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  1. Article ; Online: An observational study to evaluate the relation between infarction type, site, and the degree of conductive system damage

    K Sangeetha / S Myilsamy / Praveen Vijayakumar / Panneerselvam Periaswamy

    APIK Journal of Internal Medicine, Vol 11, Iss 1, Pp 50-

    2023  Volume 52

    Abstract: Background: Obesity, insulin resistance, and type 2 diabetes mellitus are all on the rise, and they are all significant risk factors for ischemic heart disease (IHD). The prevalence of risk factors for IHD is quickly growing in developing countries as a ... ...

    Abstract Background: Obesity, insulin resistance, and type 2 diabetes mellitus are all on the rise, and they are all significant risk factors for ischemic heart disease (IHD). The prevalence of risk factors for IHD is quickly growing in developing countries as a result of urbanization. Large rises in IHD are observed around the world, and IHD has overtaken cancer as the leading cause of death after 2020. Materials and Methods: This is a 6-month prospective observational research undertaken at a tertiary care hospital where the myocardial infarction (MI) patients admitted to the intensive coronary care unit were included in the study. Results: Atrioventricular (AV) block was absent in 178 of 200 patients with acute MI. AV block was found in 22 of the remaining cases. The following is the frequency of each form of AV block: 12 patients had type 1 AV block. In five of the cases, type 1, 3 transition was found. Type 2 AV block was found in two cases. In one case, there was a 2, 3 transition. Conclusion: Preventing conduction system block may require the effective management of hypertension and maintaining appropriate blood glucose levels.
    Keywords conduction system of heart ; coronary artery ; ischemic heart disease ; myocardial infarction ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Extraction, characterization, and application of tomato seed oil in the food industry

    K. Sangeetha / R.B. Ramyaa / Amin Mousavi Khaneghah / Mahendran Radhakrishnan

    Journal of Agriculture and Food Research, Vol 11, Iss , Pp 100529- (2023)

    An updated review

    2023  

    Abstract: Tomato seeds are the by-product of the tomato processing industry used to extract valuable compounds like tomato seed oil (TSO). The TSO is well known for its functional and health-promoting properties. Therefore, recent studies which focused on ... ...

    Abstract Tomato seeds are the by-product of the tomato processing industry used to extract valuable compounds like tomato seed oil (TSO). The TSO is well known for its functional and health-promoting properties. Therefore, recent studies which focused on application of TSO became popular among food manufacturers. This review presents comprehensive methods of TSO extraction and its unique fatty acid profile. The characterization of TSO is briefly discussed, creating a better utilization for various diseases. This review also focused on the multiple application of TSO in the food industry, from dietary supplements to food packaging films, the demand for TSO in the market to improve economic value, and the importance of TSO in the food and medical industry. The TSO can be extensively applicable as a functional compound in the food and bakery industry as a covering material in tomato-based products like tomato sauce and slices. It also acts as a better antioxidant and has antimicrobial properties due to its essential fatty acids like oleic and linoleic acid. The assessment of this article provides an overview of the importance of TSO in food application, from extraction techniques to dietary supplements and its potential for bioactive compounds.
    Keywords Tomato ; Tomato seed oil ; Bioactive compounds ; Extraction ; Fatty acids ; Agriculture (General) ; S1-972 ; Nutrition. Foods and food supply ; TX341-641
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Defense Against Protocol Level Attack in Tor Network using Deficit Round Robin Queuing Process

    K. Sangeetha / K. Ravikumar

    Egyptian Informatics Journal, Vol 19, Iss 3, Pp 199-

    2018  Volume 205

    Abstract: Among different types of network, Tor network is mostly referred as an onion-routing network which enables the anonymous communication and supports TCP applications over the network. The onion-routing is utilized by the Tor network for transmitting the ... ...

