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Artikel: Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

Yuin Ho, Jessica Sook / Wing-Yee Mok, Bobo / Campisi, Laura / Jordan, Tristan / Yildiz, Soner / Parameswaran, Sreeja / Wayman, Joseph A / Gaudreault, Natasha N / Meekins, David A / Indran, Sabarish V / Morozov, Igor / Trujillo, Jessie D / Fstkchyan, Yesai S / Rathnasinghe, Raveen / Zhu, Zeyu / Zheng, Simin / Zhao, Nan / White, Kris / Ray-Jones, Helen /
Malysheva, Valeriya / Thiecke, Michiel J / Lau, Siu-Ying / Liu, Honglian / Junxia Zhang, Anna / Chak-Yiu Lee, Andrew / Liu, Wen-Chun / Aydillo, Teresa / Salom Melo, Betsaida / Guccione, Ernesto / Sebra, Robert / Shum, Elaine / Bakker, Jan / Kaufman, David A / Moreira, Andre L / Carossino, Mariano / Balasuriya, Udeni B R / Byun, Minji / Miraldi, Emily R / Albrecht, Randy A / Schotsaert, Michael / Garcia-Sastre, Adolfo / Chanda, Sumit K / Jeyasekharan, Anand D / TenOever, Benjamin R / Spivakov, Mikhail / Weirauch, Matthew T / Heinz, Sven / Chen, Honglin / Benner, Christopher / Richt, Juergen A / Marazzi, Ivan

bioRxiv : the preprint server for biology

2020  

Abstract: The ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory ... ...

Abstract The ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory factors are associated with both increased disease severity and mortality. Here, using multidimensional epigenetic, transcriptional,
Sprache Englisch
Erscheinungsdatum 2020-12-01
Erscheinungsland United States
Dokumenttyp Preprint
DOI 10.1101/2020.12.01.404483
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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