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Article ; Online: Observation of a Large Slip Effect in the Nanoscale Flow of Highly Viscous Supercooled Liquid Metals.

Xiang, Jun-Xiang / Liu, Ze

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 32, Page(s) 11224–11230

Abstract: Understanding and controlling the flow of materials confined in channels play important roles in science and engineering. The general no-slip boundary condition will result in it being more challenging to drive the flow as the channel size decreases to ... ...

Abstract	Understanding and controlling the flow of materials confined in channels play important roles in science and engineering. The general no-slip boundary condition will result in it being more challenging to drive the flow as the channel size decreases to the nanoscale, especially for highly viscous liquids. Here, we report the observation of a large boundary slip in the nanoscale flow of highly viscous supercooled liquid metals (with viscosities of ≲10
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c00352
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Article ; Online: A Red-Light-Responsive DASA–Polymer with High Water Stability for Controlled Release

Hao Ma / Wan Li / Haojun Fan / Jun Xiang

Polymers, Vol 15, Iss 2489, p

2023 Volume 2489

Abstract: Photoresponsive polymers hold vast potential in the realm of drug delivery. Currently, most photoresponsive polymers use ultraviolet (UV) light as the excitation source. However, the limited penetration ability of UV light within biological tissues ... ...

Abstract	Photoresponsive polymers hold vast potential in the realm of drug delivery. Currently, most photoresponsive polymers use ultraviolet (UV) light as the excitation source. However, the limited penetration ability of UV light within biological tissues serves as a significant hindrance to their practical applications. Given the strong penetration ability of red light in biological tissues, the design and preparation of a novel red-light-responsive polymer with high water stability, incorporating the reversible photoswitching compound and donor-acceptor Stenhouse adducts (DASA) for controlled drug release is demonstrated. In aqueous solutions, this polymer exhibits self-assembly into micellar nanovectors (~33 nm hydrodynamic diameter), facilitating the encapsulation of the hydrophobic model drug Nile red (NR) within the micellar core. Upon irradiation by a 660 nm LED light source, photons are absorbed by DASA, leading to the disruption of the hydrophilic–hydrophobic balance of the nanovector and thereby resulting in the release of NR. This newly designed nanovector incorporates red light as a responsive switch, successfully avoiding the problems of photodamage and limited penetration of UV light within biological tissues, thereby further promoting the practical applications of photoresponsive polymer nanomedicines.
Keywords	red light ; photoresponsive polymers ; donor-acceptor Stenhouse adducts ; nanovectors ; drug release ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of a Depolymerase Encoded by Phage168 on a Carbapenem-Resistant Klebsiella pneumoniae and Its Biofilm

Xu Sun / Bingchun Pu / Jinhong Qin / Jun Xiang

Pathogens, Vol 12, Iss 12, p

2023 Volume 1396

Abstract: Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are becoming increasingly common within clinical settings, requiring the development of alternative therapies. In this study, we isolated, characterized, and sequenced the genome of a ...

Abstract	Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are becoming increasingly common within clinical settings, requiring the development of alternative therapies. In this study, we isolated, characterized, and sequenced the genome of a CRKP phage, Phage168. The total genomic DNA of Phage168 was 40,222 bp in length, encoding 49 predicted proteins. Among these proteins, Dep40, the gene product of ORF40, is a putative tail fiber protein that exhibits depolymerase activity based on the result of bioinformatics analyses. In vitro, we confirmed that the molecular weight of the Phage168 depolymerase protein was about 110 kDa, the concentration of the produced phage 168 depolymerase protein was quantified as being 1.2 mg/mL, and the depolymerase activity was still detectable after the dilution of 1.2 µg/mL. This recombinant depolymerase exhibited enzyme activity during the depolymerization of the formed CRKP biofilms. We also found that depolymerase, when combined with polymyxin B, was able to enhance the bactericidal effect of polymyxin B on CRKP strains by disrupting their biofilm. When recombinant depolymerase was used in combination with human serum, it enhanced the sensitivity of the CRKP strain UA168 to human serum, and the synergistic bactericidal effect reached the strongest level when the ratio of depolymerase to human serum was 3:1. Our results indicated that depolymerase encoded by Phage168 may be a promising strategy for combating infections caused by drug-resistant CRKP formed within the biofilm.
Keywords	depolymerase ; phage ; biofilm ; carbapenem-resistant klebsiella pneumoniae ; Medicine ; R
Subject code	572
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New insights into acupuncture techniques for poststroke spasticity.