    Abstract Among different types of network, Tor network is mostly referred as an onion-routing network which enables the anonymous communication and supports TCP applications over the network. The onion-routing is utilized by the Tor network for transmitting the information of users via virtual circuits which are created by several successive relays. The performance and security of the anonymous communication in Tor network have been improved by using Novel Traffic Dividing and Scheduling (NTDS) mechanism. Normally, this mechanism was used for preventing the basic versions of sniper attacks in the Tor network. On the other hand, protocol-level attacks were not possible to prevent since some malicious entry router may duplicate, alter, insert or delete the TCP stream cells from the sender. This may cause cell recognition errors at the exit router and these cell recognition errors were recognized at the destination which helps to identify the sender. Hence, in this article, a defense mechanism called Mid-DRRQ is proposed for protocol-level attacks against Tor network. In Mid-DRRQ mechanism, the protocol-level attacks are prevented by using indistinguishability obfuscation model which generates the fake traffic within the middle relay. This fake traffic is allowed on outgoing connections without any cover traffic. Moreover, the outgoing connections of middle relays are controlled by using Deficit Round Robin queuing process. Finally, the simulation results show that the proposed mechanism effectively prevents the protocol-level attacks against Tor network. Keywords: Tor network, Novel traffic dividing and scheduling, Protocol-level attacks, Indistinguishability obfuscation, Fake traffic, Deficit Round Robin queuing
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 303
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Unraveling Interface-Driven and Loss Mechanism-Centric Phenomena in 3D/2D Halide Perovskites: Prospects for Optoelectronic Applications.

    Singh, Balpartap / Saykar, Nilesh G / Kumar, Boddeda Sai / Afria, Dikshant / C K, Sangeetha / Rondiya, Sachin R

    ACS omega

    2024  Volume 9, Issue 9, Page(s) 10000–10016

    Abstract: In recent years, organic-inorganic metal halide perovskite solar cells (PSCs) have attracted considerable interest due to their remarkable and rapidly advancing efficiencies. Over the past decade, PSC efficiencies have significantly approached those of ... ...

    Abstract In recent years, organic-inorganic metal halide perovskite solar cells (PSCs) have attracted considerable interest due to their remarkable and rapidly advancing efficiencies. Over the past decade, PSC efficiencies have significantly approached those of state-of-the-art silicon-based photovoltaics, making them a promising material. Currently, the scientific community widely recognizes the performance of 3D-PSCs and 2D-PSCs individually. However, when both are combined to form a heterostructure, the lattice and charge dynamics at the interface undergo a multitude of mechanisms that affect their performance. The interface between heterostructures facilitates the degradation of PSCs. The degradation pathways can be attributed to lattice distortions, inhomogeneous energy landscapes, interlayer ion migration, nonradiative recombination, and charge accumulation. This Review is dedicated to examining the phenomena that arise at the interface of 3D/2D halide perovskites and their related photophysical properties and loss mechanism processes. We mainly focus on the impact of lattice mismatch, energy level alignment, anomalous carrier dynamics, and loss mechanisms. We propose a "cause-impact-identify-rectify" approach to gain a comprehensive understanding of the ultrafast processes occurring within the material. Finally, we highlight the importance of advanced spectroscopic and imaging techniques in unraveling these intricate mechanisms. This discussion delves into the future possibilities of fabricating 3D/2D heterostructure-based optoelectronic devices, pushing the boundaries of performance across diverse fields. It envisions the creation of devices with unparalleled capabilities, exceeding the limitations of current technologies.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Electro-optic characteristics investigation on NLO crystal; L-Valine doped Ethylene Diamine Tetra Acetate (EDTA) composite crystal using quantum chemical calculations

    M. Joice Malini / S. Ramalingam, M.Sc., MPhil., Ph.D / R. Kunjitham / M.K. Sangeetha

    Chemical Physics Impact, Vol 2, Iss , Pp 100021- (2021)

    2021  

    Abstract: In this research work, the attempt was made to fabricate efficient NLO crystal using organic composite; L-Valine doped Ethylene Diamine Tetra Acetate (EDTA). The observed XRD peaks intimate the crystal lattice as orthorhombic and respective lattice ... ...

