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Article ; Online: Immunophenotypic markers for the evaluation of minimal/measurable residual disease in acute megakaryoblastic leukemia.

Pinto, Carina Maria / Bertolucci, Camila Marques / Severino, Alef Rafael / Dos Santos Tosi, Juliana Fernanda / Ikoma-Colturato, Maura R V

Hematology, transfusion and cell therapy

2023

Abstract: Acute megakaryoblastic leukemia is characterized by heterogeneous biology and clinical behavior. Immunophenotypic characteristics include the expression of megakaryocytic differentiation markers (e.g. CD41, CD42a, CD42b, CD61) associated with immaturity ... ...

Abstract	Acute megakaryoblastic leukemia is characterized by heterogeneous biology and clinical behavior. Immunophenotypic characteristics include the expression of megakaryocytic differentiation markers (e.g. CD41, CD42a, CD42b, CD61) associated with immaturity markers (CD34, CD117, HLA-DR) and myeloid markers (e.g. CD13, CD33) and even with lymphoid cross-lineage markers (e.g. CD7, CD56). Although the diagnostic immunophenotype has already been well described, given the rarity of the disease, its immunophenotypic heterogeneity and post-therapeutic instability, there is no consensus on the combination of monoclonal markers to detect minimal/measurable residual disease (MRD). Currently, MRD is an important tool for assessing treatment efficacy and prognostic risk. In this study, we evaluated the immunophenotypic profile of MRD in a retrospective cohort of patients diagnosed with acute megakaryoblastic leukemia, to identify which markers, positive or negative, were more stable after treatment and which could be useful for MRD evaluation. The expression profile of each marker was evaluated in sequential MRD samples. In conclusion, the markers evaluated in this study can be combined in an MRD immunophenotypic panel to investigate for megakaryoblastic leukemia. Although this study is retrospective and some data are missing, the information obtained may contribute to prospective studies to validate more specific strategies in the detection of MRD in acute megakaryoblastic leukemia.
Language	English
Publishing date	2023-11-17
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.09.2364
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of Intrinsic Capacity Domains as a Screening Tool in Public Health

Livia Maria do Nascimento / Thainá Gabriele Camargo da Cruz / Juliana Fernanda de Lima e Silva / Letícia Prado Silva / Beatriz Bigatão Inácio / Carolina Masumi Oki Sadamitsu / Marcos Eduardo Scheicher

International Journal of Environmental Research and Public Health, Vol 20, Iss 4227, p

2023 Volume 4227

Abstract: The World Health Organization (WHO) created the concept of Integrated Care for Older People and one of its constructs is intrinsic capacity (IC). The study aimed to carry out a screening with the tools designated by the WHO to assess the IC domains and ... ...

Abstract	The World Health Organization (WHO) created the concept of Integrated Care for Older People and one of its constructs is intrinsic capacity (IC). The study aimed to carry out a screening with the tools designated by the WHO to assess the IC domains and whether they can be used as indicators for decision-making on integrated care for older people based on risk categorization. The interaction between the risk category and the domain scores was verified. One hundred and sixty three (163) community-dwelling older people of both genders were evaluated. Domains assessed: cognitive, psychological, vitality, locomotion, and sensory. Scores indicating a low, moderate and high risk were assigned to each domain. For all domains, there were individuals in all risk groups. Effect of risk on the domains: cognitive [χ 2 (2) = 134.042; p < 0.001], psychological [χ 2 (2) = 92.865; p < 0.001], vitality [χ 2 (2) = 129.564; p < 0.001], locomotion [χ 2 (2) = 144.101; p < 0.001], and sensory [χ 2 (2) = 129.037; p < 0.001]. Scores of the CI domains were affected by the risk category. There were individuals in all risk groups, demonstrating the importance of screening as a public health strategy, making it possible to know which risk category each elderly person belongs to and thus develop strategies in the short-, medium- and long-term.
Keywords	intrinsic capacity ; aging ; screening tests ; Medicine ; R
Subject code	333
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of β-blocker therapy on exercise oscillatory ventilation in reduced ejection fraction heart failure patients: A case series study.

Belli-Marin, Juliana Fernanda Calhado / Bocchi, Edimar Alcides / Ayub-Ferreira, Silvia / Junior, Nelson Carvas / Guimarães, Guilherme Veiga

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 152, Page(s) 113106

Abstract: Background: Exercise oscillatory ventilation (EOV) is an abnormal breathing pattern that occurs in ~20% of patients with heart failure (HF) and is associated with poor prognosis and exercise intolerance. β-blockers (βb) are prescribed for most HF ... ...

