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  1. AU="Junqueira, Helena Couto"
  2. AU="Kataria, Saurabh"
  3. AU=Wang Xia AU=Wang Xia
  4. AU="Tonnesen, Morten"
  5. AU="Ebrahimi-Fakhari, Darius"
  6. AU="Kalinich, Chaney C"
  7. AU="O'Neal, David N"
  8. AU="Bennett, Matthew R"
  9. AU="Chagas, Mariana W"

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  1. Artikel ; Online: Contrasting roles of oxidized lipids in modulating membrane microdomains.

    Tsubone, Tayana Mazin / Junqueira, Helena Couto / Baptista, Maurício S / Itri, Rosangela

    Biochimica et biophysica acta. Biomembranes

    2018  Band 1861, Heft 3, Seite(n) 660–669

    Abstract: Lipid rafts display a lateral heterogeneity forming membrane microdomains that hold a fundamental role on biological membranes and are indispensable to physiological functions of cells. Oxidative stress in cellular environments may cause lipid oxidation, ...

    Abstract Lipid rafts display a lateral heterogeneity forming membrane microdomains that hold a fundamental role on biological membranes and are indispensable to physiological functions of cells. Oxidative stress in cellular environments may cause lipid oxidation, changing membrane composition and organization, thus implying in effects in cell signaling and even loss of homeostasis. The individual contribution of oxidized lipid species to the formation or disruption of lipid rafts in membranes still remains unknown. Here, we investigate the role of different structures of oxidized phospholipids on rafts microdomains by carefully controlling the membrane composition. Our experimental approach based on fluorescence microscopy of giant unilamellar vesicles (GUV) enables the direct visualization of the impact of hydroperoxidized POPC lipid (referred to as POPCOOH) and shortened chain lipid PazePC (1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine) on phase separation. We found that the molecular structure of oxidized lipid is of paramount importance on lipid mixing and/or demixing. The hydrophobic mismatch promoted by POPCOOH coupled to its cylindrical molecular shape favor microdomains formation. In contrast, the conical shape of PazePC causes disarrangement of lipid 2D organized platforms. Our findings contribute to better unraveling how oxidized phospholipids can trigger formation or disruption of lipid rafts. As a consequence, phospholipid oxidation may indirectly affect association or dissociation of key biomolecules in the rafts thus altering cell signaling and homeostasis.
    Mesh-Begriff(e) Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Lipid Peroxidation/physiology ; Membrane Microdomains/chemistry ; Membrane Microdomains/drug effects ; Membrane Microdomains/metabolism ; Oxidants, Photochemical/chemistry ; Oxidants, Photochemical/pharmacology ; Oxidation-Reduction ; Phosphatidylcholines/chemistry ; Phosphatidylcholines/metabolism ; Phosphatidylcholines/pharmacology ; Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/chemistry ; Phosphorylcholine/metabolism ; Unilamellar Liposomes/chemistry ; Unilamellar Liposomes/metabolism
    Chemische Substanzen 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine ; Lipid Bilayers ; Oxidants, Photochemical ; Phosphatidylcholines ; Unilamellar Liposomes ; Phosphorylcholine (107-73-3) ; 1-palmitoyl-2-oleoylphosphatidylcholine (TE895536Y5)
    Sprache Englisch
    Erscheinungsdatum 2018-12-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2018.12.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Antioxidant role on the protection of melanocytes against visible light-induced photodamage.

    Freitas, Juliana Vescovi / Junqueira, Helena Couto / Martins, Waleska Kerllen / Baptista, Mauricio S / Gaspar, Lorena Rigo

    Free radical biology & medicine

    2018  Band 131, Seite(n) 399–407

    Abstract: Visible light can induce the generation of singlet oxygen and can cause oxidative stress, especially in melanocytes due to melanin photosensitization. Currently, there is no organic UV-filter that provide visible light protection. Previous studies showed ...

    Abstract Visible light can induce the generation of singlet oxygen and can cause oxidative stress, especially in melanocytes due to melanin photosensitization. Currently, there is no organic UV-filter that provide visible light protection. Previous studies showed that some antioxidants, such as apigenin (API), chrysin (CRI) and beta-carotene (BTC) besides neutralizing radical chain reactions can also quench singlet oxygen via physical or chemical quenching and exhibit potential for use in photoprotection. Therefore, the aim of this study is to evaluate the efficacy of API, CRI and BTC on the protection against cell death induced by melanin photosensitization and understand the underlying mechanisms that are involved in the protection. Precise protocols of melanogenesis and quantification of singlet oxygen generation were developed. Viability of B16-F10 cells with melanin basal levels and after melanogenesis induction was evaluated after visible light exposure in the presence and absence of API, CRI and BTC. Results showed that API and BTC protected cells from photoinduced cell death API exhibiting superior photoprotective effect. We noticed that the efficiency of cell protection and the rate of singlet oxygen suppression are not well correlated, at least for the studied series of antioxidants, indicating that the anti-radical capacity should be playing a major role in protecting cells against the damage induced by melanin photosensitization. In terms of sun care strategies, both API and BTC offer protection against visible light-induced damages and may be effective topical antioxidants to be added to sunscreens.
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Apigenin/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Flavonoids/pharmacology ; Light ; Melanins/antagonists & inhibitors ; Melanins/chemistry ; Melanocytes/cytology ; Melanocytes/drug effects ; Melanocytes/physiology ; Melanocytes/radiation effects ; Mice ; Photochemical Processes ; Photosensitizing Agents/antagonists & inhibitors ; Photosensitizing Agents/chemistry ; Singlet Oxygen/agonists ; Singlet Oxygen/chemistry ; Singlet Oxygen/metabolism ; beta Carotene/pharmacology
    Chemische Substanzen Antioxidants ; Flavonoids ; Melanins ; Photosensitizing Agents ; beta Carotene (01YAE03M7J) ; Singlet Oxygen (17778-80-2) ; chrysin (3CN01F5ZJ5) ; Apigenin (7V515PI7F6)
    Sprache Englisch
    Erscheinungsdatum 2018-12-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2018.12.028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Enhanced efficiency of cell death by lysosome-specific photodamage.

