LIVIVO - Search results -

Search results

Result 1 - 10 of total 250

Search options

Article ; Online: Health-Related Quality of Life and Psychologic Distress in Korean Kidney Transplant Recipients.

Kim, I-K / Bae, S H / Son, S / Kim, M S / Jun, S Y / Ju, M K

2016 Volume 48, Issue 3, Page(s) 855–857

Abstract: Background: Little is known about the extent to which transplant recipients face psychologic distress with the receipt of a transplanted organ. The purpose of this study was to investigate health-related quality of life (HRQoL) and psychologic distress ... ...

Abstract	Background: Little is known about the extent to which transplant recipients face psychologic distress with the receipt of a transplanted organ. The purpose of this study was to investigate health-related quality of life (HRQoL) and psychologic distress in 105 adults who had undergone kidney transplantation (KT). Methods: HRQoL was measured with the use of the Korean version of Medical Outcome Study Short Form 36 version 2, and psychologic distress with the use of the Transplant Effects Questionnaire (TEQ). Clinical and demographic data were collected from questionnaires. The data were collected from August 2014 to November 2014 at 2 medical centers in Korea. Results: Of the 105 patients, 53.3% were male and the overall mean age was 46.99 years. The mean score of each of the TEQ subscales ranged from 2.45 to 4.62. In the subscales of HRQoL, the mean score of physical component summary (PCS) was 50.23, and the mean score of mental component summary (MCS) was 46.19. MCS was negatively correlated with worry (P = .001) and guilt (P = .037) and positively correlated with adherence (P = .006) in the TEQ subscales, whereas there was no significant correlation between PCS and the TEQ subscales. Conclusions: The study indicates that mental HRQoL is correlated with psychologic distress. Therefore, to increase the HRQoL, continuous attention is needed in kidney transplant recipients who experience psychologic distress and adherence problem. In addition, further empirical studies should be conducted to explain the mechanisms underlying this relationship.
MeSH term(s)	Adult ; Female ; Humans ; Kidney Transplantation/psychology ; Male ; Middle Aged ; Quality of Life ; Republic of Korea ; Stress, Psychological/etiology ; Surveys and Questionnaires ; Transplant Recipients/psychology
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2015.12.084
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 835: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: GEANT4 Parameter Tuning Using Professor

Elvira, V. / Fields, L. / Genser, K. L. / Hatcher, R. / Ivanchenko, V. / Kelsey, M. / Koi, T. / Perdue, G. N. / Ribon, A. / Uzhinsky, V. / Wright, D. H. / Yarba, J. / Jun, S. Y.

2019

Abstract: The Geant4 toolkit is used extensively in high energy physics to simulate the passage of particles through matter and to predict effects such as detector efficiencies and smearing. Geant4 uses many underlying models to predict particle interaction ... ...

Abstract	The Geant4 toolkit is used extensively in high energy physics to simulate the passage of particles through matter and to predict effects such as detector efficiencies and smearing. Geant4 uses many underlying models to predict particle interaction kinematics, and uncertainty in these models leads to uncertainty in high energy physics measurements. The Geant4 collaboration recently made free parameters in some models accessible through partnership with Geant4 developers. We present a study of the impact of varying parameters in three Geant4 hadronic physics models on agreement with thin target datasets and describe fits to these datasets using the Professor model tuning framework. We find that varying parameters produces substantially better agreement with some datasets, but that more degrees of freedom are required for full agreement. This work is a first step towards a common framework for propagating uncertainties in Geant4 models to high energy physics measurements, and we outline future work required to complete that goal. Comment: 44 pages, 36 figures. Replaced with published version
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2019-10-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles.

Jun, S-Y / Ro, J Y / Kim, K-R

Histopathology

2003 Volume 43, Issue 1, Page(s) 17–25

Abstract: Aims: To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin-dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that ... ...