Wang, Jun-Xiang / Fidimanantsoa, Olivia Lai / Ma, Liang-Xiao

Frontiers in public health

2023 Volume 11, Page(s) 1155372

Abstract: With the trend of aging population getting more obvious, stroke has already been a major public health problem worldwide. As a main disabling motor impairment after stroke, spasticity has unexpected negative impacts on the quality of life and social ... ...

Abstract	With the trend of aging population getting more obvious, stroke has already been a major public health problem worldwide. As a main disabling motor impairment after stroke, spasticity has unexpected negative impacts on the quality of life and social participation in patients. Moreover, it brings heavy economic burden to the family and society. Previous researches indicated that abnormality of neural modulation and muscle property corelates with the pathogenesis of poststroke spasticity (PSS). So far, there still lacks golden standardized treatment regimen for PSS; furthermore, certain potential adverse-events of the mainstream therapy, for example, drug-induced generalized muscle weakness or high risk related surgery somehow decrease patient preference and compliance, which brings challenges to disease treatment and follow-up care. As an essential non-pharmacological therapy, acupuncture has long been used for PSS in China and shows favorable effects on improvements of spastic hypertonia and motor function. Notably, previous studies focused mainly on the research of antispastic acupoints. In comparison, few studies lay special stress on the other significant factor impacting on acupuncture efficacy, that is acupuncture technique. Based on current evidences from the clinic and laboratory, we will discuss certain new insights into acupuncture technique, in particular the antispastic needling technique, for PSS management in light of its potential effects on central modulations as well as peripheral adjustments, and attempt to provide some suggestions for future studies with respect to the intervention timing and course, application of acupuncture techniques, acupoint selection, predictive and aggravating factors of PSS, aiming at optimization of antispastic acupuncture regimen and improvement of quality of life in stroke patients. More innovations including rigorous study design, valid objective assessments for spasticity, and related experimental studies are worthy to be expected in the years ahead.
MeSH term(s)	Humans ; Aged ; Muscle Spasticity/etiology ; Muscle Spasticity/therapy ; Quality of Life ; Treatment Outcome ; Stroke/complications ; Stroke/therapy ; Acupuncture Therapy/adverse effects ; Acupuncture Therapy/methods
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1155372
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Article: The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer.

Jun, Xiang / Gao, Shengnan / Yu, Lei / Wang, Guiyu

Frontiers in oncology

2023 Volume 13, Page(s) 1123455

Abstract: Introduction: As the top 3 cancer in terms of incidence and mortality, the first-line treatment for CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug sensitivity of patients to regimens is different. There has been increasing ... ...

Abstract	Introduction: As the top 3 cancer in terms of incidence and mortality, the first-line treatment for CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug sensitivity of patients to regimens is different. There has been increasing evidence that immune components of TME can affect the sensitivity of patients to drugs. Therefore, it is necessary to define novo molecular subtypes of CRC based on TME immune components, and screen patients who are sensitive to the treatments, to make personalized therapy possible. Methods: We analyzed the expression profiles and 197 TME-related signatures of 1775 patients using ssGSEA, univariate Cox proportional risk model and LASSO-Cox regression model, and defined a novo molecular subtype (TMERSS) of CRC. Simultaneously, we compared the clinicopathological factors, antitumor immune activity, immune cell abundance and differences of cell states in different TMERSS subtypes. In addition, patients sensitive to the therapy were screened out by correlation analysis between TMERSS subtypes and drug responses. Results: Compared with low TMERSS subtype, high TMERSS subtype has a better outcome, which may be associated to higher abundance of antitumor immune cell in high TMERSS subtype. Our findings suggested that the high TMERSS subtype may have a higher proportion of respondents to Cetuximab agent and immunotherapy, while the low TMERSS subtype may be more suitable for treatment with FOLFOX and FOLFIRI regimens. Discussion: In conclusion, the TMERSS model may provide a partial reference for the prognosis evaluation of patients, the prediction of drug sensitivity, and the implementation of clinical decision-making.
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1123455
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Article ; Online: New insights into acupuncture techniques for poststroke spasticity

