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  1. AU="Julie Clarke"
  2. AU=Wybraniec Maciej T.
  3. AU="Meuwese, Christiaan L"
  4. AU="Al-Hattab, Eyad S"
  5. AU="Eduardo Díaz Cano"
  6. AU=Nrxe Dorte Schou AU=Nrxe Dorte Schou
  7. AU="Kende, Anna"
  8. AU="Nattmann, Phillip"
  9. AU="Assefa, Samuel"
  10. AU="McMahon, Teagan"
  11. AU="Radojičić Zoran"
  12. AU="Muwu Xu"
  13. AU="Sacchi, Diana"
  14. AU="Romain Berraud-Pache"
  15. AU=Johnson Paul D R
  16. AU="Sarigül-Yildirim, Figen"
  17. AU=Chang Yu-Ting
  18. AU="Xu, Ivana"
  19. AU="Linde, Lauren"
  20. AU="Brewer, Katlyn K"
  21. AU="Prow, Natalie A"
  22. AU=Venkatesan Arun
  23. AU="Russcher, H."
  24. AU="Chambino, Beatriz"
  25. AU="L'Abbé, Ericka N."
  26. AU=Moore Stephen M.
  27. AU="Gabriel, Berteșteanu Șerban Vifor" AU="Gabriel, Berteșteanu Șerban Vifor"
  28. AU="Gallo, Eduado"
  29. AU="Yurchenko, Maria"
  30. AU="Fabiana Giber"
  31. AU="Rajakumar, Gopal Suseela" AU="Rajakumar, Gopal Suseela"
  32. AU="Gutierrez, M. N"
  33. AU=Zhuo Jia L.
  34. AU=Miller Mark A
  35. AU="Dąbrowski, Leszek"
  36. AU="Röltgen, Katharina"
  37. AU="Tumanov, Alexey"
  38. AU="Berns, Lauren"
  39. AU="Elena A. Deshevaya"
  40. AU=Zhang Ruijuan
  41. AU="Mueller, Luke"
  42. AU=Barzon Luisa
  43. AU="Karunakaran, Denuja"
  44. AU="Figueroa-Rivera, Ivonne M"
  45. AU="Blackburn, Fran"
  46. AU="Lee, Hee-Kyung"
  47. AU=Kinoshita J H
  48. AU="Hernesniemi, Juha"
  49. AU="Evans, Matthew L"
  50. AU=Payne Thomas
  51. AU="Brown, Dexter"

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  1. Artikel ; Online: Missing

    Julie Clarke

    Journal of Social Inclusion, Vol 5, Iss 2, Pp 114-

    Persons and Politics

    2014  Band 117

    Schlagwörter Social history and conditions. Social problems. Social reform ; HN1-995 ; Social Sciences ; H
    Sprache Englisch
    Erscheinungsdatum 2014-12-01T00:00:00Z
    Verlag Griffith university E Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Involving Patients and Clinicians in the Design of Wireframes for Cancer Medicines Electronic Patient Reported Outcome Measures in Clinical Care

    Emma Dunlop / Aimee Ferguson / Tanja Mueller / Kelly Baillie / Jennifer Laskey / Julie Clarke / Amanj Kurdi / Ann Wales / Thomas Connolly / Marion Bennie

    JMIR Formative Research, Vol 7, p e

    Mixed Methods Study

    2023  Band 48296

    Abstract: BackgroundCancer treatment is a key component of health care systems, and the increasing number of cancer medicines is expanding the treatment landscape. However, evidence of the impact on patients has been focused more on chemotherapy toxicity and ... ...

    Abstract BackgroundCancer treatment is a key component of health care systems, and the increasing number of cancer medicines is expanding the treatment landscape. However, evidence of the impact on patients has been focused more on chemotherapy toxicity and symptom control and less on the effect of cancer medicines more broadly on patients’ lives. Evolving electronic patient-reported outcome measures (ePROMs) presents the opportunity to secure early engagement of patients and clinicians in shaping the collection of quality-of-life metrics and presenting these data to better support the patient-clinician decision-making process. ObjectiveThe aim of this study was to obtain initial feedback from patients and clinicians on the wireframes of a digital solution (patient app and clinician dashboard) for the collection and use of cancer medicines ePROMs. MethodsWe adopted a 2-stage, mixed methods approach. Stage 1 (March to June 2019) consisted of interviews and focus groups with cancer clinicians and patients with cancer to explore the face validity of the wireframes, informed by the technology acceptance model constructs (perceived ease of use, perceived usefulness, and behavioral intention to use). In stage 2 (October 2019 to February 2020), the revised wireframes were assessed through web-based, adapted technology acceptance model questionnaires. Qualitative data (stage 1) underwent a framework analysis, and descriptive statistics were performed on quantitative data (stage 2). Clinicians and patients with cancer were recruited from NHS Greater Glasgow & Clyde, the largest health board in Scotland. ResultsA total of 14 clinicians and 19 patients participated in a combination of stage 1 interviews and focus groups. Clinicians and patients indicated that the wireframes of a patient app and clinician dashboard for the collection of cancer medicines ePROMs would be easy to use and could focus discussions, and they would be receptive to using such tools in the future. In stage 1, clinicians raised the potential impact on ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 616 ; 170
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag JMIR Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Correction to