Abstract	Aims: To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin-dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that complete mole (CHM) with only the paternal genome would display reduced or nearly absent expression of p57kip2 compared to partial mole (PHM) having both paternal and maternal genomes. Methods and results: The immunohistochemical expression of p57kip2 protein was investigated using paraffin-embedded tissue sections in histologically unequivocal cases of CHM (n = 51), PHM (n = 7), invasive mole (n = 1), and hydropic miscarriage (n = 2), as well as in histologically undetermined cases (n = 9). In the histologically unequivocal complete and invasive moles, expression of p57kip2 was absent except for one case in which villous cytotrophoblast covering the villous stroma was positive (51/52) as well as villous stromal cells (51/52). In contrast, it was strongly and continuously expressed in both villous cytotrophoblast and stromal cells in all cases of PHM and hydropic miscarriage. Among the nine histologically undetermined cases, five cases showing p57kip2 immunopositivity and hyperploid DNA were classified as PHMs, two cases showing p57kip2 immunonegativity and hyperploidy as CHMs, and two cases with p57kip2 immunopositivity and diploid DNA as hydropic miscarriage and diploid PHM, respectively, upon review of the histopathological findings. Intermediate trophoblast forming trophoblastic columns or anchoring villi and extravillous trophoblast at the implantation site showed variable expression of p57kip2 in all gestational conditions. Maternal decidua showed diffuse and strong p57kip2 expression, whereas syncytiotrophoblast was completely negative in all cases regardless of the diagnosis. Conclusions: In summary, p57kip2 immunostaining results correlated well with morphological features of molar pregnancies and were helpful in determining histologically equivocal cases.
MeSH term(s)	Adolescent ; Adult ; Biomarkers, Tumor/metabolism ; Cyclin-Dependent Kinase Inhibitor p57 ; DNA, Neoplasm/analysis ; Diagnosis, Differential ; Female ; Flow Cytometry ; Genomic Imprinting ; Gestational Age ; Humans ; Hydatidiform Mole/classification ; Hydatidiform Mole/diagnosis ; Hydatidiform Mole/metabolism ; Immunoenzyme Techniques ; Middle Aged ; Nuclear Proteins/metabolism ; Ploidies ; Pregnancy ; Trophoblasts/metabolism ; Trophoblasts/pathology ; Uterine Neoplasms/classification ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/metabolism
Chemical Substances	Biomarkers, Tumor ; CDKN1C protein, human ; Cyclin-Dependent Kinase Inhibitor p57 ; DNA, Neoplasm ; Nuclear Proteins
Language	English
Publishing date	2003-06-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1046/j.1365-2559.2003.01667.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1328: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Increased expression of p63 and survivin in cholesteatomas.

Park, H R / Min, S K / Min, K / Jun, S Y / Seo, J / Kim, H J

Acta oto-laryngologica

2009 Volume 129, Issue 3, Page(s) 268–272

Abstract: Conclusion: This study showed increased expression of p63 and survivin in cholesteatoma. Our finding indicates a putative role of p63 and survivin in the development of certain cholesteatomas.: Objectives: Keratinocytes in cholesteatoma demonstrate ... ...

Abstract	Conclusion: This study showed increased expression of p63 and survivin in cholesteatoma. Our finding indicates a putative role of p63 and survivin in the development of certain cholesteatomas. Objectives: Keratinocytes in cholesteatoma demonstrate uncoordinated hyperproliferation, migration, and invasion properties. p63 is a p53 homologue and a marker expressed in replicating keratinocytes. Survivin is an inhibitor of apoptosis protein that is abundantly expressed in most solid and hematologic malignancies. The purpose of this study was to investigate the differential expression of p63 and survivin in human middle ear cholesteatoma epithelium. Materials and methods: The expression levels of p63 and survivin protein were examined by immunohistochemical analysis of 40 cholesteatomas and 5 skin tissues obtained from patients during ear surgery. Results: Expression of p63 protein was diffusely observed in entire samples of cholesteatoma, especially in acquired cholesteatoma, compared with the control group. Congenital cholesteatoma showed variable p63 reactivity in a basal cell-like pattern. Primary and recurrent cholesteatomas showed no significant difference in p63 expression. Survivin was detected in 31 of 40 cholesteatoma samples. Acquired cholesteatomas showed especially increased survivin expression compared with congenital cases. The expression of p63 was correlated with survivin expression.
MeSH term(s)	Case-Control Studies ; Cholesteatoma, Middle Ear/etiology ; Cholesteatoma, Middle Ear/metabolism ; Ear, Middle/metabolism ; Epithelium/metabolism ; Humans ; Immunohistochemistry ; Inhibitor of Apoptosis Proteins ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/metabolism
Chemical Substances	BIRC5 protein, human ; CKAP4 protein, human ; Inhibitor of Apoptosis Proteins ; Membrane Proteins ; Microtubule-Associated Proteins
Language	English
Publishing date	2009-03
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016480802251591
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul II Zs 105: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: An autopsy case of Adams-Oliver syndrome.

