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  1. AU="Junior, Roberto Carlos Vieira"
  2. AU="Lee, Darren"
  3. AU="Letheule, Martine"
  4. AU="Price, Tyler"
  5. AU="Nicolaidou, Paola"
  6. AU=Selvidge S D
  7. AU=Gonzalez-Alcaide Gregorio
  8. AU=Van Allen Eliezer M.
  9. AU="Lim, Adrian"
  10. AU="Roloff-Handschin, Tim-Christoph"
  11. AU="Portocarrero, Carla P"
  12. AU=Sokouti Massoud

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  1. Artikel ; Online: Physical and functional evaluations in oncological patients elective to medium and large operations.

    Junior, Roberto Carlos Vieira / Machado, Ailton Silva / Faria, Sergio Itacarambi Guasque / Ávila, Eudes Thiago Pereira / Ghayomzadeh, Morteza / Seyedalinaghi, Seyedahmad / Navalta, James Wilfred / Voltarelli, Fabrício Azevedo

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Band 31, Heft 7, Seite(n) 406

    Abstract: Purpose: To evaluate the risk of sarcopenia on the length of hospital stay and deaths in preoperative cancer patients as well its relation to physical and functional capacity.: Methods: Preoperative patients admitted to the Cancer Hospital of Mato ... ...

    Abstract Purpose: To evaluate the risk of sarcopenia on the length of hospital stay and deaths in preoperative cancer patients as well its relation to physical and functional capacity.
    Methods: Preoperative patients admitted to the Cancer Hospital of Mato Grosso comprised the sample. Sociodemographic data, lifestyle data, and a questionnaire for sarcopenia screening were collected. Subsequently, total body mass, height, muscle strength, muscle mass, and physical performance were evaluated. The primary, secondary and tertiary outcomes were sarcopenia, length of stay and death, respectively. The data were tabulated and analyzed using the statistical software SPSS (25.0). The significance level was 5%.
    Results: We observed 12 (7.4%) patients with low muscle strength, 20 (12.3%) patients with low muscle mass, 11 (6.8%) patients with low physical performance, and 18 (11.1%) patients with scores for possible sarcopenia. When the risk of sarcopenia was observed, 44 (27.2%) patients had at least one risk related to muscle disorder. When analyzing the prevalence and association of sarcopenia with sociodemographic variables, we observed that education level was associated with sarcopenia (p = 0.031). In addition, there was an association between preoperative sarcopenia and postoperative death (p = 0.006). Finally, there were important correlations between muscle strength and physical performance (p < 0.05), between muscle strength and the sarcopenia questionnaire (p < 0.001), and between physical performance and the sarcopenia questionnaire (p < 0.05).
    Conclusion: The results suggest the need for counseling and the need to evaluate patients for risk of sarcopenia, since early intervention, such as dietary supplementation and physical exercise, may favor a better postoperative prognosis, possibly corresponding to shorter hospital stays and longer survival and quality of life for patients, especially those who will undergo surgical procedures.
    Mesh-Begriff(e) Humans ; Sarcopenia/etiology ; Sarcopenia/complications ; Quality of Life ; Muscle Strength/physiology ; Prognosis ; Life Style ; Muscle, Skeletal/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-06-21
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07878-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin in People Living with HIV/AIDS.

    Dos Santos Trombeta, Joice Cristina / Junior, Roberto Carlos Vieira / Cavaglieri, Cláudia Regina / Bonfante, Ivan Luiz Padilha / Prestes, Jonato / Tibana, Ramires Alsamir / Ghayomzadeh, Morteza / Souza, Vinícius Carolino / Seyedalinaghi, Seyedahmad / Navalta, James W / Voltarelli, Fabrício Azevedo

    International journal of exercise science

    2021  Band 14, Heft 3, Seite(n) 1004–1017

    Abstract: This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen ... ...

    Abstract This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen HIV
    Sprache Englisch
    Erscheinungsdatum 2021-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2411342-6
    ISSN 1939-795X
    ISSN 1939-795X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape.

    Oliveira, Jamille Ramos / Ruiz, Cesar Manuel Remuzgo / Machado, Rafael Rahal Guaragna / Magawa, Jhosiene Yukari / Daher, Isabela Pazotti / Urbanski, Alysson Henrique / Schmitz, Gabriela Justamante Händel / Arcuri, Helen Andrade / Ferreira, Marcelo Alves / Sasahara, Greyce Luri / de Medeiros, Giuliana Xavier / Júnior, Roberto Carlos Vieira Silva / Durigon, Edison Luiz / Boscardin, Silvia Beatriz / Rosa, Daniela Santoro / Schechtman, Deborah / Nakaya, Helder I / Cunha-Neto, Edecio / Gadermaier, Gabriele /
    Kalil, Jorge / Coelho, Verônica / Santos, Keity Souza

    Frontiers in immunology

    2023  Band 13, Seite(n) 1010105

    Abstract: Introduction: Considering the likely need for the development of novel effective vaccines adapted to emerging relevant CoV-2 variants, the increasing knowledge of epitope recognition profile among convalescents and afterwards vaccinated with ... ...

