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Article ; Online: The protective effects of calycosin against diabetic nephropathy through Sirt3/SOD2/caspase-3 signaling pathway

Ruifeng Jiang / Jun Ge / Juanru Zhao / Xiaohui Yan

Arabian Journal of Chemistry, Vol 14, Iss 3, Pp 102988- (2021)

In vitro

2021

Abstract: One of the important mechanisms of diabetic nephropathy is the production of reactive oxidative species (ROS). Calycosin as an herbal compound with many medicinal uses from ancient times is the major active component of Radix astragali. In the present ... ...

Abstract	One of the important mechanisms of diabetic nephropathy is the production of reactive oxidative species (ROS). Calycosin as an herbal compound with many medicinal uses from ancient times is the major active component of Radix astragali. In the present study, the protective effects of calycosin against high glucose (HG)-induced oxidative stress in renal tubular epithelial cells (NRK-52E) were assessed by different cellular assays. It was indicated that calycosin recovered the viability and membrane damage of cells exposed to HG through reduction in the ROS generation, and lipid peroxidation. Moreover, it was seen that calycosin resulted in a significant increase in the expression of (sirtuin-3) SIRT-3/superoxide dismutase2 (SOD2) at both mRNA and protein levels in HG‐treated cells. Also, it was determined that calysocin increased the activity of SOD2 and SIRT-3 and reduced the activity of caspase-3 in NRK-52E incubated with HG and these antioxidative and antiapoptotic effects were inhibited in the presence of 3-TYP. These results demonstrated that calycosin can prevent the cytotoxicity induced by HG in NRK-52E through regulation of SIRT-3/SOD2 pathway and it could be used as a potential candidate in the treatment of diabetic nephropathy.
Keywords	Calycosin ; Diabetic nephropathy ; High glucose ; Renal tubular epithelial cells ; Oxidative stress ; Antioxidant ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DESIGN AND EXPERIMENT OF SELF-PROPELLED SYSTEM FOR PADDY FIELD WEEDER BASED ON THE INTERACTION MECHANISM OF WHEEL-SOIL

Liang Tian / Chengmao Cao / Kuan Qin / Jun Ge / Liangfei Fang

Engenharia Agrícola, Vol 42, Iss

2022 Volume 1

Abstract: ABSTRACT Aiming at the low mechanization of paddy field weeding and lack of dedicated agricultural machinery for paddy field weeding in China, a self-propelled system of paddy field weeding machine was designed. The overall structure and working ... ...

Abstract	ABSTRACT Aiming at the low mechanization of paddy field weeding and lack of dedicated agricultural machinery for paddy field weeding in China, a self-propelled system of paddy field weeding machine was designed. The overall structure and working principle of self-propelled system were illustrated and analyzed. The interaction mechanism of wheel-soil during weeding was analyzed. The wheel-soil interaction model was established, then, wheel traction and surface flatness were selected as the evaluation indexes for discrete element simulation experiment. The steering performance, stability, and over ridge ability of self-propelled system were analyzed, and field experiment was carried out. The simulation experiment results show that the wheel traction is approximately 600 N and the surface flatness is less than 30 mm. The field experiment results show that the minimum turning radius of the prototype is 2,050 mm in paddy, overturning limit angle of the prototype is 36°, and maximum height over the ridge is 400 mm. The speed range of the weeding machine on the road and weeding operation was 0~16.20 km/h and the 0~5.40 km/h respectively. The weeder can meet the speed demands of weeding operation. The study results can provide reference for research and development of paddy field operation machinery.
Keywords	paddy field weeder ; interaction mechanism of wheel-soil ; self-propelled system ; field experiment ; Agriculture (General) ; S1-972
Subject code	670
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Sociedade Brasileira de Engenharia Agrícola
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Species pool size and rainfall account for the relationship between biodiversity and biomass production in natural forests of China

Jia‐Jia Liu / Kevin S. Burgess / Xue‐Jun Ge

Ecology and Evolution, Vol 12, Iss 4, Pp n/a-n/a (2022)

2022

Abstract: Abstract The strength of biodiversity–biomass production relationships increases with increasing environmental stress and time. However, we know little about the effects of abiotic (e.g., climate) and biotic (e.g., species pool and community composition) ...