    Abstract In this research work, the attempt was made to fabricate efficient NLO crystal using organic composite; L-Valine doped Ethylene Diamine Tetra Acetate (EDTA). The observed XRD peaks intimate the crystal lattice as orthorhombic and respective lattice characteristics were studied. The unit cell was calculated as a = 5.811 Å, b = 11.735 Å and c = 5.014 Å and the respective refractive indices determined to be 1.547, 1.789 and 1.610. The Birefringence (Δn) Kλ/t is found to be 0.271 and the corresponding NLO efficiency calculated to be 0.846 [I/I(SiO2)]. The compositional parts activity was keenly observed from their vibrational modes and their space charge and oriental polarization characteristics were studied and thereby dielectric susceptibility for inducing NLO activity was presented. The chemical shift for both experimental and theoretical analysis was observed and the storage of chemical potential among core C was measured. The band gap and transparency for IR and UV-Visible region estimated and the wide range for both confirmed the dielectric reactance for optical energy. The DTA-DSC curve was traced and the thermal stability and Gibbs free energy profile was studied. The SEM images recorded and the surface morphology was displayed for knowing the molecular coordination arrangement. The chemi-potential energy exchange was measured for different molecular entities for non bonding system of bonded composite.
    Keywords L-Valine ; EDTA ; Birefringence ; Dielectric susceptibility ; DTA-DSC ; Gibbs and chemi-potential ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 541
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Hybrid Optimized GRU-ECNN Models for Gait Recognition with Wearable IOT Devices

    K. M. Monica / R. Parvathi / A. Gayathri / Rajanikanth Aluvalu / K. Sangeetha / Chennareddy Vijay Simha Reddy

    Computational Intelligence and Neuroscience, Vol

    2022  Volume 2022

    Abstract: With the advent of the Internet of Things (IoT), human-assistive technologies in healthcare services have reached the peak of their application in terms of diagnosis and treatment process. These devices must be aware of human movements to provide better ... ...

    Abstract With the advent of the Internet of Things (IoT), human-assistive technologies in healthcare services have reached the peak of their application in terms of diagnosis and treatment process. These devices must be aware of human movements to provide better aid in clinical applications as well as the user’s daily activities. In this context, real-time gait analysis remains to be key catalyst for developing intelligent assistive devices. In addition to machine and deep learning algorithms, gait recognition systems have significantly improved in terms of high accuracy recognition. However, most of the existing models are focused on improving gait recognition while ignoring the computational overhead that affects the accuracy of detection and even remains unsuitable for real-time implementation. In this research paper, we proposed a hybrid gated recurrent unit (GRU) based on BAT-inspired extreme convolutional networks (BAT-ECN) for the effective recognition of human activities using gait data. The gait data are collected by implanting the wearable Internet of Things (WIoT) devices invasively. Then, a novel GRU and ECN networks are employed to extract the spatio-temporal features which are then used for classification to realize gait recognition. Extensive and comprehensive experimentations have been carried out to evaluate the proposed model using real-time datasets and also other benchmarks such as whuGait and OU-ISIR datasets. To prove the excellence of the proposed learning model, we have compared the model’s performance with the other existing hybrid models. Results demonstrate that the proposed model has outperformed the other learning models in terms of high gait classification and less computational overhead.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Subject code 006
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Molecular interaction of phytochemicals with snake venom: Phytochemicals of Andrographis paniculata inhibits phospholipase A2 of Russell's viper (Daboia russelli)

    Shivashankar, Saranya / Aswini Murali / M.K. Sangeetha

    Biocatalysis and agricultural biotechnology. 2019 Mar., v. 18

    2019  

    Abstract: Andrographis paniculata belonging to Acanthaceae family is an annual herb, traditionally used for venomous bites in various parts of Asia. The plant has various phytochemicals with numerous biological properties which are chemically well characterized ... ...

