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  1. Article: Introduction to the Special Issue on "Keratinocyte Carcinomas: Biology and Evolving Non-Invasive Management Paradigms".

    González, Salvador / Gill, Melissa / Juarranz, Ángeles

    Cancers

    2023  Volume 15, Issue 8

    Abstract: Keratinocyte carcinomas (KCs) are the most prevalent form of cancer worldwide, and their incidence is rising dramatically, with an increasing trend in recent years [ ... ]. ...

    Abstract Keratinocyte carcinomas (KCs) are the most prevalent form of cancer worldwide, and their incidence is rising dramatically, with an increasing trend in recent years [...].
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082325
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  2. Article: Clinical Applications of

    Rodríguez-Luna, Azahara / Zamarrón, Alicia / Juarranz, Ángeles / González, Salvador

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 7

    Abstract: Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an ...

    Abstract Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13071513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment.

    Gilaberte, Yolanda / Moreno, Ricardo / Juarranz, Angeles / González, Salvador

    Journal of the American Academy of Dermatology

    2022  Volume 87, Issue 5, Page(s) e165

    MeSH term(s) Aminolevulinic Acid/therapeutic use ; Humans ; Keratosis, Actinic/drug therapy ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Treatment Outcome ; Vitamin D/therapeutic use
    Chemical Substances Photosensitizing Agents ; Vitamin D (1406-16-2) ; Aminolevulinic Acid (88755TAZ87)
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.05.064
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
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  4. Article: Photodynamic Therapy (PDT) in Oncology.

    Juarranz, Ángeles / Gilaberte, Yolanda / González, Salvador

    Cancers

    2020  Volume 12, Issue 11

    Abstract: The issue is focused on Photodynamic Therapy (PDT), which is a minimally invasive therapeutic modality approved for treatment of several types of cancer and non-oncological disorders [ ... ]. ...

    Abstract The issue is focused on Photodynamic Therapy (PDT), which is a minimally invasive therapeutic modality approved for treatment of several types of cancer and non-oncological disorders [...].
    Language English
    Publishing date 2020-11-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113341
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  5. Article ; Online: The role of the aqueous extract Polypodium leucotomos in photoprotection.

    Parrado, Concepción / Nicolas, Jimena / Juarranz, Angeles / Gonzalez, Salvador

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2020  Volume 19, Issue 6, Page(s) 831–843

    Abstract: Solar radiation in the ultraviolet (UV), visible (VIS), and infrared (IR) ranges produces different biological effects in humans. Most of these, particularly those derived from ultraviolet radiation (UVR) are harmful to the skin, and include cutaneous ... ...

