LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 34

Search options

  1. Book ; Thesis: Personalisierte Arzneimittelsicherheit für ältere Patienten

    Just, Katja

    2022  

    Author's details vorgelegt von Dr. med. Katja Just
    Language German ; English
    Size 202 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Rheinisch-Westfälische Technische Hochschule Aachen, 2022
    Note Text deutsch, Aufsätze englisch ; Die Habilitationsschrift besteht aus einem Text und 12 Aufsätzen, die zuvor in verschiedenen Publikationen veröffentlicht wurden
    HBZ-ID HT021580799
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 268 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Klinische Pharmakologie in der psychotherapeutischen Arbeit

    Stingl, Julia / Just, Katja / Paulzen, Michael

    ein patientenzentriertes Lehrbuch für Studium, Ausbildung und Praxis

    2023  

    Author's details Julia C. Stingl, Katja S. Just, Michael Paulzen (Hrsg.)
    Subject code 610
    Language German
    Size 228 Seiten, Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT021863667
    ISBN 978-3-17-043060-0 ; 3-17-043060-2 ; 9783170430624 ; 9783170430617 ; 3170430629 ; 3170430610
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 615 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Präoperative Medikation: aktuelle Herausforderungen in der Pharmakotherapie.

    Just, Katja S

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2021  Volume 56, Issue 10, Page(s) 652–665

    Abstract: Analysis of preoperative medication is used to assess the benefit and risk associated with continuing or discontinuing medication before and during surgery. Identifying adverse drug reactions and assessing its risks often leads to uncertainty. Typical ... ...

    Title translation Current Challenges in Pharmacotherapy.
    Abstract Analysis of preoperative medication is used to assess the benefit and risk associated with continuing or discontinuing medication before and during surgery. Identifying adverse drug reactions and assessing its risks often leads to uncertainty. Typical challenges are medication underuse, but also overuse occurs and is often more difficult to recognize, especially in the context of drug interactions and individual patient characteristics.Typical consequences of multi-medication and medical overuse may include an increased potential for drug interactions, an increased risk of adverse drug reactions and medication errors, and in particular in older adults, geriatric syndromes may occur or worsen. Adverse drug reactions may occur as a result of the dose administered and as an effect of time of exposure. Older, multi-morbid, and multi-medicated patients are often affected by adverse drug reactions. For drugs primarily metabolized via the phase I enzymes CYP2D6, CYP2C9, or CYP2C19, pharmacogenetically rapid or slow metabolism may result in altered drug exposures. Clinically relevant pharmacokinetic drug interactions frequently occur with drugs primarily metabolized via the phase I enzyme CYP3A4.
    MeSH term(s) Aged ; Cytochrome P-450 CYP2D6 ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Humans
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
    Language German
    Publishing date 2021-10-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-1226-4647
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 96: Show issues
    Zs.A 257/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Präoperative Medikation: aktuelle Herausforderungen in der Pharmakotherapie

    Just, Katja S.

    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

    2021  Volume 56, Issue 10, Page(s) 652–665

    Abstract: Die Analyse der präoperativen Medikation dient der Nutzen-Risiko-Abschätzung, ob die Dauermedikation perioperativ weitergegeben oder abgesetzt werden soll – die Risikobeurteilung sorgt aber oft für Unsicherheit. Typische Herausforderungen sind ... ...

    Abstract Die Analyse der präoperativen Medikation dient der Nutzen-Risiko-Abschätzung, ob die Dauermedikation perioperativ weitergegeben oder abgesetzt werden soll – die Risikobeurteilung sorgt aber oft für Unsicherheit. Typische Herausforderungen sind medikamentöse Unter- und Überversorgung, unerwünschte Arzneimittelwirkungen und -interaktionen sowie individuelle Besonderheiten, die zu verlängerter Wirkdauer und erhöhter Dosisexposition führen können.
    Keywords präoperative Medikation ; unerwünschte Arzneimittelwirkungen ; Multimedikation ; Pharmakogenetik ; Arzneimittelinteraktionen ; preoperative medication ; adverse drug reaction ; multimedication ; pharmacogenetics ; drug-drug interaction
    Language German
    Publishing date 2021-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-1226-4647
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 96: Show issues
    Zs.A 257/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Assessment of Substrate Status of Drugs Metabolized by Polymorphic Cytochrome P450 (CYP) 2 Enzymes: An Analysis of a Large-Scale Dataset.

    Sommer, Jakob / Wozniak, Justyna / Schmitt, Judith / Koch, Jana / Stingl, Julia C / Just, Katja S

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: Background: The analysis of substrates of polymorphic cytochrome P450 (CYP) enzymes is important information to enable drug-drug interactions (DDIs) analysis and the relevance of pharmacogenetics in this context in large datasets. Our aim was to compare ...

