Artikel ; Online: Comparison of rocuronium-induced neuromuscular blockade in second trimester pregnant women and non-pregnant women.
International journal of obstetric anesthesia
2018 Band 34, Seite(n) 10–14
Abstract: Background: This study set out to compare the onset and duration of rocuronium-induced neuromuscular blockade in second trimester pregnant women and non-pregnant women receiving general anesthesia.: Methods: Forty-seven pregnant (Group P) and forty- ... ...
Abstract | Background: This study set out to compare the onset and duration of rocuronium-induced neuromuscular blockade in second trimester pregnant women and non-pregnant women receiving general anesthesia. Methods: Forty-seven pregnant (Group P) and forty-seven non-pregnant (Group C) women were enrolled. Anesthesia was induced with propofol 2.0 mg/kg and rocuronium 0.6 mg/kg, and neuromuscular blockade was assessed with an accelerometric sensor using train-of-four stimulation (TOF-Watch® SX). Tracheal intubation was performed at maximum depression of the first twitch (T1) and anesthesia was maintained with sevoflurane 1.5-2.5% and 50% oxygen in air. We recorded the times to maximum T1 depression and 5% and 25% T1 recovery, as well as the mean arterial pressure and heart rate at baseline, injection of rocuronium, intubation, and 5% and 25% T1 recovery. Results: The onset of rocuronium-induced neuromuscular blockade (time to maximum T1 depression) did not differ significantly between the groups. The duration (time to 25% T1 recovery) was significantly longer in Group P than in Group C (45.7 ± 12.9 min vs 40.6 ± 10.4 min, P <0.037). During the recovery period from the blockade, the mean arterial pressure was significantly lower in Group P than in Group C. Conclusion: Our data showed that the rocuronium-induced neuromuscular blockade did not significantly differ in onset but lasted significantly longer in second trimester pregnant women compared with non-pregnant women. |
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Mesh-Begriff(e) | Adult ; Androstanols ; Anesthesia Recovery Period ; Anesthesia, General ; Arterial Pressure/drug effects ; Female ; Heart Rate/drug effects ; Humans ; Intubation, Intratracheal ; Neuromuscular Blockade/methods ; Neuromuscular Nondepolarizing Agents ; Pregnancy ; Pregnancy Trimester, Second |
Chemische Substanzen | Androstanols ; Neuromuscular Nondepolarizing Agents ; rocuronium (WRE554RFEZ) |
Sprache | Englisch |
Erscheinungsdatum | 2018-03-05 |
Erscheinungsland | Netherlands |
Dokumenttyp | Comparative Study ; Journal Article |
ZDB-ID | 1086024-1 |
ISSN | 1532-3374 ; 0959-289X |
ISSN (online) | 1532-3374 |
ISSN | 0959-289X |
DOI | 10.1016/j.ijoa.2018.01.005 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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