inclusion, data extraction, and trial quality evaluations. Methodological quality was assessed according to the Cochrane Handbook. Revman5.3 was used for all analyses. Results. A total of 203 trials were identified and eleven studies involved 1094 participants aged 3–70 years. EAP was better than control group interventions in terms of effectiveness (risk ratio (RR): 0.51; 95% confidence interval (CI): 0.36–0.70; P<0.0001). EAP was superior to sham EAP in terms of improvement of the total nasal symptom score (RR: −0.50; 95% CI: −0.96–0.05; P = 0.03), sneezing score (RR: −0.36; 95% CI: −0.59–0.12; P = 0.003), global QoL score (RR: 0.42; 95% CI: 0.04–0.08; P = 0.03), and eye symptom score (RR: −0.36; 95% CI: −0.67–0.05; P = 0.02). Conclusions. Despite the positive results, it is premature to confirm the efficacy of EAP for treating AR. More high-quality studies are needed to confirm safety and efficacy.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation of the Chinese Version of Relaxation Sensitivity Index

Jieting Zhang / Christina M. Luberto / Qi Huang / Jin Kuang / Juan Zhong / Albert Yeung / Liye Zou

Frontiers in Public Health, Vol

A Tool for Predicting Treatment Effect in Mindfulness Interventions

2021 Volume 9

Abstract: Background: The Relaxation Sensitivity Index (RSI) measures relaxation-related fears developed and validated in western samples. The RSI captures three facets of fear regarding relaxation: physical, cognitive, and social concerns. This study aimed to ... ...

Abstract	Background: The Relaxation Sensitivity Index (RSI) measures relaxation-related fears developed and validated in western samples. The RSI captures three facets of fear regarding relaxation: physical, cognitive, and social concerns. This study aimed to translate and identify the factor structure of the Chinese version of the RSI.Methods: In a preliminary study, 26 items were generated mainly by translation and modified from the original RSI. In Study 1, factor analysis and internal consistency reliability analysis were conducted on separated half samples of 597 Chinese college students. In Study 2, test-retest reliability, convergent, and predictive criterion validity were examined based on 465 Chinese college students.Results: Fourteen items were selected based on the factor loading and item prevalence in the preliminary study. Factor analysis based on Study 1 identified three factors: Social appealing, Social performance, and Physical concerns. In general, the RSI demonstrated good internal consistency (αs = 0.750–0.860), convergent validity and predictive criterion validity, while the test-retest reliability is relatively low (rs = 0.525–0.685). Notably, less related to the other two factors, Social performance concerns may be a unique factor solely predicting social anxiety (p <0.001), but not relaxation-induced anxiety (p = 0.442).Conclusion: The Chinese version of the RSI possesses a factor structure different from the western population. The robustness of factor structure and test-retest reliability was not as good as expected. Further research is warranted to explore the validity of the RSI in Chinese samples.
Keywords	relaxation sensitivity ; relaxation-induced anxiety ; anxiety sensitivity ; factor analysis ; validity ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heterologous WRKY and NAC transcription factors triggered resistance in Nicotiana benthamiana

Hafiz Muhammad Khalid Abbas / Aqeel Ahmad / Wubei Dong / Jingshu Xiang / Javaid Iqbal / Sajid Ali / Waheed Akram / Yu-Juan Zhong

Journal of King Saud University: Science, Vol 32, Iss 7, Pp 3005-

2020 Volume 3013

Abstract: Background: SA (Salicylic acid) and JA (Jasmonic acid)/ET (Ethylene) are the defense and growth hormone regulators involved in alleviating the biotic and abiotic stresses. WRKY and NAC genes are contributors to plant resistance due to their active role ... ...

Abstract	Background: SA (Salicylic acid) and JA (Jasmonic acid)/ET (Ethylene) are the defense and growth hormone regulators involved in alleviating the biotic and abiotic stresses. WRKY and NAC genes are contributors to plant resistance due to their active role in SA and JA/ET defense mechanism. Methods: WRKY and NAC transcription factors (ptHR293 and ptHR759, respectively) were serially selected (by performing cDNA library functional screening, homology analysis, antioxidant enzymes, ROS burst, callose deposition and qRT-PCR analysis) from Pinellia ternata and transformed into Nicotiana benthamiana. Hybrids were generated to analyze the stability of disease resistance. UPLC-QTOF-MS was performed to study the bioactive compounds. Results: Study demonstrated that ptHR293 and ptHR759 had potential to trigger ROS burst and callose deposition in N. benthamiana together with the activation of PR-genes and antioxidant enzymes. In transformed N. benthamiana, relative expression of PR-1a (Pathogenesis related-1a) and PDF1.2 (Plant defensin 1.2) was upregulated upto 21 folds and 4 folds for ptHR293 transformed N. benthamiana. While PR-1a and PDF1.2 exhibited 8 folds and 26 folds upregulation for ptHR759 transformed N. benthamiana. ptHR293 + ptHR759-F1 hybrids also exhibited a significant level of PR-gene expression. Significantly high resistance against Botrytis cinerea without influencing the standard seed germination, root and shoot length of transformed N. benthamiana was also observed. A significant induction of bioactive compounds was also observed in ptHR293 transformed N. benthamiana. Conclusion: Conclusively, heterologous transcription factors, ptHR293 and ptHR759, perform their specific role in the activation of SA and JA/ET mediated defense mechanism.
Keywords	Hypersensitive response ; Nicotiana benthamiana ; Transcription factor ; WRKY ; 3,4-Dichloromaleimide ; Science (General) ; Q1-390
Subject code	572
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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