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  1. AU="Junzhou Wu"
  2. AU="Kevin M Haigis"
  3. AU="Brühl, Marius"
  4. AU="Hawash, Mohammed"
  5. AU="Kalra, Sarathi"
  6. AU=Schwab Frank
  7. AU="Tzung-Chi Huang"
  8. AU="Nisa, Maherun"
  9. AU="Resnick, Adam C"
  10. AU="Thomas, Brodie"
  11. AU="Yaming Wang"
  12. AU="Lee, Chun‐Tsu"
  13. AU="Albert Gargallo‐Garriga"
  14. AU="Serwin, Natalia Maria"
  15. AU="La Rosa, Stefano"
  16. AU="Yin-Yin Xie"
  17. AU=White David P
  18. AU="Maria Teresa Viadero"
  19. AU="Wingeter, Márcia A"
  20. AU="Stein, Joshua D"
  21. AU="De Vecchis, Liana"
  22. AU="Chapman, Janet"
  23. AU="Umlai, Umm-Kulthum Ismail"
  24. AU="Reddi, Jyoti M"
  25. AU=Zeissig Sebastian
  26. AU="Valentini, Mariaconsuelo"

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  1. Artikel ; Online: Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6A consensus sequences

    Jessica J. Abner / Jeffrey L. Franklin / Margaret A. Clement / Scott A. Hinger / Ryan M. Allen / Xiao Liu / Stefanie Kellner / Junzhou Wu / John Karijolich / Qi Liu / Kasey C. Vickers / Peter Dedon / Alissa M. Weaver / Robert J. Coffey / James G. Patton

    Heliyon, Vol 7, Iss 12, Pp e08519- (2021)

    2021  

    Abstract: Extracellular vesicles (EVs) are capable of transferring cargo from donor to recipient cells, but precisely how cargo content is regulated for export is mostly unknown. For miRNA cargo, we previously showed that when compared to isogenic colorectal ... ...

    Abstract Extracellular vesicles (EVs) are capable of transferring cargo from donor to recipient cells, but precisely how cargo content is regulated for export is mostly unknown. For miRNA cargo, we previously showed that when compared to isogenic colorectal cancer (CRC) cells expressing wild-type KRAS, a distinct subset of miRNAs are differentially enriched in EVs from KRAS mutant active CRC cells, with miR-100 being one of the most enriched. The mechanisms that could explain how miR-100 and other miRNAs are differentially exported into EVs have not been fully elucidated. Here, we tested the effect of N6-methyladenosine (m6A) modification on miRNA export into EVs by depletion of METTL3 and ALKBH5, a writer and eraser of m6A modification, respectively. While the effects of ALKBH5 knockdown were quite modest, decreased levels of METTL3 led to reduced cellular and extracellular levels of a subset of miRNAs that contain consensus sequences for m6A modification. Functional testing of EVs prepared from cells expressing shRNAs against METTL3 showed that they were less capable of conferring colony growth in 3D to wild-type KRAS cells and were also largely incapable of conferring the spread of cetuximab resistance. Our data support a role for METTL3 modification on cellular miRNA levels and export of specific miRNAs.
    Schlagwörter miRNA ; Base modification ; Extracellular vesicle ; m6A ; RNA ; Tumor microenvironment ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation.

    Yu Yu / Lihua Qi / Junzhou Wu / Yunling Wang / Weigang Fang / Hongquan Zhang

    PLoS ONE, Vol 8, Iss 5, p e

    2013  Band 63490

    Abstract: Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates ...

    Abstract Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates myogenic regulatory factors myogenin via a canonical Wnt/β-catenin signaling. We found that knockdown of Kindlin 2 leads to the abolishment of β-catenin/TCF4-mediated transcription in C2C12 cells, followed by the impairment of myogenic differentiation. Mechanistically, nuclear translocation of both Kindlin 2 and β-catenin is induced during myogenic differentiation. In particular, Kindlin 2 forms a tripartite complex with active β-catenin and TCF4, and hence co-occupied on the promoter of myogenin to enhance its expression. Functionally, depletion of Kindlin 2 impairs myogenic differentiation via downregulation of myogenin. Taken together, our data reveal that Kindlin 2 is required for Wnt signaling-regulated myogenic differentiation, providing a mechanistic insight into the role of Kindlin-2 in muscle development.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma

    Dan Su / Dadong Zhang / Jiaoyue Jin / Lisha Ying / Miao Han / Kaiyan Chen / Bin Li / Junzhou Wu / Zhenghua Xie / Fanrong Zhang / Yihui Lin / Guoping Cheng / Jing-Yu Li / Minran Huang / Jinchao Wang / Kailai Wang / Jianjun Zhang / Fugen Li / Lei Xiong /
    Andrew Futreal / Weimin Mao

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 13

    Abstract: Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 ...

    Abstract Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 inhibitors in esophageal squamous cell carcinoma.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma

    Dan Su / Dadong Zhang / Jiaoyue Jin / Lisha Ying / Miao Han / Kaiyan Chen / Bin Li / Junzhou Wu / Zhenghua Xie / Fanrong Zhang / Yihui Lin / Guoping Cheng / Jing-Yu Li / Minran Huang / Jinchao Wang / Kailai Wang / Jianjun Zhang / Fugen Li / Lei Xiong /
    Andrew Futreal / Weimin Mao

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 13

    Abstract: Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 ...

    Abstract Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 inhibitors in esophageal squamous cell carcinoma.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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