    Laura Williams / Charlotte L. Hall / Susan Brown / Boliang Guo / Marilyn James / Matilde Franceschini / Julie Clarke / Kim Selby / Hena Vijayan / Neeta Kulkarni / Nikki Brown / Kapil Sayal / Chris Hollis / Madeleine J. Groom

    Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-

    Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial

    2021  Band 1

    Abstract: An amendment to this paper has been published and can be accessed via the original article. ...

    Abstract An amendment to this paper has been published and can be accessed via the original article.
    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Optimising medication management in children and young people with ADHD using a computerised test (QbTest)

    Laura Williams / Charlotte L. Hall / Sue Brown / Boliang Guo / Marilyn James / Matilde Franceschini / Julie Clarke / Kim Selby / Hena Vijayan / Neeta Kulkarni / Nikki Brown / Kapil Sayal / Chris Hollis / Madeleine J. Groom

    Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-

    a feasibility randomised controlled trial

    2021  Band 18

    Abstract: Abstract Background Medication for attention deficit hyperactivity disorder (ADHD) should be closely monitored to ensure optimisation. There is growing interest in using computerised assessments of ADHD symptoms to support medication monitoring. The aim ... ...

    Abstract Abstract Background Medication for attention deficit hyperactivity disorder (ADHD) should be closely monitored to ensure optimisation. There is growing interest in using computerised assessments of ADHD symptoms to support medication monitoring. The aim of this study was to assess the feasibility and acceptability of a randomised controlled trial (RCT) to evaluate the efficacy of one such computerised assessment, the Quantified Behavior (Qb) Test, as part of medication management for ADHD. Methods This feasibility multi-site RCT conducted in child and adolescent mental health and community paediatric settings recruited participants aged 6–15 years diagnosed with ADHD starting stimulant medication. Participants were randomised into one of two arms: experimental (QbTest protocol) where participants completed a QbTest at baseline and two follow-up QbTests on medication (2–4 weeks and 8–10 weeks later) and control where participants received treatment as usual, including at least two follow-up consultations. Measures of parent, teacher, and clinician-rated symptoms and global functioning were completed at each time point. Clinicians recorded treatment decision-making and health economic measures were obtained. Data were analysed using multi-level modelling and participants (children and parents) and clinicians were interviewed about their experiences, resulting data were thematically analysed. Results Forty-four children and young people were randomised. Completion of study outcome measures by care-givers and teachers ranged from 52 to 78% at baseline to 47–65% at follow-up. Participants reported the questionnaires to be useful to complete. SNAP-IV inattention scores showed greater reduction in the intervention than the control group (− 5.85, 95% CI − 10.33, − 1.36,). Engagement with the intervention ranged from 100% at baseline, to 78% follow-up 1 and 57% follow-up 2. However, only 37% of QbTests were conducted in the correct time period. Interview data highlighted that the objectivity of the QbTest was appreciated ...
    Schlagwörter Attention deficit hyperactivity disorder (ADHD) ; QbTest ; Medication management ; Acceptability ; Feasibility ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)

    Man Lee Yuen / Ling Zhuang / Emma M. Rath / Takun Yu / Ben Johnson / Kadir Harun Sarun / Yiwei Wang / Steven Kao / Anthony Linton / Candice Julie Clarke / Brian C. McCaughan / Ken Takahashi / Kenneth Lee / Yuen Yee Cheng

    International Journal of Molecular Sciences, Vol 22, Iss 10225, p

    2021  Band 10225

    Abstract: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective treatment options. Focal adhesion kinase (FAK) inhibitors have been shown to efficiently suppress MPM cell growth initially, with limited utility in the current ... ...