Jun-Xiang Wang / Olivia Lai Fidimanantsoa / Liang-Xiao Ma

Frontiers in Public Health, Vol

2023 Volume 11

Abstract	With the trend of aging population getting more obvious, stroke has already been a major public health problem worldwide. As a main disabling motor impairment after stroke, spasticity has unexpected negative impacts on the quality of life and social participation in patients. Moreover, it brings heavy economic burden to the family and society. Previous researches indicated that abnormality of neural modulation and muscle property corelates with the pathogenesis of poststroke spasticity (PSS). So far, there still lacks golden standardized treatment regimen for PSS; furthermore, certain potential adverse-events of the mainstream therapy, for example, drug-induced generalized muscle weakness or high risk related surgery somehow decrease patient preference and compliance, which brings challenges to disease treatment and follow-up care. As an essential non-pharmacological therapy, acupuncture has long been used for PSS in China and shows favorable effects on improvements of spastic hypertonia and motor function. Notably, previous studies focused mainly on the research of antispastic acupoints. In comparison, few studies lay special stress on the other significant factor impacting on acupuncture efficacy, that is acupuncture technique. Based on current evidences from the clinic and laboratory, we will discuss certain new insights into acupuncture technique, in particular the antispastic needling technique, for PSS management in light of its potential effects on central modulations as well as peripheral adjustments, and attempt to provide some suggestions for future studies with respect to the intervention timing and course, application of acupuncture techniques, acupoint selection, predictive and aggravating factors of PSS, aiming at optimization of antispastic acupuncture regimen and improvement of quality of life in stroke patients. More innovations including rigorous study design, valid objective assessments for spasticity, and related experimental studies are worthy to be expected in the years ahead.
Keywords	stroke ; spasticity ; motor dysfunction ; acupuncture technique ; rehabilitation ; non-pharmacological intervention ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Investigation of Rotary Cup Burner Assembly with Three Vehicle-Mounted Cooking Stoves by Numerical Evaluation Method

Yijian Sheng / He Liu / Limo He / Jun Xiang

Processes, Vol 10, Iss 186, p

2022 Volume 186

Abstract: The adaptability of vehicle-mounted heating systems that include burner and stove remarkably influences the system efficiency, heat flux uniformity, and pollutants emission. In this work, the performance of a rotary cup burner assembly with three ... ...

Abstract	The adaptability of vehicle-mounted heating systems that include burner and stove remarkably influences the system efficiency, heat flux uniformity, and pollutants emission. In this work, the performance of a rotary cup burner assembly with three different cooking stoves was investigated using ANSYS Fluent software based on five factors of thermal efficiency, heat transfer intensity, heating uniformity, CO emissions, and flue gas outlet temperature. The Eulerian-Lagrangian method was used to perform the diesel spray, and the shear stress transfer k-ω turbulence model and the probability density function model were employed to simulate the turbulent combustion. Based on the simulation results, the performance pentagon of the above five factors was constructed to evaluate the comprehensive performance of the new rotary cup burner system. The rotary cup burner had a good performance when it is used in two staple food stoves and a subsidiary food stove. In staple food stove A, its higher furnace increased the heat exchange area of the vessel, while the higher fireboard of staple food stove B caused a higher heat transfer intensity at the bottom of the vessel. However, the higher fireboard also led to higher CO emissions. In consideration of these two factors, the thermal efficiency of stove A was about 7% higher than that of stove B. Different from the staple food stove, the furnace of subsidiary food stove C had better wrapping to the bottom of the boiler so that it had the highest heat transfer intensity. The obtained performance pentagon shows that the comprehensive adaptability performance of stove A was the best and that of stove B was the worst, which is mainly caused by the height of the fireboard and the shape of the vessel. This research guides the optimization of the heating system and promotes the application of the rotary cup burner.
Keywords	rotary cup burner ; vehicle-mounted cooking stoves ; thermal efficiency ; heating uniformity ; CO emissions ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Characterization of DOPO-Containing Poly(2,6-dimethyl-1,4-phenylene oxide)s by Oxidative Coupling Polymerization.