Jun, S Y / Khang, S K / Park, S H

Journal of Korean medical science

2000 Volume 15, Issue 4, Page(s) 482–484

Abstract: We report an autopsy case of a male fetus with Adams-Oliver syndrome. His mother was a healthy, 31-year-old woman and her family and past histories were unremarkable. Therapeutic termination was done at 28(+6) weeks gestational age due to oligohydramnios ...

Abstract	We report an autopsy case of a male fetus with Adams-Oliver syndrome. His mother was a healthy, 31-year-old woman and her family and past histories were unremarkable. Therapeutic termination was done at 28(+6) weeks gestational age due to oligohydramnios detected by antenatal ultrasonography. Chromosomal study revealed normal karyotype. On autopsy, characteristic transverse terminal defect of four extremities was found. Both feet were short and broad. All toes were rudimentary with no nails and fingers were irregularly short. On infantogram, all toe-bones were stubby and rudimentary. The middle and terminal phalanges of 2nd, 3rd & 5th fingers and the terminal phalange of 4th finger on the right hand were absent. The middle and terminal phalanges of 2nd & 5th fingers and terminal phalange of 3rd finger were defected on the left hand. His abnormalities were consistent with features of Adams-Oliver syndrome, which has not been reported in Korea.
MeSH term(s)	Abnormalities, Multiple/embryology ; Abnormalities, Multiple/pathology ; Abortion, Habitual ; Abortion, Therapeutic ; Adult ; Autopsy ; Female ; Fetal Diseases/pathology ; Foot Deformities, Congenital/diagnostic imaging ; Foot Deformities, Congenital/embryology ; Foot Deformities, Congenital/pathology ; Genes, Dominant ; Hand Deformities, Congenital/diagnostic imaging ; Hand Deformities, Congenital/embryology ; Hand Deformities, Congenital/pathology ; Humans ; Male ; Oligohydramnios ; Pregnancy ; Radiography ; Scalp/abnormalities ; Scalp/embryology ; Skin Abnormalities/embryology ; Skin Abnormalities/pathology ; Syndrome
Language	English
Publishing date	2000-08
Publishing country	Korea (South)
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	639262-3
ISSN	1011-8934
ISSN	1011-8934
DOI	10.3346/jkms.2000.15.4.482
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.B 3163: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Complete genome sequence of a newly isolated lytic bacteriophage, EFAP-1 of Enterococcus faecalis, and antibacterial activity of its endolysin EFAL-1.

Son, J S / Jun, S Y / Kim, E B / Park, J E / Paik, H R / Yoon, S J / Kang, S H / Choi, Y-J

Journal of applied microbiology

2010 Volume 108, Issue 5, Page(s) 1769–1779

Abstract: Aims: In this work, we aimed to identify an effective treatment of infections caused by Enterococcus spp. strains resistant to conventional antibiotics.: Methods and results: We report the isolation and characterization of a new lytic bacteriophage, ... ...

Abstract	Aims: In this work, we aimed to identify an effective treatment of infections caused by Enterococcus spp. strains resistant to conventional antibiotics. Methods and results: We report the isolation and characterization of a new lytic bacteriophage, designated bacteriophage EFAP-1, that is capable of lysing Enterococcus faecalis bacteria that exhibit resistance to multiple antibiotics. EFAP-1 has low sequence similarity to all known bacteriophages. Transmission electron microscopy confirmed that EFAP-1 belongs to the Siphoviridae family. A putative lytic protein of EFAP-1, endolysin EFAL-1, is encoded in ORF 2 and was expressed in Escherichia coli. Recombinant EFAL-1 had broad-spectrum lytic activity against several Gram-positive pathogens, including Ent. faecalis and Enterococcus faecium. Conclusions: The complete genome sequence of the newly isolated enterococcal lytic phage was analysed, and it was demonstrated that its recombinant endolysin had broad lytic activity against various Gram-positive pathogens. Significance and impact of the study: Bacteriophage EFAP-1 and its lytic protein, EFAL-1, can be utilized as potent antimicrobial agents against Enterococcus spp. strains resistant to conventional antibiotics in hospital infections and also as environmental disinfectants to control disease-causing Enterococcus spp. in dairy farms.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteriophages/classification ; Bacteriophages/genetics ; Bacteriophages/isolation & purification ; Bacteriophages/ultrastructure ; Endopeptidases/genetics ; Endopeptidases/isolation & purification ; Endopeptidases/pharmacology ; Enterococcus faecalis/drug effects ; Enterococcus faecalis/virology ; Genome, Viral ; Gram-Positive Bacteria/drug effects ; Molecular Sequence Data ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/pharmacology ; Siphoviridae/classification ; Siphoviridae/genetics ; Siphoviridae/isolation & purification ; Siphoviridae/ultrastructure ; Viral Proteins/genetics ; Viral Proteins/isolation & purification ; Viral Proteins/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Recombinant Proteins ; Viral Proteins ; Endopeptidases (EC 3.4.-) ; endolysin (EC 3.4.99.-)
Language	English
Publishing date	2010-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/j.1365-2672.2009.04576.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 259: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Complete genome sequence of a newly isolated lytic bacteriophage, EFAP-1 of Enterococcus faecalis, and antibacterial activity of its endolysin EFAL-1