Abstract	Abstract The strength of biodiversity–biomass production relationships increases with increasing environmental stress and time. However, we know little about the effects of abiotic (e.g., climate) and biotic (e.g., species pool and community composition) factors on this trend. Whether variation in biomass production is best explained by phylogenetic diversity metrics or traditional measures of species richness also remains elusive. We compiled estimates of community composition and biomass production for tree species in 111 permanent quadrats spanning three natural forests (tropical, subtropical, and temperate) in China. Based on ~10 years of data, we compared temperature, rainfall, species pool size, and community composition in each forest each year. We estimated species richness and phylogenetic diversity in each quadrat each year; the latter metric was based on the sum of branch lengths of a phylogeny that connects species in each quadrat each year. Using generalized linear mixed‐effect models, we found that top‐ranked models included the interaction between forest and biodiversity and the interaction between forest and year for both biodiversity metrics. Variation in biomass production was best explained by phylogenetic diversity; biomass production generally increased with phylogenetic diversity, and the relationship was stronger in subtropical and temperate forests. Increasing species pool size, temperature, and rainfall and decreasing inter‐quadrat dissimilarity range shifted the relationship between biomass production and phylogenetic diversity from positive to neutral. When considered alone, species pool size had the strongest influence on biomass production, while species pool size, rainfall, and their interaction with phylogenetic diversity constituted the top‐ranked model. Our study highlights the importance of species pool size and rainfall on the relationship between phylogenetic diversity and biomass production in natural forest ecosystems.
Keywords	Ailao Mountain ; Changbai Mountain ; community phylogenetic dissimilarity ; environmental stress ; species richness ; temperature ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Greening vegetation cools mean and extreme near-surface air temperature in China

Yipeng Cao / Weidong Guo / Jun Ge / Yu Liu / Chaorong Chen / Xing Luo / Limei Yang

Environmental Research Letters, Vol 19, Iss 1, p

2023 Volume 014040

Abstract: Satellite observations have shown evident vegetation greening in China during the last two decades. The biophysical effects of vegetation changes on near-surface air temperature (SAT) remain elusive because prior studies focused on the effects on land ... ...

Abstract	Satellite observations have shown evident vegetation greening in China during the last two decades. The biophysical effects of vegetation changes on near-surface air temperature (SAT) remain elusive because prior studies focused on the effects on land surface temperature (LST). SAT is more relevant to climate mitigation and adaptation, as this temperature is experienced by humans. Here, we provide the first observational evidence of the greening effects on SAT and SAT extremes in China during 2001–2018 using the ‘space-for-time’ method. The results show a negative SAT sensitivity to greening (–0.35 °C m ^2 m ^–2 ) over China and a cooling effect of −0.08 °C on SAT driven by vegetation greening during the study period. Such a cooling effect is stronger on high SAT extremes, particularly over arid/semiarid areas, where greening could bring an additional cooling of −0.04 °C on the hottest days. An attribution analysis suggests that the main driving factor for the cooling effect of greening is the evapotranspiration change for arid/semiarid regions and the aerodynamic resistance change for humid regions. This study reveals a considerable climate benefit of greening on SAT, which is more concerned with natural and human system health than the greening effects on LST.
Keywords	vegetation greenness ; biophysical impacts ; near-surface air temperature ; high temperature extremes ; East Asia ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Profiling the chemistry- and confinement-controlled sensing capability of an octameric aerolysin-like protein.

Wu, Xue-Yuan / Jiang, Jie / Li, Jun-Ge / Li, Meng-Yin / Long, Yi-Tao

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 39, Page(s) 5850–5853

Abstract: Octameric Aep1 was employed, for the first time to the best of our knowledge, as a nanopore to expand applications. After investigating the optimized conditions of Aep1 for single-channel recording, the sensing features were characterized. Cyclic and ... ...

Abstract	Octameric Aep1 was employed, for the first time to the best of our knowledge, as a nanopore to expand applications. After investigating the optimized conditions of Aep1 for single-channel recording, the sensing features were characterized. Cyclic and linear molecules of varying sizes and charges were employed to probe the radius and chemical environment of the pore, providing deep insights for expected future endeavors at predicting the structure of octameric Aep1. γ-CD showed unique suitability as an 8-subunit adapter in octameric Aep1, enabling the discrimination of β-nicotinamide mononucleotide.
MeSH term(s)	Proteins ; Bacterial Toxins/chemistry ; Pore Forming Cytotoxic Proteins/chemistry ; Nanopores
Chemical Substances	aerolysin (53126-24-2) ; Proteins ; Bacterial Toxins ; Pore Forming Cytotoxic Proteins
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc01114c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Isolated systolic hypertension and insulin resistance assessment tools in young and middle-aged Chinese men with normal fasting glucose

Qing Gu / Jian Meng / Xue Hu / Jun Ge / Sui Jun Wang / Xing Zhen Liu

Scientific Reports, Vol 12, Iss 1, Pp 1-

a cross-sectional study

2022 Volume 9

Abstract: Abstract The vital role of insulin resistance (IR) in the pathogenesis of isolated systolic hypertension (ISH) has been expounded at the theoretical level. However, research on the correlation between some specific IR indicators and ISH is still rare, ... ...

