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  1. AU="Julià Blanco"
  2. AU=Pardee Arthur B
  3. AU="Moossy, John J"
  4. AU="Ledger, Elizabeth V"
  5. AU="Abichandani, Deepa"
  6. AU="Piccinelli, Fabio"
  7. AU="Malinova, Tsveta S"
  8. AU="Harwood, Janet"
  9. AU=Buscombe John R
  10. AU=Meyer-Rusenberg Birthe
  11. AU="Jiang, Weiyan"
  12. AU="Mills, W"
  13. AU="Pintó, Rosa M."
  14. AU="Voisin, Tiphaine"
  15. AU="Takahashi, Hiromi"
  16. AU="Lin, Johnny"
  17. AU="Lee, Yu-Ru"
  18. AU="Safrankova, J."
  19. AU="Lanting, Linda L"
  20. AU=Koushik Nikhil S
  21. AU="Culhane, John"
  22. AU="Chippada, Appa Rao"
  23. AU="Hiroki Sato" AU="Hiroki Sato"
  24. AU="Al-Amer Eshraq"
  25. AU="Thanacoody, Ruben"
  26. AU="Lin, Chi-Wei"
  27. AU="Chidambaram, Vignesh"

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  1. Artikel ; Online: Gisèle Sapiro, La sociología de la literatura

    María Julia Blanco

    Prismas, Vol 21, Iss

    2017  Band 1

    Abstract: Gisèle Sapiro, La sociología de la literatura, Buenos Aires, Fondo de Cultura Económica, 2016 (traducción de Laura Fólica), 168 ... ...

    Abstract Gisèle Sapiro, La sociología de la literatura, Buenos Aires, Fondo de Cultura Económica, 2016 (traducción de Laura Fólica), 168 páginas
    Schlagwörter Social Sciences ; H ; Social sciences (General) ; H1-99
    Sprache Spanisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag Universidad Nacional de Quilmes
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Leandro de Sagastizábal y Alejandra Giuliani, Un editor argentino

    María Julia Blanco

    Prismas, Vol 19, Iss

    Arturo Peña Lillo

    2015  Band 1

    Abstract: Leandro de Sagastizábal y Alejandra Giuliani, Un editor argentino: Arturo Peña Lillo, Buenos Aires, Eudeba, 2014, 176 ... ...

    Abstract Leandro de Sagastizábal y Alejandra Giuliani, Un editor argentino: Arturo Peña Lillo, Buenos Aires, Eudeba, 2014, 176 páginas
    Schlagwörter Social Sciences ; H ; Social sciences (General) ; H1-99
    Sprache Spanisch
    Erscheinungsdatum 2015-06-01T00:00:00Z
    Verlag Universidad Nacional de Quilmes
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Predicting Antibody Neutralization Efficacy in Hypermutated Epitopes Using Monte Carlo Simulations

    Pep Amengual-Rigo / Jorge Carrillo / Julià Blanco / Victor Guallar

    Polymers, Vol 12, Iss 2392, p

    2020  Band 2392

    Abstract: Human Immunodeficiency Virus 1 (HIV-1) evades adaptive immunity by means of its extremely high mutation rate, which allows the HIV envelope glycoprotein to continuously escape from the action of antibodies. However, some broadly neutralizing antibodies ( ... ...

    Abstract Human Immunodeficiency Virus 1 (HIV-1) evades adaptive immunity by means of its extremely high mutation rate, which allows the HIV envelope glycoprotein to continuously escape from the action of antibodies. However, some broadly neutralizing antibodies (bNAbs) targeting specific viral regions show the ability to block the infectivity of a large number of viral variants. The discovery of these antibodies opens new avenues in anti-HIV therapy; however, they are still suboptimal tools as their amplitude of action ranges between 50% and 90% of viral variants. In this context, being able to discriminate between sensitive and resistant strains to an antibody would be of great interest for the design of optimal clinical antibody treatments and to engineer potent bNAbs for clinical use. Here, we describe a hierarchical procedure to predict the antibody neutralization efficacy of multiple viral isolates to three well-known anti-CD4bs bNAbs: VRC01, NIH45-46 and 3BNC117. Our method consists of simulating the three-dimensional binding process between the gp120 and the antibody by using Protein Energy Landscape Exploration (PELE), a Monte Carlo stochastic approach. Our results clearly indicate that the binding profiles of sensitive and resistant strains to a bNAb behave differently, showing the latter’s weaker binding profiles, that can be exploited for predicting antibody neutralization efficacy in hypermutated HIV-1 strains.
    Schlagwörter HIV-1 ; computational modelling ; Monte Carlo simulations ; antibody binding efficacy ; CD4bs antibodies ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: HIV-1 trans -Infection Mediated by DCs

    Daniel Perez-Zsolt / Dàlia Raïch-Regué / Jordana Muñoz-Basagoiti / Carmen Aguilar-Gurrieri / Bonaventura Clotet / Julià Blanco / Nuria Izquierdo-Useros

    Pathogens, Vol 11, Iss 39, p

    The Tip of the Iceberg of Cell-to-Cell Viral Transmission

    2022  Band 39

    Abstract: HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 ... ...