Abstract	Background: Exercise oscillatory ventilation (EOV) is an abnormal breathing pattern that occurs in ~20% of patients with heart failure (HF) and is associated with poor prognosis and exercise intolerance. β-blockers (βb) are prescribed for most HF patients; however, their effect on EOV remains unclear. We evaluated the effect of βb on EOV in HF patients with reduced ejection fraction (HFrEF). Methods: Fifteen patients diagnosed with HF, ejection fraction < 45%, aged from 18 to 65 years, were included before starting βb therapy. Patients underwent clinical evaluation, cardiopulmonary exercise testing, echocardiography, laboratory exams (norepinephrine levels, B type natriuretic peptide) at baseline and after βb therapy optimized for six months. Presence of exercise oscillatory breathing was determined by two experienced observers who were blinded to the moment of the test (pre or post). Results: Fifteen patients (1 female), aged 49.5 ± 2.5 years, with HFrEF, NYHA I-III enrolled in the study. The etiologies of the HFrEF were idiopathic (n = 8) and hypertensive (n = 7). LVEF increased after βb therapy from 25.9 ± 2.5% to 33 ± 2.6%, P = 0.02; peak VO Conclusion: In patients with HF, medical therapy with βb can reverse EOV. This may explain why these patients experience symptom improvement after βb therapy.
MeSH term(s)	Exercise Test ; Female ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Oxygen Consumption ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-06-03
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113106
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Article ; Online: Clinical validation of a 10-color flow cytometry panel to detect measurable residual disease in acute myeloid leukemia.

Ikoma-Colturato, Maura R V / Severino, Alef Rafael / Dos Santos Tosi, Juliana Fernanda / Bertolucci, Camila Marques / Cuoco, Yeda Midori Nakamura / de Mattos, Ederson Roberto / Colturato, Iago / Silva, Fernanda Barbieri Rodrigues / de Souza, Mair Pedro / Simione, Anderson João / Colturato, Vergilio Antonio Rensi

Leukemia research

2024 Volume 140, Page(s) 107482

Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Letter
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2024.107482
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Article ; Online: Use of Intrinsic Capacity Domains as a Screening Tool in Public Health.

Nascimento, Livia Maria do / Cruz, Thainá Gabriele Camargo da / Silva, Juliana Fernanda de Lima E / Silva, Letícia Prado / Inácio, Beatriz Bigatão / Sadamitsu, Carolina Masumi Oki / Scheicher, Marcos Eduardo

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract	The World Health Organization (WHO) created the concept of Integrated Care for Older People and one of its constructs is intrinsic capacity (IC). The study aimed to carry out a screening with the tools designated by the WHO to assess the IC domains and whether they can be used as indicators for decision-making on integrated care for older people based on risk categorization. The interaction between the risk category and the domain scores was verified. One hundred and sixty three (163) community-dwelling older people of both genders were evaluated. Domains assessed: cognitive, psychological, vitality, locomotion, and sensory. Scores indicating a low, moderate and high risk were assigned to each domain. For all domains, there were individuals in all risk groups. Effect of risk on the domains: cognitive [χ
MeSH term(s)	Humans ; Male ; Female ; Aged ; Public Health ; Independent Living ; Quality of Life ; Geriatric Assessment ; Risk Factors
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054227
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Article ; Online: Safety of the cardiopulmonary 6-minute walk test.

Guimarães, Guilherme Veiga / Carvalho, Vitor Oliveira / Belli, Juliana Fernanda

Arquivos brasileiros de cardiologia

2011 Volume 95, Issue 5, Page(s) 671

MeSH term(s)	Exercise Test/adverse effects ; Heart Transplantation ; Humans ; Preoperative Care/adverse effects ; Reproducibility of Results ; Walking
Language	Spanish
Publishing date	2011-01-06
Publishing country	Brazil
Document type	Comment ; Letter
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.1590/s0066-782x2010001500017
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Article ; Online: AVANÇOS E RECUOS DO MERCOSUL

João Batista Pamplona / Juliana Fernanda Alves da Fonseca

Cadernos Prolam/USP, Vol 7, Iss

UM BALANÇO RECENTE DOS SEUS OBJETIVOS E RESULTADOS

2008 Volume 13

Abstract: Este artigo objetiva avaliar em que medida os objetivos estabelecidos na constituição e evolução do Mercosul foram cumpridos, para dessa forma identificar ou não a existência de uma crise no esquema de integração regional. Quatro fases são identificadas ... ...

Abstract	Este artigo objetiva avaliar em que medida os objetivos estabelecidos na constituição e evolução do Mercosul foram cumpridos, para dessa forma identificar ou não a existência de uma crise no esquema de integração regional. Quatro fases são identificadas na trajetória do Mercosul. A primeira (1991 a 1994) foi um período de avanços e consolidação do Bloco. A segunda fase (1995 a 1998) foi marcada por uma agenda mais complexa e conflituosa, mas a implementação da Tarifa Externa Comum representou avanço na integração comercial. Na terceira (1999 a 2002), deflagrou-se na região uma conjuntura de recessão e incerteza, com o comércio intrabloco sofrendo forte redução. Foi uma fase de crise para a integração. A quarta fase (2003 a 2007) foi caracterizada por forte crescimento do comércio intrabloco e a existência de conflitos que refletiram muito mais a intensificação do processo de integração do que sua crise.
Keywords	América do Sul ; Relações Internacionais ; Integração Econômica ; History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2008-12-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A segurança do teste de caminhada de seis minutos

Guilherme Veiga Guimarães / Vitor Oliveira Carvalho / Juliana Fernanda Belli

Arquivos Brasileiros de Cardiologia, Vol 95, Iss 5, Pp 671-

2010 Volume 671

Keywords	Seguridad ; caminata ; ejercicio ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	Sociedade Brasileira de Cardiologia - SBC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Behavior of central and peripheral chemoreflexes in heart failure.