Abstract	Abstract The vital role of insulin resistance (IR) in the pathogenesis of isolated systolic hypertension (ISH) has been expounded at the theoretical level. However, research on the correlation between some specific IR indicators and ISH is still rare, especially at different glycemic statuses. We conducted this study to explore the association between three IR indicators and ISH among young and middle-aged adults with normal fasting plasma glucose (NFG). This large cross-sectional study included 8246 young and middle-aged men with NFG and diastolic blood pressure < 90 mmHg. The homeostasis model assessment for IR (HOMA-IR) index, triglyceride glucose (TyG) index, and the metabolic score for IR (METS-IR) were calculated with the corresponding formula. The proportions of ISH among young and middle-aged men were 6.7% and 4.4%, respectively. After fully adjusting, only HOMA-IR rather than TyG and METS-IR was significantly associated with ISH. Moreover, fully adjusted smooth curve fitting showed that the association between HOMA-IR and ISH were approximately linear in both two age groups (P for non-linearity were 0.047 and 0.430 in young and middle-aged men, respectively). Among young and middle-aged men with NFG, using HOMA-IR instead of noninsulin-dependent IR indicators may have advantages in the hierarchical management of ISH. Further longitudinal research may be needed to determine their potential causal relationship.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Increased Tibetan Plateau vortex activities under 2 °C warming compared to 1.5 °C warming

Zhi-Qiang Lin / Wei-Dong Guo / Jun Ge / Run-Qi Wu / Jun Du

Advances in Climate Change Research, Vol 12, Iss 3, Pp 322-

NCAR CESM low-warming experiments

2021 Volume 332

Abstract: The Tibetan Plateau vortices (TPVs) are the major rain-producing systems over the Tibetan Plateau (TP). The activities of TPVs are closely related to TP's water source, which supplies fresh water to millions of people in Asia. Projection of the TPVs can ... ...

Abstract	The Tibetan Plateau vortices (TPVs) are the major rain-producing systems over the Tibetan Plateau (TP). The activities of TPVs are closely related to TP's water source, which supplies fresh water to millions of people in Asia. Projection of the TPVs can increase understanding about the future of water supply in Asia under global warming. In this study, the possible activities of TPVs under 1.5 °C and 2 °C warming scenarios above the pre-industrial level are evaluated through the NCAR CESM (Community Earth System Model) Low-warming (CESM-LW) Experiments. The results show that the CESM-LW well reproduces the spatio-temporal characteristics of TPVs in the historical run from 1985 to 2000. The CESM-LW suggests TPVs in warm season (May–September) increase by 15% due to the additional 0.5 °C warming by the end of this century (2071–2100). It implies the greater importance of TPVs to the precipitation over the TP in the future. The changes of TPVs are closely related to the large-scale circulations adjustments. The additional 0.5 °C warming strengthens the temperature difference between the TP and its surrounding areas, which results in an enhanced convergence near the TP's surface and divergence in the upper troposphere by about −0.1 × 10−6 and 0.22 × 10−6 s−1, respectively. The assessment of future TPVs provides a synoptic dynamic perspective on the climate change of precipitation and water resources.
Keywords	Tibetan Plateau vortex ; 2 °C and 1.5 °C warming ; Paris agreement ; Tibet plateau heating ; Low-warming scenarios ; Meteorology. Climatology ; QC851-999 ; Social sciences (General) ; H1-99
Subject code	550
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: "Cold" colorectal cancer faces a bottleneck in immunotherapy.

Liu, Jia-Liang / Yang, Ming / Bai, Jun-Ge / Liu, Zheng / Wang, Xi-Shan

World journal of gastrointestinal oncology

2022 Volume 15, Issue 2, Page(s) 240–250

Abstract: The advent of immunotherapy and the development of immune checkpoint inhibitors (ICIs) are changing the way we think about cancer treatment. ICIs have shown clinical benefits in a variety of tumor types, and ICI-based immunotherapy has shown effective ... ...