    Abstract HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting cells that initiate antiviral immune responses, but are also the cells with highest capacity to transfer HIV-1. This mechanism, known as trans -infection, relies on the capacity of DCs to capture HIV-1 particles via lectin receptors such as the sialic acid-binding I-type lectin Siglec-1/CD169. The discovery of the molecular interaction of Siglec-1 with sialylated lipids exposed on HIV-1 membranes has enlightened how this receptor can bind to several enveloped viruses. The outcome of these interactions can either mount effective immune responses, boost the productive infection of DCs and favour innate sensing, or fuel viral transmission via trans -infection. Here we review these scenarios focusing on HIV-1 and other enveloped viruses such as Ebola virus or SARS-CoV-2.
    Schlagwörter DC ; trans -infection ; HIV-1 ; Ebola virus ; SARS-CoV-2 ; Medicine ; R
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

    Ana Barajas / Pep Amengual-Rigo / Anna Pons-Grífols / Raquel Ortiz / Oriol Gracia Carmona / Victor Urrea / Nuria de la Iglesia / Juan Blanco-Heredia / Carla Anjos-Souza / Ismael Varela / Benjamin Trinité / Ferran Tarrés-Freixas / Carla Rovirosa / Rosalba Lepore / Miguel Vázquez / Leticia de Mattos-Arruda / Alfonso Valencia / Bonaventura Clotet / Carmen Aguilar-Gurrieri /
    Victor Guallar / Jorge Carrillo / Julià Blanco

    Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-

    2024  Band 14

    Abstract: Abstract Background Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens has evolved with the use ... ...

    Abstract Abstract Background Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens has evolved with the use of next-generation sequencing technologies and bioinformatic tools in tumor genomics. However, in-silico strategies for selecting immunogenic neoantigens still have very low accuracy rates, since they mainly focus on predicting peptide binding to Major Histocompatibility Complex (MHC) molecules, which is key but not the sole determinant for immunogenicity. Moreover, the therapeutic potential of neoantigen-based vaccines may be enhanced using an optimal delivery platform that elicits robust de novo immune responses. Methods We developed a novel neoantigen selection pipeline based on existing software combined with a novel prediction method, the Neoantigen Optimization Algorithm (NOAH), which takes into account structural features of the peptide/MHC-I interaction, as well as the interaction between the peptide/MHC-I complex and the TCR, in its prediction strategy. Moreover, to maximize neoantigens’ therapeutic potential, neoantigen-based vaccines should be manufactured in an optimal delivery platform that elicits robust de novo immune responses and bypasses central and peripheral tolerance. Results We generated a highly immunogenic vaccine platform based on engineered HIV-1 Gag-based Virus-Like Particles (VLPs) expressing a high copy number of each in silico selected neoantigen. We tested different neoantigen-loaded VLPs (neoVLPs) in a B16-F10 melanoma mouse model to evaluate their capability to generate new immunogenic specificities. NeoVLPs were used in in vivo immunogenicity and tumor challenge experiments. Conclusions Our results indicate the relevance of incorporating other immunogenic determinants beyond the binding of neoantigens to MHC-I. Thus, neoVLPs loaded with neoantigens enhancing the interaction with the TCR can promote the generation of de novo ...
    Schlagwörter Neoantigen ; Cancer vaccine ; Virus-like particle ; Immunotherapy ; T cell response ; Medicine ; R
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Revisión rápida de los efectos de la variación de la temperatura y la humedad en la morbilidad y mortalidad por Covid-19

    Magali Hurtado-Díaz / Julio Cruz de la Cruz / Julia Blanco-Muñoz / Rosa Aurora Azamar-Arizmendi / Horacio Riojas-Rodríguez

    Salud Pública de México, Vol 63, Iss 1, ene-feb, Pp 120-

    2020  Band 125

    Abstract: Objetivo. Resumir y analizar la evidencia de la asociación entre Covid-19 y factores climáticos. Material y métodos. Se utilizó la metodología de revisiones rápidas de Cochrane. Se buscaron artículos publicados del 1 de enero al 27 de abril de 2020 en ... ...

