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  1. Article ; Online: Disagreement among the three musketeers of the unfolded protein response.

    Jipa, András / Juhász, Gábor

    The Journal of cell biology

    2023  Volume 222, Issue 5

    Abstract: Jipa and Juhász preview results from the lab of Tao Wang (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208147) which show a surprising antagonism between two branches of the unfolded protein response that dictates disease progression in a model of ... ...

    Abstract Jipa and Juhász preview results from the lab of Tao Wang (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208147) which show a surprising antagonism between two branches of the unfolded protein response that dictates disease progression in a model of autosomal dominant retinitis pigmentosa.
    MeSH term(s) Unfolded Protein Response ; Retinitis Pigmentosa/pathology ; Animals ; Disease Progression
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202304013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glial cells LAP axon fragments.

    Szabó, Áron / Juhász, Gábor

    Autophagy

    2023  Volume 19, Issue 11, Page(s) 3024–3025

    Abstract: In the nervous system, dead cell-derived material arising from injuries and neurodegeneration is normally removed by the phagocytic activity of macrophages or glia. Failure in this process can lead to excessive inflammation and secondary ... ...

    Abstract In the nervous system, dead cell-derived material arising from injuries and neurodegeneration is normally removed by the phagocytic activity of macrophages or glia. Failure in this process can lead to excessive inflammation and secondary neurodegeneration. During phagocytosis, engulfed material is captured into phagosomes. Maturation and subsequent fusion of these vesicles with lysosomes may utilize components of the macroautophagy pathway that has been referred to as LC3-associated phagocytosis or LAP for short.
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2246355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Painting a picture of autophagy in

    Juhász, Gábor

    Autophagy

    2019  Volume 15, Issue 11, Page(s) 1859

    Abstract: Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell ... ...

    Abstract Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy image to engage a lay audience with the beauty of cells and explain the tremendous complexity one can extract from a single microphotograph. Unfortunately, I do not think that we as a science community are in general doing the best job at reaching out to the public and communicating what we do, why it is important and how beautiful and exciting our work is.
    MeSH term(s) Animals ; Autophagy ; Drosophila ; Humans
    Language English
    Publishing date 2019-08-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2019.1659624
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  4. Article ; Online: The Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles.

    Szenci, Győző / Glatz, Gábor / Takáts, Szabolcs / Juhász, Gábor

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3200

    Abstract: In the Drosophila larval salivary gland, developmentally programmed fusions between lysosomes and secretory granules (SGs) and their subsequent acidification promote the maturation of SGs that are secreted shortly before puparium formation. Subsequently, ...

    Abstract In the Drosophila larval salivary gland, developmentally programmed fusions between lysosomes and secretory granules (SGs) and their subsequent acidification promote the maturation of SGs that are secreted shortly before puparium formation. Subsequently, ongoing fusions between non-secreted SGs and lysosomes give rise to degradative crinosomes, where the superfluous secretory material is degraded. Lysosomal fusions control both the quality and quantity of SGs, however, its molecular mechanism is incompletely characterized. Here we identify the R-SNARE Ykt6 as a novel regulator of crinosome formation, but not the acidification of maturing SGs. We show that Ykt6 localizes to Lamp1+ carrier vesicles, and forms a SNARE complex with Syntaxin 13 and Snap29 to mediate fusion with SGs. These Lamp1 carriers represent a distinct vesicle population that are functionally different from canonical Arl8+, Cathepsin L+ lysosomes, which also fuse with maturing SGs but are controlled by another SNARE complex composed of Syntaxin 13, Snap29 and Vamp7. Ykt6- and Vamp7-mediated vesicle fusions also determine the fate of SGs, as loss of either of these SNAREs prevents crinosomes from acquiring endosomal PI3P. Our results highlight that fusion events between SGs and different lysosome-related vesicle populations are critical for fine regulation of the maturation and crinophagic degradation of SGs.
    MeSH term(s) SNARE Proteins/genetics ; SNARE Proteins/metabolism ; R-SNARE Proteins/genetics ; R-SNARE Proteins/metabolism ; Qa-SNARE Proteins/metabolism ; Secretory Vesicles/metabolism ; Membrane Fusion/physiology ; Lysosomes/metabolism
    Chemical Substances SNARE Proteins ; R-SNARE Proteins ; Qa-SNARE Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53607-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interplay between autophagy and CncC regulates dendrite pruning in

    Tan, Jue Yu Kelly / Chew, Liang Yuh / Juhász, Gábor / Yu, Fengwei

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 10, Page(s) e2310740121

    Abstract: Autophagy is essential for the turnover of damaged organelles and long-lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental and ... ...