    Abstract Solar radiation in the ultraviolet (UV), visible (VIS), and infrared (IR) ranges produces different biological effects in humans. Most of these, particularly those derived from ultraviolet radiation (UVR) are harmful to the skin, and include cutaneous aging and increased risk of cutaneous diseases, particularly skin cancer. Pharmacological photoprotection is mostly topical, but it can also be systemic. Oral photoprotectives constitute a new generation of drugs to combat the deleterious effects of solar radiation. Among these, an extract of Polypodium leucotomos (PL/Fernblock®, IFC Group, Spain) contains a high content of phenolic compounds that endow it with antioxidant activity. PL can administered orally or topically and is completely safe. PL complements and enhances endogenous antioxidant systems by neutralizing superoxide anions, hydroxyl radicals, and lipoperoxides. In addition to its antioxidant activity, PL also improves DNA repair and modulates immune and inflammatory responses. These activities are likely due to its ability to inhibit the generation and release of reactive oxygen species (ROS) by UVR, VIS, and IR radiation. PL also prevents direct DNA damage by accelerating the removal of induced photoproducts and decreasing UV-induced mutations. Oral PL increases the expression of active p53, decreases cell proliferation, and inhibits UV-induced COX-2 enzyme levels. PL has been used to treat skin diseases such as photodermatoses and pigmentary disorders and recently as a complement of photodynamic phototherapy in actinic keratoses. The photoprotective capability of PL has been proven in a multitude of in vitro and in vivo studies, which include animal models and clinical trials with human subjects. Based on this evidence, PL is a new generation photoprotector with antioxidant and anti-inflammatory properties that also protects DNA integrity and enhances the immune response.
    MeSH term(s) Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Antioxidants/pharmacology ; DNA Damage ; Humans ; Hydroxyl Radical/antagonists & inhibitors ; Hydroxyl Radical/metabolism ; Infrared Rays ; Lipid Peroxides/antagonists & inhibitors ; Lipid Peroxides/metabolism ; Mice ; Mice, Knockout ; Oxidative Stress/drug effects ; Photochemical Processes ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polypodium/chemistry ; Protective Agents/administration & dosage ; Protective Agents/chemistry ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Skin/drug effects ; Superoxides/antagonists & inhibitors ; Superoxides/metabolism ; Ultraviolet Rays ; Water/chemistry
    Chemical Substances Antioxidants ; Lipid Peroxides ; Plant Extracts ; Protective Agents ; Reactive Oxygen Species ; Water (059QF0KO0R) ; Superoxides (11062-77-4) ; Hydroxyl Radical (3352-57-6)
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1039/d0pp00124d
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  6. Article ; Online: Is haem the real target of COVID-19?

    Rapozzi, Valentina / Juarranz, Angeles / Habib, Ahsan / Ihan, Alojz / Strgar, Rebeka

    Photodiagnosis and photodynamic therapy

    2021  Volume 35, Page(s) 102381

    Abstract: Although a vaccination campaign has been launched in many countries, the COVID-19 pandemic is not under control. The main concern is the emergence of new variants of SARS-CoV-2; therefore, it is important to find approaches to prevent or reduce the ... ...

    Abstract Although a vaccination campaign has been launched in many countries, the COVID-19 pandemic is not under control. The main concern is the emergence of new variants of SARS-CoV-2; therefore, it is important to find approaches to prevent or reduce the virulence and pathogenicity of the virus. Currently, the mechanism of action of SARS-CoV-2 is not fully understood. Considering the clinical effects that occur during the disease, attacking the human respiratory and hematopoietic systems, and the changes in biochemical parameters (including decreases in haemoglobin [Hb] levels and increases in serum ferritin), it is clear that iron metabolism is involved. SARS-CoV-2 induces haemolysis and interacts with Hb molecules via ACE2, CD147, CD26, and other receptors located on erythrocytes and/or blood cell precursors that produce dysfunctional Hb. A molecular docking study has reported a potential link between the virus and the beta chain of haemoglobin and attack on haem. Considering that haem is involved in miRNA processing by binding to the DGCR8-DROSHA complex, we hypothesised that the virus may check this mechanism and thwart the antiviral response.
    MeSH term(s) COVID-19 ; Heme ; Humans ; MicroRNAs ; Molecular Docking Simulation ; Pandemics ; Photochemotherapy/methods ; Photosensitizing Agents ; RNA-Binding Proteins ; SARS-CoV-2
    Chemical Substances MicroRNAs ; Photosensitizing Agents ; RNA-Binding Proteins ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2021-06-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2021.102381
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  7. Article: Editorial: Antimicrobial Photodynamic Therapy: A New Paradigm in the Fight Against Infections.

    Gilaberte, Yolanda / Rezusta, Antonio / Juarranz, Angeles / Hamblin, Michael R

    Frontiers in medicine

    2021  Volume 8, Page(s) 788888

    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.788888
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  8. Article: In vitro 5-Fluorouracil resistance produces enhanced photodynamic therapy damage in SCC and tumor resistance in BCC

    Nicolás-Morala, Jimena / Portillo-Esnaola, Mikel / Terrén, Samuel / Gutierrez-Pérez, María / Gilaberte, Yolanda / González, Salvador / Juarranz, Ángeles

    Journal of photochemistry and photobiology. 2022 May 25,

    2022  

    Abstract: Non-melanoma skin cancer (NMSC) is the most common malignancy worldwide, with rising incidence in the recent years. It includes basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Several non-invasive therapies have been developed for its ... ...