    Abstract Objetivo. Resumir y analizar la evidencia de la asociación entre Covid-19 y factores climáticos. Material y métodos. Se utilizó la metodología de revisiones rápidas de Cochrane. Se buscaron artículos publicados del 1 de enero al 27 de abril de 2020 en una base de datos académica y preprints. Los títulos y resúmenes fueron revisados por dos investigadores y los textos completos por cinco investigadores. Resultados. De 354 artículos identificados, 26 cumplieron los criterios de elegibilidad establecidos. De éstos, 20 observaron una asociación inversa. Al evaluar su calidad, nueve calificaron con validez moderada, porque si bien ajustaron por covariables en el análisis, son estudios ecológicos. Conclusiones. A pesar de la homogeneidad de resultados, los factores climáticos explican un porcentaje pequeño de la variación de Covid-19. Son necesarios estudios con periodo de análisis más largo que capten tendencia y estacionalidad e incluyan factores de riesgo individuales.
    Schlagwörter revisión rápida ; temperatura ; humedad ; covid-19 ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Instituto Nacional de Salud Pública
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Clinical and Neuropsychological Correlates of Prefrailty Syndrome

    Laura Lorenzo-López / Julia Blanco-Fandiño / Nuria Cibeira / Ana Buján / Rocío López-López / Ana Maseda / José Carlos Millán-Calenti

    Frontiers in Medicine, Vol

    2020  Band 7

    Abstract: Physical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive neuropsychological evaluation, and to ... ...

    Abstract Physical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive neuropsychological evaluation, and to examine the association between specific frailty criteria and clinical and neuropsychological scores. Participants completed a comprehensive standardized neuropsychological evaluation (covering cognitive domains such as memory, executive functions, language and attention), and frailty assessment. Frailty was assessed according to biological criteria: unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. The sample comprised 60 dementia-free community-dwelling adults, aged 65 years or older (range 65–89 years; 60.0% women). Forty-two participants were classified as robust (no frailty criteria present), and 18 as prefrail (1 or 2 frailty criteria present). We explored neurocognitive differences between the groups and examined the association between specific criteria of frailty phenotype and clinical and neuropsychological outcomes with bivariate tests and multivariate models. Prefrail participants showed poorer cognitive performance than non-frail participants in both memory and non-memory cognitive domains. However, delayed episodic memory was the only cognitive subdomain that remained significant after controlling for age, gender, and educational level. Gait speed was significantly associated with general cognitive performance, immediate memory, and processing speed, while grip strength was associated with visual episodic memory and visuoconstructive abilities. Both gait speed and grip strength were negatively associated with depressive scores. Our results suggest that prefrailty is associated with cognitive dysfunction. The fact that specific cognitive domains may be susceptible to subclinical states of physical frailty may have important clinical implications. Indeed, early detection of specific cognitive dysfunctions may allow ...
    Schlagwörter aging ; prefrailty ; neuropsychologial assessment ; gait speed ; grip strength ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells.

    Judith Grau-Expósito / David Perea / Marina Suppi / Núria Massana / Ander Vergara / Maria José Soler / Benjamin Trinite / Julià Blanco / Javier García-Pérez / José Alcamí / Anna Serrano-Mollar / Joel Rosado / Vicenç Falcó / Meritxell Genescà / Maria J Buzon

    PLoS Pathogens, Vol 18, Iss 1, p e

    2022  Band 1010171

    Abstract: The development of physiological models that reproduce SARS-CoV-2 infection in primary human cells will be instrumental to identify host-pathogen interactions and potential therapeutics. Here, using cell suspensions directly from primary human lung ... ...

    Abstract The development of physiological models that reproduce SARS-CoV-2 infection in primary human cells will be instrumental to identify host-pathogen interactions and potential therapeutics. Here, using cell suspensions directly from primary human lung tissues (HLT), we have developed a rapid platform for the identification of viral targets and the expression of viral entry factors, as well as for the screening of viral entry inhibitors and anti-inflammatory compounds. The direct use of HLT cells, without long-term cell culture and in vitro differentiation approaches, preserves main immune and structural cell populations, including the most susceptible cell targets for SARS-CoV-2; alveolar type II (AT-II) cells, while maintaining the expression of proteins involved in viral infection, such as ACE2, TMPRSS2, CD147 and AXL. Further, antiviral testing of 39 drug candidates reveals a highly reproducible method, suitable for different SARS-CoV-2 variants, and provides the identification of new compounds missed by conventional systems, such as VeroE6. Using this method, we also show that interferons do not modulate ACE2 expression, and that stimulation of local inflammatory responses can be modulated by different compounds with antiviral activity. Overall, we present a relevant and rapid method for the study of SARS-CoV-2.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Glucocorticoids’ treatment impairs the medium-term immunogenic response to SARS-CoV-2 mRNA vaccines in Systemic Lupus Erythematosus patients

