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  1. Book ; Audio / Video ; Thesis: Fortschritte in der Behandlung maligner Erkrankungen durch die Transplantation hämatopoetischer Stammzellen

    Junghanß, Christian

    2006  

    Author's details vorgelegt von Christian Junghanß
    Language German ; English
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Habil.-Schr., 2006
    HBZ-ID HT015776631
    Database Catalogue ZB MED Medicine, Health

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    2008 MO 308 order for loan Magazin

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  2. Book ; Thesis: Bedeutung von Zytokinen und Oberflächenmarkern für das Proliferationsverhalten und das klinische Risiko bei der chronisch lymphatischen B-Zell-Leukämie

    Junghanß, Christian

    1997  

    Author's details vorgelegt von Christian Junghanß
    Language German
    Size 120 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT008593310
    Database Catalogue ZB MED Medicine, Health

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    1998 MB 1065 order for loan Magazin

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  3. Article: Abdominal venous thromboses: detection of the

    Henze, Larissa / Grunwald, Luise / Felser, Sabine / Witte, Maria / Grosse-Thie, Christina / Roolf, Catrin / Murua Escobar, Hugo / Junghanss, Christian

    Frontiers in medicine

    2024  Volume 10, Page(s) 1344769

    Abstract: Background: Abdominal venous thromboses are rare thrombotic events with heterogeneous etiologies. They are related to myeloproliferative neoplasms (MPNs) in some patients and can occur as first signs of the disease. MPNs are characterized by mutations ... ...

    Abstract Background: Abdominal venous thromboses are rare thrombotic events with heterogeneous etiologies. They are related to myeloproliferative neoplasms (MPNs) in some patients and can occur as first signs of the disease. MPNs are characterized by mutations in the genes of Janus kinase 2 (JAK2), myeloproliferative leukemia virus oncogene (MPL), and calreticulin (CALR).
    Methods: Within the prospective trial "Prevalence of JAK2 mutations in patients with abdominal venous thromboses" (JAK2 MV study; German Clinical Trials Register: DRKS00026943), the peripheral blood of patients with abdominal venous thromboses in Mecklenburg-West Pomerania, a federal state located in north-east Germany, was analyzed by next-generation ultradeep sequencing for MPN-associated mutations. Clinical characteristics and blood cell counts were also of interest. The primary endpoint was the detection of the mutation
    Results: A total of 68 patients with abdominal venous thromboses were included from February 2017 to January 2021, with splanchnic veins affected in 65 patients. The mutation
    Discussion: By analyzing peripheral blood for the mutation
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1344769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Origin of breath isoprene in humans is revealed via multi-omic investigations.

    Sukul, Pritam / Richter, Anna / Junghanss, Christian / Schubert, Jochen K / Miekisch, Wolfram

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 999

    Abstract: Plants, animals and humans metabolically produce volatile isoprene ( ... ...

    Abstract Plants, animals and humans metabolically produce volatile isoprene (C
    MeSH term(s) Animals ; Humans ; Multiomics ; Biomarkers ; Cholesterol
    Chemical Substances isoprene (0A62964IBU) ; 3,3-dimethylallyl pyrophosphate (358-72-5) ; Biomarkers ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05384-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Physical exercise recommendations for patients with chronic myeloid leukemia based on individual preferences identified in a large international patient survey study of the East German Study Group for Hematology and Oncology (OSHO #97).

    Hollenbach, Lina / Rogahn, Julia / le Coutre, Philipp / Schulze, Susann / Muegge, Lars-Olof / Geissler, Jan / Gruen, Julia / Junghanss, Christian / Felser, Sabine

    Frontiers in oncology

    2024  Volume 14, Page(s) 1345050

    Abstract: Background: Tyrosine kinase inhibitors (TKIs) have significantly lowered mortality of chronic myeloid leukemia (CML) patients adjusting life expectancy to that of the standard population. However, CML and its treatment with TKIs causes a high disease ... ...

    Abstract Background: Tyrosine kinase inhibitors (TKIs) have significantly lowered mortality of chronic myeloid leukemia (CML) patients adjusting life expectancy to that of the standard population. However, CML and its treatment with TKIs causes a high disease burden. Physical exercise (PE) could be a non-pharmacological approach to reducing these and improving quality of life.
    Purpose: The aim of this study was to determine the individual disease burden as well as PE preferences of CML patients and to deduce thereof specific PE recommendations.
    Methods: This multicenter survey was conducted in cooperation with the LeukaNET/Leukemia-patient network including CML patients aged ≥18 years (German Registry of Clinical Trials, DRKS00023698). The severity of selected symptoms was assessed using the adapted Myeloproliferative Neoplasms Symptom Assessment Form: 0 (absent), 1-30 (mild), 31-70 (moderate), or 71-100 (severe). Information about patients' PE needs and preferences depending on their motivation was recorded.
    Results: A total of 212 questionnaires were analyzed (52% female, median age 54 years). The prevalence of moderate-to-severe symptoms was 49% for fatigue, 40% for musculoskeletal pain, and 37% for concentration problems. Other commonly reported symptoms included skin reactions (42%) and weight gain (24%). The proportion of overweight/obese patients was 52%. Half of all respondents requested more information regarding PE. Patients with CML preferred individual training (82%), located outdoors (71%), at home (47%), or in an indoor swimming pool (31%). Regarding the training frequency, sports-inactive patients preferred a frequency of 1-2 training sessions per week, whereas sports-active patients preferred 3-4 sessions per week (p <0.001). Sports-inactive patients preferred a training time of 15-45 minutes, while sports-active patients preferred 30-60 minutes (p = 0.002). Subsequently, PE recommendations were developed for patients with CML. Combined resistance and endurance training (moderate intensity twice per week for 30 minutes) was recommended for beginners. Obese patients should prioritize joint-relieving sports. To reduce the risk of skin reactions, direct sunlight and possibly water sports should be avoided, and UV protection should be used.
    Conclusion: Counseling and motivation of CML patients to be physically active should be part of the standard of care as well as support for implementation.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1345050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparative Analyses of Targeted Myeloid Cancer Next-Generation Sequencing Panel in Fresh Blood, Bone Marrow and FFPE Material.