    Abstract Introduction: Considering the likely need for the development of novel effective vaccines adapted to emerging relevant CoV-2 variants, the increasing knowledge of epitope recognition profile among convalescents and afterwards vaccinated with identification of immunodominant regions may provide important information.
    Methods: We used an RBD peptide microarray to identify IgG and IgA binding regions in serum of 71 COVID-19 convalescents and 18 vaccinated individuals.
    Results: We found a set of immunodominant RBD antibody epitopes, each recognized by more than 30% of the tested cohort, that differ among the two different groups and are within conserved regions among betacoronavirus. Of those, only one peptide, P44 (S415-429), recognized by 68% of convalescents, presented IgG and IgA antibody reactivity that positively correlated with nAb titers, suggesting that this is a relevant RBD region and a potential target of IgG/IgA neutralizing activity.
    Discussion: This peptide is localized within the area of contact with ACE-2 and harbors the mutation hotspot site K417 present in gamma (K417T), beta (K417N), and omicron (K417N) variants of concern. The epitope profile of vaccinated individuals differed from convalescents, with a more diverse repertoire of immunodominant peptides, recognized by more than 30% of the cohort. Noteworthy, immunodominant regions of recognition by vaccinated coincide with mutation sites at Omicron BA.1, an important variant emerging after massive vaccination. Together, our data show that immune pressure induced by dominant antibody responses may favor hotspot mutation sites and the selection of variants capable of evading humoral response.
    Mesh-Begriff(e) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Antibody Formation ; Immunodominant Epitopes/genetics ; Epitopes ; Immunoglobulin A ; Mutation ; Immunoglobulin G
    Chemische Substanzen Immunodominant Epitopes ; Epitopes ; Immunoglobulin A ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2023-01-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1010105
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Effect of administration of high-protein diet in rats submitted to resistance training.

    da Rosa Lima, Thiago / Ávila, Eudes Thiago Pereira / Fraga, Géssica Alves / de Souza Sena, Mariana / de Souza Dias, Arlyson Batista / de Almeida, Paula Caroline / Dos Santos Trombeta, Joice Cristina / Junior, Roberto Carlos Vieira / Damazo, Amílcar Sabino / Navalta, James Wilfred / Prestes, Jonato / Voltarelli, Fabrício Azevedo

    European journal of nutrition

    2017  Band 57, Heft 3, Seite(n) 1083–1096

    Abstract: Purpose: Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and ... ...

    Abstract Purpose: Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and excretion. The aim of this study was to verify the effects of HD on biochemical and morphological parameters of rats that completed a resistance training protocol (RT; aquatic jump) for 8 weeks.
    Methods: Thirty-two adult male Wistar rats were divided into four groups (n = 8 for each group): sedentary normal protein diet (SN-14%), sedentary high-protein diet (SH-35%), trained normal protein diet (TN-14%), and trained high-protein diet (TH-35%). Biochemical, tissue, and morphological measurements were made.
    Results: Kidney (1.91 ± 0.34) and liver weights (12.88 ± 1.42) were higher in the SH. Soleus muscle weight was higher in the SH (0.22 ± 0.03) when compared to all groups. Blood glucose (123.2 ± 1.8), triglycerides (128.5 ± 44.0), and HDL cholesterol levels (65.7 ± 20.9) were also higher in the SH compared with the other experimental groups. Exercise reduced urea levels in the trained groups TN and TH (31.0 ± 4.1 and 36.8 ± 6.6), respectively. Creatinine levels were lower in TH and SH groups (0.68 ± 0.12; 0.54 ± 0.19), respectively. HD negatively altered renal morphology in SH, but when associated with RT, the apparent damage was partially reversed. In addition, the aquatic jump protocol reversed the damage to the gastrocnemius muscle caused by the HD.
    Conclusions: A high-protein diet promoted negative metabolic and morphological changes, while RT was effective in reversing these deleterious effects.
    Mesh-Begriff(e) Animals ; Biomarkers/blood ; Blood Glucose/analysis ; Cholesterol, HDL/blood ; Creatinine/blood ; Diet, High-Protein/adverse effects ; Hyperglycemia/blood ; Hyperglycemia/etiology ; Hyperglycemia/pathology ; Hyperglycemia/prevention & control ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/etiology ; Hypertriglyceridemia/pathology ; Hypertriglyceridemia/prevention & control ; Hypertrophy/blood ; Hypertrophy/etiology ; Hypertrophy/pathology ; Hypertrophy/prevention & control ; Kidney/cytology ; Kidney/growth & development ; Kidney/pathology ; Liver/cytology ; Liver/growth & development ; Liver/pathology ; Male ; Muscle Development ; Muscle, Skeletal/cytology ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/pathology ; Organ Size ; Random Allocation ; Rats, Wistar ; Resistance Training/adverse effects ; Triglycerides/blood ; Urea/blood
    Chemische Substanzen Biomarkers ; Blood Glucose ; Cholesterol, HDL ; Triglycerides ; Urea (8W8T17847W) ; Creatinine (AYI8EX34EU)
    Sprache Englisch
    Erscheinungsdatum 2017-02-24
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-017-1391-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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