    Silvia Garcia-Cirera / Joan Calvet / Antoni Berenguer-Llergo / Edwards Pradenas / Silvia Marfil / Marta Massanella / Lourdes Mateu / Benjamin Trinité / Maria Llop / Marta Arévalo / Carlos Galisteo / Cristóbal Orellana / Rafael Gómez / María Nieves Gómez-Gerique / Inma Carmona / Bonaventura Clotet / Julià Blanco / Jordi Gratacós

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Abstract Limited data exists on SARS-CoV-2 sustained-response to vaccine in patients with rheumatic diseases. This study aims to evaluate neutralizing antibodies (nAB) induced by SARS-CoV-2 vaccine after 3 to 6 months from administration in Systemic ... ...

    Abstract Abstract Limited data exists on SARS-CoV-2 sustained-response to vaccine in patients with rheumatic diseases. This study aims to evaluate neutralizing antibodies (nAB) induced by SARS-CoV-2 vaccine after 3 to 6 months from administration in Systemic Lupus Erythematosus (SLE) patients, as a surrogate of sustained-immunological response. This cross-sectional study compared nAB titre of 39 SLE patients and 37 Healthy individuals with no previous SARS-CoV-2 infection, who had all received a complete regimen of a mRNA SARS-CoV-2 vaccine within the last 3 to 6 months. We included four lines of SLE treatment including Not-treated, Hydroxychloroquine, immunosuppressive drugs and biological therapy. Glucocorticoids were allowed in all groups. Healthy and Not-treated individuals showed the highest levels of nAB. Treated patients presented lower nAB titres compared to Healthy: a 73% decrease for First-Line patients, 56% for Second-Line treatment and 72% for Third-Line. A multivariate analysis pointed to Glucocorticoids as the most associated factor with declining nAB levels (75% decrease) in treated SLE. Furthermore, a significant reduction in nAB titres was observed for Rituximab-users compared to Healthy subjects (89% decrease). Medium-term response of SLE patients to SARS-CoV-2 mRNA vaccines is negatively impacted in Glucocorticoids and Rituximab users. These findings might help to inform recommendations in vaccination protocols for SLE patients.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Impact of hybrid immunity booster vaccination and Omicron breakthrough infection on SARS-CoV-2 VOCs cross-neutralization

    Edwards Pradenas / Silvia Marfil / Víctor Urrea / Macedonia Trigueros / Tetyana Pidkova / Anna Pons-Grífols / Raquel Ortiz / Carla Rovirosa / Ferran Tarrés-Freixas / Carmen Aguilar-Gurrieri / Ruth Toledo / Anna Chamorro / Marc Noguera-Julian / Lourdes Mateu / Ignacio Blanco / Eulàlia Grau / Marta Massanella / Jorge Carrillo / Bonaventura Clotet /
    Benjamin Trinité / Julià Blanco

    iScience, Vol 26, Iss 4, Pp 106457- (2023)

    2023  

    Abstract: Summary: The elicitation of cross-variant neutralizing antibodies against SARS-CoV-2 represents a major goal for current COVID-19 vaccine strategies. Additionally, natural infection may also contribute to broaden neutralizing responses. To assess the ... ...

    Abstract Summary: The elicitation of cross-variant neutralizing antibodies against SARS-CoV-2 represents a major goal for current COVID-19 vaccine strategies. Additionally, natural infection may also contribute to broaden neutralizing responses. To assess the contribution of vaccines and natural infection, we cross-sectionally analyzed plasma neutralization titers of six groups of individuals, organized according to the number of vaccines they received and their SARS-CoV-2 infection history. Two doses of vaccine had a limited capacity to generate cross-neutralizing antibodies against Omicron variants of concern (VOCs) in uninfected individuals, but efficiently synergized with previous natural immunization in convalescent individuals. In contrast, booster dose had a critical impact on broadening the cross-neutralizing response in uninfected individuals, to level similar to hybrid immunity, while still improving cross-neutralizing responses in convalescent individuals. Omicron breakthrough infection improved cross-neutralization of Omicron subvariants in non-previously infected vaccinated individuals. Therefore, ancestral Spike-based immunization, via infection or vaccination, contributes to broaden SARS-CoV-2 humoral immunity.
    Schlagwörter Biochemistry ; Immune response ; Microbiology ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Elsevier
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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