    Abstract Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective treatment options. Focal adhesion kinase (FAK) inhibitors have been shown to efficiently suppress MPM cell growth initially, with limited utility in the current clinical setting. In this study, we utilised a large collection of MPM cell lines and MPM tissue samples to study the role of E-cadherin (CDH1) and microRNA on the efficacy of FAK inhibitors in MPM. The immunohistochemistry (IHC) results showed that the majority of MPM FFPE samples exhibited either the absence of, or very low, E-cadherin protein expression in MPM tissue. We showed that MPM cells with high CDH1 mRNA levels exhibited resistance to the FAK inhibitor PND-1186. In summary, MPM cells that did not express CDH1 mRNA were sensitive to PND-1186, and MPM cells that retained CDH1 mRNA were resistant. A cell cycle analysis showed that PND-1186 induced cell cycle disruption by inducing the G2/M arrest of MPM cells. A protein−protein interaction study showed that EGFR is linked to the FAK pathway, and a target scan of the microRNAs revealed that microRNAs (miR-17, miR221, miR-222, miR137, and miR148) interact with EGFR 3′UTR. Transfection of MPM cells with these microRNAs sensitised the CHD1-expressing FAK-inhibitor-resistant MPM cells to the FAK inhibitor.
    Schlagwörter E-cadherin ; FAK inhibitor ; microRNA ; malignant pleural mesothelioma (MPM) ; drug resistant ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Correction to

    Samantha O. Sterndale / Danica J. Evans / Josephine P. Mansfield / Julie Clarke / Shafi Sahibzada / Sam Abraham / Mark O’Dea / David W. Miller / Jae Cheol Kim / John R. Pluske

    Journal of Animal Science and Biotechnology, Vol 10, Iss 1, Pp 1-

    Effect of mucin 4 allele on susceptibility to experimental infection with enterotoxigenic F4 Escherichia coli in pigs fed experimental diets

    2019  Band 1

    Abstract: In the original publication of this article [1] the corresponding author wants to change “At the XbaI polymorphism, the C allele is associated with resistance and the G allele [6]. It should be read as “At the XbaI polymorphism, the C allele is ... ...

    Abstract In the original publication of this article [1] the corresponding author wants to change “At the XbaI polymorphism, the C allele is associated with resistance and the G allele [6]. It should be read as “At the XbaI polymorphism, the C allele is associated with resistance and the G allele to susceptibility [6].”
    Schlagwörter Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Consensus workshops on the development of an ADHD medication management protocol using QbTest

    Charlotte L. Hall / Susan Brown / Marilyn James / Jennifer L. Martin / Nikki Brown / Kim Selby / Julie Clarke / Laura Williams / Kapil Sayal / Chris Hollis / Madeleine J. Groom

    BMC Medical Research Methodology, Vol 19, Iss 1, Pp 1-

    developing a clinical trial protocol with multidisciplinary stakeholders

    2019  Band 13

    Abstract: Abstract Background The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their ... ...

    Abstract Abstract Background The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity such as participant recruitment and retention, identifying a meaningful change, and non-adherence to the protocol. For clinical RCTs, involving patients and clinicians in protocol design provides the opportunity to develop research protocols that are meaningful to their target audience and may help overcome some of the inherent threats in conducting RCTs. However, the majority of protocols do not describe the methodology underpinning their development, limiting the amount of learned experience shared between research groups. Method With the purpose of reporting a collaborative approach towards developing a protocol, we present the findings from three sequential workshops that were conducted with the aim of developing a protocol to investigate the feasibility of adding a computerised test of attention, impulsivity and activity (QbTest) to medication management of children and young people with Attention deficit hyperactivity disorder (ADHD). Based on previous qualitative interviews with clinicians and families, each workshop prioritised topics for focused discussion. Information from the workshops was fed back to the participants for reflection in advance of the next workshop. Results The workshops involved 21 multi-disciplinary ADHD experts, including clinicians, patient and public involvement (PPI) members, parents of young people with ADHD and researchers. The consensus workshops addressed key research issues such as: the most relevant outcome measures/ resource drivers; methods and time points for data collection; and the clinical protocol for utilising the QbTest, including when best to use this within the medication management process. The resulting protocol details a feasibility RCT design describing these factors. Conclusion Protocols which are ...
    Schlagwörter Protocol development ; Expert workshop ; QbTest ; Medication ; Management ; Titration ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Effect of mucin 4 allele on susceptibility to experimental infection with enterotoxigenic F4 Escherichia coli in pigs fed experimental diets

    Samantha O. Sterndale / Danica J. Evans / Josephine P. Mansfield / Julie Clarke / Shafi Sahibzada / Sam Abraham / Mark O’Dea / David W. Miller / Jae Cheol Kim / John R. Pluske

    Journal of Animal Science and Biotechnology, Vol 10, Iss 1, Pp 1-

    2019  Band 9

    Abstract: Abstract Background This study investigated the validity of the DNA-marker based test to determine susceptibility to ETEC-F4 diarrhoea by comparing the results of two DNA sequencing techniques in weaner pigs following experimental infection with F4 ... ...