    Abstract Andrographis paniculata belonging to Acanthaceae family is an annual herb, traditionally used for venomous bites in various parts of Asia. The plant has various phytochemicals with numerous biological properties which are chemically well characterized and available in the database out of which 22 phytochemicals was used for the study. Our study focuses on finding a lead phytochemical by employing various in-silico methods (Metapocket and Autodock) for the inhibition of venomous protein, namely phospholipase A2. Phospholipase A2 (PLA A2) is conserved in snakes and also considered to be the major toxin possessing equally lethal effect, neurotoxic and myotoxic. Though the PLA A2 three dimensional structure is available, finding the active motif of PLA A2 will make the molecular interaction (docking) studies accurate. Hence, MetaPocket, a tool used for finding the active site as it encompass the results of eight independent pocket site prediction methods. The ability of phytochemical to bind the predicted active site of PLA A2 is carried out with the widely used simulation method, Autodock. Results provided a strong evidence for the presence of multiple putative anti-venom (inhibitor of PLA A2) phytochemicals in A. paniculata (esp., Deoxyandrographolide, Andrograpanin, etc.) and A. paniculata is also found to be a potent free radical scavenger (anti-oxidant) assessed by DPPH in in-vitro condition. Oxidative stress is of major complication reported in snake bitten patient's further worsening the clinical condition and requiring an additional treatment with anti-oxidants in long-term. In conclusion, the phytochemicals of A. paniculata is found to be a potent inhibitor of natural origin targeting PLA A2 to neutralize snake venom.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Andrographis paniculata ; Daboia russelii ; active sites ; chemical constituents of plants ; databases ; enzyme inhibition ; free radical scavengers ; lead ; neurotoxicity ; neutralization ; oxidative stress ; patients ; phospholipase A2 ; prediction ; snake venoms ; snakes ; Asia
    Language English
    Dates of publication 2019-03
    Size p. 101058.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2642052-1
    ISSN 1878-8181
    ISSN 1878-8181
    DOI 10.1016/j.bcab.2019.101058
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Prevalence of Onychomycosis in the Psoriatic Patients in a Tertiary Care Hospital, Chennai, Tamil Nadu, India

    K. Sangeetha / K.S. Sridharan / S Murugan / P Kennedy Kumar

    National Journal of Laboratory Medicine, Vol 8, Iss 2, Pp MO08-MO

    2019  Volume 10

    Abstract: Introduction: Psoriasis is a common chronic hyper proliferative skin disorder, with involvement of nail in about 25% patients. Onychomycosis is the fungal infection of the nail which also affects the psoriatic patients and thereby increasing ... ...

    Abstract Introduction: Psoriasis is a common chronic hyper proliferative skin disorder, with involvement of nail in about 25% patients. Onychomycosis is the fungal infection of the nail which also affects the psoriatic patients and thereby increasing disfigurement of nail in already clinically affected condition. Aim: To know the prevalence of onychomycosis in psoriatic patient with nail involvement. To determine the mycological profile of onychomycosis in psoriasis patient and to perform the antifungal susceptibility testing for the fungus isolated. Materials and Methods: A cross-sectional study was done for period of one year in a tertiary care center after obtaining institutional ethical clearance. Nail scrapings were taken after proper disinfection and subjected to KOH and cultured in Sabouraud's dextrose agar and Dermatophyte test medium and incubated upto four weeks. Tubes which were showing growth were further processed for identification of species and antifungal susceptibility test was done. Tubes which did not show growth at the end of four weeks were reported as no growth. Results: Total number of samples was 86. We had around 61.62% of males and rest were females. Most of our patients were in the age group of 51 to 70 years. Four out of 86 samples grew fungus of which two were Candida tropicalis and Fusarium oxysporum and Alternaria alternata. There was no dermatophyte isolated. We did not encountered any resistance. Conclusion: It is better to screen for fungal infection of nails in psoriatic patients with nail involvement. As the fungal infection will cause more destruction and disfigurement, appropriate antifungal therapy if started early will have better clinical outcome.
    Keywords alternaria alternata ; candida tropicalis ; dermatophyte ; fusarium oxysporum ; Microbiology ; QR1-502 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher JCDR Research and Publications Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Groundwater Modelling Using Visual Modflow in Tirupur Region, Tamilnadu, India

