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  1. Article ; Online: Evolution and structure of clinically relevant gene fusions in multiple myeloma

    Steven M. Foltz / Qingsong Gao / Christopher J. Yoon / Hua Sun / Lijun Yao / Yize Li / Reyka G. Jayasinghe / Song Cao / Justin King / Daniel R. Kohnen / Mark A. Fiala / Li Ding / Ravi Vij

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Multiple myeloma is characterised by frequent gene fusions. Here, the authors use data from the Multiple Myeloma Research Foundation CoMMpass Study to further investigate fusion genes in this disease and their clinical relevance. ...

    Abstract Multiple myeloma is characterised by frequent gene fusions. Here, the authors use data from the Multiple Myeloma Research Foundation CoMMpass Study to further investigate fusion genes in this disease and their clinical relevance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Evolution and structure of clinically relevant gene fusions in multiple myeloma

    Steven M. Foltz / Qingsong Gao / Christopher J. Yoon / Hua Sun / Lijun Yao / Yize Li / Reyka G. Jayasinghe / Song Cao / Justin King / Daniel R. Kohnen / Mark A. Fiala / Li Ding / Ravi Vij

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Multiple myeloma is characterised by frequent gene fusions. Here, the authors use data from the Multiple Myeloma Research Foundation CoMMpass Study to further investigate fusion genes in this disease and their clinical relevance. ...

    Abstract Multiple myeloma is characterised by frequent gene fusions. Here, the authors use data from the Multiple Myeloma Research Foundation CoMMpass Study to further investigate fusion genes in this disease and their clinical relevance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Co-evolution of tumor and immune cells during progression of multiple myeloma

    Ruiyang Liu / Qingsong Gao / Steven M. Foltz / Jared S. Fowles / Lijun Yao / Julia Tianjiao Wang / Song Cao / Hua Sun / Michael C. Wendl / Sunantha Sethuraman / Amila Weerasinghe / Michael P. Rettig / Erik P. Storrs / Christopher J. Yoon / Matthew A. Wyczalkowski / Joshua F. McMichael / Daniel R. Kohnen / Justin King / Scott R. Goldsmith /
    Julie O’Neal / Robert S. Fulton / Catrina C. Fronick / Timothy J. Ley / Reyka G. Jayasinghe / Mark A. Fiala / Stephen T. Oh / John F. DiPersio / Ravi Vij / Li Ding

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 18

    Abstract: Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune ... ...

    Abstract Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune cell composition throughout progression.
    Keywords Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article: 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma

    de la Puente, Pilar / Abdel Kareem Azab / Barbara Muz / Feda Azab / Justin King / Micah Luderer / Ravi Vij / Rebecca C. Gilson / Samuel Achilefu

    Biomaterials. 2015 Dec., v. 73

    2015  

    Abstract: Multiple myeloma (MM) is the second most prevalent hematological malignancy and it remains incurable despite the introduction of several novel drugs. The discrepancy between preclinical and clinical outcomes can be attributed to the failure of classic ... ...

    Abstract Multiple myeloma (MM) is the second most prevalent hematological malignancy and it remains incurable despite the introduction of several novel drugs. The discrepancy between preclinical and clinical outcomes can be attributed to the failure of classic two-dimensional (2D) culture models to accurately recapitulate the complex biology of MM and drug responses observed in patients. Experimental design: We developed 3D tissue engineered bone marrow (3DTEBM) cultures derived from the BM supernatant of MM patients to incorporate different BM components including MM cells, stromal cells, and endothelial cells. Distribution and growth were analyzed by confocal imaging, and cell proliferation of cell lines and primary MM cells was tested by flow cytometry. Oxygen and drug gradients were evaluated by immunohistochemistry and flow cytometry, and drug resistance was studied by flow cytometry.3DTEBM cultures allowed proliferation of MM cells, recapitulated their interaction with the microenvironment, recreated 3D aspects observed in the bone marrow niche (such as oxygen and drug gradients), and induced drug resistance in MM cells more than 2D or commercial 3D tissue culture systems.3DTEBM cultures not only provide a better model for investigating the pathophysiology of MM, but also serve as a tool for drug development and screening in MM. In the future, we will use the 3DTEBM cultures for developing personalized therapeutic strategies for individual MM patients.
    Keywords bone marrow ; cell proliferation ; drugs ; endothelial cells ; experimental design ; flow cytometry ; image analysis ; immunohistochemistry ; models ; multiple drug resistance ; myeloma ; oxygen ; pathophysiology ; patients ; screening ; stromal cells ; tissue culture ; tissue engineering
    Language English
    Dates of publication 2015-12
    Size p. 70-84.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2015.09.017
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

    Cinzia Federico / Kinan Alhallak / Jennifer Sun / Kathleen Duncan / Feda Azab / Gail P. Sudlow / Pilar de la Puente / Barbara Muz / Vaishali Kapoor / Luna Zhang / Fangzheng Yuan / Matea Markovic / Joseph Kotsybar / Katherine Wasden / Nicole Guenthner / Shannon Gurley / Justin King / Daniel Kohnen / Noha N. Salama /
    Dinesh Thotala / Dennis E. Hallahan / Ravi Vij / John F. DiPersio / Samuel Achilefu / Abdel Kareem Azab

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-agent ... ...

    Abstract The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-agent controls and reduces BTZ-related side effects.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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