    Tsubone, Tayana Mazin / Martins, Waleska Kerllen / Pavani, Christiane / Junqueira, Helena Couto / Itri, Rosangela / Baptista, Maurício S

    Scientific reports

    2017  Band 7, Heft 1, Seite(n) 6734

    Abstract: Mobilization of specific mechanisms of regulated cell death is a promising alternative to treat challenging illness such as neurodegenerative disease and cancer. The use of light to activate these mechanisms may provide a route for target-specific ... ...

    Abstract Mobilization of specific mechanisms of regulated cell death is a promising alternative to treat challenging illness such as neurodegenerative disease and cancer. The use of light to activate these mechanisms may provide a route for target-specific therapies. Two asymmetric porphyrins with opposite charges, the negatively charged TPPS
    Mesh-Begriff(e) Apoptosis/drug effects ; Apoptosis/radiation effects ; Benzenesulfonates/chemistry ; Benzenesulfonates/pharmacology ; Cell Membrane/drug effects ; Cell Membrane/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; HeLa Cells ; Humans ; Kinetics ; Light ; Lysosomes/drug effects ; Lysosomes/metabolism ; Lysosomes/radiation effects ; Membranes, Artificial ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/radiation effects ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Pyridinium Compounds/chemistry ; Pyridinium Compounds/pharmacology ; Static Electricity ; Structure-Activity Relationship
    Chemische Substanzen 5,15-bis(4-N-methylpyridyl)-10,20-diphenylporphyrin ; Benzenesulfonates ; Membranes, Artificial ; Photosensitizing Agents ; Porphyrins ; Pyridinium Compounds ; TPPS2a chlorin
    Sprache Englisch
    Erscheinungsdatum 2017-07-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-06788-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Lipofuscin Generated by UVA Turns Keratinocytes Photosensitive to Visible Light.

    Tonolli, Paulo Newton / Chiarelli-Neto, Orlando / Santacruz-Perez, Carolina / Junqueira, Helena Couto / Watanabe, Ii-Sei / Ravagnani, Felipe Gustavo / Martins, Waleska Kerllen / Baptista, Maurício S

    The Journal of investigative dermatology

    2017  Band 137, Heft 11, Seite(n) 2447–2450

    Mesh-Begriff(e) Cells, Cultured ; Dermatitis, Phototoxic/physiopathology ; Humans ; Keratinocytes/radiation effects ; Light ; Lipofuscin/metabolism ; Lipofuscin/radiation effects ; Photosensitivity Disorders/physiopathology ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/radiation effects ; Reference Values ; Risk Assessment ; Ultraviolet Rays/adverse effects
    Chemische Substanzen Lipofuscin ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2017-07-12
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.06.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.124: Hefte anzeigen Standort:
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  5. Artikel: Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications.

    Tardivo, João Paulo / Del Giglio, Auro / de Oliveira, Carla Santos / Gabrielli, Dino Santesso / Junqueira, Helena Couto / Tada, Dayane Batista / Severino, Divinomar / de Fátima Turchiello, Rozane / Baptista, Mauricio S

    Photodiagnosis and photodynamic therapy

    2005  Band 2, Heft 3, Seite(n) 175–191

    Abstract: Methylene blue (MB) is a molecule that has been playing important roles in microbiology and pharmacology for some time. It has been widely used to stain living organisms, to treat methemoglobinemia, and lately it has been considered as a drug for ... ...

    Abstract Methylene blue (MB) is a molecule that has been playing important roles in microbiology and pharmacology for some time. It has been widely used to stain living organisms, to treat methemoglobinemia, and lately it has been considered as a drug for photodynamic therapy (PDT). In this review, we start from the fundamental photophysical, photochemical and photobiological characteristics of this molecule and evolved to show in vitro and in vivo applications related to PDT. The clinical cases shown include treatments of basal cell carcinoma, Kaposi's Sarcoma, melanoma, virus and fungal infections. We concluded that used together with a recently developed continuous light source (RL50(®)), MB has the potential to treat a variety of cancerous and non-cancerous diseases, with low toxicity and no side effects.
    Sprache Englisch
    Erscheinungsdatum 2005-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/S1572-1000(05)00097-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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