    Abstract Abstract Background This study investigated the validity of the DNA-marker based test to determine susceptibility to ETEC-F4 diarrhoea by comparing the results of two DNA sequencing techniques in weaner pigs following experimental infection with F4 enterotoxigenic Escherichia coli (ETEC-F4). The effects of diet and genetic susceptibility were assessed by measuring the incidence of piglet post-weaning diarrhoea (PWD), faecal E. coli shedding and the diarrhoea index. Results A DNA marker-based test targeting the mucin 4 gene (MUC4) that encodes F4 fimbria receptor identified pigs as either fully susceptible (SS), partially or mildly susceptible (SR), and resistant (RR) to developing ETEC-F4 diarrhoea. To further analyse this, DNA sequencing was undertaken, and a significantly higher proportion of C nucleotides was observed for RR and SR at the XbaI cleavage site genotypes when compared to SS. However, no significant difference was found between SR and RR genotypes. Therefore, results obtained from Sanger sequencing retrospectively allocated pigs into a resistant genotype (MUC4–), in the case of a C nucleotide, and a susceptible genotype (MUC4+), in the case of a G nucleotide, at the single nucleotide polymorphism site. A total of 72 weaner pigs (age ~ 21 days), weighing 6.1 ± 1.2 kg (mean ± SEM), were fed 3 different diets: (i) positive control (PC) group supplemented with 3 g/kg zinc oxide (ZnO), (ii) negative control (NC) group (no ZnO or HAMSA), and (iii) a diet containing a 50 g/kg high-amylose maize starch product (HAMSA) esterified with acetate. At days five and six after weaning, all pigs were orally infected with ETEC (serotype O149:F4; toxins LT1, ST1, ST2 and EAST). The percentage of pigs that developed diarrhoea following infection was higher (P = 0.05) in MUC4+ pigs compared to MUC4– pigs (50% vs. 26.8%, respectively). Furthermore, pigs fed ZnO had less ETEC-F4 diarrhoea (P = 0.009) than pigs fed other diets, however faecal shedding of ETEC was similar (P > 0.05) between diets. Conclusion These ...
    Schlagwörter Diarrhoea ; Escherichia coli ; F4 ; MUC4 ; Weaner pigs ; Zinc oxide ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2019-07-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Genomic Deletion of BAP1 and CDKN2A Are Useful Markers for Quality Control of Malignant Pleural Mesothelioma (MPM) Primary Cultures

    Kadir Harun Sarun / Kenneth Lee / Marissa Williams / Casey Maree Wright / Candice Julie Clarke / Ngan Ching Cheng / Ken Takahashi / Yuen Yee Cheng

    International Journal of Molecular Sciences, Vol 19, Iss 10, p

    2018  Band 3056

    Abstract: Malignant pleural mesothelioma (MPM) is a deadly cancer that is caused by asbestos exposure and that has limited treatment options. The current standard of MPM diagnosis requires the testing of multiple immunohistochemical (IHC) markers on formalin-fixed ...

    Abstract Malignant pleural mesothelioma (MPM) is a deadly cancer that is caused by asbestos exposure and that has limited treatment options. The current standard of MPM diagnosis requires the testing of multiple immunohistochemical (IHC) markers on formalin-fixed paraffin-embedded tissue to differentiate MPM from other lung malignancies. To date, no single biomarker exists for definitive diagnosis of MPM due to the lack of specificity and sensitivity; therefore, there is ongoing research and development in order to identify alternative biomarkers for this purpose. In this study, we utilized primary MPM cell lines and tested the expression of clinically used biomarker panels, including CK8/18, Calretinin, CK 5/6, CD141, HBME-1, WT-1, D2-40, EMA, CEA, TAG72, BG8, CD15, TTF-1, BAP1, and Ber-Ep4. The genomic alteration of CDNK2A and BAP1 is common in MPM and has potential diagnostic value. Changes in CDKN2A and BAP1 genomic expression were confirmed in MPM samples in the current study using Fluorescence In situ Hybridization (FISH) analysis or copy number variation (CNV) analysis with digital droplet PCR (ddPCR). To determine whether MPM tissue and cell lines were comparable in terms of molecular alterations, IHC marker expression was analyzed in both sample types. The percentage of MPM biomarker levels showed variation between original tissue and matched cells established in culture. Genomic deletions of BAP1 and CDKN2A, however, showed consistent levels between the two. The data from this study suggest that genomic deletion analysis may provide more accurate biomarker options for MPM diagnosis.
    Schlagwörter mesothelioma ; biomarker ; FISH ; genomic deletion ; copy number variation ; ddPCR ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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