    Abstract Background: The analysis of substrates of polymorphic cytochrome P450 (CYP) enzymes is important information to enable drug-drug interactions (DDIs) analysis and the relevance of pharmacogenetics in this context in large datasets. Our aim was to compare different approaches to assess the substrate properties of drugs for certain polymorphic CYP2 enzymes.
    Methods: A standardized manual method and an automatic method were developed and compared to assess the substrate properties for the metabolism of drugs by CYP2D6, 2C9, and 2C19. The automatic method used a matching approach to three freely available resources. We applied the manual and automatic methods to a large real-world dataset deriving from a prospective multicenter study collecting adverse drug reactions in emergency departments in Germany (ADRED).
    Results: In total, 23,878 medication entries relating to 895 different drugs were analyzed in the real-world dataset. The manual method was able to assess 12.2% (
    Conclusion: A closer look at different classifications between methods revealed that both methods are prone to error in different ways. While the automated method excels in time efficiency, completeness, and actuality, the manual method might be better able to identify CYP2 substrates with clinical relevance.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online: U-PGx - Ubiquitous Pharmacogenomics

    Just, Katja / Stingl, Julia / Rühberg, Stefan

    European pharmacogenomics implementation project : funded by the European Union's Horizon 2020 research and innovation programme

    2016  

    Title variant Ubiquitous Pharmacogenomics
    Author's details director: Michael Harkämper ; screenwriters: Katja Just, Julia Stingl ; film editor: Stefan Rühberg
    Language English
    Size 1 Online-Ressource (1 Videodatei)
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Online
    Note This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668353
    HBZ-ID HT019735796
    DOI 10.4126/FRL01-006408622
    Database Repository for Life Sciences

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book ; Online: U-PGx - Ubiquitous Pharmacogenomics (Short version)

    Just, Katja / Stingl, Julia / Rühberg, Stefan

    European pharmacogenomics implementation project : funded by the European Union's Horizon 2020 research and innovation programme

    2016  

    Title variant Ubiquitous Pharmacogenomics
    Author's details director: Michael Harkämper ; screenwriters: Katja Just, Julia Stingl ; film editor: Stefan Rühberg
    Language English
    Size 1 Online-Ressource (1 Videodatei)
    Edition Short version
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Online
    Note This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668353
    HBZ-ID HT019743040
    DOI 10.4126/FRL01-006408750
    Database Repository for Life Sciences

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book ; Online ; Thesis: Theory of mind und Objektwahrnehmung

    Just, Katja / Vogeley, Kai / Kessler, Josef

    ein interaktives Paradigma zur Erforschung des Zusammenhangs zwischen Objektbewertung und intersubjektivem Blickverhalten

    2013  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Psychosomatik und Psychotherapie
    Author's details von Katja Weber ; 1. Berichterstatter: Universitätsprofessor Dr. med. Dr. phil. K. Vogeley, 2. Berichterstatter: Professor Dr. rer. soc. J. Kessler ; aus dem Zentrum für Neurologie und Psychiatrie der Universität zu Köln, Klinik und Poliklinik für Psychiatrie und Psychotherapie
    Subject code 610
    Language German
    Size 97 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT017561280
    DOI 10.4126/38m-004960663
    Database Repository for Life Sciences

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Thesis: Theory of mind und Objektwahrnehmung

    Just, Katja / Vogeley, Kai / Kessler, Josef

    ein interaktives Paradigma zur Erforschung des Zusammenhangs zwischen Objektbewertung und intersubjektivem Blickverhalten

    2013  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Psychosomatik und Psychotherapie
    Author's details von Katja Weber ; 1. Berichterstatter: Universitätsprofessor Dr. med. Dr. phil. K. Vogeley, 2. Berichterstatter: Professor Dr. rer. soc. J. Kessler ; aus dem Zentrum für Neurologie und Psychiatrie der Universität zu Köln, Klinik und Poliklinik für Psychiatrie und Psychotherapie
    Subject code 610
    Language German
    Size 99 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT017606200
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 D 285 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant - implications for precision dosing in a global perspective.

    Langmia, Immaculate M / Just, Katja S / Yamoune, Sabrina / Müller, Julian Peter / Stingl, Julia C

    British journal of clinical pharmacology

    2022  Volume 88, Issue 12, Page(s) 5149–5165

    Abstract: Ketamine and its enantiomer S-ketamine (esketamine) are known to produce rapid-onset antidepressant effects in major depression. Intranasal esketamine has recently come onto the market as an antidepressant. Besides experience from short-term use in ... ...

    Abstract Ketamine and its enantiomer S-ketamine (esketamine) are known to produce rapid-onset antidepressant effects in major depression. Intranasal esketamine has recently come onto the market as an antidepressant. Besides experience from short-term use in anaesthesia and analgesia, the experience with ketamine as long-term medication is rather low. The use of ketamine and esketamine is limited due to potential neurotoxicity, psychotomimetic side effects, potential abuse and interindividual variability in treatment response including cessation of therapy. Therefore, taking a look at individual patient risks and potential underlying variability in pharmacokinetics may improve safety and dosing of these new antidepressant drugs in clinical practice. Differential drug metabolism due to polymorphic cytochrome P450 (CYP) enzymes and gene-drug interactions are known to influence the efficacy and safety of many drugs. Ketamine and esketamine are metabolized by polymorphic CYP enzymes including CYP2B6, CYP3A4, CYP2C9 and CYP2A6. In antidepressant drug therapy, usually multiple drugs are administered which are substrates of CYP enzymes, increasing the risk for drug-drug interactions. We reviewed the potential impact of polymorphic CYP variants and common drug-drug interactions in antidepressant drug therapy affecting ketamine pharmacokinetics, and the role for dose optimization. The use of ketamine or intranasal esketamine as antidepressants demands a better understanding of the factors that may impact its metabolism and efficacy in long-term use. In addition to other clinical and environmental confounders, prior information on the pharmacodynamic and pharmacokinetic determinants of response variability to ketamine and esketamine may inform on dose optimization and identification of individuals at risk of adverse drug reactions.
    MeSH term(s) Humans ; Ketamine/adverse effects ; Pharmacogenetics ; Antidepressive Agents ; Drug Interactions ; Cytochrome P-450 Enzyme System/genetics
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Antidepressive Agents ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15467
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top