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  1. Article ; Online: The extracellular matrix glycoprotein fibrillin-1 in health and disease

    Li Li / Junxin Huang / Youhua Liu

    Frontiers in Cell and Developmental Biology, Vol

    2024  Volume 11

    Abstract: Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by FBN1 gene. It serves as a structural component of microfibrils and provides force-bearing mechanical support in elastic and nonelastic connective ... ...

    Abstract Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by FBN1 gene. It serves as a structural component of microfibrils and provides force-bearing mechanical support in elastic and nonelastic connective tissue. As such, mutations in the FBN1 gene can cause a wide variety of genetic diseases such as Marfan syndrome, an autosomal dominant disorder characterized by ocular, skeletal and cardiovascular abnormalities. FBN1 also interacts with numerous microfibril-associated proteins, growth factors and cell membrane receptors, thereby mediating a wide range of biological processes such as cell survival, proliferation, migration and differentiation. Dysregulation of FBN1 is involved in the pathogenesis of many human diseases, such as cancers, cardiovascular disorders and kidney diseases. Paradoxically, both depletion and overexpression of FBN1 upregulate the bioavailability and signal transduction of TGF-β via distinct mechanisms in different settings. In this review, we summarize the structure and expression of FBN1 and present our current understanding of the functional role of FBN1 in various human diseases. This knowledge will allow to develop better strategies for therapeutic intervention of FBN1 related diseases.
    Keywords FBN1 ; extracellular matrix ; marfan syndrome ; TGF-β ; chronic kidney diseases ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: pShare

    Junxin Huang / Yuchuan Luo / Ming Xu / Bowen Hu / Jian Long

    Applied Sciences, Vol 12, Iss 842, p

    Privacy-Preserving Ride-Sharing System with Minimum-Detouring Route

    2022  Volume 842

    Abstract: Online ride-hailing (ORH) services allow people to enjoy on-demand transportation services through their mobile devices in a short responding time. Despite the great convenience, users need to submit their location information to the ORH service provider, ...

    Abstract Online ride-hailing (ORH) services allow people to enjoy on-demand transportation services through their mobile devices in a short responding time. Despite the great convenience, users need to submit their location information to the ORH service provider, which may incur unexpected privacy problems. In this paper, we mainly study the privacy and utility of the ride-sharing system, which enables multiple riders to share one driver. To solve the privacy problem and reduce the ride-sharing detouring waste, we propose a privacy-preserving ride-sharing system named pShare . To hide users’ precise locations from the service provider, we apply a zone-based travel time estimation approach to privately compute over sensitive data while cloaking each rider’s location in a zone area. To compute the matching results along with the least-detouring route, the service provider first computes the shortest path for each eligible rider combination, then compares the additional traveling time (ATT) of all combinations, and finally selects the combination with minimum ATT. We designed a secure comparing protocol by utilizing the garbled circuit, which enables the ORH server to execute the protocol with a crypto server without privacy leakage. Moreover, we apply the data packing technique, by which multiple data can be packed as one to reduce the communication and computation overhead. Through the theoretical analysis and evaluation results, we prove that pShare is a practical ride-sharing scheme that can find out the sharing riders with minimum ATT in acceptable accuracy while protecting users’ privacy.
    Keywords online ride-hailing ; ride-sharing matching ; privacy-preserving ; location privacy ; path planning ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 005
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chlamydia-related knowledge, opinion to opportunistic testing, and practices of providers among different sexually transmitted infections related departments in hospitals in Shenzhen city, China

    Rongxing Weng / Chunlai Zhang / Lizhang Wen / Yiting Luo / Jianbin Ye / Honglin Wang / Jing Li / Ning Ning / Junxin Huang / Xiangsheng Chen / Yumao Cai

    BMC Health Services Research, Vol 22, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract Background Chlamydia trachomatis (CT) infection could lead to seriously adverse outcomes if left untreated. This study aimed to determine CT-related knowledge, opinion to testing, and practices of providers among different sexually transmitted ... ...

    Abstract Abstract Background Chlamydia trachomatis (CT) infection could lead to seriously adverse outcomes if left untreated. This study aimed to determine CT-related knowledge, opinion to testing, and practices of providers among different sexually transmitted infections (STI) related departments in hospitals in Shenzhen city, China, and also to explore the differences in these responses. Materials and methods From 1st April 2018 to 15th April 2018, a cross-sectional study was conducted in Shenzhen and 64 of 66 hospitals agreed to participate in this study. In the hospital sites, all the providers from the department of obstetrics and gynecology, department of dermatology and venereology, department of urology, and anorectal surgical department were recruited. A structured paper-based questionnaire was used to obtain data on CT-related information. Results A total of 355 providers from 64 hospitals participated in the current study. Compared to providers from the department of dermatology and venereology, those from the department of obstetrics and gynecology (OR = 0.31, 95% CI 0.16—0.62), department of urology (OR = 0.32, 95% CI 0.16—0.65), and anorectal surgical department (OR = 0.25, 95% CI 0.09—0.71) were less likely to identify that “Be in a long-term mutually monogamous relationship with a partner who has been tested and has negative STI test results.” is an appropriate way for a sexually active person to reduce risk of getting CT. Also, those from the department of obstetrics and gynecology (OR = 0.45, 95% CI 0.23—0.87) were less likely to identify that “Use latex condoms the right way every time you have sex” is another appropriate way. A high proportion of providers agreed that all sexually active patients attending to their department should be screened regularly (77.1%), and they are willing to offer opportunistic CT screening (96.0%). Only 11.4% of respondents correctly identified that the appropriate time frame of the CT retesting is three months. Conclusions Providers among STI-related departments in ...
    Keywords Chlamydia trachomatis ; Providers ; Opportunistic testing ; Public aspects of medicine ; RA1-1270
    Subject code 650
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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