Lu, Cheng-Hao / Chang, Chi / Huang, Yu-Chen / You, Jun-Xiang / Liang, Mong

Polymers

2024 Volume 16, Issue 2

Abstract: A set of polyphenylene oxides incorporating DOPO (9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) functionality, denoted as DOPO-R-PPO, was synthesized by copolymerization of 2,6-dimethylphenol (2,6-DMP) with various DOPO-substituted tetramethyl ... ...

Abstract	A set of polyphenylene oxides incorporating DOPO (9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) functionality, denoted as DOPO-R-PPO, was synthesized by copolymerization of 2,6-dimethylphenol (2,6-DMP) with various DOPO-substituted tetramethyl bisphenol monomers. In the initial step, a Friedel-Crafts acylation reaction was employed to react 2,6-DMP with different acyl chlorides, leading to the formation of ketone derivatives substituted with 2,6-dimethylphenyl groups. Subsequently, the ketones, along with DOPO and 2,6-DMP, underwent a condensation reaction to yield a series of DOPO-substituted bisphenol derivatives. Finally, polymerizations of 2,6-dimethylphenol with these DOPO-substituted bisphenols were carried out in organic solvents using copper(I) bromide/
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16020303
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Article: Retrospective Investigation and Research on Fall Events Among Hospitalized Patients in the Rehabilitation Department.

Lin, Fang-Fang / Yang, Wei-Yuan / Zhou, Jun-Xiang / Cao, Luo-Yuan / Huang, Ling-Ling

Risk management and healthcare policy

2024 Volume 17, Page(s) 1069–1078

Abstract: Objective: We investigated the clinical characteristics, fall outcomes, and related factors of falls in patients who were hospitalized in the rehabilitation department, and explored strategies to reduce the incidence of falls and prevent falls in ... ...

Abstract	Objective: We investigated the clinical characteristics, fall outcomes, and related factors of falls in patients who were hospitalized in the rehabilitation department, and explored strategies to reduce the incidence of falls and prevent falls in patients. Methods: Data from 60 patients who fell in the rehabilitation department between 2016 and 2021 were analyzed for clinical characteristics, associated factors, incidence of falls, injuries, and patient demographics. Under the random stratified sampling method, 60 patients who did not fall during the same period were selected as the control group, and relevant data was collected. Measurement data were compared using an independent sample Results: The median annual incidence of falls among patients who were hospitalized in the rehabilitation department was 0.04%, while the overall fall injury rate was 60%. Falls were most prevalent within 30 days of hospitalization (71.67%). The most common fall-related condition was craniocerebral disease (83.33%). The incidents of falls location of fall were mainly reported in nearby areas of rehabilitation ward (70%). Most accidents occurred between 7:00 a.m.-12:00 p.m. and 3:01 p.m.-6:00 p.m. (63.33%), and dyskinesia was the most common cause of falls (71.67%). There were 39 patients (65.00%) with Barthel Index (BI) scores ranging between 40-60. Conclusion: Patients in the rehabilitation department had a greater incidence of falls and fall injuries. Within 30 days of admission, patients with moderately dependent craniocerebral disorders and dyskinesia frequently experienced falls during typical daytime shifts in areas characterized by endemic conditions.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S445808
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Article: Two new diatom species of the genus

Li, Lang / Nong, Qun-Zhuan / Chen, Chang-Ping / Li, Yu-Hang / Lai, Jun-Xiang

PhytoKeys

2024 Volume 239, Page(s) 255–266

Abstract: Two new diatom species belonging to the ... ...

Abstract	Two new diatom species belonging to the genus
Language	English
Publishing date	2024-03-26
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.239.114018
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