    Abstract Non-melanoma skin cancer (NMSC) is the most common malignancy worldwide, with rising incidence in the recent years. It includes basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Several non-invasive therapies have been developed for its treatment such as topical 5-Fluorouracil (5FU) and photodynamic therapy (PDT), among others. Despite both are appropriated for NMSC treatment, recurrence cases have been reported. To prevent this, in this work we explore the potential of the combination of PDT and 5FU to treat SCC and BCC. First we evaluate the efficacy of PDT in cells resistant to 5FU. For this purpose, we use SCC-13 and CSZ-1 cells, obtained from a human SCC and a murine BCC, respectively. We first induced 5FU resistance in these cell lines by repeated treatments with the drug and then, the efficacy to PDT was evaluated. The results obtained indicated that SCC-5FU resistant cells were sensible to PDT administration, whereas BCC-5FU resistant cells were also resistant to PDT. The observed responses in both cell lines are in concordance to Protoporphyrin IX (PpIX) and reactive oxygen species (ROS) levels produced after the incubation with MAL and subsequent light exposure. The obtained data support the fact that PDT seems be an appropriate therapeutic option to be administered after 5FU resistance in SCC. However, PDT would not be a choice therapy for resistant BCC cells to 5FU.
    Keywords fluorouracil ; humans ; mice ; photobiology ; photochemistry ; photochemotherapy ; protoporphyrin ; reactive oxygen species ; skin neoplasms ; squamous cell carcinoma
    Language English
    Dates of publication 2022-0525
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2022.112483
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Plasmonic Hot-Electron Reactive Oxygen Species Generation: Fundamentals for Redox Biology.

    Carrasco, Elisa / Stockert, Juan Carlos / Juarranz, Ángeles / Blázquez-Castro, Alfonso

    Frontiers in chemistry

    2020  Volume 8, Page(s) 591325

    Abstract: For decades, the possibility to generate Reactive Oxygen Species (ROS) in biological systems through the use of light was mainly restricted to the photodynamic effect: the photoexcitation of molecules which then engage in charge- or energy-transfer to ... ...

    Abstract For decades, the possibility to generate Reactive Oxygen Species (ROS) in biological systems through the use of light was mainly restricted to the photodynamic effect: the photoexcitation of molecules which then engage in charge- or energy-transfer to molecular oxygen (O
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2020.591325
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  10. Article ; Online: Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation.

    Zamarrón, Alicia / Lorrio, Silvia / González, Salvador / Juarranz, Ángeles

    International journal of molecular sciences

    2018  Volume 19, Issue 8

    Abstract: Sun overexposure leads to higher risk of photoaging and skin cancer. The contribution of infrared (IR) and visible light (VIS) radiation is currently being taken into account in their pathogenesis. Erythema, hyperpigmentation, genotoxicity or the ... ...

    Abstract Sun overexposure leads to higher risk of photoaging and skin cancer. The contribution of infrared (IR) and visible light (VIS) radiation is currently being taken into account in their pathogenesis. Erythema, hyperpigmentation, genotoxicity or the increase of matrix metalloproteinases (MMPs) expression are some of the effects induced by these types of radiation. Extracts of various botanicals endowed with antioxidant activity are emerging as new photoprotective compounds. A natural extract from
    MeSH term(s) Dermis/injuries ; Dermis/metabolism ; Dermis/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Infrared Rays/adverse effects ; Plant Extracts/pharmacology ; Skin Aging/drug effects ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Skin Neoplasms/prevention & control
    Chemical Substances Plant Extracts ; fernblock
    Language English
    Publishing date 2018-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19082250
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