    Abstract Autophagy is essential for the turnover of damaged organelles and long-lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental and neurodegenerative diseases in humans. However, the role of autophagy in neuronal pruning during development remains poorly understood. Here, we report that autophagy regulates dendrite-specific pruning of ddaC sensory neurons in parallel to local caspase activation. Impaired autophagy causes the formation of ubiquitinated protein aggregates in ddaC neurons, dependent on the autophagic receptor Ref(2)P. Furthermore, the metabolic regulator AMP-activated protein kinase and the insulin-target of rapamycin pathway act upstream to regulate autophagy during dendrite pruning. Importantly, autophagy is required to activate the transcription factor CncC (Cap "n" collar isoform C), thereby promoting dendrite pruning. Conversely, CncC also indirectly affects autophagic activity via proteasomal degradation, as impaired CncC results in the inhibition of autophagy through sequestration of Atg8a into ubiquitinated protein aggregates. Thus, this study demonstrates the important role of autophagy in activating CncC prior to dendrite pruning, and further reveals an interplay between autophagy and CncC in neuronal pruning.
    MeSH term(s) Animals ; Humans ; Autophagy/physiology ; Dendrites/metabolism ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Neuronal Plasticity ; Quaternary Ammonium Compounds ; Ubiquitinated Proteins/metabolism
    Chemical Substances Drosophila Proteins ; N,N-dimethyl-N-hexadecyl-1-octadecylammonium (32288-33-8) ; Quaternary Ammonium Compounds ; Ubiquitinated Proteins ; cnc protein, Drosophila
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2310740121
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  6. Article ; Online: The role of crinophagy in quality control of the regulated secretory pathway.

    Szenci, Győző / Csizmadia, Tamás / Juhász, Gábor

    Journal of cell science

    2023  Volume 136, Issue 8

    Abstract: In specialized secretory cells that produce and release biologically active substances in a regulated fashion, tight control of both the quantity and quality of secretory material is of paramount importance. During crinophagy, abnormal, excess or ... ...

    Abstract In specialized secretory cells that produce and release biologically active substances in a regulated fashion, tight control of both the quantity and quality of secretory material is of paramount importance. During crinophagy, abnormal, excess or obsolete secretory granules directly fuse with lysosomes to yield crinosomes, in which the delivered secretory material is degraded. Crinophagy maintains the proper intracellular pool of secretory granules, and it is enhanced when secretory material accumulates because of compromised secretion. Recent studies highlight that it can even degrade newly formed, nascent secretory granules that shed from the trans-Golgi network. This implies that crinophagy provides a quality control checkpoint acting at the formation of secretory vesicles, and this degradation mechanism might survey secretory granules throughout their maturation. Of note, a plethora of human disorders is associated with defective lysosomal clearance of secretory material via crinophagy or similar pathways, including macro- or micro-autophagic degradation of secretory granules (referred to here as macro- and micro-secretophagy, respectively). In our Review, we summarize key recent advances in this field and discuss potential links with disease.
    MeSH term(s) Humans ; Secretory Pathway ; Lysosomes/metabolism ; Autophagy ; trans-Golgi Network/metabolism ; Secretory Vesicles/metabolism
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.260741
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    Zs.MG 14: Show issues

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  7. Article ; Online: A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17.

    Juhász, Gábor

    The Journal of cell biology

    2016  Volume 214, Issue 3, Page(s) 241–243

    Abstract: Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE ... ...

    Abstract Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.
    MeSH term(s) Animals ; Cytoplasmic Vesicles/metabolism ; Drosophila melanogaster/metabolism ; Endoplasmic Reticulum/metabolism ; Endosomes/metabolism ; Humans ; Lysosomes/metabolism ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Models, Biological ; Multiprotein Complexes/metabolism ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Phagosomes/metabolism ; Qa-SNARE Proteins/metabolism ; SNARE Proteins/metabolism
    Chemical Substances Mitochondrial Proteins ; Multiprotein Complexes ; Qa-SNARE Proteins ; SNARE Proteins
    Language English
    Publishing date 2016-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201607024
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  8. Article ; Online: Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.

    Maruzs, Tamás / Feil-Börcsök, Dalma / Lakatos, Enikő / Juhász, Gábor / Blastyák, András / Hargitai, Dávid / Jean, Steve / Lőrincz, Péter / Juhász, Gábor

    Molecular biology of the cell

    2023  Volume 34, Issue 9, Page(s) ar87

    Abstract: Proper balance of exocytosis and endocytosis is important for the maintenance of plasma membrane lipid and protein homeostasis. This is especially critical in human podocytes and the podocyte- ... ...

    Abstract Proper balance of exocytosis and endocytosis is important for the maintenance of plasma membrane lipid and protein homeostasis. This is especially critical in human podocytes and the podocyte-like
    MeSH term(s) Animals ; Humans ; Drosophila Proteins/metabolism ; Sorting Nexins/metabolism ; Diaphragm/metabolism ; Ultrafiltration ; Drosophila/metabolism ; rab GTP-Binding Proteins/metabolism ; Endocytosis ; Endosomes/metabolism
    Chemical Substances Drosophila Proteins ; Sorting Nexins ; rab GTP-Binding Proteins (EC 3.6.5.2) ; Rab11 protein, Drosophila (EC 3.6.1.-)
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E22-09-0421
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    Zs.MO 410: Show issues

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  9. Article: A comparative analysis of fruit fly and human glutamate dehydrogenases in

    Vedelek, Viktor / Vedelek, Balázs / Lőrincz, Péter / Juhász, Gábor / Sinka, Rita

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1281487

    Abstract: Glutamate dehydrogenases are enzymes that take part in both amino acid and energy metabolism. Their role is clear in many biological processes, from neuronal function to cancer development. The putative testis- ... ...

    Abstract Glutamate dehydrogenases are enzymes that take part in both amino acid and energy metabolism. Their role is clear in many biological processes, from neuronal function to cancer development. The putative testis-specific
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1281487
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  10. Article: Reversible binding of divalent cations to

    Sebők-Nagy, Krisztina / Blastyák, András / Juhász, Gábor / Páli, Tibor

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1195010

    Abstract: ... ...

    Abstract Ductins
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1195010
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