Abstract	The advent of immunotherapy and the development of immune checkpoint inhibitors (ICIs) are changing the way we think about cancer treatment. ICIs have shown clinical benefits in a variety of tumor types, and ICI-based immunotherapy has shown effective clinical outcomes in immunologically "hot" tumors. However, for immunologically "cold" tumors such as colorectal cancer (CRC), only a limited number of patients are currently benefiting from ICIs due to limitations such as individual differences and low response rates. In this review, we discuss the classification and differences between hot and cold CRC and the current status of research on cold CRC, and summarize the treatment strategies and challenges of immunotherapy for cold CRC. We also explain the mechanism, biology, and role of immunotherapy for cold CRC, which will help clarify the future development of immunotherapy for cold CRC and discovery of more emerging strategies for the treatment of cold CRC.
Language	English
Publishing date	2022-08-18
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v15.i2.240
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Article ; Online: Safety and accuracy of transbronchial lung cryobiopsy in diagnosing desquamative interstitial pneumonia.

Zhao, Jun-Ge / Zhou, Guo-Wu / Zhao, Ling / Liu, Min / Ren, Yan-Hong / Dai, Hua-Ping

The clinical respiratory journal

2022 Volume 16, Issue 4, Page(s) 309–316

Abstract: Introduction: Transbronchial lung cryobiopsy (TBLC) is a new technique to obtain specimens for diagnosis of interstitial lung disease (ILD) in recent years. The objective of this study is to evaluate the safety and the diagnostic accuracy of TBLC in ... ...

Abstract	Introduction: Transbronchial lung cryobiopsy (TBLC) is a new technique to obtain specimens for diagnosis of interstitial lung disease (ILD) in recent years. The objective of this study is to evaluate the safety and the diagnostic accuracy of TBLC in patients of desquamative interstitial pneumonia (DIP). Methods: In this study twelve patients confirmed with DIP were selected from January 2019 to December 2020 at the department of pulmonary and critical care medicine in China-Japan Friendship Hospital. All cases underwent TBLC in a hybrid cone beam CT (CBCT) operation room with a single general anesthesia. The definitive diagnosis was made by a multidisciplinary team that involved clinicians, radiologists and pathologists. This study analyzed the biopsy sample surface areas, main complications and the consistency between TBLC pathology and multidisciplinary discussion (MDD) diagnosis for DIP. Results: An average of 3.1 ± 1.1 specimens were obtained per patient. The mean surface area of the specimen was 23.7 ± 6.1 mm Conclusion: TBLC can obtain sufficient samples for the pathological diagnosis of DIP, which has high security and accuracy in experienced specialist centers.
MeSH term(s)	Biopsy/adverse effects ; Biopsy/methods ; Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Hemorrhage ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/pathology ; Pneumothorax/diagnosis ; Pneumothorax/pathology
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13483
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Article ; Online: Electrically Evoked Auditory Brainstem Responses in Children Fitted with Hearing Aids Prior to Cochlear Implantation.

Chen, Li / Zhang, Jun-Ge / Zhu, Han-Yu / Hou, Xiao-Yan / Tang, Zheng-Quan / Sun, Jing-Wu / Sun, Jia-Qiang / Guo, Xiao-Tao

Trends in hearing

2023 Volume 27, Page(s) 23312165221148846

Abstract: This study investigates the effect of hearing aid use on the peripheral auditory pathways in children with sensorineural hearing loss prior to cochlear implantation, as revealed by the electrically evoked auditory brainstem response (EABR). Forty ... ...

Abstract	This study investigates the effect of hearing aid use on the peripheral auditory pathways in children with sensorineural hearing loss prior to cochlear implantation, as revealed by the electrically evoked auditory brainstem response (EABR). Forty children with hearing aids were recruited. Half of them had normal inner ear structures and the other half had inner ear malformations (IEMs). The EABR was evoked by electrically stimulating the round window niche (RWN) and round window membrane (RWM) during the cochlear implantation operation. The onset age of hearing aid use was significantly correlated with the peak latencies, but not amplitudes, of the wave III (eIII) and wave V (eV). Higher EABR thresholds were found for RWN stimulation than for RWM stimulation and in the children with IEMs than in those without IEMs. Our study provides neurophysiological evidence that earlier use of hearing aids may ameliorate physiological functions of the peripheral auditory pathway in children with and without IEMs. The EABR evoked by the electrical stimulation at RWM is more sensitive compared with that at RWN for evaluating functions of the auditory conduction pathway.
MeSH term(s)	Child ; Humans ; Cochlear Implantation ; Hearing Aids ; Evoked Potentials, Auditory, Brain Stem/physiology ; Cochlear Implants ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/therapy ; Auditory Threshold/physiology
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2778755-2
ISSN	2331-2165 ; 2331-2165
ISSN (online)	2331-2165
ISSN	2331-2165
DOI	10.1177/23312165221148846
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