Article ; Online: Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults.
Diabetes research and clinical practice
2024 Volume 208, Page(s) 111109
Abstract: Aim: This study aimed to examine whether cumulative exposure to hypertriglyceridemia is associated with an increased risk of developing type 2 diabetes in young adults.: Methods: The study included 1,840,251 participants aged 20-39 years who had ... ...
| Abstract | Aim: This study aimed to examine whether cumulative exposure to hypertriglyceridemia is associated with an increased risk of developing type 2 diabetes in young adults. Methods: The study included 1,840,251 participants aged 20-39 years who had undergonefourconsecutiveannualhealth checkups and had no history of type 2 diabetes. Participants werecategorized into five groups (exposure score 0-4) based on the frequencies of hypertriglyceridemia diagnosis over a four-year period. The primary outcome was newly diagnosed type 2 diabetes. Exploratory analyses were performed for the different subgroups. Results: During a follow-up period of 6.53 years, 40,286 participants developed type 2 diabetes. The cumulative incidence of type 2 diabetes significantly increased with higher exposure scores for hypertriglyceridemia (log-rank test, P < 0.001). The multivariable-adjusted hazard ratios for incident diabetes were 1.674 (95 % CI, 1.619, 1.732), 2.192 (95 % CI, 2.117, 2.269), 2.637 (95 % CI, 2.548, 2.73), and 3.715 (95 % CI, 3.6, 3.834) for participants with scores of 1-4, respectively, compared with those with an exposure score of 0. Conclusions: In this large-scale prospective cohort study of young adults, cumulative exposure to hypertriglyceridemia was significantly associated with an increased risk of type 2 diabetes, independent of lifestyle-related factors. |
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| MeSH term(s) | Humans ; Young Adult ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Prospective Studies ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/epidemiology ; Incidence ; Life Style ; Risk Factors | |||||
| Language | English | |||||
| Publishing date | 2024-01-21 | |||||
| Publishing country | Ireland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 632523-3 | |||||
| ISSN | 1872-8227 ; 0168-8227 | |||||
| ISSN (online) | 1872-8227 | |||||
| ISSN | 0168-8227 | |||||
| DOI | 10.1016/j.diabres.2024.111109 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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