Son, J.S / Jun, S.Y / Kim, E.B / Park, J.E / Paik, H.R / Yoon, S.J / Kang, S.H / Choi, Y.-J

Journal of applied microbiology. 2010 May, v. 108, no. 5

2010

Abstract: In this work, we aimed to identify an effective treatment of infections caused by Enterococcus spp. strains resistant to conventional antibiotics. We report the isolation and characterization of a new lytic bacteriophage, designated bacteriophage EFAP-1, ...

Abstract	In this work, we aimed to identify an effective treatment of infections caused by Enterococcus spp. strains resistant to conventional antibiotics. We report the isolation and characterization of a new lytic bacteriophage, designated bacteriophage EFAP-1, that is capable of lysing Enterococcus faecalis bacteria that exhibit resistance to multiple antibiotics. EFAP-1 has low sequence similarity to all known bacteriophages. Transmission electron microscopy confirmed that EFAP-1 belongs to the Siphoviridae family. A putative lytic protein of EFAP-1, endolysin EFAL-1, is encoded in ORF 2 and was expressed in Escherichia coli. Recombinant EFAL-1 had broad-spectrum lytic activity against several Gram-positive pathogens, including Ent. faecalis and Enterococcus faecium. The complete genome sequence of the newly isolated enterococcal lytic phage was analysed, and it was demonstrated that its recombinant endolysin had broad lytic activity against various Gram-positive pathogens. Bacteriophage EFAP-1 and its lytic protein, EFAL-1, can be utilized as potent antimicrobial agents against Enterococcus spp. strains resistant to conventional antibiotics in hospital infections and also as environmental disinfectants to control disease-causing Enterococcus spp. in dairy farms.
Keywords	Enterococcus faecalis ; Enterococcus
Language	English
Dates of publication	2010-05
Size	p. 1769-1779.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	1358023-1
ISSN	1364-5072
ISSN	1364-5072
DOI	10.1111/j.1365-2672.2009.04576.x
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 259: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Microbial quality assessment and pathogen inactivation by electron beam and gamma irradiation of commercial seed sprouts

Waje, C.K / Jun, S.Y / Lee, Y.K / Kim, B.N / Han, D.H / Jo, C / Kwon, J.H

Food control. 2009 Mar., v. 20, no. 3

2009

Keywords	food safety ; raw foods ; sprouts (food) ; seeds ; risk assessment ; food pathogens ; bacterial contamination ; coliform bacteria ; food analysis ; microbiological quality ; alfalfa ; broccoli ; radishes ; Listeria monocytogenes ; decontamination ; inactivation ; food irradiation ; gamma radiation ; dosage ; Salmonella typhimurium ; Bacillus cereus ; Escherichia coli
Language	English
Dates of publication	2009-03
Size	p. 200-204.
Document type	Article
ZDB-ID	1027805-9
ISSN	0956-7135
ISSN	0956-7135
DOI	10.1016/j.foodcont.2008.04.005
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 5255: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Stages at presentation, prognostic factors, and outcome of breast cancer in males.

Vetto, J / Jun, S Y / Paduch, D / Eppich, H / Shih, R / Padduch, D

American journal of surgery

1999 Volume 177, Issue 5, Page(s) 379–383

Abstract: Background: In order to support or refute conventional notions of breast cancer in males as a late-presenting disease associated with a worse prognosis than the same disease in females, we reviewed a recent, multi-institutional experience.: Methods: ... ...