Guimarães, Guilherme Veiga / Belli, Juliana Fernanda Canhadas / Bacal, Fernando / Bocchi, Edimar Alcides

Arquivos brasileiros de cardiologia

2011 Volume 96, Issue 2, Page(s) 161–167

Abstract: The heart failure (HF) syndrome can be defined as the final pathway of any type of heart disease. The sympatho-inhibitory cardiovascular reflexes, such as the arterial baroreceptor reflex, are significantly decreased in HF. Patients with HF present ... ...

Abstract	The heart failure (HF) syndrome can be defined as the final pathway of any type of heart disease. The sympatho-inhibitory cardiovascular reflexes, such as the arterial baroreceptor reflex, are significantly decreased in HF. Patients with HF present higher ventilation for a certain workload when compared with normal individuals. This fact generates low ventilatory efficiency and is related to higher ventilation associated with the carbon dioxide production, which is a predictor of bad prognosis, in addition to being a limiting factor for the practice of exercises. There is evidence that the autonomic imbalance contributes to the pathogenesis and the progression of heart failure. The chemoreflexes are the main mechanisms of control and regulation of the ventilatory responses to the changes in concentrations of arterial oxygen and carbon dioxide. The chemoreflex activation causes an increase in the sympathetic activity, heart rate, arterial pressure and minute volume. However, the increase in the minute volume and the arterial pressure, due to negative feedback, cause inhibition of the sympathetic response at the chemoreflex activation. In spite of the functional alterations of the reflexes, their behavior in normal and pathological conditions, especially their contribution to the sympathoexcitatory state observed in HF has not been broadly studied. Therefore, this review aims at integrating the knowledge on central and peripheral chemoreflexes in HF syndrome, as well as clarifying the influence of the heart failure drug therapy on the chemoreflexes.
MeSH term(s)	Baroreflex/drug effects ; Baroreflex/physiology ; Chemoreceptor Cells/metabolism ; Chemoreceptor Cells/physiology ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/physiology
Language	Spanish
Publishing date	2011-01-07
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.1590/s0066-782x2011005000003
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Article ; Online: Ergoreflex activity in heart failure.

Belli, Juliana Fernanda Canhadas / Bacal, Fernando / Bocchi, Edimar Alcides / Guimarães, Guilherme Veiga

Arquivos brasileiros de cardiologia

2011 Volume 97, Issue 2, Page(s) 171–178

Abstract: A large body of evidence has suggested the existence of a reflex network that becomes hyperactive secondary to musculoskeletal alterations that occur in heart failure (HF) syndrome. Together with sympathoinhibitory cardiovascular reflexes, suppressed in ... ...

Abstract	A large body of evidence has suggested the existence of a reflex network that becomes hyperactive secondary to musculoskeletal alterations that occur in heart failure (HF) syndrome. Together with sympathoinhibitory cardiovascular reflexes, suppressed in the presence of the syndrome, heart failure can contribute to physical exercise intolerance. The hyperactivation of signals originated from receptors located in skeletal muscles (mechanoreceptors - metaboreceptors) is a recently proposed hypothesis to explain the origin of fatigue and dyspnea symptoms in HF. In HF, other alterations in the reflex control system, which are not mutually exclusive, contribute to dyspnea. The inappropriate stimulation of the arterial baroreceptors, with the consequent lack of inhibition of the muscle metaboreflex and carotid chemoreflex unloading and the increase in the renal vasoconstriction with angiotensin II release can also be considered. Although the functional alterations of the reflexes were used independently to illustrate the sympathetic excitation observed in HF, the interaction between these reflexes under normal and pathological conditions, especially its contribution to the sympathoexcitatory state found in HF, has not been broadly investigated. Therefore, questions about a possible association between the muscle receptors (mechano and metaboreceptors) in the genesis of the ergoreflex exacerbation, observed in HF, remain. Thus, the objective of this review was to integrate the knowledge on the mechano and metaboreflex (ergoreflex) in HF syndrome, as well as to clarify the influence of HF drug therapy on the ergoreflex.
MeSH term(s)	Chemoreceptor Cells/drug effects ; Chemoreceptor Cells/physiology ; Exercise Tolerance/physiology ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Muscle Fatigue/physiology ; Muscle, Skeletal/innervation ; Oxygen Consumption/physiology ; Pressoreceptors/drug effects ; Pressoreceptors/physiopathology ; Reflex/physiology ; Syndrome
Language	Spanish
Publishing date	2011-06-10
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.1590/s0066-782x2011005000072
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