    K. Arumugam, T. Karthika, K. Elangovan, R.K. Sangeetha and S. Vikashini

    Nature Environment and Pollution Technology, Vol 19, Iss 4, Pp 1423-

    2020  Volume 1433

    Abstract: Most of the textile and dying process industries in Tirupur region do not have proper wastewater treatment plants and they discharge the effluents in unlined channels and streams. Due to the issue, the groundwater in Tirupur is highly polluted. For ... ...

    Abstract Most of the textile and dying process industries in Tirupur region do not have proper wastewater treatment plants and they discharge the effluents in unlined channels and streams. Due to the issue, the groundwater in Tirupur is highly polluted. For analysing groundwater condition, groundwater modelling is used. For groundwater hydrologist, groundwater models are a vital tool. Nowadays, a lot of computer programs have been used for modelling groundwater. Visual MODFLOW software uses a finite difference method for solving the complexity. They can be used for simulating the behaviour of composite aquifers as well as the effects of irregular boundaries and different processes such as solute transport and groundwater flow. This paper evaluates the impact of industrial effluent in groundwater value in Tirupur region by five different scenarios.
    Keywords environment ; Environmental effects of industries and plants ; TD194-195 ; Science (General) ; Q1-390
    Subject code 550
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Technoscience Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Spectral characterisation, antiviral activities, in silico ADMET and molecular docking of the compounds isolated from Tectona grandis to chikungunya virus.

    K, Sangeetha / Purushothaman, Indu / S, Rajarajan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2017  Volume 87, Page(s) 302–310

    Abstract: Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the ... ...

    Abstract Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the need for the development of potential antiviral drugs to Chikungunya virus. Hence, we studied the antiviral activity of the extracts and compounds isolated from Tectona grandis leaves to both the Asian and East central South African strains of Chikungunya virus. Five compounds were isolated from the ethanolic extract of Tectona grandis by bioactivity guided fractionation followed by Spectral Characterisation through GC-MS and NMR spectroscopy and investigated for the antiviral activity. Also in silico ADMET and Molecular Docking of the characterised compounds against the structural and non structural proteins of Chikungunya virus were performed. The characterised compound Benzene-1-carboxylic acid hexadeconate was effective at IC 50 3.036μg/ml (7.5μM) and 76.46μg/ml (189.02μM) to Asian and ECSA strain of CHIKV respectively. The compound showed desirable pharmacokinetic properties and significant molecular interactions with the E1 protein of Chikungunya virus by in silico analysis. Thus Benzene-1-carboxylic acid-2-hexadeconate isolated from Tectona grandis was found to be a promising drug candidate to both the Asian and ECSA strains of Chikungunya virus with high selectivity indices in comparison to the reference RNA antiviral drug Ribavirin.
    MeSH term(s) Animals ; Antiviral Agents/isolation & purification ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Cercopithecus aethiops ; Chikungunya virus/drug effects ; Chikungunya virus/metabolism ; Computer Simulation ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Lamiaceae ; Magnetic Resonance Spectroscopy/methods ; Molecular Docking Simulation/methods ; Plant Extracts/isolation & purification ; Plant Extracts/metabolism ; Plant Extracts/pharmacology ; Vero Cells
    Chemical Substances Antiviral Agents ; Plant Extracts
    Language English
    Publishing date 2017-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2016.12.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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