Article: Intraoperative [
2021 Volume 11, Issue 1, Page(s) 28
Abstract: Introduction: In women undergoing breast-conserving surgery (BCS), 20-25% require a re-operation as a result of incomplete tumour resection. An intra-operative technique to assess tumour margins accurately would be a major advantage. A novel method for ... ...
| Abstract | Introduction: In women undergoing breast-conserving surgery (BCS), 20-25% require a re-operation as a result of incomplete tumour resection. An intra-operative technique to assess tumour margins accurately would be a major advantage. A novel method for intraoperative margin assessment was developed by applying a thin flexible scintillating film to specimens-flexible autoradiography (FAR) imaging. A single-arm, multi-centre study was conducted to evaluate the feasibility of intraoperative [ Methods: Eighty-eight patients with invasive breast cancer undergoing BCS received ≤ 300 MBq of [ Results: Data analysis was performed on 66 patients. Intraoperative margin assessment using FAR was completed on 385 margins with 46.2% sensitivity, 81.7% specificity, 8.1% PPV, 97.7% NPV and an overall accuracy of 80.5%, detecting both invasive carcinoma and DCIS. A subgroup analysis based on [ Conclusion: [ Trial registration: Identifier: NCT02666079. Date of registration: 28 January 2016. URL: https://clinicaltrials.gov/ct2/show/NCT02666079 . ISRCTN registry: Reference: ISRCTN17778965. Date of registration: 11 February 2016. URL: http://www.isrctn.com/ISRCTN17778965 . |
|---|---|
| Language | English |
| Publishing date | 2021-03-18 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2619892-7 |
| ISSN | 2191-219X |
| ISSN | 2191-219X |
| DOI | 10.1186/s13550-021-00759-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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