    Hobeck, Andrea Daniela / Wendt, Sophia / Krohn, Saskia / Knuebel, Gudrun / Bartels, Stephan / Schipper, Elisa / Junghanss, Christian / Murua Escobar, Hugo

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Next-generation sequencing is a vital tool for personalized diagnostics and therapies in cancer. Despite numerous advantages, the method depends on multiple parameters regarding the sample material, e.g., sample fixation. A panel's ability to ensure ... ...

    Abstract Next-generation sequencing is a vital tool for personalized diagnostics and therapies in cancer. Despite numerous advantages, the method depends on multiple parameters regarding the sample material, e.g., sample fixation. A panel's ability to ensure balanced pre-amplification of the regions of interest is challenging, especially in targeted sequencing approaches, but of significant importance to its applicability across hematological malignancies and solid tumors. This study comparatively evaluated the technical performance of the commercially available Oncomine
    MeSH term(s) Humans ; Bone Marrow/pathology ; Formaldehyde ; Neoplasms/genetics ; Neoplasms/pathology ; Myeloproliferative Disorders ; High-Throughput Nucleotide Sequencing/methods ; Paraffin Embedding ; Tissue Fixation ; Mutation
    Chemical Substances Formaldehyde (1HG84L3525)
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Untersuchungen zur Versorgung bei palliativmedizinischen Patienten mit Ileus und Subileus an der Universitätsmedizin Rostock

    Behrendt, Falco [Verfasser] / Junghanß, Christian [Gutachter] / Lamprecht, Georg [Gutachter] / Oechsle, Karin [Gutachter]

    2023  

    Author's details Falco Behrendt ; Gutachter: Christian Junghanß, Georg Lamprecht, Karin Oechsle
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Rostock
    Publishing place Rostock
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  8. Book ; Online ; Thesis: Characterization of pathway specific inhibitor response in pancreatic ductal adenocarcinoma in vitro models with different genetic backgrounds

    Ma, Yixuan [Verfasser] / Junghanß, Christian [Gutachter] / Sendler, Matthias [Gutachter] / Jaster, Robert [Gutachter]

    2023  

    Author's details Yixuan Ma ; Gutachter: Christian Junghanß, Matthias Sendler, Robert Jaster
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Rostock
    Publishing place Rostock
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Book ; Online ; Thesis: Palliative Chemotherapie bei lokal fortgeschrittenem oder metastasiertem Pankreaskarzinom

    Harder, Pia [Verfasser] / Junghanß, Christian [Gutachter] / Kahl, Christoph [Gutachter] / Schafmayer, Clemens [Gutachter]

    Ergebnisse im klinischen Alltag der Universitätsmedizin Rostock im Vergleich zu Studienbedingungen

    2023  

    Author's details Pia Harder ; Gutachter: Christian Junghanß, Christoph Kahl, Clemens Schafmayer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Rostock
    Publishing place Rostock
    Document type Book ; Online ; Thesis
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  10. Article: Long-term survivor of metastatic squamous-cell head and neck carcinoma with occult primary after cetuximab-based chemotherapy: A case report.

    Große-Thie, Christina / Maletzki, Claudia / Junghanss, Christian / Schmidt, Kathie

    World journal of clinical cases

    2021  Volume 9, Issue 24, Page(s) 7092–7098

    Abstract: Background: Cancer of unknown primary (CUP) is a histological proven malignant tumor whose origin cannot be detected despite careful examination. Most cervical lymph node metastases in CUP (80%) will originate from head and neck sites, and 15% show ... ...

    Abstract Background: Cancer of unknown primary (CUP) is a histological proven malignant tumor whose origin cannot be detected despite careful examination. Most cervical lymph node metastases in CUP (80%) will originate from head and neck sites, and 15% show infiltration of squamous carcinoma cells. The survival rates of CUP are poor: The 5-year-survival rate ranges from 10% to 15%. First-line treatment recommendation for advanced, inoperable squamous cell carcinoma of head/neck (HNSCC) was cetuximab plus platinum-fluorouracil chemotherapy until recently, when checkpoint inhibitors proved clinically beneficial therapies.
    Case summary: Here, we report a case of a 42-year-old female patient with cervical and abdominal lymph node and distant bone metastases of an occult primary of the head and neck (squamous cell carcinoma, human papillomavirus positive). The cancer was diagnosed during pregnancy 10 years ago, and after giving birth, the patient was treated with cetuximab plus platinum-fluorouracil chemotherapy achieving complete remission (CR). CR lasted 26 mo when new metastases (abdominal lymph node, lumbar vertebral body) emerged. Both manifestations were irradiated. From then on, the patient has not received any further treatment, and her disease has remained controlled. Ten years after the initial cancer diagnosis, the patient is still alive and in good health, representing an exceptional case of HNSCC.
    Conclusion: This case illustrates the exceptional clinical course and benefits of combined therapy approaches in advanced metastatic HNSCC with occult primary.
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i24.7092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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