Abstract	Background: In order to support or refute conventional notions of breast cancer in males as a late-presenting disease associated with a worse prognosis than the same disease in females, we reviewed a recent, multi-institutional experience. Methods: A case series from three area hospital system cancer data bases was reviewed. Demographics, pathology, stages at presentation, and treatment were determined from the data set and correlated with outcomes (recurrence/survival). Results: Fifty-four patients (mean age 64.5, SD = 12.8) were identified; half of the tumors were stage T0 or T1, 62% were node negative (N0), and 57% had an American Joint Committee on Cancer (AJCC) stage grouping of IIA or less. Eighty-five percent of tumors examined expressed hormone receptors. There were no local-only recurrences in the 50 cases resected for cure, including 5 cases of minimal breast cancer treated by lumpectomy only. Five- and 10-year overall disease-free survival was AJCC stage related: 100% and 71%, respectively, for early stage (0-IIA) disease, and 71% and 20%, respectively, for advanced (IIB-IV) stage (P = 0.0051 by log-rank). Only AJCC stage and its components (tumor size, nodal status, presence of metastases) correlated with survival by multivariate analysis; other factors such as age, family history, and presenting symptoms/signs did not. Conclusions: The majority of breast cancers in males present at early stages and are hormone receptor positive. In contrast to older notions of this disease as uniformly aggressive, we conclude that prognostic factors and stage-for-stage outcomes for breast cancer in males are similar to those published for the disease in females.
MeSH term(s)	Adult ; Breast Neoplasms, Male/epidemiology ; Breast Neoplasms, Male/pathology ; Breast Neoplasms, Male/surgery ; Databases, Factual ; Disease-Free Survival ; Female ; Humans ; Male ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Staging ; Prognosis ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	1999-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/s0002-9610(99)00067-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.42: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Aspartate aminotransferase to platelet ratio index (APRI) can predict liver fibrosis in chronic hepatitis B.

Shin, W G / Park, S H / Jang, M K / Hahn, T H / Kim, J B / Lee, M S / Kim, D J / Jun, S-Y / Park, C K

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2008 Volume 40, Issue 4, Page(s) 267–274

Abstract: Background: There have been still few valuable markers that can be used as indirect markers of liver fibrosis in chronic hepatitis B.: Aims: This study aimed to evaluate efficacy of several indirect markers of liver fibrosis and to identify the most ... ...

Abstract	Background: There have been still few valuable markers that can be used as indirect markers of liver fibrosis in chronic hepatitis B. Aims: This study aimed to evaluate efficacy of several indirect markers of liver fibrosis and to identify the most valuable test in chronic hepatitis B. Patients and methods: A total of 264 patients with chronic hepatitis B were consecutively enrolled. Fibrosis was staged by a single blinded pathologist according to the METAVIR system. Significant fibrosis was defined as stage >or=2. We investigated diagnostic accuracy of four indirect markers including aspartate aminotransferase to platelet ratio index for predicting significant fibrosis. Results: Mean age was 28 years. 53% (141/264) had significant hepatic fibrosis. Of indirect markers, aspartate aminotransferase to platelet ratio index yielded the best area under the receiver operating characteristic curve (0.86; 95% confidence interval, 0.82-0.91). Positive predictive value/negative predictive value at 0.5, 1.5 and 2.0 of aspartate aminotransferase to platelet ratio index score for predicting significant fibrosis were 63%/91%, 83%/74% and 86%/65%, respectively. The odds ratio for aspartate aminotransferase to platelet ratio index >or=1.4 relative to less than aspartate aminotransferase to platelet ratio index of 1.4 was 17.971 (p<0.0001; 95% confidence interval, 9.677-33.376). Conclusions: Of simple markers already developed in chronic hepatitis C, aspartate aminotransferase to platelet ratio index may be the most accurate and simple marker for predicting significant fibrosis in chronic hepatitis B.
MeSH term(s)	Adolescent ; Adult ; Aspartate Aminotransferases/blood ; Biomarkers ; Biopsy, Needle ; Female ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/pathology ; Humans ; Liver Cirrhosis/blood ; Male ; Middle Aged ; Platelet Count ; Predictive Value of Tests ; ROC Curve
Chemical Substances	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2008-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1459373-7
ISSN	1590-8658 ; 1125-8055
ISSN	1590-8658 ; 1125-8055
DOI	10.1016/j.dld.2007.10.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1134: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito