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Article ; Online: Clinician acceptability of an antibiotic prescribing knowledge support system for primary care: a mixed-method evaluation of features and context.

Hurley, Ruth / Jury, Francine / van Staa, Tjeerd P / Palin, Victoria / Armitage, Christopher J

2023 Volume 23, Issue 1, Page(s) 367

Abstract: Background: Overprescribing of antibiotics is a major concern as it contributes to antimicrobial resistance. Research has found highly variable antibiotic prescribing in (UK) primary care, and to support more effective stewardship, the BRIT Project ( ... ...

Abstract	Background: Overprescribing of antibiotics is a major concern as it contributes to antimicrobial resistance. Research has found highly variable antibiotic prescribing in (UK) primary care, and to support more effective stewardship, the BRIT Project (Building Rapid Interventions to optimise prescribing) is implementing an eHealth Knowledge Support System. This will provide unique individualised analytics information to clinicians and patients at the point of care. The objective of the current study was to gauge the acceptability of the system to prescribing healthcare professionals and highlight factors to maximise intervention uptake. Methods: Two mixed-method co-design workshops were held online with primary care prescribing healthcare professionals (n = 16). Usefulness ratings of example features were collected using online polls and online whiteboards. Verbal discussion and textual comments were analysed thematically using inductive (participant-centred) and deductive perspectives (using the Theoretical Framework of Acceptability). Results: Hierarchical thematic coding generated three overarching themes relevant to intervention use and development. Clinician concerns (focal issues) were safe prescribing, accessible information, autonomy, avoiding duplication, technical issues and time. Requirements were ease and efficiency of use, integration of systems, patient-centeredness, personalisation, and training. Important features of the system included extraction of pertinent information from patient records (such as antibiotic prescribing history), recommended actions, personalised treatment, risk indicators and electronic patient communication leaflets. Anticipated acceptability and intention to use the knowledge support system was moderate to high. Time was identified as a focal cost/ burden, but this would be outweighed if the system improved patient outcomes and increased prescribing confidence. Conclusion: Clinicians anticipate that an eHealth knowledge support system will be a useful and acceptable way to optimise antibiotic prescribing at the point of care. The mixed method workshop highlighted issues to assist person-centred eHealth intervention development, such as the value of communicating patient outcomes. Important features were identified including the ability to efficiently extract and summarise pertinent information from the patient records, provide explainable and transparent risk information, and personalised information to support patient communication. The Theoretical Framework of Acceptability enabled structured, theoretically sound feedback and creation of a profile to benchmark future evaluations. This may encourage a consistent user-focused approach to guide future eHealth intervention development.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Health Personnel ; Communication ; Medical Records ; Primary Health Care
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-09239-4
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Article ; Online: The long-term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor-partner interdependence model.

Maharani, Asri / Zaidi, Syeda Nosheen Zehra / Jury, Francine / Vatter, Sabina / Hill, Derek / Leroi, Iracema

Alzheimer's & dementia (New York, N. Y.)

2022 Volume 8, Issue 1, Page(s) e12235

Abstract: Introduction: This study examined the long-term influence of loneliness and social isolation on mental health outcomes in memory assessment service (MAS) attendees and their care partners, with a focus on interdependence and bidirectionality.: Methods! ...

Abstract	Introduction: This study examined the long-term influence of loneliness and social isolation on mental health outcomes in memory assessment service (MAS) attendees and their care partners, with a focus on interdependence and bidirectionality. Methods: Longitudinal data from 95 clinic attendees with cognitive impairment, and their care partners (dyads), from four MAS in the North of England were analyzed. We applied the actor-partner interdependence model, seeking associations within the dyad. At baseline and 12-month follow-up, clinic attendees and care partners completed measures of loneliness and social isolation, depression, and anxiety. Results: Social isolation at baseline was more prevalent in care partners compared to MAS attendees. Social isolation in MAS attendees was associated with higher anxiety symptoms (β = 0.28, 95% confidence intervals [CIs] = 0.11 to 0.45) in themselves at 12 months. We found significant positive actor and partner effects of loneliness on depression (actor effect: β = 0.36, 95% CIs = 0.19 to 0.53; partner effect: β = 0.23, 95% CIs = 0.06 to 0.40) and anxiety (actor effect: β = 0.39, 95% CIs = 0.23 to 0.55; partner effect: β = 0.22, 95% CIs = 0.05 to 0.39) among MAS attendees 1 year later. Loneliness scores of the care partners have a significant and positive association with depressive (β = 0.36, 95% CIs = 0.19 to 0.53) and anxiety symptoms (β = 0.32, 95% CIs = 0.22 to 0.55) in themselves at 12 months. Discussion: Loneliness and social isolation in MAS clinic attendees had a downstream effect on their own and their care partners' mental health. This highlights the importance of including care partners in assessments of mental health and social connectedness and expanding the remit of social prescribing in the MAS context.
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12235
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Article ; Online: Knowledge support for optimising antibiotic prescribing for common infections in general practices: evaluation of the effectiveness of periodic feedback, decision support during consultations and peer comparisons in a cluster randomised trial (BRIT2) - study protocol.

van Staa, Tjeerd / Sharma, Anita / Palin, Victoria / Fahmi, Ali / Cant, Harriet / Zhong, Xiaomin / Jury, Francine / Gold, Natalie / Welfare, William / Ashcroft, Darren / Tsang, Jung Yin / Elliott, Rachel Ann / Sutton, Christopher / Armitage, Chris / Couch, Philip / Moulton, Georgina / Tempest, Edward / Buchan, Iain Edward

BMJ open

2023 Volume 13, Issue 8, Page(s) e076296

Abstract: Introduction: This project applies a Learning Healthcare System (LHS) approach to antibiotic prescribing for common infections in primary care. The approach involves iterations of data analysis, feedback to clinicians and implementation of quality ... ...

Abstract	Introduction: This project applies a Learning Healthcare System (LHS) approach to antibiotic prescribing for common infections in primary care. The approach involves iterations of data analysis, feedback to clinicians and implementation of quality improvement activities by the clinicians. The main research question is, can a knowledge support system (KSS) intervention within an LHS implementation improve antibiotic prescribing without increasing the risk of complications? Methods and analysis: A pragmatic cluster randomised controlled trial will be conducted, with randomisation of at least 112 general practices in North-West England. General practices participating in the trial will be randomised to the following interventions: periodic practice-level and individual prescriber feedback using dashboards; or the same dashboards plus a KSS. Data from large databases of healthcare records are used to characterise heterogeneity in antibiotic uses, and to calculate risk scores for clinical outcomes and for the effectiveness of different treatment strategies. The results provide the baseline content for the dashboards and KSS. The KSS comprises a display within the electronic health record used during the consultation; the prescriber (general practitioner or allied health professional) will answer standard questions about the patient's presentation and will then be presented with information (eg, patient's risk of complications from the infection) to guide decision making. The KSS can generate information sheets for patients, conveyed by the clinicians during consultations. The primary outcome is the practice-level rate of antibiotic prescribing (per 1000 patients) with secondary safety outcomes. The data from practices participating in the trial and the dashboard infrastructure will be held within regional shared care record systems of the National Health Service in the UK. Ethics and dissemination: Approved by National Health Service Ethics Committee IRAS 290050. The research results will be published in peer-reviewed journals and also disseminated to participating clinical staff and policy and guideline developers. Trial registration number: ISRCTN16230629.
MeSH term(s)	Humans ; Feedback ; State Medicine ; General Practice ; Referral and Consultation ; Anti-Bacterial Agents/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-076296
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Article ; Online: Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study.

Fox, Sarah / Brown, Laura J E / Antrobus, Steven / Brough, David / Drake, Richard J / Jury, Francine / Leroi, Iracema / Parry-Jones, Adrian R / Machin, Matthew

JMIR mHealth and uHealth

2022 Volume 10, Issue 1, Page(s) e24483

Abstract: Background: The benefits of involving those with lived experience in the design and development of health technology are well recognized, and the reporting of co-design best practices has increased over the past decade. However, it is important to ... ...

Abstract	Background: The benefits of involving those with lived experience in the design and development of health technology are well recognized, and the reporting of co-design best practices has increased over the past decade. However, it is important to recognize that the methods and protocols behind patient and public involvement and co-design vary depending on the patient population accessed. This is especially important when considering individuals living with cognitive impairments, such as dementia, who are likely to have needs and experiences unique to their cognitive capabilities. We worked alongside individuals living with dementia and their care partners to co-design a mobile health app. This app aimed to address a gap in our knowledge of how cognition fluctuates over short, microlongitudinal timescales. The app requires users to interact with built-in memory tests multiple times per day, meaning that co-designing a platform that is easy to use, accessible, and appealing is particularly important. Here, we discuss our use of Agile methodology to enable those living with dementia and their care partners to be actively involved in the co-design of a mobile health app. Objective: The aim of this study is to explore the benefits of co-design in the development of smartphone apps. Here, we share our co-design methodology and reflections on how this benefited the completed product. Methods: Our app was developed using Agile methodology, which allowed for patient and care partner input to be incorporated iteratively throughout the design and development process. Our co-design approach comprised 3 core elements, aligned with the values of patient co-design and adapted to meaningfully involve those living with cognitive impairments: end-user representation at research and software development meetings via a patient proxy; equal decision-making power for all stakeholders based on their expertise; and continuous user consultation, user-testing, and feedback. Results: This co-design approach resulted in multiple patient and care partner-led software alterations, which, without consultation, would not have been anticipated by the research team. This included 13 software design alterations, renaming of the product, and removal of a cognitive test deemed to be too challenging for the target demographic. Conclusions: We found patient and care partner input to be critical throughout the development process for early identification of design and usability issues and for identifying solutions not previously considered by our research team. As issues addressed in early co-design workshops did not reoccur subsequently, we believe this process made our product more user-friendly and acceptable, and we will formally test this assumption through future pilot-testing.
MeSH term(s)	Dementia ; Humans ; Mobile Applications ; Telemedicine
Language	English
Publishing date	2022-01-14
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719220-9
ISSN	2291-5222 ; 2291-5222
ISSN (online)	2291-5222
ISSN	2291-5222
DOI	10.2196/24483
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Article ; Online: Developing an Intervention to Implement Electronic Patient-Reported Outcomes in Renal Services in the UK.

Van Der Veer, Sabine N / Ercia, Angelo / Caskey, Fergus J / Farrington, Ken / Jury, Francine / Rees, Michael / Whitlock, Tim / Knowles, Sarah

Studies in health technology and informatics

2020 Volume 270, Page(s) 936–940

Abstract: Routinely collecting and using electronic patient-reported outcome (ePRO) data in clinical practice can improve patients' experience and outcomes, but implementing this at scale has proved challenging. As part of the Optimising routine collection of ... ...

Abstract	Routinely collecting and using electronic patient-reported outcome (ePRO) data in clinical practice can improve patients' experience and outcomes, but implementing this at scale has proved challenging. As part of the Optimising routine collection of electronic patient-reported outcomes (OPT-ePRO) study, we therefore developed an intervention that aimed to facilitate the implementation of ePROs. We are conducting OPT-ePRO in the context of secondary care for people with chronic kidney disease in the UK, with three renal units participating as our study sites. Intervention design was guided by Normalisation Process Theory, and informed by published literature and qualitative research. The intervention consisted of a national infrastructure to securely collect, transfer and display ePRO data, complemented with materials and procedures to support kidney patients and renal unit staff with embedding ePROs in usual care pathways. The next step will be to bring the OPT-ePRO intervention into practice and iteratively refine it.
MeSH term(s)	Computer Systems ; Humans ; Patient Reported Outcome Measures ; Renal Insufficiency, Chronic ; United Kingdom
Language	English
Publishing date	2020-05-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI200299
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Article: Sources of variability between biobanks in the estimation of DNA concentration.

Jury, Francine / Morris, Julie / Davis, Emma / Ollier, William / Yuille, Martin

Biopreservation and biobanking

2012 Volume 10, Issue 1, Page(s) 55–61

Abstract: In biobank networks, accrual, aggregation, and retrieval of samples and data are impeded if minimal standards are not agreed in advance by the network members. The critical requirement is that outputs be standardized between biobanks. To start to address ...

Abstract	In biobank networks, accrual, aggregation, and retrieval of samples and data are impeded if minimal standards are not agreed in advance by the network members. The critical requirement is that outputs be standardized between biobanks. To start to address this problem of minimal standards, we undertook a pilot study and now report a follow-up study with 79 centers to identify sources of variability in a common measurement-the estimation of DNA concentration. Our main findings include confirmation of the results of the pilot study on overall variability between centers; fluorescence spectroscopy yields lower estimates of concentration and has less accuracy than absorption spectroscopy; and the 2 technologies differ in their sensitivity to mixing of the samples before measurement. We found that more recent servicing of liquid handling devices contributes to accuracy (at least when deploying absorption spectroscopy). We conclude that, while further study is required, there is a need to promote the development of complete Standard Operating Procedures in academic and commercial laboratories with the implementation of management systems that ensure full adherence to those procedures. There also needs to be a consensus on how much variability in measurements is acceptable for each downstream platform for technologies, including genotyping, sequencing, and epigenetics.
Language	English
Publishing date	2012-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2593993-2
ISSN	1947-5543 ; 1947-5535
ISSN (online)	1947-5543
ISSN	1947-5535
DOI	10.1089/bio.2011.0043
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Article ; Online: Assessing and managing concurrent hearing, vision and cognitive impairments in older people: an international perspective from healthcare professionals.

Leroi, Iracema / Himmelsbach, Ines / Wolski, Lucas / Littlejohn, Jenna / Jury, Francine / Parker, Angela / Charalambous, Anna Pavlina / Dawes, Piers / Constantinidou, Fofi / Thodi, Chryssoula

Age and ageing

2019 Volume 48, Issue 4, Page(s) 580–587

Abstract: Background: there is a significant gap in the understanding, assessment and management of people with dementia and concurrent hearing and vision impairments.: Objective: from the perspective of professionals in dementia, hearing and vision care, we ... ...

Abstract	Background: there is a significant gap in the understanding, assessment and management of people with dementia and concurrent hearing and vision impairments. Objective: from the perspective of professionals in dementia, hearing and vision care, we aimed to: (1) explore the perceptions of gaps in assessment and service provision in ageing-related hearing, vision and cognitive impairment; (2) consider potential solutions regarding this overlap and (3) ascertain the attitudes, awareness and practice, with a view to implementing change. Methods: our two-part investigation with hearing, vision, and dementia care professionals involved: (1) an in-depth, interdisciplinary, international Expert Reference Group (ERG; n = 17) and (2) a wide-scale knowledge, attitudes and practice survey (n = 653). The ERG involved consensus discussions around prototypic clinical vignettes drawn from a memory centre, an audiology clinic, and an optometry clinic, analysed using an applied content approach. Results: the ERG revealed several gaps in assessment and service provision, including a lack of validated assessment tools for concurrent impairments, poor interdisciplinary communication and care pathways, and a lack of evidence-based interventions. Consensus centred on the need for flexible, individualised, patient-centred solutions, using an interdisciplinary approach. The survey data validated these findings, highlighting the need for clear guidelines for assessing and managing concurrent impairments. Conclusions: this is the first international study exploring professionals' views of the assessment and care of individuals with age-related hearing, vision and hearing impairment. The findings will inform the adaptation of assessments, the development of supportive interventions, and the new provision of services.
MeSH term(s)	Aged ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/therapy ; Consensus ; Dementia/diagnosis ; Dementia/therapy ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Hearing Loss/diagnosis ; Hearing Loss/therapy ; Humans ; Interdisciplinary Communication ; Internationality ; Memory Disorders/diagnosis ; Memory Disorders/therapy ; Vision Disorders/diagnosis ; Vision Disorders/therapy
Language	English
Publishing date	2019-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afy183
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Genetic susceptibility to total hip arthroplasty failure--positive association with mannose-binding lectin.

Malik, Mohammad H A / Bayat, Ardeshir / Jury, Francine / Kay, Peter R / Ollier, William E R

The Journal of arthroplasty

2007 Volume 22, Issue 2, Page(s) 265–270

Abstract: Mannose-binding lectin (MBL) may be involved in the biologic cascade of events initiated by wear debris and bacterial infection around loosened total hip arthroplasties (THAs). Individual responses to such stimuli may be dictated by genetic variation ... ...

Abstract	Mannose-binding lectin (MBL) may be involved in the biologic cascade of events initiated by wear debris and bacterial infection around loosened total hip arthroplasties (THAs). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). We performed a case-control study on 4 MBL SNPs using case patients (n = 91) with aseptic loosening or deep infection (n = 71). Control subjects (n = 150) had clinically and radiologically well-fixed THAs for more than 10 years. Frequency of the C allele (P = .001) and that of the genotype C/C (P = .004) for the -550 SNP were associated with aseptic failure. The codon 54 SNP G allele (P = .012) and G/G genotype (P = .027) frequencies were associated with aseptic failure as well. In the septic group, the frequency of the C allele (P = .01) and that of the genotype C/C (P = .05) for the -550 SNP were significant. Failure of THAs may be under genetic influence to candidate susceptibility genes such as MBL.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Hip ; Chi-Square Distribution ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Mannose-Binding Lectin/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Prosthesis Failure
Chemical Substances	Mannose-Binding Lectin
Language	English
Publishing date	2007-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632770-9
ISSN	0883-5403
ISSN	0883-5403
DOI	10.1016/j.arth.2006.02.163
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Zs.A 2134: Show issues

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Article ; Online: Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility.

Emsley, Hedley C A / Appleton, Richard E / Whitmore, Catherine L / Jury, Francine / Lamb, Janine A / Martin, Joanne E / Ollier, William E R / de la Morandière, Katherine Potier / Southern, Kevin W / Allan, Stuart M

Seizure

2014 Volume 23, Issue 6, Page(s) 457–461

Abstract: Purpose: To investigate whether genetic variants in inflammation-related genes are associated with increased risk of childhood-onset febrile seizures.: Method: Tagging single nucleotide polymorphisms (SNPs) from 19 inflammation-related candidate ... ...

Abstract	Purpose: To investigate whether genetic variants in inflammation-related genes are associated with increased risk of childhood-onset febrile seizures. Method: Tagging single nucleotide polymorphisms (SNPs) from 19 inflammation-related candidate genes were identified and genotyped on the Sequenom platform in a sample of Caucasian childhood-onset febrile seizures cases (n=98) compared to ethnicity, age and gender matched febrile controls presenting without seizures (n=123). Tests for allelic association were carried out using PLINK. SNPs generating empirical P-values (P<0.05) were analysed in an expanded Caucasian control sample (n=2692) from the 1958 Birth Cohort. Results: Six SNPs generated empirical pointwise significance values P<0.05 in the febrile seizures case-control analysis in the P2X7R (purinergic receptor P2X7), TLR4 (toll-like receptor 4), IL6R (interleukin 6 receptor) and PTGER3 (prostaglandin E receptor 3, subtype EP3) genes. The most significant result was for missense SNP rs208294 in P2X7R (P=0.009); this novel association was supported in the expanded case-control analysis using the 1958 Birth Cohort (pointwise P=0.009, OR=0.63, familywise P=0.039). Conclusion: Genetic variants in inflammation-related genes, specifically purinergic receptor P2X7, may be involved in susceptibility to childhood-onset febrile seizures.
MeSH term(s)	Case-Control Studies ; Cohort Studies ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Prospective Studies ; Receptors, Interleukin-6/genetics ; Receptors, Prostaglandin E, EP3 Subtype/genetics ; Receptors, Purinergic P2X7/genetics ; Seizures, Febrile/genetics ; Seizures, Febrile/immunology ; Toll-Like Receptor 4/genetics ; Whites/genetics
Chemical Substances	IL6R protein, human ; PTGER3 protein, human ; Receptors, Interleukin-6 ; Receptors, Prostaglandin E, EP3 Subtype ; Receptors, Purinergic P2X7 ; TLR4 protein, human ; Toll-Like Receptor 4
Language	English
Publishing date	2014-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2014.03.006
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Zs.A 3573: Show issues

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Article ; Online: Development of a multiplex primer extension assay for rapid detection of Salmonella isolates of diverse serotypes.

Ben-Darif, Elloulu / Jury, Francine / De Pinna, Elizabeth / Threlfall, E John / Bolton, Frederick J / Fox, Andrew J / Upton, Mathew

Journal of clinical microbiology

2010 Volume 48, Issue 4, Page(s) 1055–1060

Abstract: Food-borne salmonellosis is a major manifestation of gastrointestinal disease in humans across the globe. Accurate and rapid identification methods could positively impact the identification of isolates, enhance outbreak investigation, and aid infection ... ...

Abstract	Food-borne salmonellosis is a major manifestation of gastrointestinal disease in humans across the globe. Accurate and rapid identification methods could positively impact the identification of isolates, enhance outbreak investigation, and aid infection control. The SNaPshot multiplex system is a primer extension-based method that enables multiplexing of single nucleotide polymorphisms (SNPs). Here the method has been developed for the identification of five Salmonella serotypes, commonly detected in the United Kingdom, based on serotype-specific SNPs identified in the multilocus sequence typing (MLST) database of Salmonella enterica. The SNPs, in genes hemD, thrA, purE, and sucA, acted as surrogate markers for S. enterica serovars Typhimurium, Enteritidis, Virchow, Infantis, and Braenderup. The multiplex primer extension assay (MPEA) was conducted in two separate panels and evaluated using 152 Salmonella enterica isolates that were characterized by MLST. The MPEA was shown to be 100% specific and sensitive, within this collection of isolates. The MPEA is a sensitive and specific method for the identification and detection of Salmonella serotypes based upon SNPs seen in MLST data. The method can be applied in less than 6 h and has the potential to improve patient care and source tracing. The utility of the assay for identification of Salmonella serotypes directly from clinical specimens and food samples warrants further investigation.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Typing Techniques ; DNA, Bacterial/genetics ; Foodborne Diseases/microbiology ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Salmonella Infections/diagnosis ; Salmonella Infections/microbiology ; Salmonella enterica/classification ; Salmonella enterica/genetics ; Salmonella enterica/isolation & purification ; Sensitivity and Specificity ; Serotyping ; United Kingdom
Chemical Substances	Bacterial Proteins ; DNA, Bacterial
Language	English
Publishing date	2010-02-17
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01566-09
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